Concentrated insulins: the new basal insulins

scientific article

Concentrated insulins: the new basal insulins is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2147/TCRM.S99855
P932PMC publication ID4790523
P698PubMed publication ID27022271

P2093author name stringElizabeth M Lamos
Lisa M Younk
Stephen N Davis
P2860cites workThe relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveysQ31112204
U-500 regular insulin: clinical experience and pharmacokinetics in obese, severely insulin-resistant type 2 diabetic patientsQ33602161
Glucose-lowering effect of insulin degludec is independent of subcutaneous injection regionQ34085107
Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority triaQ34269828
Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/mlQ34543063
Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine.Q34583341
New insulin glargine 300 units/mL versus glargine 100 units/mL in people with type 2 diabetes using oral agents and basal insulin: glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 2).Q35240456
New insulin glargine 300 U/ml compared with glargine 100 U/ml in insulin-naïve people with type 2 diabetes on oral glucose-lowering drugs: a randomized controlled trial (EDITION 3).Q35538347
Pharmacokinetics and pharmacodynamics of high-dose human regular U-500 insulin versus human regular U-100 insulin in healthy obese subjectsQ35563634
Durability of glycemic control using U-500 insulinQ35783956
Clinical use of U-500 regular insulin: review and meta-analysisQ36051311
Low within- and between-day variability in exposure to new insulin glargine 300 U/mlQ36361469
Patient-level meta-analysis of the EDITION 1, 2 and 3 studies: glycaemic control and hypoglycaemia with new insulin glargine 300 U/ml versus glargine 100 U/ml in people with type 2 diabetesQ36366184
Comparison of Pharmacokinetics and Dynamics of the Long-Acting Insulin Analogs Glargine and Detemir at Steady State in Type 1 Diabetes: A double-blind, randomized, crossover studyQ57951497
Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemiaQ72874429
Successful outcome of pregnancy in a patient with generalized lipoatrophic diabetes mellitusQ74070281
Twice-daily compared with once-daily insulin glargine in people with Type 1 diabetes using meal-time insulin aspartQ80119501
Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetesQ84440683
Cost-effectiveness of insulin degludec compared with insulin glargine for patients with type 2 diabetes treated with basal insulin - from the UK health care cost perspectiveQ87006980
Higher insulin detemir doses are required for the similar glycemic control: comparison of insulin detemir and glargine in children with type 1 diabetes mellitusQ87413740
New insulin glargine 300 Units · mL-1 provides a more even activity profile and prolonged glycemic control at steady state compared with insulin glargine 100 Units · mL-1Q87643980
One-year sustained glycaemic control and less hypoglycaemia with new insulin glargine 300 U/ml compared with 100 U/ml in people with type 2 diabetes using basal plus meal-time insulin: the EDITION 1 12-month randomized trial, including 6-month extenQ36366198
Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): a 26-week randomized, treat-to-target trial with a 26-week extensionQ36730246
How hypoglycaemia can affect the life of a person with diabetesQ37035202
Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: a 24-week, randomized, placebo-controlled study (GetGoal-Duo 1).Q37106467
Low-volume insulin degludec 200 units/ml once daily improves glycemic control similarly to insulin glargine with a low risk of hypoglycemia in insulin-naive patients with type 2 diabetes: a 26-week, randomized, controlled, multinational, treat-to-taQ37106509
Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre-planned meta-analysis of phase 3 trialsQ37119978
Elderly patients with diabetes experience a lower rate of nocturnal hypoglycaemia with insulin degludec than with insulin glargine: a meta-analysis of phase IIIa trialsQ37321746
High-dose insulin therapy: is it time for U-500 insulin?Q37391062
Insulin degludec: pharmacokinetic properties in subjects with hepatic impairmentQ37506417
Insulin degludec: pharmacokinetics in patients with renal impairmentQ37506526
Fear of hypoglycaemia in adults with Type 1 diabetes.Q37790425
U500 regular insulin use in insulin-resistant type 2 diabetic veteran patientsQ37899649
Clinical experience with U500 insulin: risks and benefitsQ37908817
Evaluation of dosing and clinical outcomes in patients undergoing conversion of insulin glargine to insulin detemirQ38073204
Are you ready for more insulin concentrations?Q38266858
Design of DEVOTE (Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients With Type 2 Diabetes at High Risk of Cardiovascular Events) - DEVOTE 1.Q39421962
Preserved pharmacokinetic exposure and distinct glycemic effects of insulin degludec and liraglutide in IDegLira, a fixed-ratio combination therapyQ40914196
Clinical efficacy and patient satisfaction with U-500 insulin use.Q42100513
Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin.Q42240405
A prospective trial of U500 insulin delivered by Omnipod in patients with type 2 diabetes mellitus and severe insulin resistanceQ43115619
New insulin glargine 300 units/mL versus glargine 100 units/mL in people with type 2 diabetes using basal and mealtime insulin: glucose control and hypoglycemia in a 6-month randomized controlled trial (EDITION 1).Q44485772
Healthcare costs and adherence associated with human regular U-500 versus high-dose U-100 insulin in patients with diabetesQ44533647
A comparison of the steady-state pharmacokinetic and pharmacodynamic profiles of 100 and 200 U/mL formulations of ultra-long-acting insulin degludecQ44599380
The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patientsQ44631767
The effect of long-term use of U-500 insulin via continuous subcutaneous infusion on durability of glycemic control and weight in obese, insulin-resistant patients with type 2 diabetesQ45893987
Efficacy and Safety of Insulin Degludec 200 U/mL and Insulin Degludec 100 U/mL in Patients with Type 2 Diabetes (Begin: Compare).Q46247786
Steady state is reached within 2-3 days of once-daily administration of degludec, a basal insulin with an ultralong duration of actionQ46358093
Evaluation of the cost-utility of insulin degludec vs insulin glargine in SwedenQ46967505
Insulin glargine improves glycemic control and quality of life in type 2 diabetic patients on hemodialysisQ48487507
Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetesQ49174475
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)389-400
P577publication date2016-01-01
P1433published inTherapeutics and Clinical Risk ManagementQ15766913
P1476titleConcentrated insulins: the new basal insulins
P478volume12

Reverse relations

cites work (P2860)
Q64904369Basal insulin reductions in anticipation of multiple exercise sessions in people with type 1 diabetes-a clinical perspective.
Q64239470Basal insulin therapy: Unmet medical needs in Asia and the new insulin glargine in diabetes treatment
Q52606010Conversion from insulin glargine U-100 to insulin glargine U-300 or insulin degludec and the impact on dosage requirements.
Q92100367Glargine-300: An updated literature review on randomized controlled trials and real-world studies
Q47621392Hypoglycemia Reduction Strategies in the ICU.
Q92550113Insulin Initiation and Titration in Patients With Type 2 Diabetes
Q41006286Microfabrication for Drug Delivery
Q92188767Nocturnal Glycemic Control with New Insulin Glargine 300 U/mL
Q44372707Novel Concentrated Insulin Delivery Devices: Developments for Safe and Simple Dose Conversions
Q41963319Translating U-500R Randomized Clinical Trial Evidence to the Practice Setting: A Diabetes Educator/Expert Prescriber Team Approach

Search more.