Targeting folate receptor alpha for cancer treatment

scientific article

Targeting folate receptor alpha for cancer treatment is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.9651
P3181OpenCitations bibliographic resource ID4315249
P932PMC publication ID5239573
P698PubMed publication ID27248175

P50authorAnita GrigoriadisQ42396329
Sophia N. KaragiannisQ40726155
James OpzoomerQ58664750
Matthew FittallQ58664760
James SpicerQ86599148
P2093author name stringDebra H Josephs
Heather J Bax
Silvana Canevari
Andrew N Tutt
Mariangela Figini
Kristina M Ilieva
Anthony Cheung
Giulia Pellizzari
Jacinta Bloomfield
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Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinomaQ33179143
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Releasing the Brakes on Cancer Immunotherapy.Q45976317
Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy.Q46028084
Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor betaQ46111695
A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophagesQ46294712
Folate receptor α associated with triple-negative breast cancer and poor prognosisQ46471016
Expression status of folate receptor alpha is significantly correlated with prognosis in non-small-cell lung cancers.Q46818493
Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity.Q52833032
Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases.Q53358319
Phase I clinical trial of 99mTc-etarfolatide, an imaging agent for folate receptor in healthy Japanese adults.Q53396871
Folate receptor overexpression is associated with poor outcome in breast cancer.Q53554648
Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.Q53555425
New Strategies in Breast Cancer: Immunotherapy.Q54215651
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Targeting the folate receptor: diagnostic and therapeutic approaches to personalize cancer treatmentsQ38524502
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Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expressionQ38940035
Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathwayQ39200111
Farletuzumab, an anti-folate receptor α antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitroQ39340367
Serous ovarian carcinoma patients with high alpha-folate receptor had reducing survival and cytotoxic chemo-response.Q39408740
Antitumor effects of a human dimeric antibody fragment 131I-AFRA-DFM5.3 in a mouse model for ovarian cancerQ39446133
Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity.Q39543380
Multicenter trial of EC145 in advanced, folate-receptor positive adenocarcinoma of the lungQ39552028
Breast cancers: MR imaging of folate-receptor expression with the folate-specific nanoparticle P1133.Q39711656
In vivo structural activity and optimization studies of folate-tubulysin conjugatesQ39821190
Conversion of murine antibodies to human antibodies and their optimization for ovarian cancer therapy targeted to the folate receptor.Q40059215
Flow cytometric method for determining folate receptor expression on ovarian carcinoma cellsQ40090882
IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells.Q40091329
Role of IgE receptors in IgE antibody-dependent cytotoxicity and phagocytosis of ovarian tumor cells by human monocytic cells.Q40101714
Folate receptor-specific antitumor activity of EC131, a folate-maytansinoid conjugateQ40110187
Three-colour flow cytometric method to measure antibody-dependent tumour cell killing by cytotoxicity and phagocytosisQ40127445
Complement activated by chimeric anti-folate receptor antibodies is an efficient effector system to control ovarian carcinomaQ40296292
Escalating protein doses of chimeric monoclonal antibody MOv18 immunoglobulin G in ovarian carcinoma patients: a phase I studyQ40644063
Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studiesQ40646570
Regression of Advanced Ovarian Carcinoma by Intraperitoneal Treatment With Autologous TLymphocytes Retargeted by a Bispecific Monoclonal AntibodyQ40678959
Chimeric murine-human antibodies directed against folate binding receptor are efficient mediators of ovarian carcinoma cell killingQ41472501
A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumorsQ57975528
Single-dose intraperitoneal radioimmunotherapy with the murine monoclonal antibody I-131 MOv18: Clinical results in patients with minimal residual disease of ovarian cancerQ60442191
Kinetics and tissue distribution of the radiolabeled chimeric monoclonal antibody MOv18 IgG and F(ab')2 fragments in ovarian carcinoma patientsQ72559537
Development of a tumor-targeting MR contrast agent using the high-affinity folate receptor: work in progressQ73364096
Cellular and humoral responses after multiple injections of unconjugated chimeric monoclonal antibody MOv18 in ovarian cancer patients: a pilot studyQ74813455
Dosimetric analysis of chimeric monoclonal antibody cMOv18 IgG in ovarian carcinoma patients after intraperitoneal and intravenous administrationQ77501378
Level of anti-mouse-antibody response induced by bi-specific monoclonal antibody OC/TR in ovarian-carcinoma patients is associated with longer survivalQ78167058
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazideQ79998073
Vaccination with dendritic cells transfected with mRNA-encoded folate-receptor-alpha for relapsed metastatic ovarian cancerQ80233809
Reducing Undesirable Hepatic Clearance of a Tumor-Targeted Vinca Alkaloid via Novel Saccharopeptidic ModificationsQ82067772
The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancerQ84290611
Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancerQ86328482
PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancerQ86532062
Degradation of BMS-753493, a novel epothilone folate conjugate anticancer agentQ87412887
Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancerQ34979610
A step further in understanding the biology of the folate receptor in ovarian carcinoma.Q35066040
Membrane transport of folatesQ35173884
Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospects.Q35204546
Folate receptor-α (FOLR1) expression and function in triple negative tumorsQ35225064
Oncolytic virotherapy for ovarian cancerQ35597082
Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapyQ35749863
Folate receptor endocytosis and traffickingQ35749871
Antifolates targeted specifically to the folate receptorQ35749876
Folate-receptor-targeted radionuclide imaging agentsQ35749885
Folate receptor alpha expression in lung cancer: diagnostic and prognostic significanceQ36050687
High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutationQ36059727
The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathwayQ36222686
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancerQ36299662
Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome.Q36380927
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsQ36467564
Phase 1b safety study of farletuzumab, carboplatin and pegylated liposomal doxorubicin in patients with platinum-sensitive epithelial ovarian cancerQ36508941
Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptorQ36557169
The folate receptor: what does it promise in tissue-targeted therapeutics?Q36749423
In vitro assembly of repertoires of antibody chains on the surface of phage by renaturationQ36751560
Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4.Q36808757
Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative diseaseQ37052124
Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patientsQ37109499
Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124Q37148242
Folate receptor alpha as a tumor target in epithelial ovarian cancerQ37254805
Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945.Q37479804
The antitumor activity of the human FOLR1-specific monoclonal antibody, farletuzumab, in an ovarian cancer mouse model is mediated by antibody-dependent cellular cytotoxicity.Q37586901
IgE immunotherapy: a novel concept with promise for the treatment of cancerQ37593712
Comparative reactivity of human IgE to cynomolgus monkey and human effector cells and effects on IgE effector cell potency.Q37698945
Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application.Q37964490
EC145: a novel targeted agent for adenocarcinoma of the lungQ37998528
Anti-tumour strategies aiming to target tumour-associated macrophages.Q38056746
Folate and fetal programming: a play in epigenomics?Q38087764
Imaging the folate receptor on cancer cells with 99mTc-etarfolatide: properties, clinical use, and future potential of folate receptor imaging.Q38204578
P275copyright licenseCreative Commons Attribution 2.5 GenericQ18810333
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectfolic acidQ127060
neoplasmQ1216998
Folate receptor alphaQ21107386
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)52553-52574
P577publication date2016-05-27
2016-08-09
P1433published inOncotargetQ1573155
P1476titleTargeting folate receptor alpha for cancer treatment
P478volume7

Reverse relations

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