Current status of PET imaging in Huntington's disease

scientific article

Current status of PET imaging in Huntington's disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P6179Dimensions Publication ID1039382297
P356DOI10.1007/S00259-016-3324-6
P3181OpenCitations bibliographic resource ID4258211
P932PMC publication ID4844650
P698PubMed publication ID26899245
P5875ResearchGate publication ID295542462

P50authorMarios PolitisQ64856266
Flavia NiccoliniQ90879542
Gennaro PaganoQ38321619
P2860cites workStriatal D1 and D2 receptor binding in patients with Huntington's disease and other choreas A PET studyQ45307413
Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatumQ23909635
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Striatal glucose metabolism and dopamine D2 receptor binding in asymptomatic gene carriers and patients with Huntington's diseaseQ28302222
The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's diseaseQ28705237
Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's diseaseQ28748849
Huntington disease: natural history, biomarkers and prospects for therapeuticsQ30774172
Neuroimaging in Huntington's diseaseQ30834004
Neuroimaging in Parkinson disease: from research setting to clinical practiceQ30868628
Recent imaging advances in neurology.Q30916063
Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475.Q31118947
Differential excitability and modulation of striatal medium spiny neuron dendritesQ33382961
Differential loss of striatal projection neurons in Huntington diseaseQ33637273
Disorders of the basal ganglia and their modern management.Q33725428
Optimizing functional imaging protocols for assessing the outcome of fetal cell transplantation in Parkinson's diseaseQ33898436
Neuronal localization of cannabinoid receptors in the basal ganglia of the rat.Q34602111
CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approachesQ34624785
Thalamic metabolism and symptom onset in preclinical Huntington's diseaseQ34692568
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathologyQ35134776
Microglial functions and proteasesQ35141400
Central motor processing in Huntington's disease. A PET studyQ45295098
Cortical control of movement in Huntington's disease. A PET activation studyQ45295104
Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumesQ45295568
[11C]raclopride-PET studies of the Huntington's disease rate of progression: relevance of the trinucleotide repeat lengthQ45295668
The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's diseaseQ45296236
PET imaging shows loss of striatal PDE10A in patients with Huntington diseaseQ45296605
Positron emission tomography in the early diagnosis of Huntington's diseaseQ45297664
Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutationQ45297722
Cross sectional PET study of cerebral adenosine A₁ receptors in premanifest and manifest Huntington's diseaseQ45297840
Positron emission tomography after fetal transplantation in Huntington's diseaseQ45297853
PET scan investigations of Huntington's disease: cerebral metabolic correlates of neurological features and functional declineQ45297931
Reduced cerebral glucose metabolism in asymptomatic subjects at risk for Huntington's diseaseQ45298088
Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease.Q45298570
Positron emission tomographic scan investigations of Huntington's disease: cerebral metabolic correlates of cognitive functionQ45299001
Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomographyQ45299145
Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivoQ45299326
Neurotransmitter receptor alterations in Huntington's disease: autoradiographic and homogenate studies with special reference to benzodiazepine receptor complexesQ45299456
Extrastriatal dopamine D(2) receptor binding in Huntington's diseaseQ45299934
Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease.Q45299986
Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington miceQ45300196
Decreased striatal monoaminergic terminals in Huntington diseaseQ45300337
Benzodiazepine receptor binding in Huntington's disease: [11C]flumazenil uptake measured using positron emission tomographyQ45300345
The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's diseaseQ45300428
Diagnostic criteria for Huntington's disease based on natural historyQ45301388
Microglial activation correlates with severity in Huntington disease: a clinical and PET study.Q45301519
Motor and cognitive improvements in patients with Huntington's disease after neural transplantationQ45301920
The phosphodiesterase 10 positron emission tomography tracer, [18F]MNI-659, as a novel biomarker for early Huntington diseaseQ45302323
Regional cerebral glucose metabolism after pridopidine (ACR16) treatment in patients with Huntington diseaseQ45302933
Huntington's disease: effect of memantine on FDG-PET brain metabolism?Q45303289
Microglial activation in presymptomatic Huntington's disease gene carriersQ45304723
Regional and progressive thinning of the cortical ribbon in Huntington's diseaseQ45305508
The dynamics of cortical and hippocampal atrophy in Alzheimer diseaseQ35643088
Decreased Metabolism in the Cerebral Cortex in Early-Stage Huntington's Disease: A Possible Biomarker of Disease Progression?Q36528726
Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [(11)C]CB184 and [ (11)C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ (11)C](R)-PK11195.Q36809409
Metabolic network as a progression biomarker of premanifest Huntington's diseaseQ37123932
Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneityQ37132239
Brain imaging after neural transplantationQ37796021
Brain networks in Huntington diseaseQ37834193
Positron emission tomography neuroimaging in Parkinson's diseaseQ37929598
Positron emission tomography imaging in neurological disordersQ37980609
Integrating neurotransmission in striatal medium spiny neurons.Q37986667
Imaging of microglia in patients with neurodegenerative disordersQ38015834
The incidence and prevalence of Huntington's disease: a systematic review and meta-analysisQ38018281
Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration.Q38515285
The Neuropathology of Huntington´s disease: classical findings, recent developments and correlation to functional neuroanatomyQ38696568
Alterations in the benzodiazepine receptor of Huntington's diseased human brainQ39242585
Cerebral glucose and dopa metabolism in movement disorders.Q39483640
The GABA Neurons and their axon terminals in rat corpus striatum as demonstrated by GAD immunocytochemistryQ40260170
Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucoseQ40324066
Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriersQ40617788
Huntington's disease progression. PET and clinical observations.Q40787958
Modulation of neurotransmission by cannabinoids in the basal gangliaQ41371378
Identifying improved TSPO PET imaging probes through biomathematics: the impact of multiple TSPO binding sites in vivoQ41823077
Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflowQ42467111
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosageQ42512972
Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriersQ43255746
Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging studyQ43469689
Metabolic network abnormalities in early Huntington's disease: an [(18)F]FDG PET study.Q43790732
Opioid peptides in Huntington's disease: alterations in prodynorphin and proenkephalin systemQ44344438
Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET study.Q44400030
Striatal neural grafting improves cortical metabolism in Huntington's disease patientsQ44649029
Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptomsQ44748091
18F-FDG PET uptake in the pre-Huntington disease caudate affects the time-to-onset independently of CAG expansion sizeQ45288484
Altered PDE10A expression detectable early before symptomatic onset in Huntington's diseaseQ45289206
Dopamine D1 receptor number--a sensitive PET marker for early brain degeneration in Huntington's diseaseQ45290030
Positron emission tomography measures of benzodiazepine receptors in Huntington's diseaseQ45290810
Hypothalamic involvement in Huntington's disease: an in vivo PET studyQ45291041
Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's diseaseQ45291252
Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins.Q45293052
Functional brain changes in presymptomatic Huntington's diseaseQ45293738
PET study of the pre- and post-synaptic dopaminergic markers for the neurodegenerative process in Huntington's diseaseQ45294163
A PET study of word generation in Huntington's disease: effects of lexical competition and verb/noun categoryQ45294571
Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease.Q45294680
11C-diprenorphine binding in Huntington's disease: a comparison of region of interest analysis with statistical parametric mappingQ45295068
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectHuntington's diseaseQ190564
positron emission tomographyQ208376
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)1171-82
P577publication date2016-06-01
P1433published inEuropean Journal of Nuclear Medicine and Molecular ImagingQ15708890
P1476titleCurrent status of PET imaging in Huntington's disease
P478volume43

Reverse relations

cites work (P2860)
Q28075227A systematic review of lessons learned from PET molecular imaging research in atypical parkinsonism
Q49719233Alteration of GABAergic neurotransmission in Huntington's disease.
Q45303467Altered behavioral responses to gamma-aminobutyric acid pharmacological agents in a mouse model of Huntington's disease.
Q92852974Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease
Q41566638Chronic exposure to dopamine agonists affects the integrity of striatal D2 receptors in Parkinson's patients
Q34547558Current Pharmacological Approaches to Reduce Chorea in Huntington's Disease
Q48044131Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy
Q39165036Huntington Disease: Linking Pathogenesis to the Development of Experimental Therapeutics
Q92923586Huntington's Disease: A Review of the Known PET Imaging Biomarkers and Targeting Radiotracers
Q29248766Molecular Imaging Markers to Track Huntington’s Disease Pathology
Q89338605Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration
Q57493665Neuroimaging of Sleep Disturbances in Movement Disorders
Q57021540Novel Imaging Biomarkers for Huntington's Disease and Other Hereditary Choreas
Q42369736PET Molecular Imaging Research of Levodopa-Induced Dyskinesias in Parkinson's Disease
Q33831774Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity
Q45295893Striatal hypometabolism in premanifest and manifest Huntington's disease patients
Q48272772TAK-063, a novel PDE10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia
Q88960978TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31
Q28072937The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease
Q48372783The serotonergic system in Parkinson's patients with dyskinesia: evidence from imaging studies

Search more.