Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production

scientific article

Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPLS.2016.00329
P932PMC publication ID4796020
P698PubMed publication ID27047510
P5875ResearchGate publication ID298795390

P50authorSoraya PelazQ43122379
P2093author name stringGiuseppe Pulice
Luis Matías-Hernández
P2860cites workA new world malaria map: Plasmodium falciparum endemicity in 2010Q17485680
Spread of artemisinin resistance in Plasmodium falciparum malariaQ21032481
The economic and social burden of malariaQ21032507
Assessing the future threat from vivax malaria in the United Kingdom using two markedly different modelling approachesQ21034122
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coliQ21143865
History of the discovery of the malaria parasites and their vectorsQ21198929
Nicotiana benthamiana as a production platform for artemisinin precursorsQ21562149
Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annuaQ47842916
Dihydroartemisinin-piperaquine failure in CambodiaQ47877123
Towards real-time monitoring of artemisinin resistanceQ47903047
Drug discovery: Priming the antimalarial pipelineQ47942284
The production of artemisinin precursors in tobaccoQ47950708
Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin contentQ47981992
The jasmonate-responsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L.Q47995555
Generation of the potent anti-malarial drug artemisinin in tobaccoQ47997211
Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest CambodiaQ48037074
AaORA, a trichome-specific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinereaQ48040643
Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plantsQ48520508
Functional expression and characterization of sesquiterpene synthases from Artemisia annua L. using transient expression system in Nicotiana benthamiana.Q48527000
Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plantsQ49171078
Agrobacterium tumefaciens-mediated transformation of Artemisia annua L. and regeneration of transgenic plantsQ49174920
Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplastsQ49522968
Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae.Q51226370
UV-B and UV-C pre-treatments induce physiological changes and artemisinin biosynthesis in Artemisia annua L. - an antimalarial plant.Q51849912
Developmental studies of Artemisia annua: flowering and artemisinin production under greenhouse and field conditions.Q52208980
Influence of Artemisia annua extract derivatives on proliferation, apoptosis and metastasis of osteosarcoma cells.Q52957224
Isolation of a cotton reversibly glycosylated polypeptide (GhRGP1) promoter and its expression activity in transgenic tobacco.Q54619593
Abscisic acid response element binding factor 1 is required for establishment of Arabidopsis seedlings during winter.Q54624831
MalariaQ56420006
β-Cyclodextrins enhance artemisinin production in Artemisia annua suspension cell culturesQ57765182
Ozone-induced cell death occurs via two distinct mechanisms in Arabidopsis: the role of salicylic acidQ58055337
APETALA2/ETHYLENE RESPONSE FACTOR and basic helix-loop-helix tobacco transcription factors cooperatively mediate jasmonate-elicited nicotine biosynthesisQ59166219
Activation Tagging Identifies a Conserved MYB Regulator of Phenylpropanoid BiosynthesisQ63641044
Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformationQ73800937
The regulation of solasodine production by Agrobacterium rhizogenes-transformed roots of Solanum aviculareQ74049124
The Biochemistry and Molecular Biology of Isoprenoid MetabolismQ74781149
Agrobacterium rhizogenes-mediated transformation of Artemisia annua: production of transgenic plantsQ79658324
Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathwaysQ80821540
UV-B as an environmental factor in plant life: stress and regulationQ83212844
Volatile fingerprints of artemisinin-rich Artemisia annua cultivars by headspace solid-phase microextraction gas chromatography/ mass spectrometryQ84937096
Localization of Artemisinin and Artemisitene in Foliar Tissues of Glanded and Glandless Biotypes of Artemisia annua L.Q104887688
In vivo transformations of artemisinic acid in Artemisia annua plantsQ104985414
The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowersQ33756633
A Research Agenda to Underpin Malaria EradicationQ33818020
Why do chloroplasts and mitochondria contain so many copies of their genome?Q34050314
The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin.Q34092854
Gibberellin biosynthetic inhibitors make human malaria parasite Plasmodium falciparum cells swell and rupture to death.Q34193063
Changes in leaf trichomes and epicuticular flavonoids during leaf development in three birch taxaQ34331604
Localized permanent epidemics: the genesis of chloroquine resistance in Plasmodium falciparum.Q34367571
Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annuaQ34389188
Use of neem oil as a mosquito repellent in tribal villages of mandla district, madhya pradeshQ34408563
Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistanceQ34453540
Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.Q34491483
Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in CambodiaQ34560158
Current status of metabolic phytochemistryQ34583118
Engineering secondary metabolite production in plants.Q34598092
AaERF1 positively regulates the resistance to Botrytis cinerea in Artemisia annuaQ34612313
Synergistic derepression of gibberellin signaling by removing RGA and GAI function in Arabidopsis thalianaQ34613421
Plant-based vaccines against viruses.Q34687464
The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.Q34780368
Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.Q34986438
The economic impact of malaria in Africa: a critical review of the evidenceQ35017939
Artemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced ProductionQ35112713
Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern GhatsQ35121567
Cloning and characterization of AabHLH1, a bHLH transcription factor that positively regulates artemisinin biosynthesis in Artemisia annuaQ35195899
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular markerQ35217991
Costs and cost-effectiveness of malaria control interventions--a systematic reviewQ35589032
Proteomic analysis of Artemisia annua--towards elucidating the biosynthetic pathways of the antimalarial pro-drug artemisininQ35686598
Ethnopharmacological evaluation of medicinal plants used against malaria by quilombola communities from Oriximiná, BrazilQ35731956
Plants as antimalarial agents in Sub-Saharan AfricaQ35752933
Larvicidal effects of a neem (Azadirachta indica) oil formulation on the malaria vector Anopheles gambiaeQ35834325
Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trialQ35845345
Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malariaQ35846117
Antiplasmodial and cytotoxic activities of the constituents of Turraea robusta and Turraea niloticaQ36273939
Call to action: priorities for malaria eliminationQ36442842
Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sitesQ36478703
Indigenous health in Latin America and the CaribbeanQ36497278
Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010.Q36558557
Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunityQ36796548
Improving containment strategies in biopharmingQ36889031
The role of biotechnology for agricultural sustainability in AfricaQ36924651
Production of artemisinin by genetically-modified microbesQ37002883
Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate studyQ37205700
Multiple populations of artemisinin-resistant Plasmodium falciparum in CambodiaQ37253966
Synthetic medicinal chemistry of selected antimalarial natural productsQ37373893
The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao).Q37804673
Role of transgenic plants in agriculture and biopharmingQ37940792
Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes--current status and future opportunities.Q38061502
Plant biofarming: novel insights for peptide expression in heterologous systemsQ38063510
Artemisinins: pharmacological actions beyond anti-malarialQ38169463
Engineered Biosynthesis of Medicinally Important Plant Natural Products in MicroorganismsQ38604498
Sesquiterpene lactone engineering in microbial and plant platforms: parthenolide and artemisinin as case studies.Q38633017
Quality assessment and antiplasmodial activity of West African Cochlospermum speciesQ39158654
Intercontinental spread of pyrimethamine-resistant malariaQ39408056
A basic leucine zipper transcription factor, AabZIP1, connects abscisic acid signaling with artemisinin biosynthesis in Artemisia annuaQ39625342
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system.Q40381469
Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of dolichols in plantsQ40422623
Artemisinin induces apoptosis in human cancer cells.Q40522295
Role of repellents in vector control and disease prevention.Q40667795
An ethnobotanical study of anti-malarial plants among indigenous people on the upper Negro River in the Brazilian AmazonQ40689746
mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether.Q40712192
ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolismQ40868493
TRICHOME AND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annuaQ41078103
Effect of sugars on artemisinin production in Artemisia annua L.: transcription and metabolite measurements.Q41990471
Roles of ethylene and jasmonic acid in systemic induced defense in tomato (Solanum lycopersicum) against Helicoverpa zea.Q42005786
Antimalarial drug resistanceQ22061790
Artemisinin Resistance in Plasmodium falciparum MalariaQ22061852
Evidence of Artemisinin-Resistant Malaria in Western CambodiaQ22061854
Production of the antimalarial drug precursor artemisinic acid in engineered yeastQ22061873
Gibberellin signaling: biosynthesis, catabolism, and response pathwaysQ24553331
Global warming and malaria: a call for accuracyQ24597614
The impact of malaria parasitism: from corpuscles to communitiesQ24644343
Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua LQ28141191
Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesisQ28142187
Engineering a mevalonate pathway in Escherichia coli for production of terpenoidsQ28207854
A phase 3 trial of RTS,S/AS01 malaria vaccine in African infantsQ28278852
High-level semi-synthetic production of the potent antimalarial artemisininQ28288734
Metabolic engineering of artemisinin biosynthesis in Artemisia annua LQ28301798
Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai-Myanmar border, 1999-2011: an observational studyQ28487636
Malaria in Greece: historical and current reflections on a re-emerging vector borne diseaseQ30223340
Autochthonous Plasmodium vivax malaria in Greece, 2011.Q30224920
Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis.Q30646171
Impact of climate change on global malaria distributionQ30770519
Climatic effects on mosquito abundance in Mediterranean wetlandsQ30836819
Early flower development in ArabidopsisQ33351057
Artemisia annua as a self-reliant treatment for malaria in developing countriesQ33381961
Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern CambodiaQ33399259
Combined effects of Psoralens and ultraviolet-B on growth, pigmentation and biochemical parameters of Abelmoschus esculentus L.Q33404949
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.Q33491911
Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesisQ33514236
Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapyQ33596081
Neurotoxicity and artemisinin compounds do the observations in animals justify limitation of clinical use?Q33599534
Abscisic Acid and abiotic stress signalingQ42217250
Structural and functional characterization of HMG-COA reductase from Artemisia annuaQ42609578
Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annuaQ42931841
Effects of zinc manganese and boron on artemisinin and yields of Artemisia annuaQ43084274
Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 studyQ43237058
Arsenic, chromium and NaCl induced artemisinin biosynthesis in Artemisia annua L.: a valuable antimalarial plantQ43422871
Deoxyarteannuin B, dihydro-deoxyarteannuin B and trans-5-hydroxy-2-isopropenyl-5-methylhex-3-en-1-ol from Artemisia anuuaQ43818965
Overexpression in Catharanthus roseus hairy roots of a truncated hamster 3-hydroxy-3-methylglutaryl-CoA reductase gene.Q43983417
Effect of salicylic acid, methyl jasmonate, ethephon and cantharidin on anthraquinone production by Rubia cordifolia callus cultures transformed with the rolB and rolC genes.Q44041680
THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE.Q44073104
Field investigation on the repellent activity of some aromatic plants by traditional means against Anopheles arabiensis and An. pharoensis (Diptera: Culicidae) around Koka, central EthiopiaQ44146794
Traditional use of mosquito-repellent plants in western Kenya and their evaluation in semi-field experimental huts against Anopheles gambiae: ethnobotanical studies and application by thermal expulsion and direct burningQ44148658
Repellency of live potted plants against Anopheles gambiae from human baits in semi-field experimental huts.Q44149455
Operational feasibility of malaria control by burning neem oil in kerosene lamp in Beel Akbarpur village, District Ghaziabad, IndiaQ44174361
Interactive Effects of Jasmonic Acid, Salicylic Acid, and Gibberellin on Induction of Trichomes in ArabidopsisQ44613160
Jasmonic acid enhances plant cyanogenesis and resistance to herbivory in lima beanQ45047898
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African childrenQ46182948
Making artemisininQ46269584
Mutations in AtCML9, a calmodulin-like protein from Arabidopsis thaliana, alter plant responses to abiotic stress and abscisic acidQ46471559
Laboratory and field evaluation of neem (Azadirachta indica A. Juss) and Chinaberry (Melia azedarach L.) oils as repellents against Phlebotomus orientalis and P. bergeroti (Diptera: Psychodidae) in EthiopiaQ46504567
Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencingQ46531939
Overexpression of 1-Deoxy-D-xylulose-5-phosphate reductoisomerase gene in chloroplast contributes to increment of isoprenoid productionQ46536709
Methyl jasmonate stimulates the de novo biosynthesis of vitamin C in plant cell suspensionsQ46630048
The activity of the artemisinic aldehyde Δ11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L.Q46782982
Artemisinin in traditional tea preparations of Artemisia annuaQ47205841
A new approach to community healthQ47371268
Some preliminary considerations on the sobada: a traditional treatment for gastrointestinal illness in Costa RicaQ47388140
Plural medicine in Sri Lanka: do Ayurvedic and Western medical practices differ?Q47389629
P407language of work or nameEnglishQ1860
P921main subjectagricultureQ11451
Artemisia annuaQ1308044
malariaQ12156
P304page(s)329
P577publication date2016-01-01
P1433published inFrontiers in Plant ScienceQ27723840
P1476titleMolecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production
P478volume7

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cites work (P2860)
Q46253594A Review of Biotechnological Artemisinin Production in Plants
Q28072152A Systematic Review of Anti-malarial Properties, Immunosuppressive Properties, Anti-inflammatory Properties, and Anti-cancer Properties of Artemisia Annua
Q46416931AaMYB1 and its orthologue AtMYB61 affect terpene metabolism and trichome development in Artemisia annua and Arabidopsis thaliana
Q39123543Endophyte bioprospecting in South Asian medicinal plants: an attractive resource for biopharmaceuticals
Q55246933Increase in Artemisia annua Plant Biomass Artemisinin Content and Guaiacol Peroxidase Activity Using the Arbuscular Mycorrhizal Fungus Rhizophagus irregularis.
Q62496001Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery
Q40498913New insights into artemisinin regulation
Q55021631Silencing amorpha-4,11-diene synthase Genes in Artemisia annua Leads to FPP Accumulation.
Q97067832Transcriptome analyses revealed the ultraviolet B irradiation and phytohormone gibberellins coordinately promoted the accumulation of artemisinin in Artemisia annua L

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