First-line therapy in HER2 positive metastatic breast cancer: is the mosaic fully completed or are we missing additional pieces?

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First-line therapy in HER2 positive metastatic breast cancer: is the mosaic fully completed or are we missing additional pieces? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1028228182
P356DOI10.1186/S13046-016-0380-5
P3181OpenCitations bibliographic resource ID338496
P932PMC publication ID4928292
P698PubMed publication ID27357210

P2093author name stringFrancesco Cognetti
Alessandra Fabi
Sabrina Vari
Paola Malaguti
P2860cites workUse of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
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Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancerQ27852071
Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancerQ27853134
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
New trends for overcoming ABCG2/BCRP-mediated resistance to cancer therapiesQ28067499
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Sequence analysis of mutations and translocations across breast cancer subtypesQ34032470
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexQ34314489
Molecular signatures of lymph node status by intrinsic subtype: gene expression analysis of primary breast tumors from patients with and without metastatic lymph nodesQ35066446
Treatment of HER2-positive breast cancer.Q35740877
Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancerQ35987082
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Present and future breast cancer management--bench to bedside and back: a positioning paper of academia, regulatory authorities and pharmaceutical industry.Q51327778
Effects on quality of life of combined trastuzumab and chemotherapy in women with metastatic breast cancer.Q53426459
Ado-trastuzumab Emtansine (T-DM1): an antibody-drug conjugate (ADC) for HER2-positive breast cancer.Q54342129
Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer - results of the eLEcTRA trial.Q54566127
CEREBEL (EGF111438): A Phase III, Randomized, Open-Label Study of Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.Q55068564
Central Nervous System Metastases in HER-2 Positive Metastatic Breast Cancer Patients Treated with Trastuzumab: Incidence, Survival, and Risk FactorsQ58849618
Clinical implementation of the intrinsic subtypes of breast cancerQ59565395
Clinical Utility of Continuing Trastuzumab Beyond Brain Progression in HER-2 Positive Metastatic Breast CancerQ62581294
HER2 inhibition: from discovery to clinical practiceQ79476874
Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane studyQ80574611
Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumabQ81151636
Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEMQ84592604
HER-2-positive metastatic breast cancer: trastuzumab and beyondQ94706721
Early-onset colorectal cancer patients without family history are "at very low risk" for lynch syndromeQ37479736
Locally recurrent or metastatic breast cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up.Q37489025
Baseline staging tests based on molecular subtype is necessary for newly diagnosed breast cancerQ37716326
New target therapies for brain metastases from breast cancerQ37977974
Trastuzumab emtansine (T-DM1) for HER2-positive breast cancer.Q38080898
Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology clinical practice guidelineQ38209628
Neratinib Plus Paclitaxel vs Trastuzumab Plus Paclitaxel in Previously Untreated Metastatic ERBB2-Positive Breast Cancer: The NEfERT-T Randomized Clinical TrialQ38393636
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor modelsQ39771295
Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumorsQ40059109
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.Q40073729
Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapyQ40138970
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic diseaseQ40630247
Potential biomarkers of long-term benefit from single-agent trastuzumab or lapatinib in HER2-positive metastatic breast cancerQ41134799
Activity of T-DM1 in Her2-positive breast cancer brain metastasesQ41455800
Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1): a phase 3, randomised, double-blind, multicentre trial.Q41655720
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancerQ43270036
Breast cancer brain metastases responding to primary systemic therapy with T-DM1.Q43621364
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancerQ43937165
Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 StudyQ46256397
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmetastatic breast cancerQ12859063
Erb-b2 receptor tyrosine kinase 2Q415271
breast neoplasmQ23929670
antineoplastic combined chemotherapy protocolsQ66764603
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)104
P577publication date2016-06-30
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleFirst-line therapy in HER2 positive metastatic breast cancer: is the mosaic fully completed or are we missing additional pieces?
P478volume35

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cites work (P2860)
Q90482919Administration of trastuzumab with heart irradiation induced acute cardiotoxicity in mice
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Q57111760Cardiac Toxicity from Breast Cancer Treatment: Can We Avoid This?
Q52627331Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells.
Q47435154Efficacy and safety of a combination of HER2-targeted agents as first-line treatment for metastatic HER2-positive breast cancer: a network meta-analysis
Q90412342HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases
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Q54979386Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion.

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