The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update

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The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1289/EHP.02110S5767
P932PMC publication ID1241242
P698PubMed publication ID12426129
P5875ResearchGate publication ID11040955

P2093author name stringDavid J Thomas
Ilona Jaspers
Miroslav Stýblo
Zuzana Drobná
Shan Lin
P2860cites workArsenic induces oxidant stress and NF-KB activation in cultured aortic endothelial cellsQ23909531
Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivationQ23923186
Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamilyQ24291575
The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphataseQ24561826
Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urineQ24811006
Dermatotoxic chemical stimulate of c-jun and c-fos transcription and AP-1 DNA binding in human keratinocytesQ26344234
Mechanisms of arsenic carcinogenicity: genetic or epigenetic mechanisms?Q26345064
Thioredoxin and glutaredoxin systemsQ28271236
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductaseQ28377855
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosolQ28584169
Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductaseQ33887956
Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytesQ33891890
Speciation of key arsenic metabolic intermediates in human urine.Q33925487
Methylated trivalent arsenic species are genotoxicQ33942554
Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolitesQ33943279
Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase.Q33951760
Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liverQ34062420
Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfideQ34313529
The cellular metabolism and systemic toxicity of arsenicQ34401625
Drinking water and cancerQ34834122
Arsenic ingestion and internal cancers: a reviewQ36039612
Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenicQ40751318
Determination of trivalent methylated arsenicals in biological matrices.Q40788453
Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytesQ40811439
Induction of p53 protein expression by sodium arseniteQ41071070
Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India.Q43576159
Reactions of arsenic(III) and arsenic(V) species with glutathioneQ46619791
Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in man.Q49226505
Arsenic in drinking water and incidence of urinary cancers.Q50938966
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cellsQ56114256
Mono- and dimethylation of arsenic in rat liver cytosol in vitroQ71056467
Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance studyQ72360120
Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductaseQ73091945
Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiolsQ73165117
P407language of work or nameEnglishQ1860
P921main subjectarsenicQ871
inorganic compoundQ190065
toxicityQ274160
dysplasiaQ1128996
P304page(s)767-771
P577publication date2002-10-01
P1433published inEnvironmental Health PerspectivesQ1345904
P1476titleThe role of biomethylation in toxicity and carcinogenicity of arsenic: a research update
P478volume110 Suppl 5

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