Leveraging big data to transform target selection and drug discovery

scientific article

Leveraging big data to transform target selection and drug discovery is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/CPT.318
P8608Fatcat IDrelease_2wsgazkz4rfkrj434ba5gz23bu
P3181OpenCitations bibliographic resource ID1691237
P932PMC publication ID4785018
P698PubMed publication ID26659699

P2093author name stringB Chen
A J Butte
P2860cites workCancer genome landscapesQ22242276
International network of cancer genome projectsQ24611474
DrugBank 3.0: a comprehensive resource for 'omics' research on drugsQ24612505
Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
Predicting new molecular targets for known drugsQ24649687
Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortalityQ24745996
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interferenceQ26852489
Preclinical mouse cancer models: a maze of opportunities and challengesQ27322080
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyQ27824812
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancerQ27851588
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyQ27860519
A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning PredictionsQ28550159
Public data and open source tools for multi-assay genomic investigation of diseaseQ28596241
Genetics of rheumatoid arthritis contributes to biology and drug discoveryQ29417000
Network medicine: a network-based approach to human diseaseQ29547462
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
Epidermal growth factor receptor mutations in lung cancerQ29615474
A new initiative on precision medicineQ29615654
A draft map of the human proteomeQ29617250
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.Q30384542
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel diseaseQ30526431
Biology: The big challenges of big dataQ30647898
Inferring tumour purity and stromal and immune cell admixture from expression dataQ30674996
Raw data from clinical trials: within reach?Q30705429
Characteristics of drug combination therapy in oncology by analyzing clinical trial data on ClinicalTrials.govQ30884583
Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational researchQ30965534
Identification of small molecules enhancing autophagic function from drug network analysisQ33712703
HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cellsQ33760690
A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinomaQ33854958
Computational repositioning and preclinical validation of pentamidine for renal cell cancer.Q33875574
Discovery and preclinical validation of drug indications using compendia of public gene expression dataQ33995422
Identification and characterization of essential genes in the human genome.Q34045164
Discovery of drug mode of action and drug repositioning from transcriptional responsesQ34093341
Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorinQ34131764
Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancerQ34135362
MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survivalQ34177820
Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with imatinibQ34191711
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Q34268870
Comparing bioinformatic gene expression profiling methods: microarray and RNA-SeqQ34434633
In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunitiesQ34466574
A systematic assessment of linking gene expression with genetic variants for prioritizing candidate targetsQ34988225
A guide to drug discovery: Target selection in drug discoveryQ35037671
Exploiting drug-disease relationships for computational drug repositioningQ35109885
The Comparative Toxicogenomics Database's 10th year anniversary: update 2015.Q35254732
A community computational challenge to predict the activity of pairs of compoundsQ35446621
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.Q35531740
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependenciesQ35609041
The support of human genetic evidence for approved drug indicationsQ35677036
Elucidating Compound Mechanism of Action by Network Perturbation Analysis.Q35694439
Subtype and pathway specific responses to anticancer compounds in breast cancerQ35779241
Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetesQ35935710
Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models.Q36113762
Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer.Q36139333
Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathwayQ36179224
Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical recordsQ36972534
Evaluating cell lines as tumour models by comparison of genomic profilesQ37025950
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantationQ37246506
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomasQ37281335
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancerQ37331472
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.Q37395737
Validation of the 12-gene colon cancer recurrence score in NSABP C-07 as a predictor of recurrence in patients with stage II and III colon cancer treated with fluorouracil and leucovorin (FU/LV) and FU/LV plus oxaliplatin.Q37411227
A comprehensive transcriptional portrait of human cancer cell linesQ37854720
Validating therapeutic targets through human geneticsQ38122628
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.Q38275613
Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma.Q39104237
canSAR: an integrated cancer public translational research and drug discovery resourceQ39455504
Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemiaQ40764658
Network medicine in disease analysis and therapeuticsQ41890269
Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profilingQ42704783
Objective assessment of cancer genes for drug discoveryQ57001160
Reproducibility crisis: Blame it on the antibodiesQ59060328
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivativesQ6937225
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttargeted therapyQ492646
big dataQ858810
drug discoveryQ1418791
precision medicineQ17075943
biomedical investigative techniqueQ66648976
P304page(s)285-97
P577publication date2016-03-01
P1433published inClinical Pharmacology & TherapeuticsQ1101529
P1476titleLeveraging big data to transform target selection and drug discovery
P478volume99

Reverse relations

cites work (P2860)
Q92328880A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder
Q42698699A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine.
Q98784944ADRML: anticancer drug response prediction using manifold learning
Q92320711AICM: A Genuine Framework for Correcting Inconsistency Between Large Pharmacogenomics Datasets
Q114871132Application of Artificial Intelligence in Discovery and Development of Anticancer and Antidiabetic Therapeutic Agents
Q64988161Artificial Intelligence and Personalized Medicine.
Q28591396BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry
Q89875046Bayesian Framework for Detecting Gene Expression Outliers in Individual Samples
Q35926778Big Data Transforms Discovery-Utilization Therapeutics Continuum.
Q91117785Big data in IBD: a look into the future
Q31141724Clinical Research Informatics for Big Data and Precision Medicine
Q38598719Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses
Q26746941Computational approaches in target identification and drug discovery
Q96836052Concise Polygenic Models for Cancer-Specific Identification of Drug-Sensitive Tumors from Their Multi-Omics Profiles
Q93086929Creating reproducible pharmacogenomic analysis pipelines
Q89928441Critical Factors Shaping Strategy Development of an Innovative Medicine in Oncology
Q58552664Developments with 3D bioprinting for novel drug discovery
Q64915233Differential Expression and Pathway Analysis in Drug-Resistant Triple-Negative Breast Cancer Cell Lines Using RNASeq Analysis.
Q36315748Ethics and Epistemology in Big Data Research
Q52316006From gene networks to drugs: systems pharmacology approaches for AUD.
Q52580320Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn's Disease.
Q28551995Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database
Q50083199Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies
Q47910117Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice.
Q92407464Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma
Q30491667Harnessing public domain data to discover and validate therapeutic targets
Q38646272Improved anticancer drug response prediction in cell lines using matrix factorization with similarity regularization.
Q93061511In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR
Q39039446Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases.
Q36946947Isolation of the Binding Protein of Periplocoside E from BBMVs in Midgut of the Oriental Amyworm Mythimna separata Walker (Lepidoptera: Noctuidae) through Affinity Chromatography
Q52681322It is time to apply biclustering: a comprehensive review of biclustering applications in biological and biomedical data.
Q64086525Large-scale in-silico identification of a tumor-specific antigen pool for targeted immunotherapy in triple-negative breast cancer
Q36229691Macromolecular target prediction by self-organizing feature maps
Q64081579Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
Q64119088Mining data and metadata from the gene expression omnibus
Q47366650Molecular property diagnostic suite (MPDS): Development of disease-specific open source web portals for drug discovery.
Q60953364Persistence of Drug Memories: Melting Transcriptomes
Q56961708Protein-ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modelling
Q33903831Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
Q93116011Signaling pathways and gene co-expression modules associated with cytoskeleton and axon morphology in breast cancer survivors with chronic paclitaxel-induced peripheral neuropathy
Q92547592Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms
Q36391199The Utility of Gene Expression Profiling from Tissue Samples to Support Drug Safety Assessments
Q39029383The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies
Q47116549Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics
Q47226520Translating Knowledge Into Therapy for Acute Kidney Injury
Q47732489Update on Data Reuse in Health Care
Q47252941gene2drug: a Computational Tool for Pathway-based Rational Drug Repositioning

Search more.