On the structural possibility of pore-forming mitochondrial FoF1 ATP synthase

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On the structural possibility of pore-forming mitochondrial FoF1 ATP synthase is …
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scholarly articleQ13442814

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P356DOI10.1016/J.BBABIO.2016.03.008
P698PubMed publication ID26968896
P5875ResearchGate publication ID297673271

P50authorChristoph GerleQ41612234
P2093author name stringChristoph Gerle
P2860cites workBovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystalsQ21973554
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Role of the c subunit of the FO ATP synthase in mitochondrial permeability transitionQ24606978
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Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquilineQ27342142
Molecular architecture of the rotary motor in ATP synthaseQ27620502
Mechanism of aquaporin-4's fast and highly selective water conduction and proton exclusionQ27655332
High-resolution structure of the rotor ring of a proton-dependent ATP synthaseQ27657584
The structure of the membrane extrinsic region of bovine ATP synthaseQ27658548
Crystal Structure of the Mg·ADP-inhibited State of the Yeast F 1 c 10 -ATP SynthaseQ27663260
Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondriaQ27664534
Structure of dimeric ATP synthase from mitochondria: an angular association of monomers induces the strong curvature of the inner membraneQ47710969
A 0.1-700 Hz current through a voltage-clamped pore: candidate protein for initiator of neural oscillationsQ48635251
Relevance of divalent cations to ATP-driven proton pumping in beef heart mitochondrial F0F1-ATPase.Q50756366
Biased Brownian stepping rotation of FoF1-ATP synthase driven by proton motive force.Q54314527
Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ).Q54452905
The Ca2+-induced membrane transition in mitochondriaQ57309821
Structural and energetic basis for H+ versus Na+ binding selectivity in ATP synthase Fo rotorsQ58876292
The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkageQ69397085
Mutations in the beta-subunit Thr(159) and Glu(184) of the Rhodospirillum rubrum F(0)F(1) ATP synthase reveal differences in ligands for the coupled Mg(2+)- and decoupled Ca(2+)-dependent F(0)F(1) activitiesQ73334352
The central plug in the reconstituted undecameric c cylinder of a bacterial ATP synthase consists of phospholipidsQ74567318
Structural organization of mitochondrial ATP synthaseQ81293706
Microscopic rotary mechanism of ion translocation in the F(o) complex of ATP synthasesQ27665340
Common architecture of the flagellar type III protein export apparatus and F- and V-type ATPasesQ27666617
Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristaeQ27671154
The c-ring stoichiometry of ATP synthase is adapted to cell physiological requirements of alkaliphilic Bacillus pseudofirmus OF4Q27677536
Structure of the c10 ring of the yeast mitochondrial ATP synthase in the open conformationQ27678521
Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondriaQ27730864
The Ca2+-induced membrane transition in mitochondria. III. Transitional Ca2+ releaseQ28211160
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell deathQ28242641
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell deathQ28242653
An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition poreQ28243052
Dimers of mitochondrial ATP synthase form the permeability transition poreQ28287824
The Ca2+-induced membrane transition in mitochondria. I. The protective mechanismsQ28305411
Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complexQ28507223
Common evolutionary origin for the rotor domain of rotary ATPases and flagellar protein export apparatusQ28533330
Association of two proteolipids of unknown function with ATP synthase from bovine heart mitochondriaQ28566113
Direct observation of the rotation of F1-ATPaseQ29615360
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanismQ29616055
The ATP synthase--a splendid molecular machineQ29617444
Essentials for ATP synthesis by F1F0 ATP synthasesQ30268372
36 degrees step size of proton-driven c-ring rotation in FoF1-ATP synthaseQ30490478
Macromolecular organization of ATP synthase and complex I in whole mitochondria.Q30503729
Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondriaQ30546211
Phospholipids occupy the internal lumen of the c ring of the ATP synthase of Escherichia coliQ33233160
Channel formation by yeast F-ATP synthase and the role of dimerization in the mitochondrial permeability transitionQ33718426
ATP formation caused by acid-base transition of spinach chloroplastsQ33802630
Structure of dimeric mitochondrial ATP synthase: novel F0 bridging features and the structural basis of mitochondrial cristae biogenesis.Q33933881
ATP synthase--a marvellous rotary engine of the cell.Q33954372
Structure of the rotor of the V-Type Na+-ATPase from Enterococcus hiraeQ33986124
The ATP synthase is involved in generating mitochondrial cristae morphologyQ34085619
Mitochondrial permeability transition in the crustacean Artemia franciscana: absence of a calcium-regulated pore in the face of profound calcium storageQ34395582
ATP synthaseQ34470136
Direct observation of stepped proteolipid ring rotation in E. coli F₀F₁-ATP synthaseQ34488395
Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.Q34496933
ATP synthase: an electrochemical transducer with rotatory mechanicsQ34743829
Human F1F0 ATP synthase, mitochondrial ultrastructure and OXPHOS impairment: a (super-)complex matter?Q35009110
Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondriaQ35063443
F-ATPase of Drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ releaseQ35103850
Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore.Q35602894
Engineering rotor ring stoichiometries in the ATP synthaseQ36056515
Arrangement of subunits in intact mammalian mitochondrial ATP synthase determined by cryo-EM.Q36122751
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.Q36146320
An investigation of mitochondrial inner membranes by rapid-freeze deep-etch techniquesQ36220864
Superoxide flashes in single mitochondriaQ36900957
Foundations of vectorial metabolism and osmochemistryQ37072399
Torque generation and elastic power transmission in the rotary F(O)F(1)-ATPase.Q37490835
What is the nature of the mitochondrial permeability transition pore and what is it not?Q38076069
The ATP synthase: the understood, the uncertain and the unknown.Q38077205
The mitochondrial permeability transition pore: a mystery solved?Q38106976
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transitionQ38204222
Rotary ATPases: A New Twist to an Ancient MachineQ38670458
Induction of the permeability transition pore in cells depleted of mitochondrial DNA.Q39383128
Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescenceQ40137371
The proton-driven rotor of ATP synthase: ohmic conductance (10 fS), and absence of voltage gatingQ40286222
On the structure of the stator of the mitochondrial ATP synthaseQ41446369
GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM.Q41604454
Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopyQ41618424
The c13 ring from a thermoalkaliphilic ATP synthase reveals an extended diameter due to a special structural region.Q41621301
Dimer ribbons of ATP synthase shape the inner mitochondrial membraneQ41623192
A heart mitochondrial Ca2(+)-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open statesQ41782125
Mass spectrometry of intact V-type ATPases reveals bound lipids and the effects of nucleotide bindingQ41961293
Mitochondrial channel activity studied by patch-clamping mitoplastsQ42014495
The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical AppraisalQ42082300
Cyclophilin D links programmed cell death and organismal aging in Podospora anserinaQ42971802
The affinity purification and characterization of ATP synthase complexes from mitochondria.Q43223605
The mitochondrial megachannel is the permeability transition poreQ44175602
Proton-powered subunit rotation in single membrane-bound F0F1-ATP synthase.Q44733437
The inner mitochondrial membrane contains ion-conducting channels similar to those found in bacteria.Q44810762
Structure of the rotor ring of F-Type Na+-ATPase from Ilyobacter tartaricusQ46463032
Lipid organization of the plasma membraneQ46837671
Inventing the dynamo machine: the evolution of the F-type and V-type ATPasesQ47265660
Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase.Q47435178
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1191-1196
P577publication date2016-03-09
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleOn the structural possibility of pore-forming mitochondrial FoF1 ATP synthase
P478volume1857

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cites work (P2860)
Q41526704Cell Death in the Developing Brain after Hypoxia-Ischemia
Q99418944Cryo-EM structure of the entire mammalian F-type ATP synthase
Q60954151Cyclophilin D, Somehow a Master Regulator of Mitochondrial Function
Q92403742Essay on Biomembrane Structure
Q90232741Metabolomics of Aurantio-Obtusin-Induced Hepatotoxicity in Rats for Discovery of Potential Biomarkers
Q64885181Mitochondria and aging: A role for the mitochondrial transition pore?
Q47980436Mitochondrial bioenergetics decay in aging: beneficial effect of melatonin
Q48348421Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation
Q47843948Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Q90287798Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore
Q99233690Structure of the dimeric ATP synthase from bovine mitochondria
Q48393368Sulphoraphane Improves Neuronal Mitochondrial Function in Brain Tissue in Acute Carbon Monoxide Poisoning Rats
Q38945146The Mitochondrial Permeability Transition Pore and ATP Synthase.
Q57177821The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore

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