A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve

scientific article

A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/EURHEARTJ/EHV647
P8608Fatcat IDrelease_zty4lkdnyfhfdlyx6l6vy66h5u
P932PMC publication ID4872284
P698PubMed publication ID26614823

P50authorC. Noel Bairey MerzQ23662175
Eileen M HandbergQ56983411
Carl J PepineQ57013135
André RogatkoQ58345885
Chrisandra L ShufeltQ89697810
Puja K MehtaQ89697814
Margo B MinissianQ89697816
Janet WeiQ89697820
Daniel S BermanQ89697826
John W PetersenQ89697829
R David AndersonQ89697832
Galen Cook-WiensQ89697835
Leslee J ShawQ94570815
P2093author name stringJonathan J Shuster
Louise E J Thomson
Garrett H Brown
P2860cites workPatient non-compliance with paper diariesQ24524128
Clinical implications of the Women's Ischemia Syndrome Evaluation: inter-relationships between symptoms, psychosocial factors and cardiovascular outcomesQ26861338
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).Q33198363
Diastolic dysfunction in women with signs and symptoms of ischemia in the absence of obstructive coronary artery disease: a hypothesis-generating studyQ33650828
Effects of sex on coronary microvascular dysfunction and cardiac outcomesQ33825527
Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study.Q33967744
Reproducibility of adenosine stress cardiovascular magnetic resonance in multi-vessel symptomatic coronary artery diseaseQ34039759
Development and evaluation of the Seattle Angina Questionnaire: a new functional status measure for coronary artery diseaseQ34316735
Effects of ivabradine and ranolazine in patients with microvascular angina pectorisQ34337197
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trialQ34544699
Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe anginaQ34547211
The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health--National Heart, Lung, and Blood Institute--sponsored Women's Ischemia Syndrome EvaluationQ34559278
Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trialQ34569443
Development and validation of a short version of the Seattle angina questionnaireQ34807134
Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction. A National Heart, Lung, and Blood Institute-sponsored study from the Women's Ischemia Syndrome Evaluation.Q35222305
Emergence of Nonobstructive Coronary Artery Disease: A Woman's Problem and Need for Change in Definition on AngiographyQ36202061
Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditionsQ36485492
Reproducibility of myocardial perfusion reserve - variations in measurements from post processing using commercially available softwareQ37339320
Cardiac risk factors and myocardial perfusion reserve in women with microvascular coronary dysfunctionQ37339431
Evidence that ranolazine behaves as a weak beta1- and beta2-adrenoceptor antagonist in the rat [correction of cat] cardiovascular systemQ43593148
Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE).Q44936581
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).Q45038648
Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease.Q45083293
Comparative efficacy of ranolazine versus atenolol for chronic angina pectorisQ45238077
Myocardial ischemia in the absence of obstructive coronary artery disease in systemic lupus erythematosusQ45844952
Antiadrenergic and hemodynamic effects of ranolazine in conscious dogsQ46416183
Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetesQ46715059
Interstudy reproducibility of quantitative perfusion cardiovascular magnetic resonanceQ46850464
Angina pectoris in a contemporary population: characteristics and therapeutic implications. TIDES Investigators.Q50859363
Adaptive randomization procedures for the web-based randomization system RANDI2.Q51466320
Validation of the Short Form 36 (SF-36) health survey questionnaire among stroke patients.Q52007374
Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique.Q52906468
A brief self-administered questionnaire to determine functional capacity (The Duke Activity Status Index)Q56928615
2013 ESC guidelines on the management of stable coronary artery diseaseQ57243329
Coronary flow reserve calculated from pressure measurements in humans. Validation with positron emission tomographyQ61651540
Symptoms of angina pectoris increase the probability of disability pension and premature exit from the workforce even in the absence of obstructive coronary artery diseaseQ61875221
Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazemQ67900095
Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor testQ69813910
Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart diseaseQ72585308
Gender comparison of efficacy and safety of ranolazine for chronic angina pectoris in four randomized clinical trialsQ79464002
Ischemic heart disease in womenQ82468268
Effects of ranolazine on noninvasive coronary flow reserve in patients with myocardial ischemia but without obstructive coronary artery diseaseQ87415438
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectplaceboQ269829
placebo-controlled trialQ108853737
P304page(s)1504-1513
P577publication date2016-05-14
P1433published inEuropean Heart JournalQ2286839
P1476titleA randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve
P478volume37

Reverse relations

cites work (P2860)
Q38904539Advanced Imaging and Diagnostic Methods in the Assessment of Suspected Ischemic Heart Disease in Women
Q89700406Angina: contemporary diagnosis and management
Q47190217Autologous CD34+ cell therapy improves exercise capacity, angina frequency and reduces mortality in no-option refractory angina: a patient-level pooled analysis of randomized double-blinded trials
Q93353860Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review
Q47171821Daily Activity Measured With Wearable Technology as a Novel Measurement of Treatment Effect in Patients With Coronary Microvascular Dysfunction: Substudy of a Randomized Controlled Crossover Trial.
Q92319527Diagnosis of patients with angina and non-obstructive coronary disease in the catheter laboratory
Q39102158Drug Therapy for Stable Angina Pectoris
Q48022963Expert consensus document: A 'diamond' approach to personalized treatment of angina
Q53528056Extreme-Dipper Profile, Increased Aortic Stiffness, and Impaired Subendocardial Viability in Hypertension.
Q92618268How to Diagnose and Manage Angina Without Obstructive Coronary Artery Disease: Lessons from the British Heart Foundation CorMicA Trial
Q56761527Inverse association of MRI-derived native myocardial T1 and perfusion reserve index in women with evidence of ischemia and no obstructive CAD: A pilot study
Q39176512Ischemia and No Obstructive Coronary Artery Disease (INOCA): Developing Evidence-Based Therapies and Research Agenda for the Next Decade.
Q57191197Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction ancillary study
Q88734513Left ventricular diastolic dysfunction in women with nonobstructive ischemic heart disease: insights from magnetic resonance imaging and spectroscopy
Q47580858Mental stress peripheral vascular reactivity is elevated in women with coronary vascular dysfunction: Results from the NHLBI-sponsored Cardiac Autonomic Nervous System (CANS) study
Q38741610Myocardial perfusion imaging in women for the evaluation of stable ischemic heart disease-state-of-the-evidence and clinical recommendations
Q48582664Myocardial tissue deformation is reduced in subjects with coronary microvascular dysfunction but not rescued by treatment with ranolazine
Q26740252No reflow phenomenon in percutaneous coronary interventions in ST-segment elevation myocardial infarction
Q92477674Ranolazine Reduces Angina in Women with Ischemic Heart Disease: Results of an Open-Label, Multicenter Trial
Q38971758Ranolazine for stable angina pectoris
Q38377198Ranolazine in Symptomatic Diabetic Patients Without Obstructive Coronary Artery Disease: Impact on Microvascular and Diastolic Function
Q26765421Ranolazine: A Contemporary Review
Q55386798Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Angina (CorMicA) stratified medicine clinical trial.
Q30234726Sex differences in cardiovascular disease - Impact on care and outcomes
Q64091904Stable Angina Medical Therapy Management Guidelines: A Critical Review of Guidelines from the European Society of Cardiology and National Institute for Health and Care Excellence
Q48188618Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need
Q54444751Syncope and sudden cardiac death: some answers to clinical challenges.
Q38821307The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine
Q38846938Treatment of Angina Pectoris Associated with Coronary Microvascular Dysfunction
Q89840343Treatment of coronary microvascular dysfunction
Q38671970Typical angina is associated with greater coronary endothelial dysfunction but not abnormal vasodilatory reserve
Q62632824Why names matter for women: MINOCA/INOCA (myocardial infarction/ischemia and no obstructive coronary artery disease)
Q89471695Women's health: making cardiovascular disease real

Search more.