Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy

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Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FIMMU.2016.00157
P3181OpenCitations bibliographic resource ID2104780
P932PMC publication ID4842769
P698PubMed publication ID27199983
P5875ResearchGate publication ID301221115

P50authorDorin-Bogdan BorzaQ40709048
P2093author name stringDorin-Bogdan Borza
P2860cites workA Temporal Model of Human IgE and IgG Antibody FunctionQ21131207
The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activationQ81009325
Urinary heparanase activity in patients with Type 1 and Type 2 diabetesQ83082153
IgG subclass staining in renal biopsies with membranous glomerulonephritis indicates subclass switch during disease progressionQ85913681
Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasisQ22010222
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complementQ24619612
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathyQ24652978
Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical reviewQ26782025
Structural basis for sialic acid-mediated self-recognition by complement factor HQ27696183
Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complementQ28141398
The human complement factor H: functional roles, genetic variations and disease associationsQ28263548
A new map of glycosaminoglycan and C3b binding sites on factor HQ28289935
Heparanase in glomerular diseasesQ28303555
Complement: a key system for immune surveillance and homeostasisQ29615484
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndromeQ33347509
Attachment of the soluble complement regulator factor H to cell and tissue surfaces: relevance for pathologyQ33358401
Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndromeQ33364092
Mechanisms of immune-deposit formation and the mediation of immune renal injuryQ33368686
Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functionsQ33369509
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndromeQ33375219
Factor H family proteins and human diseasesQ33380214
Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regionsQ33405609
Autoimmunity in membranous nephropathy targets aldose reductase and SOD2.Q33530824
Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor HQ33596128
Glomerular disease: looking beyond pathologyQ33715776
Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal diseaseQ33764140
Membranous nephropathy: from models to manQ33872569
Experimental membranous nephropathy reduxQ34248969
Rituximab therapy in idiopathic membranous nephropathy: a 2-year studyQ34362660
IgG subclasses and allotypes: from structure to effector functionsQ34368678
Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient miceQ34537391
Early-childhood membranous nephropathy due to cationic bovine serum albuminQ34660515
Complement in kidney disease: core curriculum 2015.Q34747321
Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathyQ34783516
The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr miceQ34813568
The role of properdin in the assembly of the alternative pathway C3 convertases of complementQ46814862
Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritisQ47298666
Differential expression of agrin in renal basement membranes as revealed by domain-specific antibodiesQ47891468
Membranous nephropathy in a patient with hereditary complete complement C4 deficiencyQ47924846
Urinary C5b-9 excretion and clinical course in idiopathic human membranous nephropathy.Q51038554
Factors influencing susceptibility of LEW rats to heymann nephritisQ52212072
Immunohistopathologic evaluation of C1q in 800 renal biopsy specimens.Q55061113
Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm ExchangeQ55178105
A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in miceQ61415573
Inhibition of complement activation by IgG4 antibodiesQ61601640
Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathiesQ61849373
Antenatal Membranous Glomerulonephritis Due to Anti–Neutral Endopeptidase AntibodiesQ61849375
Urinary C3dg and C5b-9 indicate active immune disease in human membranous nephropathyQ67547023
Demonstration of C3d deposits in membranous nephropathyQ70370081
Distribution of IgG subclasses in membranous nephropathyQ70380725
The temporal relationship between urinary C5b-9 and C3dg and clinical parameters in human membranous nephropathyQ70467772
Distribution of GBM heparan sulfate proteoglycan core protein and side chains in human glomerular diseasesQ70580293
Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritisQ71682513
Identification of complement regulatory domains in human factor HQ71700078
Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding proteinQ71803052
No complement receptor 1 stumps on podocytes in human glomerulopathiesQ73338477
Reduction in glomerular heparan sulfate correlates with complement deposition and albuminuria in active Heymann nephritisQ78124929
Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfacesQ79287502
Glomerular deposition and urinary excretion of complement factor H in idiopathic membranous nephropathyQ80497195
A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritisQ80907742
Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathyQ35142743
Hyperlipidemia and thrombotic complications in patients with membranous nephropathyQ35201542
Murine membranous nephropathy: immunization with α3(IV) collagen fragment induces subepithelial immune complexes and FcγR-independent nephrotic syndrome.Q35851046
The role of complement in inflammatory diseases from behind the scenes into the spotlightQ35963146
Contrasting roles of complement activation and its regulation in membranous nephropathyQ36084446
Cellular response to injury in membranous nephropathyQ36084457
Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunizationQ36084460
Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy.Q36199508
Treatment of idiopathic membranous nephropathyQ36280345
Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathyQ36280364
Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritisQ36401571
Recurrent membranous nephropathy in an allograft caused by IgG3κ targeting the PLA2 receptorQ36426142
Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration.Q36804333
Immunosuppression for membranous nephropathy: a systematic review and meta-analysis of 36 clinical trialsQ36810470
A new role for complement in experimental membranous nephropathy in ratsQ37026755
The C-terminus of complement factor H is essential for host cell protectionQ37238656
Rituximab therapy for membranous nephropathy: a systematic reviewQ37412829
A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injuryQ37434667
The pathogenesis of idiopathic membranous nephropathy: a 50-year odysseyQ37727594
Neonatal Fc receptor promotes immune complex-mediated glomerular diseaseQ37733571
CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulationQ38080868
Properdin in complement activation and tissue injuryQ38118454
The role of complement in membranous nephropathyQ38155652
The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?Q38171012
Glomerular deposition of mannose-binding lectin in human glomerulonephritisQ38324829
Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathyQ39476063
Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus nephritis in miceQ40607655
Efficacy of Targeted Complement Inhibition in Experimental C3 GlomerulopathyQ40865063
Pathogenesis of glomerular damage in glomerulonephritisQ40866501
Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathyQ40922243
Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in ratsQ41866765
Glomerular C3c localization indicates ongoing immune deposit formation and complement activation in experimental glomerulonephritisQ41885401
IgG subclasses and complement pathway in segmental and global membranous nephropathy.Q43164390
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assemblyQ44441855
Effect of nephritogenic antibody on complement regulation in cultured rat glomerular epithelial cellsQ44939623
The Heymann nephritis antigenic complex: megalin (gp330) and RAP.Q46239590
Idiopathic membranous nephropathy: diagnosis and treatmentQ46781970
Genetic homogeneity but IgG subclass-dependent clinical variability of alloimmune membranous nephropathy with anti-neutral endopeptidase antibodiesQ46789719
P407language of work or nameEnglishQ1860
P921main subjectkidney diseaseQ1054718
P304page(s)157
P577publication date2016-04-25
P1433published inFrontiers in ImmunologyQ27723748
P1476titleAlternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy
P478volume7

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cites work (P2860)
Q50327901A New Classification System for IgG4 Autoantibodies
Q90424188Advances of the experimental models of idiopathic membranous nephropathy (Review)
Q55459963Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy.
Q39200048Complement regulation and kidney diseases: recent knowledge of the double-edged roles of complement activation in nephrology.
Q90398431Expression levels of complement regulatory proteins (CD35, CD55 and CD59) on peripheral blood cells of patients with chronic kidney disease
Q38949784Glomerular basement membrane heparan sulfate in health and disease: A regulator of local complement activation
Q38959093Membranous nephropathy in the kidney allograft
Q37699835Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy
Q49947954The role of the alternative pathway of complement activation in glomerular diseases

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