Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition)

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Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition) is …
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P356DOI10.3978/J.ISSN.2305-5839.2015.12.23
P932PMC publication ID4690993
P698PubMed publication ID26734632

P2093author name stringFang Li
Yongqian Shu
Di Wu
Kejun Nan
Min Tao
Aiping Lu
Xiubao Ren
Yiping Zhang
Baocheng Wang
Shukui Qin
Houjie Liang
Jun Guo
Junling Li
Tongyu Lin
Xiaohui Niu
Jun Liang
Xin Song
Chuanliang Cui
Lu Si
Zhihong Chi
Hongming Pan
Xiaolin Xu
Xiaohong Chen
Wenbin Wei
Xiaoshi Zhang
Junyi Zhang
Jiwei Liu
Nan Du
Yun Fan
Huiyan Zhu
Man Lu
Lingying Wu
Aiwen Wu
Guoxin Ren
Kangsheng Gu
Yongheng Li
P2860cites workThe prognostic importance of tumor mitotic rate confirmed in 1317 patients with primary cutaneous melanoma and long follow-upQ79890286
Primary mucosal melanoma of the head and neck: a proposal for microstaging localized, Stage I (lymph node-negative) tumorsQ79899321
Phase II evaluation of paclitaxel by short intravenous infusion in metastatic melanomaQ79947173
Identification of high-risk patients among those diagnosed with thin cutaneous melanomasQ79975637
Adjuvant radiotherapy for cutaneous melanoma: comparing hypofractionation to conventional fractionationQ80263164
Phase II trial of weekly paclitaxel in patients with advanced melanomaQ81251337
Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neckQ81388196
Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma: Collaborative Ocular Melanoma Study Group Report No. 26Q81606793
[Hepatic intra-arterial bio-chemotherapy for the treatment of melanoma patients with liver metastasis: a phase II clinical study]Q81797318
Radiation therapy field extent for adjuvant treatment of axillary metastases from malignant melanomaQ81936078
Importance of clear resection margins in anorectal malignant melanomaQ82257147
Results of sentinel lymph node biopsy in patients with thin melanomaQ82584808
Copy number variations and clinical outcome in atypical spitz tumorsQ83288549
Predictors of positive sentinel lymph node in thin melanomaQ83514090
A randomised phase II trial of 1month versus 1year of adjuvant high-dose interferon α-2b in high-risk acral melanoma patientsQ83863771
Intensity-modulated radiotherapy for sinonasal cancer: improved outcome compared to conventional radiotherapyQ83908819
First-line temozolomide combined with bevacizumab in metastatic melanoma: a multicentre phase II trial (SAKK 50/07)Q83992836
Efficacy of 2-cm surgical margins for intermediate-thickness melanomas (1 to 4 mm). Results of a multi-institutional randomized surgical trialQ24530611
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenibQ24594790
Mutations in GNA11 in uveal melanomaQ24625723
Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutationsQ24632064
Frequent somatic mutations of GNAQ in uveal melanoma and blue naeviQ24646052
The clinical features and optimal treatment of anorectal malignant melanomaQ26828599
F-18-fluoro-2-deoxyglucose positron emission tomography (PET) and PET/computed tomography imaging in primary staging of patients with malignant melanoma: a systematic reviewQ26830033
Phase II, Open-Label, Single-Arm Trial of Imatinib Mesylate in Patients With Metastatic Melanoma Harboring c-Kit Mutation or AmplificationQ27851656
Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trialQ27853021
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in MelanomaQ27860650
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Q27861047
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
Ipilimumab plus dacarbazine for previously untreated metastatic melanomaQ28131634
Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entitiesQ28204383
Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III studyQ28250432
Prognostic implications of monosomy 3 in uveal melanomaQ28277919
Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic deathQ28288495
Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanomaQ28378420
Phase II DeCOG-study of ipilimumab in pretreated and treatment-naïve patients with metastatic uveal melanomaQ28543960
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trialQ29614756
Final version of 2009 AJCC melanoma staging and classificationQ29614803
Distinct sets of genetic alterations in melanomaQ29614965
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993Q29619885
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumabQ29620596
Improved survival with MEK inhibition in BRAF-mutated melanomaQ29620663
Nivolumab in previously untreated melanoma without BRAF mutationQ29620688
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trialQ29620814
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escapeQ29620881
Vulvar Melanoma: A Retrospective Analysis and Literature ReviewQ30308344
Study design and rationale for a randomised, placebo-controlled, double-blind study to assess the efficacy of selumetinib (AZD6244; ARRY-142886) in combination with dacarbazine in patients with metastatic uveal melanoma (SUMIT).Q30384829
Anal melanomaQ30437650
Phase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitorQ36929804
A Phase II, Randomized, Double-blind, Placebo-controlled Multicenter Trial of Endostar in Patients With Metastatic MelanomaQ36984477
Genetic mutations involved in melanoma: a summary of our current understandingQ37045209
Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the managementQ37060742
Sinonasal melanoma: a clinicopathologic review of 61 casesQ37099296
Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccinesQ37129949
Recent approaches to improve the antitumor efficacy of temozolomide.Q37370405
Diagnosis and treatment of melanoma brain metastasis: a literature reviewQ37531863
Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results.Q37660804
Outcome of sinonasal melanoma: clinical experience and review of the literatureQ37690271
Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis.Q37697383
Postoperative radiotherapy in head and neck mucosal melanoma: a GETTEC studyQ37822609
Treatment and outcomes of anorectal melanomaQ37825002
AJCC melanoma staging update: impact on dermatopathology practice and patient managementQ37850827
Mucosal melanoma of the head and neck: predictors of prognosisQ37866566
Lentigo Maligna: Melanoma In Situ on Chronically Sun-Damaged SkinQ37898119
Adjuvant interferon alfa in malignant melanoma: an interdisciplinary and multinational expert reviewQ38033002
Mucosal melanoma of the head and neck: 32-year experience in a tertiary referral hospitalQ38060660
Radiation Therapy for Mucosal Melanoma of the Head and NeckQ38096789
Anorectal Malignant Melanoma: Extensive 45-Year Review and Proposal for a Novel Staging ClassificationQ38108649
Clinicopathologic predictors of sentinel lymph node metastasis in thin melanomaQ38159945
Head and neck mucosal melanoma: a reviewQ38178433
Update on primary mucosal melanoma.Q38210789
Abdominoperineal resection provides better local control but equivalent overall survival to local excision of anorectal malignant melanoma: a systematic reviewQ38239550
Investigating the role of melanin in UVA/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cellsQ39426359
Epidemiologic aspects of uveal melanomaQ39632521
A single-institution validation of the AJCC staging system for stage IV melanomaQ40094305
International Validation of the American Joint Committee on Cancer's 7th Edition Classification of Uveal MelanomaQ41630935
Cytogenetic characterization of tumors of the vulva and vaginaQ42446612
A phase II trial of bevacizumab with dacarbazine and daily low-dose interferon-alpha2a as first line treatment in metastatic melanomaQ43106634
The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and deathQ43286776
Epidemiology and prognosis of anorectal melanomaQ43694744
Phase II Randomized Trial Comparing High-Dose IFN-α2b with Temozolomide Plus Cisplatin as Systemic Adjuvant Therapy for Resected Mucosal MelanomaQ43842013
Tumour regression does not increase the risk of sentinel node involvement in thin melanomasQ44353499
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trialQ44442912
Management of vulvar melanomaQ44517049
2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: a randomised, multicentre trial.Q44543762
Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanomaQ44932116
Fraction size in external beam radiation therapy in the treatment of melanomaQ45031579
Large-Scale Analysis of KIT Aberrations in Chinese Patients with MelanomaQ45036059
Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative GroupQ74463785
Guidelines of care for primary cutaneous melanomaQ74544679
Mohs micrographic surgery for melanoma: a case series, a comparative study of immunostains, an informative case report, and a unique mapping techniqueQ74601046
Primary mucosal malignant melanoma of the head and neckQ77759737
Acral lentiginous melanomaQ77761855
BRAF and RAS mutations in human lung cancer and melanomaQ78598197
The prognostic importance of sentinel lymph node biopsy in thin melanomaQ79761878
Primary cutaneous melanoma with regression does not require a lower threshold for sentinel lymph node biopsyQ79838122
Tumor-infiltrating lymphocytes predict sentinel lymph node positivity in patients with cutaneous melanomaQ79843514
[Prognosis after sentinel node biopsy in malignant melanoma]Q79848521
The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer SocietyQ31995716
Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): randomised controlled trialQ33224408
Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study GroupQ33372613
Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanomaQ33384029
Noncutaneous malignant melanoma: a prognostic model from a retrospective multicenter studyQ33567330
Practice patterns and outcomes for anorectal melanoma in the USA, reviewing three decades of treatment: is more extensive surgical resection beneficial in all patients?Q33604057
Positive iliac and obturator nodes in melanoma: survival and prognostic factorsQ33642969
Does the extent of operation influence the prognosis in patients with melanoma metastatic to inguinal nodes?Q33642975
A molecular revolution in uveal melanoma: implications for patient care and targeted therapyQ33717375
Final trial report of sentinel-node biopsy versus nodal observation in melanomaQ33760173
Ipilimumab for patients with advanced mucosal melanomaQ33777469
Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: a study of 522 consecutive casesQ33829284
A randomized phase 2 study of temozolomide and bevacizumab or nab-paclitaxel, carboplatin, and bevacizumab in patients with unresectable stage IV melanoma : a North Central Cancer Treatment Group study, N0775Q33871014
Prognosis in patients with sentinel node-positive melanoma is accurately defined by the combined Rotterdam tumor load and Dewar topography criteriaQ33881765
High- and low-dose interferon alfa-2b in high-risk melanoma: first analysis of intergroup trial E1690/S9111/C9190.Q33905836
Management options and survival in malignant melanoma of the sinonasal mucosaQ33965635
Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging systemQ34086787
Adjuvant Interferon Therapy for Patients at High Risk for Recurrent Melanoma: An Updated Systematic Review and Practice GuidelineQ34127695
Therapeutic implications of the emerging molecular biology of uveal melanoma.Q34173920
Guidelines of care for the management of primary cutaneous melanoma. American Academy of DermatologyQ34210955
Oncogenic GNAQ and GNA11 mutations in uveal melanoma in ChineseQ34287626
Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastasesQ34315676
Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.Q34371245
Contemporary Diagnostic Imaging Modalities for the Staging and Surveillance of Melanoma Patients: a Meta-analysisQ34498776
High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival updateQ34507305
Long-term results of a prospective surgical trial comparing 2 cm vs. 4 cm excision margins for 740 patients with 1-4 mm melanomasQ34514256
Excision margins in high-risk malignant melanomaQ34545721
Mitotic rate and younger age are predictors of sentinel lymph node positivity: lessons learned from the generation of a probabilistic modelQ34545994
Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas.Q34557221
Combination of paclitaxel and carboplatin as second-line therapy for patients with metastatic melanomaQ34563261
Somatic activation of KIT in distinct subtypes of melanomaQ34569987
Sentinel-node biopsy or nodal observation in melanomaQ34571347
The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanomaQ34573029
Temozolomide in advanced malignant melanoma with small brain metastases: can we withhold cranial irradiation?Q34573039
Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trialQ34594112
Role of sentinel lymph node biopsy in patients with thin melanomaQ34607033
A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.Q34608282
The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanomaQ34611113
Long-term outcome of hyperthermic isolated limb perfusion (HILP) in the treatment of locoregionally metastasised malignant melanoma of the extremitiesQ34616174
Effect of paclitaxel/carboplatin salvage chemotherapy in noncutaneous versus cutaneous metastatic melanomaQ34648335
Efficacy and safety of ipilimumab 3mg/kg in patients with pretreated, metastatic, mucosal melanomaQ34656538
Sentinel node biopsy improves prognostic stratification in patients with thin (pT1) melanomas and an additional risk factor.Q34660516
Genomic Classification of Cutaneous MelanomaQ34670776
Taxol in malignant melanoma.Q34724520
Phase III trial of dacarbazine versus dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: an Eastern Cooperative Oncology GrQ34747181
Surgical techniques of melanoma and sentinel node biopsyQ34778792
Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging databaseQ35023404
A phase 2 trial of bevacizumab and high-dose interferon alpha 2B in metastatic melanoma.Q35050558
Surgical therapy for anorectal melanomaQ35069381
Incidence of uveal melanoma in the United States: 1973-1997.Q35128733
Ocular melanoma: a review and the relationship to cutaneous melanomaQ35202353
Systematic review of medical treatment in melanoma: current status and future prospects.Q35584299
Primary malignant melanoma of the vulva--an aggressive tumor for modeling the genesis of non-UV light-associated melanomasQ35883874
Ultraviolet Radiation-Induced Cytogenetic Damage in White, Hispanic and Black Skin Melanocytes: A Risk for Cutaneous MelanomaQ36102856
Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanomaQ36113448
Vulvar melanoma: review of diagnosis, staging, and therapyQ36116819
Serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasisQ36117266
BEAM: a randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma.Q36346020
Futility of fluorodeoxyglucose F 18 positron emission tomography in initial evaluation of patients with T2 to T4 melanomaQ36426516
Pathology of melanomaQ36445925
Sentinel node mapping for melanoma: results of trials and current applicationsQ36750546
Primary mucosal melanomaQ36756223
Sentinel lymph node molecular ultrastaging in patients with melanoma: a systematic review and meta-analysis of prognosisQ36795247
Frequency and Duration of Remission After Isolated Limb Perfusion for MelanomaQ36878183
Importance of sentinel lymph node biopsy in patients with thin melanomaQ36923881
Biochemotherapy in patients with advanced vulvovaginal mucosal melanomaQ45172068
Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanomaQ45300701
Biochemotherapy in patients with advanced head and neck mucosal melanomaQ46362485
Analysis of sentinel lymph node positivity in patients with thin primary melanomaQ46495695
Inefficacy of F-18 fluorodeoxy-D-glucose-positron emission tomography scans for initial evaluation in early-stage cutaneous melanomaQ46565593
Utility of preoperative [(18)]f fluorodeoxyglucose-positron emission tomography scanning in high-risk melanoma patientsQ46941511
Phase II study of nab-paclitaxel and bevacizumab as first-line therapy for patients with unresectable stage III and IV melanomaQ46951033
Partial regression of primary cutaneous melanoma: is there an association with sub-clinical sentinel lymph node metastasis?Q47615560
Adjuvant radiotherapy versus observation alone for patients at risk of lymph-node field relapse after therapeutic lymphadenectomy for melanoma: a randomised trial.Q47781508
Randomised trial of interferon alpha-2a as adjuvant therapy in resected primary melanoma thicker than 1.5 mm without clinically detectable node metastases. French Cooperative Group on MelanomaQ47880534
Dose-intensified bi-weekly temozolomide in patients with asymptomatic brain metastases from malignant melanoma: a phase II DeCOG/ADO study.Q48411500
Phase II study of temozolomide and thalidomide in patients with metastatic melanoma in the brain: high rate of thromboembolic events (CALGB 500102).Q48417717
Development of a biochemotherapy regimen with concurrent administration of cisplatin, vinblastine, dacarbazine, interferon alfa, and interleukin-2 for patients with metastatic melanomaQ48469829
American Joint Committee on Cancer Classification of Uveal Melanoma (Anatomic Stage) Predicts Prognosis in 7,731 Patients: The 2013 Zimmerman Lecture.Q48517902
Important prognostic significance of a sentinel-node biopsy in patients with malignant melanomaQ50489771
Incidence of sentinel node metastasis in patients with thin primary melanoma (< or = 1 mm) with vertical growth phaseQ50511958
Population-based incidence of uveal melanoma in various races and ethnic groupsQ50770910
Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanomaQ50935715
Sentinel lymph node biopsy in patients with thin primary cutaneous melanoma.Q51002866
Adjuvant interferon in high-risk melanoma: the AIM HIGH Study--United Kingdom Coordinating Committee on Cancer Research randomized study of adjuvant low-dose extended-duration interferon Alfa-2a in high-risk resected malignant melanomaQ51012672
Preliminary experience with transarterial chemoembolization (TACE) in liver metastases of uveal malignant melanoma: local tumor control and survivalQ51124070
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanomaQ51787742
Variates of survival in metastatic uveal melanomaQ51834538
Craniofacial resection for malignant melanoma of the skull base: report of an international collaborative studyQ53261505
A genome-based strategy uncovers frequent BRAF mutations in melanomaQ53388101
Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: a randomised trialQ53473469
F-18 fluorodeoxy-D-glucose positron emission tomography scan in the initial evaluation of patients with a primary melanoma thicker than 4 mm.Q53481364
Sentinel lymph node biopsy: A new perspective in head and neck mucosal melanoma?Q53518414
Dacarbazine in combination with bevacizumab for the treatment of unresectable/metastatic melanoma: a phase II studyQ53587515
Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohortQ54357561
Whole-genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanomaQ54429549
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.Q54610975
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagementQ56908957
Dacarbazine-based chemotherapy as first-line treatment in noncutaneous metastatic melanoma: multicenter, retrospective analysis in AsiaQ57226549
Phase II Pilot Study of Intravenous High-Dose Interferon With or Without Maintenance Treatment in Melanoma at High Risk of RecurrenceQ57569597
Histopathologic characteristics of uveal melanomas in eyes enucleated from the collaborative ocular melanoma study COMS report no. 6Q57619765
Sentinel Node Biopsy in Thin and Thick MelanomaQ59489494
Radiotherapy after surgical resection for head and neck mucosal melanoma.Q64915450
A clinicopathological study of 30 melanomas of the vulvaQ68011921
A phase II trial of taxol in metastatic melanomaQ68087518
A phase II study of taxol in patients with malignant melanomaQ68298891
"Microscopic satellites" are more highly associated with regional lymph node metastases than is primary melanoma thicknessQ71293134
The classification of malignant melanomaQ71500917
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2Q72275233
Tumor mitotic rate is a more powerful prognostic indicator than ulceration in patients with primary cutaneous melanoma: an analysis of 3661 patients from a single centerQ73102827
Vertical growth phase and positive sentinel node in thin melanomaQ73135038
Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanomaQ73181804
Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging systemQ73322618
Pretreatment factors predicting quality of life after treatment for head and neck cancerQ73912410
The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings. COMS Report No. 18Q74184049
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)322
P577publication date2015-12-01
P1433published inAnnals of Translational MedicineQ26842362
P1476titleChinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition)
P478volume3