| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Karl Peter Giese | Q51007195 |
| P2093 | author name string | Anshua Ghosh | |
| P2860 | cites work | Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease | Q57132920 |
| Calmodulin kinase II in pure cultured astrocytes | Q69814656 | ||
| Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules | Q71171772 | ||
| Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in | Q77544092 | ||
| Plasticity in the human central nervous system | Q22337156 | ||
| Amyloid plaque core protein in Alzheimer disease and Down syndrome | Q24568384 | ||
| Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory | Q24645499 | ||
| Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau | Q24648590 | ||
| Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake | Q24656613 | ||
| Activation of CaMKII in single dendritic spines during long-term potentiation | Q24658061 | ||
| Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus | Q26823646 | ||
| Neuropathological stageing of Alzheimer-related changes | Q27860862 | ||
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics | Q27860914 | ||
| Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo | Q28131779 | ||
| Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor | Q28202320 | ||
| alphaCaMKII autophosphorylation: a fast track to memory | Q28249015 | ||
| Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning | Q28260712 | ||
| Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules | Q28282209 | ||
| New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry | Q28290064 | ||
| Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII | Q28571729 | ||
| Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment | Q29547294 | ||
| Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins | Q29547593 | ||
| Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein | Q29547803 | ||
| Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology | Q29617284 | ||
| Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease | Q29617285 | ||
| Amyloid deposition as the central event in the aetiology of Alzheimer's disease | Q29619450 | ||
| Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice | Q30633001 | ||
| Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. | Q31146509 | ||
| Synaptic targeting by Alzheimer's-related amyloid beta oligomers. | Q33288786 | ||
| Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease | Q33615147 | ||
| Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. | Q33642350 | ||
| Calcium signaling and amyloid toxicity in Alzheimer disease | Q33799937 | ||
| A developmental switch in the signaling cascades for LTP induction | Q33962983 | ||
| L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease | Q34135977 | ||
| Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme | Q34472571 | ||
| Properties of contextual memory formed in the absence of αCaMKII autophosphorylation | Q34573770 | ||
| Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease | Q34988301 | ||
| Neurotrophins enhance CaMKII activity and rescue amyloid-β-induced deficits in hippocampal synaptic plasticity | Q35073796 | ||
| Neuronal Ca2+/calmodulin-dependent protein kinases | Q35231384 | ||
| Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration | Q35327851 | ||
| Mechanism for long-term memory formation when synaptic strengthening is impaired. | Q35546780 | ||
| η-Secretase processing of APP inhibits neuronal activity in the hippocampus | Q35760228 | ||
| Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability | Q35868150 | ||
| A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII | Q35992894 | ||
| Single App knock-in mouse models of Alzheimer's disease. | Q50670713 | ||
| Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. | Q51794745 | ||
| Immunostaining of calmodulin and aluminium in Alzheimer's disease-affected brains. | Q53243202 | ||
| The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. | Q53266380 | ||
| Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons. | Q53313495 | ||
| Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Disease | Q36790422 | ||
| Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease | Q36934762 | ||
| Amyloid flirting with synaptic failure: towards a comprehensive view of Alzheimer's disease pathogenesis. | Q37123855 | ||
| {beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution | Q37155459 | ||
| Localization of alpha type II calcium calmodulin-dependent protein kinase at glutamatergic but not gamma-aminobutyric acid (GABAergic) synapses in thalamus and cerebral cortex | Q37502868 | ||
| The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag? | Q37649267 | ||
| Novel insights into CaMKII function and regulation during memory formation. | Q37808784 | ||
| CaMKII: claiming center stage in postsynaptic function and organization | Q38181739 | ||
| Altered calmodulin degradation and signaling in non-neuronal cells from Alzheimer's disease patients. | Q39449684 | ||
| beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity | Q41089179 | ||
| Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. | Q41229492 | ||
| Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated | Q41381112 | ||
| Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation | Q41588964 | ||
| Expression and phosphorylation of delta-CaM kinase II in cultured Alzheimer fibroblasts | Q42466239 | ||
| CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons. | Q42611589 | ||
| APP processing is regulated by cytoplasmic phosphorylation | Q42917696 | ||
| The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia. | Q43548494 | ||
| Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR. | Q43556227 | ||
| In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs: species differences and relative preservation in Alzheimer's disease | Q43726718 | ||
| Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII transduction pathway | Q44173419 | ||
| Quantitative assessment of cortical synaptic density in Alzheimer's disease. | Q44558369 | ||
| Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry | Q44686316 | ||
| Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity | Q44847913 | ||
| Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons. | Q45083445 | ||
| Dendrite and dendritic spine alterations in Alzheimer models | Q45099584 | ||
| Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus. | Q45173071 | ||
| Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase | Q45273785 | ||
| βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses. | Q45786919 | ||
| Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids. | Q45976976 | ||
| Attenuation of beta-amyloid neurotoxicity in vitro by potassium-induced depolarization | Q46198723 | ||
| Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain | Q46586214 | ||
| Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation | Q46641415 | ||
| Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease | Q46642796 | ||
| Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease | Q46764167 | ||
| Quantitative synaptic alterations in the human neocortex during normal aging | Q46773797 | ||
| NMDA receptor-dependent long-term potentiation in mouse hippocampal interneurons shows a unique dependence on Ca(2+)/calmodulin-dependent kinases | Q46989427 | ||
| Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. | Q48182788 | ||
| Handling and environmental enrichment do not rescue learning and memory impairments in alphaCamKII(T286A) mutant mice | Q48220792 | ||
| Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease | Q48341418 | ||
| Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE varepsilon4. | Q48482230 | ||
| Autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse | Q48521560 | ||
| Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning. | Q48577304 | ||
| Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein | Q48634030 | ||
| An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde". | Q48903618 | ||
| alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease | Q48934721 | ||
| Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity | Q48983820 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | enzyme | Q8047 |
| peptide | Q172847 | ||
| Alzheimer's disease | Q11081 | ||
| Ca2+/calmodulin-dependent protein kinase | Q26261927 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 78 | |
| P577 | publication date | 2015-11-24 | |
| P1433 | published in | Molecular Brain | Q6895938 |
| P1476 | title | Calcium/calmodulin-dependent kinase II and Alzheimer's disease | |
| P478 | volume | 8 |
| Q64054584 | A Comprehensive Analysis of the CaMK2A Gene and Susceptibility to Alzheimer's Disease in the Han Chinese Population |
| Q54963859 | A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability. |
| Q47141209 | A meta-analysis of cerebrospinal fluid visinin-like protein-1 in alzheimers disease patients relative to healthy controls and mild cognitive impairment patients |
| Q50420723 | AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy |
| Q93273205 | Alzheimer's Disease: A short introduction to the calmodulin hypothesis |
| Q96431918 | Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing |
| Q27303472 | Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss |
| Q64880227 | Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila. |
| Q47587356 | Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy |
| Q33899308 | CaMK II γ down regulation protects dorsal root ganglion neurons from ropivacaine hydrochloride neurotoxicity |
| Q57524986 | CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity |
| Q41105294 | Characterization of postsynaptic calcium signals in the pyramidal neurons of anterior cingulate cortex. |
| Q41279397 | Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice |
| Q38958106 | Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity? |
| Q47393215 | Enhanced Peptide Detection Toward Single-Neuron Proteomics by Reversed-Phase Fractionation Capillary Electrophoresis Mass Spectrometry |
| Q47704920 | In vitro neurotoxicity by ropivacaine is reduced by silencing Cav3.3 T-type calcium subunits in neonatal rat sensory neurons |
| Q64998890 | Involvement of calpain in the neuropathogenesis of Alzheimer's disease. |
| Q90706367 | Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE-/- Mice Experimental Model |
| Q41928616 | Memory Erasure Experiments Indicate a Critical Role of CaMKII in Memory Storage |
| Q38962796 | Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer's Disease |
| Q60689081 | Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases |
| Q92281827 | Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory |
| Q58727014 | Postsynaptic Proteome of Non-Demented Individuals with Alzheimer's Disease Neuropathology |
| Q57492342 | Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer's Disease |
| Q59812522 | Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains |
| Q61443149 | S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy |
| Q91952785 | Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models |
| Q52310268 | VariFunNet, an integrated multiscale modeling framework to study the effects of rare non-coding variants in Genome-Wide Association Studies: applied to Alzheimer's Disease. |
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