Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity

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Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.0020005
P3181OpenCitations bibliographic resource ID437232
P932PMC publication ID1354197
P698PubMed publication ID16446783
P5875ResearchGate publication ID7326709

P50authorPaul SumbyQ42578429
Frank R. DeLeoQ48467582
James M MusserQ87137865
P2093author name stringEdward A Graviss
Adeline R Whitney
P2860cites workVariation occurring in group A streptococci during human infection; progressive loss of M substance correlated with increasing susceptibility to bacteriostasisQ42240866
Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyogenes result in enhanced virulence in a murine model of skin and soft tissue infectionQ43834347
Mouse skin passage of Streptococcus pyogenes results in increased streptokinase expression and activityQ44758447
Binding of the global response regulator protein CovR to the sag promoter of Streptococcus pyogenes reveals a new mode of CovR-DNA interactionQ46713390
Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A StreptococcusQ48014401
Invasion and survival of Streptococcus pyogenes in eukaryotic cells correlates with the source of the clinical isolates.Q48023972
Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule.Q51610762
Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes.Q53662483
An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infectionsQ57661129
A secreted streptococcal cysteine protease can cleave a surface-expressed M1 protein and alter the immunoglobulin binding propertiesQ77489074
Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulinQ77772105
Evolutionary Origin and Emergence of a Highly Successful Clone of Serotype M1 Group A Streptococcus Involved Multiple Horizontal Gene Transfer EventsQ22066116
Phase and antigenic variation in bacteriaQ24561666
C5a peptidase alters clearance and trafficking of group A streptococci by infected miceQ24672257
Pathogenesis of group A streptococcal infectionsQ29615547
Insight into the molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cellsQ30732369
Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB.Q31030256
alpha2-Macroglobulin-proteinase complexes protect Streptococcus pyogenes from killing by the antimicrobial peptide LL-37.Q33208588
Genetic inactivation of an extracellular cysteine protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organsQ33750595
Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenesQ33769440
Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune responseQ33818341
Growth characteristics of and virulence factor production by group A Streptococcus during cultivation in human salivaQ33946900
Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infectionQ33986323
A response regulator that represses transcription of several virulence operons in the group A streptococcusQ33992290
Absence of SpeB production in virulent large capsular forms of group A streptococcal strain 64Q34003284
Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection casesQ34005015
Reciprocal, temporal expression of SpeA and SpeB by invasive M1T1 group a streptococcal isolates in vivoQ34008621
STUDIES ON THE BIOLOGY OF STREPTOCOCCUS : I. ANTIGENIC RELATIONSHIPS BETWEEN STRAINS OF STREPTOCOCCUS HAEMOLYTICUSQ34019938
Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenesQ34118071
Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modelingQ34161889
Proteolysis and its regulation at the surface of Streptococcus pyogenesQ34585533
The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+Q34923224
Group A Streptococcus transcriptome dynamics during growth in human blood reveals bacterial adaptive and survival strategiesQ35083669
Toward a genome-wide systems biology analysis of host-pathogen interactions in group A StreptococcusQ35094453
Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactionsQ35143103
Bacterial pathogens modulate an apoptosis differentiation program in human neutrophilsQ35978720
Streptococcus pyogenes infection in mouse skin leads to a time-dependent up-regulation of protein H expressionQ36046972
Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenesQ36483726
Contribution of CsrR-regulated virulence factors to the progress and outcome of murine skin infections by Streptococcus pyogenes.Q40469599
Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosisQ40592686
Comparison of pathogenic factors expressed by group A Streptococci isolated from patients with streptococcal toxic shock syndrome and scarlet feverQ40632161
VARIANTS OF HEMOLYTIC STREPTOCOCCI; THEIR RELATION TO TYPE-SPECIFIC SUBSTANCE, VIRULENCE, AND TOXINQ42202163
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
P304page(s)e5
P577publication date2006-01-27
P1433published inPLOS PathogensQ283209
P1476titleGenome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity
P478volume2