Barriers to a cure for HIV in women

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Barriers to a cure for HIV in women is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.7448/IAS.19.1.20706
P3181OpenCitations bibliographic resource ID2842035
P932PMC publication ID4761692
P698PubMed publication ID26900031

P2093author name stringAthe Tsibris
Sara Gianella
Catherine Godfrey
Liz Barr
P2860cites workDecay of cell-associated HIV-1 DNA correlates with residual replication in patients treated during acute HIV-1 infectionQ73386724
Initial plasma HIV-1 RNA levels and progression to AIDS in women and menQ73583102
Gender differences in virologic response to treatment in an HIV-positive population: a cohort studyQ73594410
Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproductionQ79718078
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Self-Collected versus Clinician-Collected Sampling for Chlamydia and Gonorrhea Screening: A Systemic Review and Meta-AnalysisQ27025596
Immune cells in the female reproductive tractQ28086783
Vaginal microbiome of reproductive-age womenQ28284755
Effect of tamoxifen on regulation of viral replication and human immunodeficiency virus (HIV) long terminal repeat-directed transcription in cells chronically infected with HIV-1Q28332975
Recovery of replication-competent HIV despite prolonged suppression of plasma viremiaQ29615995
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
Progestin-Containing Contraceptives Alter Expression of Host Defense-Related Genes of the Endometrium and CervixQ30358037
Sex differences in nevirapine rashQ31704898
Comparison of self-collected and physician-collected vaginal swabs for microbiome analysisQ33536622
Type-specific cervico-vaginal human papillomavirus infection increases risk of HIV acquisition independent of other sexually transmitted infectionsQ33553333
17β-estradiol protects primary macrophages against HIV infection through induction of interferon-alphaQ33631612
Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.Q33649753
Population biology of HIV-1 infection: viral and CD4+ T cell demographics and dynamics in lymphatic tissuesQ33652519
Single and multiple dose pharmacokinetics of dolutegravir in the genital tract of HIV-negative womenQ33686465
Modulation of 17beta-estradiol on the number and cytotoxicity of NK cells in vivo related to MCM and activating receptorsQ38296538
Hormonal modulation of the immune system - A spotlight on the role of progestogensQ38362237
Sex-driven differences in immunological responses: challenges and opportunities for the immunotherapies of the third millenniumQ38435403
A Systematic Review of the Inclusion (or Exclusion) of Women in HIV Research: From Clinical Studies of Antiretrovirals and Vaccines to Cure StrategiesQ38584993
Phytoestrogens mediated anti-inflammatory effect through suppression of IRF-1 and pSTAT1 expressions in lipopolysaccharide-activated microgliaQ39111345
TLR7 ligands induce higher IFN-alpha production in females.Q40247926
Estradiol negatively regulates HIV-LTR promoter activity in glial cellsQ40290453
Levels of intracellular HIV-DNA in patients with suppressive antiretroviral therapyQ40998951
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.Q41880147
How Might We Cure HIV?Q42227337
HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects.Q43130032
Residual human immunodeficiency virus (HIV) Type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 yearsQ43569408
Female sex but not ethnicity is a strong predictor of non-nucleoside reverse transcriptase inhibitor-induced rashQ43652265
Protease inhibitor and nonnucleoside reverse transcriptase inhibitor concentrations in the genital tract of HIV-1-infected womenQ43770289
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Differences between women and men in adverse events and CD4+ responses to nucleoside analogue therapy for HIV infection. The Aids Clinical Trials Group 175 TeamQ44074077
Genital tract HIV-1 RNA shedding among women with below detectable plasma viral loadQ44314022
Sex differences in HIV-1 viral load and progression to AIDS.Q44567818
Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cellsQ44934441
Enrollment of women in National Heart, Lung, and Blood Institute-funded cardiovascular randomized controlled trials fails to meet current federal mandates for inclusionQ45161542
Estrogen stimulates transcription of human immunodeficiency virus type 1 (HIV-1).Q45421017
Effect of gender and race on the week 48 findings in treatment-naïve, HIV-1-infected patients enrolled in the randomized, phase III trials ECHO and THRIVE.Q45746984
Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone.Q45958804
Estradiol and progesterone regulate HIV type 1 replication in peripheral blood cellsQ46608228
Antiretroviral drug concentrations and HIV RNA in the genital tract of HIV-infected women receiving long-term highly active antiretroviral therapyQ46791174
Cervicovaginal microbiota: simple is better.Q46832874
Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort studyQ37628108
The X chromosome in immune functions: when a chromosome makes the differenceQ37774853
Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tractQ37966624
Low-level viraemia on HAART: significance and managementQ37966778
Inclusion of minorities and women in cancer clinical trials, a decade later: Have we improved?Q38106914
Estrogen's effects in chronic autoimmune/inflammatory diseases and progression to cancerQ38168954
Influence of common mucosal co-factors on HIV infection in the female genital tract.Q38195075
Steroids and the blood-brain barrier: therapeutic implicationsQ38259311
Gender difference in CD4+ cell counts persist after HIV-1 infection. SEROCO Study Group.Q50946624
X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.Q51105373
The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.Q51386967
Effect of menstrual cycle variation in female sex hormones on cellular immunity and regulation.Q51488407
Estradiol-dependent perforin expression by human regulatory T-cells.Q51629955
Structured treatment interruptions in primary HIV-1 infection: the ANRS 100 PRIMSTOP trial.Q51835167
Biomedical research. Of mice and women: the bias in animal models.Q53065986
Sex bias in trials and treatment must end.Q53068521
Gender agenda: sex bias can be justified in animal research.Q53069925
Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study.Q53608173
Female genital-tract HIV load correlates inversely with Lactobacillus species but positively with bacterial vaginosis and Mycoplasma hominis.Q53880710
Outcomes in the first year after initiation of first-line HAART among heterosexual men and women in the UK CHIC StudyQ57180108
HIV Persistence in the Gut Mucosa of HIV-Infected Subjects Undergoing Antiretroviral Therapy Correlates with Immune Activation and Increased Levels of LPSQ57573965
Access to Antiretroviral Treatment, Incidence of Sustained Therapy Interruptions, and Risk of Clinical Events According to SexQ57632363
Do gender differences in CD4 cell counts matter?Q73271751
Hormonal milieu at time of B cell activation controls duration of autoantibody responseQ35300035
Human adipose tissue as a reservoir for memory CD4+ T cells and HIV.Q35318746
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tractQ35636288
Sex differences in pharmacokinetics and pharmacodynamicsQ35639177
Sex-based differences in immune function and responses to vaccinationQ35661949
Inflammation and race and gender differences in computerized tomography-measured adipose depotsQ35707614
Hydrogen Peroxide-Producing Lactobacilli Are Associated With Lower Levels of Vaginal Interleukin-1β, Independent of Bacterial VaginosisQ35903302
Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosisQ35931083
Characterization of the immune cell repertoire in the normal fallopian tube.Q36198864
Progesterone and autoimmune diseaseQ36202227
Dialogues on diversifying clinical trials: successful strategies for engaging women and minorities in clinical trials.Q36204611
17beta-Estradiol utilizes the estrogen receptor to regulate CD16 expression in monocytesQ36248880
Bacterial Vaginosis and Subclinical Markers of Genital Tract Inflammation and Mucosal ImmunityQ36294698
Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmissionQ36353342
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapyQ36499290
Estrogen signaling multiple pathways to impact gene transcriptionQ36499769
Innate and adaptive anti-HIV immune responses in the female reproductive tractQ36637034
Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure.Q36824026
The complex role of estrogens in inflammation.Q36886660
Persistent HIV-1 replication maintains the tissue reservoir during therapyQ36897321
Sex issues in HIV-1-infected persons during highly active antiretroviral therapy: a systematic reviewQ36917426
Estrogen and CD4+ T cellsQ36925326
Participation of women and sex analyses in late-phase clinical trials of new molecular entity drugs and biologics approved by the FDA in 2007-2009.Q36991121
Association of genital human papillomavirus infection with HIV acquisition: a systematic review and meta-analysisQ37030414
17β-Estradiol inhibits HIV-1 by inducing a complex formation between β-catenin and estrogen receptor α on the HIV promoter to suppress HIV transcriptionQ37043012
Higher expression of several interferon-stimulated genes in HIV-1-infected females after adjusting for the level of viral replication.Q37070383
The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosisQ37173351
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapyQ37200979
Gender differences in the treatment of HIV infectionQ37245490
The X-files in immunity: sex-based differences predispose immune responsesQ37252714
Noncalcified coronary atherosclerotic plaque and immune activation in HIV-infected womenQ37272371
Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysisQ37326860
Policy: NIH to balance sex in cell and animal studiesQ37403351
Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal womenQ37626039
Estrogen receptor alpha inhibits the estrogen-mediated suppression of HIV transcription in astrocytes: implications for estrogen neuroprotection in HIV dementiaQ33686905
Immune activation and HIV persistence: considerations for novel therapeutic interventionsQ33698781
Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxisQ33821257
PD-1, gender, and autoimmunityQ33910421
Reference ranges and sources of variability of CD4 counts in HIV-seronegative women and men.Q33935910
Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapyQ33962223
Behavioral, biological, and demographic risk and protective factors for new HIV infections among youth in Rakai, UgandaQ34040924
Sex-based differences in HIV type 1 pathogenesisQ34148475
Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllersQ34189960
Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesisQ34260259
Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapyQ34384134
CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cellsQ34395160
Sex bias in neuroscience and biomedical researchQ34433270
Estrogen enhances immunoglobulin production by human PBMCsQ34491431
Sex differences in atazanavir pharmacokinetics and associations with time to clinical events: AIDS Clinical Trials Group Study A5202.Q34495619
Human papillomavirus seropositivity and subsequent risk of HIV acquisition in rural South African womenQ34551969
Lack of decay of HIV-1 in gut-associated lymphoid tissue reservoirs in maximally suppressed individualsQ34561005
Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected womenQ34568436
Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapyQ34588169
Sex-based outcomes of darunavir-ritonavir therapy: a single-group trialQ34664004
HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cellsQ34672568
Does patient sex affect human immunodeficiency virus levels?Q34736412
Darunavir, ritonavir, and etravirine pharmacokinetics in the cervicovaginal fluid and blood plasma of HIV-infected womenQ34737260
Sex, race, and geographic region influence clinical outcomes following primary HIV-1 infectionQ34764377
Early HIV-1 target cells in human vaginal and ectocervical mucosaQ34796617
Sex, age, race and intervention type in clinical studies of HIV cure: a systematic reviewQ34870233
Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV.Q34981137
Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infectionsQ34982527
Raltegravir concentrations in the genital tract of HIV-1-infected women treated with a raltegravir-containing regimen (DIVA 01 study)Q35005146
Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapyQ35077988
Factors associated with D-dimer levels in HIV-infected individualsQ35120065
Estrogen receptors regulate innate immune cells and signaling pathwaysQ35236340
Select host restriction factors are associated with HIV persistence during antiretroviral therapyQ35271996
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthuman immunodeficiency virus infectious diseaseQ18556697
RNA virus infectious diseaseQ18967413
Retroviridae infectious diseaseQ19000689
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)20706
P577publication date2016-02-18
P1433published inJournal of the International AIDS SocietyQ6296158
P1476titleBarriers to a cure for HIV in women
P478volume19

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cites work (P2860)
Q56517281Analysis of complement-mediated lysis of SIV and SIV-infected cells reveals sex differences in vaccine-induced immune responses in Rhesus macaques
Q39366791Barriers to HIV remission research in low- and middle-income countries.
Q93147329Gender differences in innate responses and gene expression profiles in memory CD4 T cells are apparent very early during acute simian immunodeficiency virus infection
Q56762706International Congress of Drug Therapy in HIV Infection 23-26 October 2016, Glasgow, UK
Q90241137Participant Perspectives in an HIV Cure-Related Trial Conducted Exclusively in Women in the United States: Results from AIDS Clinical Trials Group 5366
Q60434051Pharmacology of Antiretrovirals in the Female Genital Tract for HIV Prevention
Q92456846Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting
Q46049688Research on HIV cure: Mapping the ethics landscape
Q92702667Revisiting the 'sterilising cure' terminology: a call for more patient-centred perspectives on HIV cure-related research
Q90348296Screening and Enrollment by Sex in HIV Clinical Trials in the United States
Q58104425Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune Activation

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