New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies

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New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/IJMS17050627
P3181OpenCitations bibliographic resource ID2044887
P932PMC publication ID4881453
P698PubMed publication ID27128908
P5875ResearchGate publication ID301706071

P50authorCharles H. LawrieQ55292658
Lorea ManterolaQ55459506
Ibai GoicoecheaQ57551608
Maria M CaffarelQ58887967
P2093author name stringMaría Arestin
María Armesto
María Araiz
Marta Fernandez-Mercado
Erika Larrea
Carla Sole
Angela M Araujo
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Tumor microRNA expression profiling identifies circulating microRNAs for early breast cancer detection.Q53474457
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Prognostic value of miR-106b expression in breast cancer patients.Q53628965
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Clinical significance of serum miR-223, miR-25 and miR-375 in patients with esophageal squamous cell carcinoma.Q54229169
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Circulating microRNAs in the cerebrospinal fluid of patients with brain diseases.Q54257764
Serum miR-21 and miR-92a as biomarkers in the diagnosis and prognosis of colorectal cancer.Q54261802
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Circulating miR-155 expression in plasma: a potential biomarker for early diagnosis of esophageal cancer in humans.Q54296735
Impact of miR-155 and miR-126 as novel biomarkers on the assessment of disease progression and prognosis in adult T-cell leukemia.Q54297101
Circulating miRNA is a novel marker for head and neck squamous cell carcinoma.Q54300178
Circulating microRNA profiles as potential biomarkers for diagnosis of papillary thyroid carcinoma.Q54316362
Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma.Q54339320
Analysis of circulating microRNA: preanalytical and analytical challenges.Q54378210
Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease.Q54408211
MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3.Q54424273
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer.Q54439228
Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer.Q54456800
Serum miR-210 as a potential biomarker of early clear cell renal cell carcinoma.Q54628347
Plasma miR-21 is a novel diagnostic biomarker for biliary tract cancer.Q54775725
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.Q54780999
The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platformQ54997659
Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival.Q34123686
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosisQ34125617
Circulating miR‐221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expressionQ34140780
MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive breast cancers by targeting PTEN.Q34179919
Circulating microRNAs (miRNA) in serum of patients with prostate cancerQ34182161
The majority of microRNAs detectable in serum and saliva is concentrated in exosomesQ34199626
Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosusQ34224780
miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitionsQ34237504
Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic CancerQ34241079
Promising Candidate Urinary MicroRNA Biomarkers for the Early Detection of Hepatocellular Carcinoma among High-Risk Hepatitis C Virus Egyptian PatientsQ34243908
Serum microRNA profiling and breast cancer risk: the use of miR-484/191 as endogenous controlsQ34251299
Analysis of serum genome-wide microRNAs for breast cancer detection.Q34258421
MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.Q34271306
The expression of microRNA-375 in plasma and tissue is matched in human colorectal cancerQ34273062
Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studiesQ34291952
Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancerQ34310243
miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPsQ34316535
Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF.Q34328740
Standardization of sample collection, isolation and analysis methods in extracellular vesicle researchQ34369038
Plasma microRNA are disease response biomarkers in classical Hodgkin lymphoma.Q34384556
microRNA-221 and microRNA-18a identification in stool as potential biomarkers for the non-invasive diagnosis of colorectal carcinoma.Q34439377
Circulating miR-17, miR-20a, miR-29c, and miR-223 combined as non-invasive biomarkers in nasopharyngeal carcinomaQ34441361
Deregulation of serum microRNA expression is associated with cigarette smoking and lung cancer.Q34441708
Serum microRNA-155 as a potential biomarker to track disease in breast cancerQ34447755
MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1Q34455072
Serum microRNA panel as biomarkers for early diagnosis of colorectal adenocarcinomaQ34499638
Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancerQ34526484
miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancerQ34544501
Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancerQ34591159
Identification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemiaQ34599349
Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancerQ34613472
Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancerQ34614989
Circulating miR-221 expression level and prognosis of cutaneous malignant melanomaQ34655391
Salivary microRNAs as promising biomarkers for detection of esophageal cancerQ34656109
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cellsQ24300024
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulatorsQ24336898
miRBase: microRNA sequences, targets and gene nomenclatureQ24538656
Characterization of extracellular circulating microRNAQ24603537
MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3Q24607952
Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic CancerQ24609577
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersQ24614672
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescenceQ24617045
MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1)Q24617676
miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancerQ24630894
let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblastsQ24644238
The potential of plasma miRNAs for diagnosis and risk estimation of colorectal cancer.Q35919291
Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinomaQ35926157
De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancerQ35927834
MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathwaysQ35930474
MicroRNA screening identifies circulating microRNAs as potential biomarkers for osteosarcomaQ35943345
Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer.Q35959203
MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activityQ36010084
Diagnostic, prognostic and predictive value of MicroRNA-21 in breast cancer patients, their daughters and healthy individuals.Q36057142
Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal NeoplasiaQ36070308
MicroRNAs in body fluids--the mix of hormones and biomarkersQ36176435
MicroRNA-125b functions as a tumor suppressor in hepatocellular carcinoma cellsQ36197303
MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasionQ36215845
Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemiaQ36262865
Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinomaQ36294432
Cell-free Circulating miRNA Biomarkers in CancerQ36316601
Serum miR-21 level: a potential diagnostic and prognostic biomarker for non-small cell lung cancerQ36317309
MicroRNA miR-16-1 regulates CCNE1 (cyclin E1) gene expression in human cervical cancer cellsQ36317789
Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarkerQ36324338
Circulating cell-free DNA in plasma/serum of lung cancer patients as a potential screening and prognostic toolQ36372817
Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancerQ36388236
miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours.Q36389324
Detection of Exosomal miRNAs in the Plasma of Melanoma PatientsQ36409368
miR-21 expression predicts prognosis in diffuse large B-cell lymphomaQ36464776
Differential Expression of MicroRNAs in Tissues and Plasma Co-exists as a Biomarker for Pancreatic CancerQ36498615
Serum miR-30e and miR-223 as Novel Noninvasive Biomarkers for Hepatocellular CarcinomaQ36509109
miR-34 miRNAs provide a barrier for somatic cell reprogrammingQ36522839
Differential expression of miRNAs in the serum of patients with high-risk oral lesionsQ36530712
Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5.Q36545576
MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathwayQ36557155
Analysis of miR-205 and miR-155 expression in the blood of breast cancer patientsQ36563207
Macrophage microvesicles induce macrophage differentiation and miR-223 transferQ36595322
Circulating miR-150 and miR-342 in plasma are novel potential biomarkers for acute myeloid leukemiaQ36630868
MicroRNAs in vitreus humor from patients with ocular diseasesQ36634670
Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cellsQ24649539
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.Q24651016
Suppression of non-small cell lung tumor development by the let-7 microRNA familyQ24651985
Circulating microRNAs as stable blood-based markers for cancer detectionQ24652098
A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequenceQ24652491
Most mammalian mRNAs are conserved targets of microRNAsQ24655061
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulationQ24655473
HuR recruits let-7/RISC to repress c-Myc expressionQ24657731
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationQ24658400
The tumor suppressor microRNA let-7 represses the HMGA2 oncogeneQ24681392
Circulating microRNAs: a potential role in diagnosis and prognosis of acute myocardial infarctionQ26862733
Extracellular microRNAs in urologic malignancies: chances and challengesQ26866043
MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastomaQ27320938
Prediction of mammalian microRNA targetsQ27860498
RAS is regulated by the let-7 microRNA familyQ27860522
An extensive class of small RNAs in Caenorhabditis elegansQ27860626
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsQ27860960
MicroRNA expression profiles classify human cancersQ28032481
MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin EQ28117082
Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinomaQ28118779
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseasesQ28131780
Tumour invasion and metastasis initiated by microRNA-10b in breast cancerQ28131829
let-7 microRNA functions as a potential growth suppressor in human colon cancer cellsQ28237683
The let-7 microRNA represses cell proliferation pathways in human cellsQ28240833
The role of let-7 in cell differentiation and cancerQ28259549
miRNA-34c regulates Notch signaling during bone developmentQ28264397
Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cellsQ28277441
let-7 regulates Dicer expression and constitutes a negative feedback loopQ28290736
The let-7 family of microRNAsQ28293181
The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factorsQ28295428
Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signalingQ28297583
Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous systemQ28302231
MicroRNA regulation of DNA repair gene expression in hypoxic stressQ28306694
miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcomaQ39178990
miR-30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinomaQ39181606
Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: a case control study.Q39217323
MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cellsQ39251799
The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis.Q39255444
MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expressionQ39274559
miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcomaQ39291006
MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cellsQ39292548
MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R.Q39309630
MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expressionQ39314459
Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism.Q39351138
miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditionsQ39364639
miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancerQ39403567
MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expressionQ39403675
miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3.Q39441445
MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivoQ39447513
Pilot Study of Serum MicroRNA-21 as a Diagnostic and Prognostic Biomarker in Egyptian Breast Cancer PatientsQ39529523
Regulation of vascular endothelial growth factor signaling by miR-200b.Q39547800
Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancerQ39577078
miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cellsQ39608849
The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastomaQ39621978
MiR-125b targets BCL3 and suppresses ovarian cancer proliferationQ39675974
Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3.Q39706915
Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cellsQ39789168
Differential profiling of human red blood cells during storage for 52 selected microRNAsQ39900387
Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3.Q39945284
MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of diseaseQ39950193
Circulating microRNAs in plasma of patients with gastric cancersQ39986294
MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphomaQ40135314
Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factorsQ40171554
Exosome-Carried microRNA-375 Inhibits Cell Progression and Dissemination via Bcl-2 Blocking in Colon CancerQ40178075
Up-regulated Circulating miR-106a by DNA Methylation Promised a Potential Diagnostic and Prognostic Marker for Gastric CancerQ40731890
Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disordersQ40787161
Serum miR-200c expression level as a prognostic biomarker for gastric cancerQ41054869
MicroRNA-200c as a Prognostic Biomarker for Pancreatic CancerQ41193023
RNA as a target and an initiator of post-transcriptional gene silencing in transgenic plantsQ41288716
Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression.Q41377326
Circulating microRNAs as biomarkers for diagnosis of early hepatocellular carcinoma associated with hepatitis B virusQ41492063
Circulating miR-375 and miR-199a-3p as potential biomarkers for the diagnosis of hepatocellular carcinomaQ41530973
Expression of serum let-7c, let-7i, and let-7f microRNA with its target gene, pepsinogen C, in gastric cancer and precancerous diseaseQ41570877
Enhanced miR-210 expression promotes the pathogenesis of endometriosis through activation of signal transducer and activator of transcription 3.Q41680433
Plasma miR-200c and miR-18a as potential biomarkers for the detection of colorectal carcinomaQ41921103
Dysregulation of circulating microRNAs and prediction of aggressive prostate cancerQ42112822
An elevated serum miR-141 level in patients with bone-metastatic prostate cancer is correlated with more bone lesionsQ42140417
Expression and clinical significance of plasma microRNA-125b level in patients with oral squamous cell carcinomaQ50437031
Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer.Q50448025
Deregulated serum concentrations of circulating cell-free microRNAs miR-17, miR-34a, miR-155, and miR-373 in human breast cancer development and progression.Q50924410
MicroRNA-200c and microRNA-141 as potential diagnostic and prognostic biomarkers for ovarian cancer.Q51061144
Neuroprotective effects of microRNA-210 against oxygen-glucose deprivation through inhibition of apoptosis in PC12 cells.Q51065337
Expression of serum miR-16, let-7f, and miR-21 in patients with hepatocellular carcinoma and their clinical significances.Q51149290
Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer.Q51535040
Overexpression of miR-210, a downstream target of HIF1α, causes centrosome amplification in renal carcinoma cells.Q51582002
MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.Q52582850
Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours.Q52843051
Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study.Q52896892
Non-small cell lung cancer detection using microRNA expression profiling of bronchoalveolar lavage fluid and sputum.Q52952354
Salivary microRNAs in oral cancer.Q52958113
MicroRNA-29b is a Novel Prognostic Marker in Colorectal Cancer.Q52996440
Upregulated miR-106a plays an oncogenic role in pancreatic cancer.Q53071807
Serum expression levels of miR-17, miR-21, and miR-92 as potential biomarkers for recurrence after adjuvant chemotherapy in colon cancer patients.Q53207870
A novel serum microRNA panel to discriminate benign from malignant ovarian disease.Q53227286
Three dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening.Q53228625
Negative feedback of miR-29 family TET1 involves in hepatocellular cancer.Q53228628
Serum miR-21, miR-26a and miR-101 as potential biomarkers of hepatocellular carcinoma.Q53248858
Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29.Q53253196
Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis.Q53280056
MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2.Q53295486
[Chemotherapy with paclitaxel leads to microRNA release].Q53317976
Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis.Q53356232
The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancerQ35138997
Circulating exosomal microRNAs as biomarkers of colon cancer.Q35140085
Serum miR-125a-5p, miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancerQ35145235
Exosomes: secreted vesicles and intercellular communicationsQ35161550
The purple color reaction given by diphenylamine reagent. I. With normal and rheumatic fever seraQ35186399
miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT.Q35207623
miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis.Q35238507
Low serum miR-19a expression as a novel poor prognostic indicator in multiple myelomaQ35246395
Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarkerQ35247522
Serum microRNA-210 as a potential noninvasive biomarker for the diagnosis and prognosis of gliomaQ35275041
Expression of circulating microRNA-20a and let-7a in esophageal squamous cell carcinomaQ35473128
Circulating MiR-16-5p and MiR-19b-3p as Two Novel Potential Biomarkers to Indicate Progression of Gastric CancerQ35475974
Circulating miR-200c and miR-141 and outcomes in patients with breast cancer.Q35518887
MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma.Q35551867
Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric CancerQ35612605
Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of gliomaQ35633805
miR-16 promotes the apoptosis of human cancer cells by targeting FEATQ35648747
MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1.Q35672735
Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancerQ35675384
Salivary MicroRNA in Pancreatic Cancer Patients.Q35677442
miR-34 and p53: New Insights into a Complex Functional RelationshipQ35692651
Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder CancerQ35740045
An electrochemical nanobiosensor for plasma miRNA-155, based on graphene oxide and gold nanorod, for early detection of breast cancer.Q35784691
Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndromeQ35802426
Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?Q35828512
miR-155 targets Caspase-3 mRNA in activated macrophagesQ35843434
Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA).Q35856812
Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancerQ35863159
Circulating microRNAs in esophageal squamous cell carcinoma: association with locoregional staging and survival.Q35870720
Apoptosis and the target genes of microRNA-21.Q35871493
Changes in circulating microRNA levels associated with prostate cancerQ35879858
A Circulating MicroRNA Signature as a Biomarker for Prostate Cancer in a High Risk GroupQ35902208
MicroRNA miR-30 family regulates non-attachment growth of breast cancer cellsQ36697933
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformationQ36706938
MicroRNA-20a in human faeces as a non-invasive biomarker for colorectal cancerQ36738904
miR-16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathwaysQ36772022
Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions.Q36887378
MicroRNA expression in lymphomaQ36922250
Consistent high concentration of the viral microRNA BART17 in plasma samples from nasopharyngeal carcinoma patients--evidence of non-exosomal transportQ36937666
Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer.Q36942423
Circulating miRNAs: cell-cell communication function?Q36962750
BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification.Q36964364
Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinomaQ37015623
Predictive Value of Serum miR-10b, miR-29c, and miR-205 as Promising Biomarkers in Esophageal Squamous Cell Carcinoma ScreeningQ37026076
Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinomaQ37155033
Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemiaQ37188389
MicroRNA-375 targets the 3-phosphoinositide-dependent protein kinase-1 gene in pancreatic carcinomaQ37229396
Identification of serum miRNAs as novel non-invasive biomarkers for detection of high risk for early gastric cancerQ37279280
Diagnostic and prognostic value of circulating miR-221 for extranodal natural killer/T-cell lymphomaQ37329665
Plasma microRNA 210 levels correlate with sensitivity to trastuzumab and tumor presence in breast cancer patientsQ37394399
High serum miR-19a levels are associated with inflammatory breast cancer and are predictive of favorable clinical outcome in patients with metastatic HER2+ inflammatory breast cancerQ37451898
Tumour angiogenesis regulation by the miR-200 familyQ37523569
Global analysis of serum microRNAs as potential biomarkers for lung adenocarcinoma.Q37548836
Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinomaQ37548853
Differential expression of serum miR-126, miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancerQ37608685
Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significanceQ37618914
Distinct microRNA-155 expression in the vitreous of patients with primary vitreoretinal lymphoma and uveitisQ37653084
MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling.Q37993984
Role of miR-155 in the regulation of lymphocyte immune function and disease.Q38168572
Role of microRNA-34 family in cancer with particular reference to cancer angiogenesis.Q38237787
Circulating microRNA biomarker studies: pitfalls and potential solutionsQ38267750
MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).Q38303663
Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3.Q38333929
MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10.Q38336556
Physiological roles of miR-155.Q38398527
Exosomes decrease sensitivity of breast cancer cells to adriamycin by delivering microRNAsQ38455097
Membrane microparticles: shedding new light into cancer cell communication.Q38569109
The potential for circulating microRNAs in the diagnosis of myocardial infarction: a novel approach to disease diagnosis and treatmentQ38631508
MicroRNA-34a and its target genes: Key factors in cancer multidrug resistanceQ38663296
Extracellular vesicle-mediated modulation of angiogenesis.Q38667863
Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancerQ38675709
miR-30d Blocked Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition by Targeting Snail in Ovarian Cancer CellsQ38824925
MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221/222 cluster functions as a tumour suppressor and disease progression markerQ38839158
miR-34c-3p functions as a tumour suppressor by inhibiting eIF4E expression in non-small cell lung cancerQ38845695
MiR-375 targets KLF4 and impacts the proliferation of colorectal carcinomaQ38847978
Suppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B.Q38850720
Augmented miR-10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma.Q38851262
MicroRNA-222 promotes human non-small cell lung cancer H460 growth by targeting p27.Q38858232
miR-155 regulative network in FLT3 mutated acute myeloid leukemiaQ38866003
The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-β-Responsive Colon Carcinoma.Q38870781
Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinomaQ38876546
MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin.Q38878623
Downregulation of miR-375 in aldosterone-producing adenomas promotes tumour cell growth via MTDH.Q38878739
MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherinQ38886948
Over-expression of microRNA-375 inhibits papillary thyroid carcinoma cell proliferation and induces cell apoptosis by targeting ERBB2.Q38916685
SHIP1 is targeted by miR-155 in acute myeloid leukemiaQ38961035
Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer.Q38977396
c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT.Q38987143
Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancerQ38995808
Expression of serum miR-200a, miR-200b, and miR-200c as candidate biomarkers in epithelial ovarian cancer and their association with clinicopathological featuresQ38996872
Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2.Q39007403
Circulating miR-18a in plasma contributes to cancer detection and monitoring in patients with gastric cancerQ39015764
Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3.Q39017421
MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA.Q39033124
Decreased circulating miR-375: a potential biomarker for patients with non-small-cell lung cancerQ39036116
Clinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese populationQ39036472
microRNA-155 regulates cell proliferation and invasion by targeting FOXO3a in gliomaQ39106292
MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.Q39139064
Clinical impact of circulating miR-18a in plasma of patients with oesophageal squamous cell carcinomaQ39167703
Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosisQ34693160
MicroRNAs in stool samples as potential screening biomarkers for pancreatic ductal adenocarcinoma cancer.Q34704824
Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanomaQ34713622
MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathyQ34718910
Individuality and variation in gene expression patterns in human bloodQ34762457
Plasma processing conditions substantially influence circulating microRNA biomarker levelsQ34769479
Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancerQ34775829
Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.Q34785335
Downregulation of serum miR-17 and miR-106b levels in gastric cancer and benign gastric diseasesQ34785913
Role of microRNAs in vascular diseases, inflammation, and angiogenesisQ34786294
Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 proteinQ34786521
The functional significance of microRNA-29c in patients with colorectal cancer: a potential circulating biomarker for predicting early relapse.Q34806020
Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancerQ34816422
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cellsQ34842477
Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritisQ34853050
MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2Q34993681
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT.Q34995499
Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detectionQ34999442
MicroRNA 29b functions in acute myeloid leukemiaQ35009142
Circulating nucleic acids in plasma and serum as a noninvasive investigation for cancer: time for large-scale clinical studies?Q35010397
Analysis of tissue and serum microRNA expression in patients with upper urinary tract urothelial cancerQ35023641
Plasma miRNAs as diagnostic and prognostic biomarkers for ovarian cancerQ35040690
Reduced expression levels of let-7c in human breast cancer patientsQ35042277
MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathwayQ35051948
Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infectionQ35076724
Identification and validation of miRNAs as endogenous controls for RQ-PCR in blood specimens for breast cancer studiesQ35082591
Quantitative measurement of serum microRNA-21 expression in relation to breast cancer metastasis in Chinese femalesQ35088480
A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentationQ35091710
Expression of miR-29c, miR-93, and miR-429 as potential biomarkers for detection of early stage non-small lung cancerQ35093548
RETRACTED: Role of microRNA 30a targeting insulin receptor substrate 2 in colorectal tumorigenesisQ35097075
Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1RQ35103309
A critical evaluation of microRNA biomarkers in non-neoplastic diseaseQ35107632
Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinomaQ35108381
Combinations of serum prostate-specific antigen and plasma expression levels of let-7c, miR-30c, miR-141, and miR-375 as potential better diagnostic biomarkers for prostate cancerQ35110766
Simultaneous Underexpression of let-7a-5p and let-7f-5p microRNAs in Plasma and Stool Samples from Early Stage Colorectal Carcinoma.Q42150614
Role of Notch signaling pathway in gastric cancer pathogenesisQ42161527
Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factorsQ42833178
Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosisQ42876911
Exosomal microRNA-141 is upregulated in the serum of prostate cancer patientsQ42956859
Plasma MicroRNAs as sensitive and specific biomarkers of tissue injuryQ43278313
Serum miR-21 is a diagnostic and prognostic marker of primary central nervous system lymphomaQ43879777
Prognostic implications of serum microRNA-21 in colorectal cancer.Q43937592
Circulating miR-22, miR-24 and miR-34a as novel predictive biomarkers to pemetrexed-based chemotherapy in advanced non-small cell lung cancerQ44023844
Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancerQ44030040
Fecal miR-106a is a useful marker for colorectal cancer patients with false-negative results in immunochemical fecal occult blood test.Q44126830
Extracellular miRNAs: the mystery of their origin and functionQ44235487
A panel of five circulating microRNAs as potential biomarkers for prostate cancerQ44430269
Potential diagnostic value of miR-155 in serum from lung adenocarcinoma patientsQ44476266
A three-plasma miRNA signature serves as novel biomarkers for osteosarcomaQ44481241
Serum miR-19a expression correlates with worse prognosis of patients with non-small cell lung cancerQ44499697
microRNA expression profile in stage III colorectal cancer: circulating miR-18a and miR-29a as promising biomarkersQ44586065
miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cellsQ44685681
Higher circulating expression levels of miR-221 associated with poor overall survival in renal cell carcinoma patients.Q45202446
Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancerQ45426468
Detection of microRNA as novel biomarkers of epithelial ovarian cancer from the serum of ovarian cancer patientsQ45729971
Analysis of cell-free Epstein-Barr virus associated RNA in the plasma of patients with nasopharyngeal carcinoma.Q45748068
Serum miR-210 as a novel biomarker for molecular diagnosis of clear cell renal cell carcinomaQ45836927
Plasma post-operative miR-21 expression in the prognosis of gastric cancersQ45888049
Plasma microRNA, a potential biomarker for acute rejection after liver transplantationQ46147230
The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma.Q46198060
Circulating miR-200c levels significantly predict response to chemotherapy and prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancerQ46422776
Integrative functional genetic-epigenetic approach for selecting genes as urine biomarkers for bladder cancer diagnosisQ46477217
MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherinQ48011302
Plasma MicroRNA-21 concentration may be a useful biomarker in glioblastoma patientsQ48409555
Serum MicroRNA-125b as a Potential Biomarker for Glioma Diagnosis.Q55460538
Free DNA in the serum of cancer patients and the effect of therapy.Q55492005
Human seminal fluid as a source of prostate cancer-specific microRNA biomarkersQ57230543
miRNA profiling reveals a potential role of milk stasis in breast carcinogenesisQ57630095
Circulating miRNA Signatures: Promising Prognostic Tools for CancerQ57693485
Germline mutation of microRNA-125a is associated with breast cancerQ57828433
Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemiaQ60305981
MicroRNAs modulate the angiogenic properties of HUVECsQ62083234
Soluble normal and mutated DNA sequences from single-copy genes in human bloodQ72268467
Dicer dependent microRNAs regulate gene expression and functions in human endothelial cellsQ80019578
Do platform-specific factors explain microRNA profiling disparities?Q82315386
High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancerQ83943983
Circulating miRNAs are correlated with tumor progression in prostate cancerQ84232903
MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphomaQ84449890
Short structured RNAs with low GC content are selectively lost during extraction from a small number of cellsQ84503442
Evaluation of dynamic change of serum miR-21 and miR-24 in pre- and post-operative lung carcinoma patientsQ84561982
Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosisQ84582500
Serum miRNA‐21: Elevated levels in patients with metastatic hormone‐refractory prostate cancer and potential predictive factor for the efficacy of docetaxel‐based chemotherapyQ85032624
Serum microRNAs are promising novel biomarkers for diffuse large B cell lymphomaQ85071854
Urinary cell-free microRNA-106b as a novel biomarker for detection of bladder cancerQ85209395
MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5Q85753535
Prognostic impact of circulating miR-21 in the plasma of patients with gastric carcinomaQ85785866
Circulating levels of the miRNAs, miR-194, and miR-29b, as clinically useful biomarkers for colorectal cancerQ86028719
Serum miR-152, miR-148a, miR-148b, and miR-21 as novel biomarkers in non-small cell lung cancer screeningQ86267440
Salivary microRNAs show potential as a noninvasive biomarker for detecting resectable pancreatic cancerQ86397679
Discovery and prevalidation of salivary extracellular microRNA biomarkers panel for the noninvasive detection of benign and malignant parotid gland tumorsQ86574422
Lack of detectable oral bioavailability of plant microRNAs after feeding in miceQ86698065
Circulating Serum Exosomal miRNAs As Potential Biomarkers for Esophageal AdenocarcinomaQ87248595
MiR-221 as a pre- and postoperative plasma biomarker for larynx cancer patientsQ87252521
Prognostic value of the microRNA-29 family in patients with primary osteosarcomasQ87387709
MiR-16 induced the suppression of cell apoptosis while promote proliferation in esophageal squamous cell carcinomaQ87929436
Study of circulating microRNA-125b levels in serum exosomes in advanced melanomaQ87985149
Serum microRNA-210 as a predictive biomarker for treatment response and prognosis in patients with hepatocellular carcinoma undergoing transarterial chemoembolizationQ88092055
Overexpression of circulating miRNA-21 and miRNA-146a in plasma samples of breast cancer patientsQ95393010
Identification of serum microRNA-21 as a biomarker for early detection and prognosis in human epithelial ovarian cancerQ95536716
Differential microRNA expression by Solexa sequencing in the sera of ovarian cancer patientsQ95567834
Circulating cell-free cancer-testis MAGE-A RNA, BORIS RNA, let-7b and miR-202 in the blood of patients with breast cancer and benign breast diseasesQ34113528
MicroRNAs and prostate cancerQ34120269
MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2.Q34120830
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MicroRNA-106b promotes colorectal cancer cell migration and invasion by directly targeting DLC1Q28384675
The Regulatory Role of MicroRNAs in EMT and CancerQ28391426
Circulating MiR-125b as a marker predicting chemoresistance in breast cancerQ28482362
MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell linesQ28748642
MicroRNA biogenesis: coordinated cropping and dicingQ29547496
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancerQ29547523
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasmaQ29547772
Export of microRNAs and microRNA-protective protein by mammalian cellsQ29614234
MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancerQ29614237
Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphomaQ29614238
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteinsQ29615034
The MicroRNA Spectrum in 12 Body FluidsQ29618068
Functional delivery of viral miRNAs via exosomesQ29619574
Augmentation of tumor angiogenesis by a Myc-activated microRNA clusterQ29620726
Increased circulating microRNA-155 as a potential biomarker for breast cancer screening: a meta-analysis.Q31161472
Characterization of salivary RNA by cDNA library analysisQ33260959
MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growthQ33326420
Detection of cancer with serum miRNAs on an oligonucleotide microarrayQ33481633
Serum microRNA 125b as a diagnostic or prognostic biomarker for advanced NSCLC patients receiving cisplatin-based chemotherapyQ33572407
Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancerQ33613644
Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancerQ33654179
miR-375 inhibits the proliferation of gastric cancer cells by repressing ERBB2 expressionQ33706171
Expression of serum exosomal microRNA-21 in human hepatocellular carcinomaQ33736118
microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphomaQ33780259
Oncogenic microRNAs: miR-155, miR-19a, miR-181b, and miR-24 enable monitoring of early breast cancer in serumQ33824699
Clinical impact of down-regulated plasma miR-92a levels in non-Hodgkin's lymphomaQ33839512
Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemiaQ33862129
SHOX2 is a direct miR-375 target and a novel epithelial-to-mesenchymal transition inducer in breast cancer cellsQ33891236
Genomewide Study of Salivary MicroRNAs for Detection of Oral Cancer.Q33936552
miR-221/222 control luminal breast cancer tumor progression by regulating different targets.Q33952998
MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression.Q33967256
Purification and characterization of PCR-inhibitory components in blood cellsQ33971131
microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancerQ34008192
Haemolysis during sample preparation alters microRNA content of plasma.Q34016595
Circulating miR-19a and miR-205 in serum may predict the sensitivity of luminal A subtype of breast cancer patients to neoadjuvant chemotherapy with epirubicin plus paclitaxelQ34066078
miR-375 suppresses IGF1R expression and contributes to inhibition of cell progression in laryngeal squamous cell carcinomaQ34092121
MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zetaQ34103001
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
biomarkerQ864574
neoplasmQ1216998
liquid biopsyQ22349364
tumor biomarkerQ66205818
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)627
P577publication date2016-04-27
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleNew Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies
P478volume17

Reverse relations

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