Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase

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Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JM801556H
P932PMC publication ID2782628
P698PubMed publication ID19323559

P50authorRobert H MachQ88117640
P2093author name stringDong Zhou
Michael J Welch
Delphine L Chen
Hsiaoju Lee
Justin M Rothfuss
Datta E Ponde
P2860cites work2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivoQ24755844
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Inhibition of nitric oxide synthase as a potential therapeutic targetQ33636670
Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitorsQ33793673
Nitric oxide in the pathogenesis of vascular diseaseQ33843539
Blocking NO synthesis: how, where and why?Q35013972
The role of nitric oxide in cancerQ35045661
Regulatory effects of iNOS on acute lung inflammatory responses in miceQ35843243
Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coinQ36137784
Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donorsQ36138113
Molecular pathophysiology of Parkinson's diseaseQ36196507
Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expressionQ38339628
BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthaseQ40027935
The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthaseQ40362241
Molecular mechanisms and therapeutic strategies related to nitric oxide.Q40413002
GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivoQ40444904
Nitric oxide synthase structure and mechanismQ40487439
Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracersQ41144499
Identification of N-iminoethyl-l-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cellsQ41706646
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivityQ42068720
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.Q42275426
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivoQ42551195
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potencyQ43591287
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.Q44910629
Effects of NG-nitro-L-arginine and L-arginine on regional cerebral blood flow in the catQ45177787
Importance of basal nitric oxide synthesis in regulation of myocardial blood flow.Q54291105
Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysacchride treatment in vivo in the ratQ61712889
Control of regional blood flow by endothelium-derived nitric oxideQ68767825
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoformsQ70939319
Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrullineQ71650800
Immunochemical localization of inducible nitric oxide synthase in endotoxin-treated ratsQ71657787
S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivoQ71692350
Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysineQ73604406
A potent inhibitor of inducible nitric oxide synthase, ONO-1714, a cyclic amidine derivativeQ73642569
Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitorQ73698455
Substituted 2-aminopyridines as inhibitors of nitric oxide synthasesQ74315108
Lung, spleen, and kidney are the major places for inducible nitric oxide synthase expression in endotoxic shock: role of p38 mitogen-activated protein kinase in signal transduction of inducible nitric oxide synthase expressionQ75447445
Catalysis by nitric oxide synthaseQ77565785
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectdrug discoveryQ1418791
P304page(s)2443-53
P577publication date2009-04-23
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleDesign and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase
P478volume52

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