The current status of targeting BAFF/BLyS for autoimmune diseases

scientific article

The current status of targeting BAFF/BLyS for autoimmune diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1026373629
P356DOI10.1186/AR1222
P932PMC publication ID546289
P698PubMed publication ID15380033
P5875ResearchGate publication ID8334948

P2093author name stringAnne Davidson
Meera Ramanujam
P2860cites workSynthesis and release of B-lymphocyte stimulator from myeloid cellsQ73335981
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in miceQ74108088
Lymphoid neogenesis in rheumatoid synovitisQ74147962
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLySQ74419758
Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivityQ74433998
Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cellsQ74460576
BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complexQ79313873
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune diseaseQ22254041
DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFFQ24309087
APRIL modulates B and T cell immunityQ24552299
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2Q27639845
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulatorQ28139180
Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulatorQ28183674
BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseasesQ28205999
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRILQ28216755
APRIL-deficient mice have normal immune system developmentQ28511017
BCMA is essential for the survival of long-lived bone marrow plasma cellsQ28587037
Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient miceQ28587370
Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases.Q33951524
B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a "natural immune memory".Q33996226
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndromeQ34108411
Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptorQ34178508
BAFF AND APRIL: a tutorial on B cell survivalQ34994661
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.Q35140484
TWE-PRIL; a fusion protein of TWEAK and APRILQ35557596
Peripheral B-cell maturation: the intersection of selection and homeostasisQ35666676
Pathogenic roles of B cells in human autoimmunity; insights from the clinicQ35772863
Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune responseQ36368953
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestationsQ36375661
G-CSF-stimulated neutrophils are a prominent source of functional BLySQ41818295
Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cellsQ42079747
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.Q44223059
Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF.Q44471579
Engineering an APRIL-specific B cell maturation antigenQ44756940
Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritisQ46397162
Cutting edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival functionQ47283207
Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.Q47365613
BAFF production by antigen-presenting cells provides T cell co-stimulation.Q51025017
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
A single autosomal gene defect severely limits IgG but not IgM responses in B lymphocyte-deficient A/WySnJ miceQ52078930
Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.Q52114309
Mechanism of action of transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosusQ56903374
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent PathwayQ57230082
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectpeptideQ172847
membrane proteinQ423042
blood proteinsQ425056
cell surface receptorQ2476074
autoimmune diseaseQ8084905
tumor necrosis factorQ21173843
P304page(s)197-202
P577publication date2004-07-29
P1433published inArthritis Research and TherapyQ15757229
P1476titleThe current status of targeting BAFF/BLyS for autoimmune diseases
P478volume6

Reverse relations

cites work (P2860)
Q30482886Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea
Q36158684B cells as a therapeutic target in autoimmune diseases
Q33573335BAFF mediates splenic B cell response and antibody production in experimental Chagas disease.
Q87115803BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice
Q37236244CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells.
Q36993221Developments in the scientific understanding of lupus
Q33373525High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura
Q33380975Prevention of murine antiphospholipid syndrome by BAFF blockade
Q34350295Similarities and differences between selective and nonselective BAFF blockade in murine SLE
Q37060593Targeting of the immune system in systemic lupus erythematosus
Q36321299The BAFF/APRIL system in systemic autoimmune diseases with a special emphasis on Sjögren's syndrome
Q24681044The future of biologic agents in the treatment of Sjögren's syndrome
Q34514923The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus
Q56902282[New therapeutic approaches to autoimmune diseases]

Search more.