Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa

scientific article

Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1037818345
P356DOI10.1186/1475-2875-2-46
P932PMC publication ID317348
P698PubMed publication ID14675491
P5875ResearchGate publication ID8960400

P50authorAlexis NzilaQ28913763
Kevin MarshQ30102986
Theonest MutabingwaQ79073290
P2093author name stringEdwin Ochong
Serah Kimani
William Watkins
Gilbert Kokwaro
P2860cites workMolecular surveillance of the antifolate-resistant mutation I164L in imported African isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEuropQ24807035
The development of Lapdap, an affordable new treatment for malariaQ28180054
Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasitesQ33979170
Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?Q34470236
Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatmentQ38958419
The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analysesQ41913682
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in TanzaniaQ41918630
Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malariaQ43796087
Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from TanzaniaQ43949629
A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasitesQ44495547
P433issue1
P921main subjectpyrimethamineQ421072
P304page(s)46
P577publication date2003-12-15
P1433published inMalaria JournalQ15749954
P1476titleMolecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa
P478volume2

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cites work (P2860)
Q37223629Chloroquine resistance before and after its withdrawal in Kenya
Q37333178In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation
Q34657000Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure
Q36075911Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?

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