Personalized antiplatelet therapy with P2Y12 receptor inhibitors: benefits and pitfalls

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Personalized antiplatelet therapy with P2Y12 receptor inhibitors: benefits and pitfalls is …
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P356DOI10.5114/PWKI.2015.55596
P932PMC publication ID4679793
P698PubMed publication ID26677375
P5875ResearchGate publication ID285574594

P50authorJacek KubicaQ49506302
Jolanta M Siller-MatulaQ37837348
Max-Paul WinterQ41577394
Marek KozińskiQ68692877
P2093author name stringDaniel Aradi
P2860cites workImpact of CYP2C19 polymorphism on residual platelet reactivity in patients with coronary heart disease during antiplatelet therapyQ82942386
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Residual platelet reactivity after aspirin and clopidogrel treatment predicts 2-year major cardiovascular events in patients undergoing percutaneous coronary interventionQ84956961
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Antiplatelet effects of prasugrel vs. double clopidogrel in patients on hemodialysis and with high on-treatment platelet reactivityQ85068323
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Bedside monitoring to adjust antiplatelet therapy for coronary stentingQ85345517
High on-treatment platelet reactivity--definition and measurementQ86174316
Comparison of antiplatelet effects of prasugrel and ticagrelor in cynomolgus monkeys by an ELISA-based VASP phosphorylation assay and platelet aggregationQ87175690
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Central role of the P2Y12 receptor in platelet activationQ24618777
Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleedingQ26829251
Response variability to P2Y12 receptor inhibitors: expectations and realityQ26999243
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Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarctionQ28168881
Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery diseaseQ28176445
Stent thrombosis is associated with an impaired response to antiplatelet therapyQ28176582
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Platelet activation predicts recurrent ischemic events after percutaneous coronary angioplasty: a 6 months prospective studyQ28193902
High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndromeQ28194081
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Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylationQ28196513
Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatmentQ28199546
Platelet function in patients with acute coronary syndrome (ACS) predicts recurrent ACSQ28200553
Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosisQ28213327
Resistance to antiplatelet drugs: molecular mechanisms and laboratory detectionQ28218540
High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromesQ28218589
Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate?Q28218910
Thienopyridines in cardiovascular disease: focus on clopidogrel resistanceQ28219790
Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectivesQ28222158
Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery diseaseQ28222643
Ticagrelor versus clopidogrel in patients with acute coronary syndromesQ29619002
The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score.Q33303244
Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stentsQ33335010
A novel modification of the Thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregationQ33360658
Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventionsQ33509256
Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery diseaseQ33667980
Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseasesQ33685876
Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance--the BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapyQ33791290
Interplay between genetic and clinical variables affecting platelet reactivity and cardiac adverse events in patients undergoing percutaneous coronary interventionQ33933475
High residual platelet reactivity after clopidogrel loading and long-term clinical outcome after drug-eluting stenting for unprotected left main coronary diseaseQ43240996
Predictive values of post-treatment adenosine diphosphate-induced aggregation and vasodilator-stimulated phosphoprotein index for stent thrombosis after acute coronary syndrome in clopidogrel-treated patientsQ43267576
Influence of C3435T multidrug resistance gene-1 (MDR-1) polymorphism on platelet reactivity and prognosis in patients with acute coronary syndromesQ43270415
Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized studyQ43275236
Predictive value of post-treatment platelet reactivity for occurrence of post-discharge bleeding after non-ST elevation acute coronary syndrome. Shifting from antiplatelet resistance to bleeding risk assessment?Q43279859
Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosisQ43416611
Platelet hyperactivity and abnormal Ca(2+) homeostasis in diabetes mellitusQ43541597
Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro.Q43554882
Impact of preoperative use of P2Y12 receptor inhibitors on clinical outcomes in cardiac and non-cardiac surgery: A systematic review and meta-analysisQ43740353
Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromesQ43815690
High on-treatment platelet reactivity to both aspirin and clopidogrel is associated with the highest risk of adverse events following percutaneous coronary interventionQ43989417
Residual platelet reactivity, bleedings, and adherence to treatment in patients having coronary stent implantation treated with prasugrelQ44305048
Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: results from the double-blind, prospective, randomized Tailoring Treatment with Tirofiban in PatienQ44475877
Platelet reactivity to adenosine diphosphate and long-term ischemic event occurrence following percutaneous coronary intervention: a potential antiplatelet therapeutic targetQ44479790
Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects.Q44545487
Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidityQ44642265
Clopidogrel and bleeding in patients undergoing elective coronary artery bypass graftingQ45049123
Ticagrelor induces adenosine triphosphate release from human red blood cellsQ45158070
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) studyQ45287859
Prospective evaluation of on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention relationship with gene polymorphisms and clinical outcome.Q45947797
The CYP2C19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute coronary syndrome.Q45982700
Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: a prospective, randomized study.Q46000153
Evaluation of the Platelet Mapping Assay on rotational thromboelastometry ROTEM.Q46113377
Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention results of the ARMYDA-PRO (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-PlateleQ46119763
Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary interventionQ46133343
Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometryQ46142958
Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-upQ46178120
Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosisQ46187200
Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrelQ46199177
Impact of clopidogrel resistance on thrombotic events after percutaneous coronary intervention with drug-eluting stentQ46223773
Calcium-channel blockers reduce the antiplatelet effect of clopidogrelQ46248005
Effects of aspirin and clopidogrel in healthy men measured by platelet aggregation and PFA-100.Q46367587
Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents.Q46418076
A point-of-care platelet function assay and C-reactive protein for prediction of major cardiovascular events after drug-eluting stent implantationQ46531708
Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectorisQ46543532
Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective studyQ46665436
Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantationQ46761762
Dual non-responsiveness to antiplatelet treatment is a stronger predictor of cardiac adverse events than isolated non-responsiveness to clopidogrel or aspirinQ46782610
Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stentingQ46789035
Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST StudyQ46802481
Platelet inhibition by insulin is absent in type 2 diabetes mellitusQ46843983
Prasugrel versus clopidogrel in patients with acute coronary syndromesQ46915044
Clinical implications of very low on-treatment platelet reactivity in patients treated with thienopyridine: the POBA study (predictor of bleedings with antiplatelet drugs).Q47723344
Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridinesQ48303367
ADP receptors of platelets and their inhibitionQ74314926
The antiplatelet effects of ticlopidine and clopidogrelQ77292679
Alterations of adenine nucleotide metabolism and function of blood platelets in patients with diabetesQ79678239
A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 daysQ79710766
The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metaboliteQ80209388
Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatmentQ80543316
Functional impact of high clopidogrel maintenance dosing in patients undergoing elective percutaneous coronary interventions. Results of a randomized studyQ80543338
The use of the VerifyNow P2Y12 point-of-care device to monitor platelet function across a range of P2Y12 inhibition levels following prasugrel and clopidogrel administrationQ80710251
Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathwayQ81163093
ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndromeQ81445965
Effect of CYP2C19*2 and *3 loss-of-function alleles on platelet reactivity and adverse clinical events in East Asian acute myocardial infarction survivors treated with clopidogrel and aspirinQ82300414
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus after drug-eluting stent implantation in Japanese patients receiving clopidogrelQ82566275
Combined influence of proton-pump inhibitors, calcium-channel blockers and CYP2C19*2 on on-treatment platelet reactivity and on the occurrence of atherothrombotic events after percutaneous coronary intervention.Q33997642
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) studyQ34009506
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapyQ34019082
Efficacy and safety of intensified antiplatelet therapy on the basis of platelet reactivity testing in patients after percutaneous coronary intervention: systematic review and meta-analysisQ34306772
Platelet dysfunction in type 2 diabetesQ34319534
Platelet function analyzer (PFA-100): a tool to quantify congenital or acquired platelet dysfunctionQ34350327
Cangrelor: an emerging therapeutic option for patients with coronary artery diseaseQ34395970
Individualising dual antiplatelet therapy after percutaneous coronary intervention: the IDEAL-PCI registryQ34439089
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysisQ34564576
Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrelQ34568130
Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trialQ34622955
Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular diseaseQ34633709
Morphine decreases clopidogrel concentrations and effects: a randomized, double-blind, placebo-controlled trialQ34658201
Low responsiveness to clopidogrel increases risk among CKD patients undergoing coronary interventionQ34726838
Genetic determinants of response to clopidogrel and cardiovascular eventsQ34910210
Cytochrome p-450 polymorphisms and response to clopidogrelQ34910228
Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort studyQ34910745
Evaluation of clinical risk factors to predict high on-treatment platelet reactivity and outcome in patients with stable coronary artery disease (PREDICT-STABLE).Q35208684
Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary interventionQ35610354
Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study GroupQ36244558
Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trialQ36460862
Platelet activation and atherothrombosisQ37031278
Cell adhesion mechanisms in plateletsQ37049884
Platelet ADP-receptor antagonists for cardiovascular disease: past, present and futureQ37310828
Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directionsQ37428365
Ticagrelor--a new platelet aggregation inhibitor in patients with acute coronary syndromes. An improvement of other inhibitors?Q37641001
Effect of proton pump inhibitors on clinical outcome in patients treated with clopidogrel: a systematic review and meta-analysis.Q37787305
Functional testing methods for the antiplatelet effects of aspirinQ37841562
Diabetes and antiplatelet therapy in acute coronary syndrome.Q37846051
Ischaemic and bleeding complications with new, compared to standard, ADP-antagonist regimens in acute coronary syndromes: a meta-analysis of randomized trialsQ37875612
TRITON and beyond: new insights into the profile of prasugrelQ37925009
Pharmacokinetic basis of the antiplatelet action of prasugrelQ37927151
Pharmacokinetic, pharmacodynamic and pharmacogenetic profile of the oral antiplatelet agent ticagrelorQ38001453
The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day.Q38053481
A critical overview on ticagrelor in acute coronary syndromesQ38055461
Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysisQ38173831
Clinical implications of drug-drug interactions with P2Y12 receptor inhibitorsQ38177048
Off-target effects of glycoprotein IIb/IIIa receptor inhibitorsQ38187933
Novel antiplatelet agents in acute coronary syndromeQ38257119
Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantationQ38375573
Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with ST-segment-elevation myocardial infarctionQ38460956
Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudyQ38461756
Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement.Q38489276
Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trialQ38493350
Switching P2Y12-receptor inhibitors in patients with coronary artery diseaseQ38568711
Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine modelQ39519989
Clinical, angiographic, and genetic factors associated with early coronary stent thrombosisQ39693579
Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis.Q39996910
Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with EptifibatiQ40000958
P2Y12 Receptor Inhibitors in Acute Coronary Syndromes: What Is New on the Horizon?Q41511099
A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humansQ41868121
Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trialQ42164176
Effects of CYP2C19 genotype on outcomes of clopidogrel treatmentQ42846150
Cytochrome P450 2C19 polymorphism, suboptimal reperfusion and all-cause mortality in patients with acute myocardial infarctionQ42869136
Genetic variability in response to clopidogrel therapy: clinical implicationsQ42905464
CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control studyQ42910083
Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular eventsQ42913374
Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients: initial evidence of a therapeutic windowQ42969238
Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placementQ43051165
Dual low response to acetylsalicylic acid and clopidogrel is associated with myonecrosis and stent thrombosis after coronary stent implantationQ43077318
Relationship between platelet reactivity inhibition and non-CABG related major bleeding in patients undergoing percutaneous coronary interventionQ43174983
Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placementQ43190644
Pantoprazole may enhance antiplatelet effect of enteric-coated aspirin in patients with acute coronary syndrome.Q43233276
Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placementQ43234546
Multiple electrode aggregometry predicts stent thrombosis better than the vasodilator-stimulated phosphoprotein phosphorylation assayQ43234549
A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery diseaseQ50199243
The use of amlodipine, but not of P-glycoprotein inhibiting calcium channel blockers is associated with clopidogrel poor-responseQ50199244
The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis.Q50847978
Platelet inhibition by abciximab bolus-only administration and oral ADP receptor antagonist loading in acute coronary syndrome patients: the blocking and bridging strategy.Q50887397
Genetic variation of platelet function and pharmacology: an update of current knowledge.Q50965674
How to improve the concept of individualised antiplatelet therapy with P2Y12 receptor inhibitors--is an algorithm the answer?Q51036458
The net clinical benefit of personalized antiplatelet therapy in patients undergoing percutaneous coronary intervention.Q51063040
Monitoring survival and function of transfused platelets in Bernard-Soulier syndrome by flow cytometry and a cone and plate(let) analyzer (Impact-R).Q51088245
Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement.Q51109075
Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation.Q51127260
Hirudin anticoagulation allows more rapid determination of P2Y₁₂ inhibition by the VerifyNow P2Y12 assay.Q51277912
Why have studies of tailored anti-platelet therapy failed so far?Q51795662
Association of cytochrome P450 2C19*2 polymorphism with clopidogrel response variability and cardiovascular events in Koreans treated with drug-eluting stents.Q53418798
The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics studyQ53461746
Vasodilator-stimulated phosphoprotein phosphorylation analysis prior to percutaneous coronary intervention for exclusion of postprocedural major adverse cardiovascular events.Q53554561
No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting.Q53672191
Pharmacodynamic evaluation of switching from ticagrelor to prasugrel in patients with stable coronary artery disease: Results of the SWAP-2 Study (Switching Anti Platelet-2).Q54447617
Prasugrel or double-dose clopidogrel to overcome clopidogrel low-response--the TAILOR (Thrombocytes And IndividuaLization of ORal antiplatelet therapy in percutaneous coronary intervention) randomized trial.Q54580380
Prasugrel versus ticagrelor in acute coronary syndrome: a randomized comparison.Q54600153
2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of CardiolQ55056448
Effect of Paraoxonase-1 Polymorphism on Clinical Outcomes in Patients Treated With Clopidogrel After an Acute Myocardial InfarctionQ57243379
Impact of Insulin Receptor Substrate-1 Genotypes on Platelet Reactivity and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Coronary Artery DiseaseQ57764490
Personalized antiplatelet treatment after percutaneous coronary intervention: The MADONNA studyQ58071003
Phenotyping vs. genotyping for prediction of clopidogrel efficacy and safety: the PEGASUS-PCI studyQ58071120
CYP2C19 But Not PON1 Genetic Variants Influence Clopidogrel Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy in Post–Myocardial Infarction PatientsQ60018251
Comparison of the antiplatelet effect of two clopidogrel bisulfate formulations: Plavix and generic-EgitrombQ60189773
Time-related changes in determinants of antiplatelet effect of clopidogrel in patients after myocardial infarctionQ60189807
Prasugrel overcomes high on-clopidogrel platelet reactivity in the acute phase of acute coronary syndrome and maintains its antiplatelet potency at 30-day follow-upQ60189859
Ticagrelor, but not clopidogrel and prasugrel, prevents ADP-induced vascular smooth muscle cell contraction: A placebo-controlled study in ratsQ60189923
Diurnal variation in platelet inhibition by clopidogrelQ60190017
Predictors of antiplatelet response to prasugrel during maintenance treatmentQ60195438
No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stentingQ60195531
AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human plateletsQ60760894
Relationship between paraoxonase Q192R gene polymorphism and on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary interventionQ61402343
Prognostic value of serial platelet reactivity measurements on long-term clinical outcome in patients with ST-elevation myocardial infarction undergoing primary PCIQ61402668
Influence of CYP2C19 Polymorphisms in Platelet Reactivity and Prognosis in an Unselected Population of Non ST Elevation Acute Coronary SyndromeQ62090494
Comparison of Prasugrel and Ticagrelor Loading Doses in ST-Segment Elevation Myocardial Infarction PatientsQ63342280
Agranlocytosis caused by ticlopindine and its mechanismQ67924218
Effects of insulin on calcium metabolism and platelet aggregationQ71258054
Transmission of a procoagulant signal from tissue factor-bearing cell to plateletsQ71612091
Platelets from diabetic subjects show diminished sensitivity to prostacyclinQ71634275
Inhibition of integrin-mediated platelet aggregation, fibrinogen-binding, and interactions with extracellular matrix by nonpeptidic mimetics of Arg-Gly-AspQ72381191
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)259-80
P577publication date2015-01-01
P1433published inPostępy w Kardiologii InterwencyjnejQ26853806
P1476titlePersonalized antiplatelet therapy with P2Y12 receptor inhibitors: benefits and pitfalls
P478volume11

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