Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy

scientific article

Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.2147/DDDT.S104225
P3181OpenCitations bibliographic resource ID4635657
P932PMC publication ID4939993
P698PubMed publication ID27462141

P50authorElena VerzoniQ39606195
Giuseppe ProcopioQ39606238
Paolo GrassiQ42343466
Raffaele RattaQ56697492
Filippo de BraudQ37837953
P2093author name stringAlessia Mennitto
P2860cites workThe Met receptor tyrosine kinase: a key player in oncogenesis and drug resistanceQ38175267
A phase I study of cabozantinib (XL184) in patients with renal cell cancer.Q38430335
Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesionsQ39085630
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growthQ39472261
Nivolumab versus Everolimus in Advanced Renal-Cell CarcinomaQ41316099
HGF/c-Met Acts as an Alternative Angiogenic Pathway in Sunitinib-Resistant TumorsQ42819341
MET is a potential target across all papillary renal cell carcinomas: result from a large molecular study of pRCC with CGH array and matching gene expression arrayQ46111473
Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors.Q53494761
MET as a target in papillary renal cell carcinomaQ87843055
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisQ24608039
c-Met as a Target for Personalized TherapyQ26775483
Cancer treatment and survivorship statistics, 2012Q27020961
Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinomaQ27851979
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trialQ29618031
Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trialQ33946929
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cellsQ33959078
High expression of the Met receptor in prostate cancer metastasis to boneQ34163761
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Q34217927
Cabozantinib versus Everolimus in Advanced Renal-Cell CarcinomaQ34495684
Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma modelsQ34978329
MET and VEGF: synergistic targets in castration-resistant prostate cancerQ35575488
c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinomaQ36551653
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancerQ36822111
Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screenQ36954859
Targeting the Met signaling pathway in renal cancer.Q37331862
Novel therapeutic inhibitors of the c-Met signaling pathway in cancerQ37422804
Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.Q37430185
Importance of fibroblast growth factor receptor in neovascularization and tumor escape from antiangiogenic therapyQ37989752
Targeting the hepatocyte growth factor/c-Met signaling pathway in renal cell carcinomaQ38122564
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P407language of work or nameEnglishQ1860
P921main subjectrenal cell carcinomaQ1164529
antineoplasticQ2853144
drug designQ2991682
anilidesQ4066270
pyridineQ47317020
kidney neoplasmQ13641482
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)2167-72
P577publication date2016-07-05
P1433published inDrug Design, Development and TherapyQ2566724
P1476titleCabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy
P478volume10

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cites work (P2860)
Q47143379A network meta-analysis of short-term efficacy of different single-drug targeted therapies in the treatment of renal cell carcinoma
Q39026733Cabozantinib: A Review in Advanced Renal Cell Carcinoma
Q47283034Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma
Q49887919Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors
Q41346916Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in in vitro and in vivo models of renal cell carcinoma
Q39092934Treatment options in advanced renal cell carcinoma after first-line treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors

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