| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | David Komander | Q28050888 |
| P2093 | author name string | Paul R Elliott | |
| P2860 | cites work | Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction | Q22001513 |
| LUBAC synthesizes linear ubiquitin chains via a thioester intermediate | Q24293061 | ||
| The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis | Q24293633 | ||
| OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin | Q24294696 | ||
| The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2 | Q24294888 | ||
| OTULIN restricts Met1-linked ubiquitination to control innate immune signaling | Q24296844 | ||
| OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis | Q24297538 | ||
| Linear ubiquitination prevents inflammation and regulates immune signalling | Q24298581 | ||
| SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex | Q24298605 | ||
| SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis | Q24298626 | ||
| De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling | Q24299573 | ||
| Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8 | Q24299638 | ||
| A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7 | Q24300148 | ||
| UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids | Q24300880 | ||
| Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6 | Q24301569 | ||
| HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death. | Q50630569 | ||
| A genetic screen for mutations that affect cranial nerve development in the mouse. | Q51923232 | ||
| Linear ubiquitin chains: NF-κB signalling, cell death and beyond. | Q54171066 | ||
| The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity | Q57334872 | ||
| The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types | Q64166837 | ||
| Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN | Q87160378 | ||
| Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency | Q24301912 | ||
| Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl | Q24302528 | ||
| A ubiquitin ligase complex assembles linear polyubiquitin chains | Q24305030 | ||
| A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex | Q24307922 | ||
| Structural basis and specificity of human otubain 1-mediated deubiquitination | Q24309375 | ||
| The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling | Q24314649 | ||
| Defining the human deubiquitinating enzyme interaction landscape | Q24315885 | ||
| Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation | Q24315943 | ||
| Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains | Q24316967 | ||
| The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module | Q24319910 | ||
| Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain | Q24320937 | ||
| AMSH is an endosome-associated ubiquitin isopeptidase | Q24676880 | ||
| NF-κB, the first quarter-century: remarkable progress and outstanding questions | Q26822516 | ||
| Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde | Q27640257 | ||
| Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation | Q27644749 | ||
| Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation | Q27654230 | ||
| Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation | Q27674024 | ||
| Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex | Q27675967 | ||
| Engineering and structural characterization of a linear polyubiquitin-specific antibody | Q27676630 | ||
| Regulation of A20 and other OTU deubiquitinases by reversible oxidation | Q27676707 | ||
| The mechanism of OTUB1-mediated inhibition of ubiquitination | Q27677504 | ||
| Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP | Q27680404 | ||
| Mechanism Underlying I B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex | Q27681474 | ||
| Molecular Basis and Regulation of OTULIN-LUBAC Interaction | Q27683237 | ||
| Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling | Q27690030 | ||
| The ubiquitin system | Q27860803 | ||
| Identification of the familial cylindromatosis tumour-suppressor gene | Q28145560 | ||
| CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members | Q28201693 | ||
| Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB | Q28201706 | ||
| The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination | Q28201717 | ||
| Modification of proteins by ubiquitin and ubiquitin-like proteins | Q28244250 | ||
| The PUB domain functions as a p97 binding module in human peptide N-glycanase | Q28249124 | ||
| A dynamic role of HAUSP in the p53-Mdm2 pathway | Q28253645 | ||
| Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system | Q28258706 | ||
| The ubiquitin code | Q28265104 | ||
| Ubiquitin chain conformation regulates recognition and activity of interacting proteins | Q28280440 | ||
| Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP | Q28593538 | ||
| MEROPS: the database of proteolytic enzymes, their substrates and inhibitors | Q28660722 | ||
| Signaling to NF-kappaB | Q29547844 | ||
| The two NF-kappaB activation pathways and their role in innate and adaptive immunity | Q29614355 | ||
| Regulation and function of NF-kappaB transcription factors in the immune system | Q29616427 | ||
| Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. | Q33569888 | ||
| USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses | Q33655162 | ||
| Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family | Q34156341 | ||
| Constructing and decoding unconventional ubiquitin chains. | Q34182233 | ||
| Generation and physiological roles of linear ubiquitin chains | Q34197025 | ||
| Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions | Q34266494 | ||
| Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes | Q34512302 | ||
| HERC2-USP20 axis regulates DNA damage checkpoint through Claspin | Q34579692 | ||
| New ATPase regulators--p97 goes to the PUB. | Q34984975 | ||
| Screening of DUB activity and specificity by MALDI-TOF mass spectrometry | Q35232335 | ||
| Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation | Q35560951 | ||
| Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia | Q35671268 | ||
| Deubiquitinases as a signaling target of oxidative stress | Q36501472 | ||
| Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription | Q36535326 | ||
| Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells. | Q36737013 | ||
| Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains | Q37191956 | ||
| CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes | Q37448141 | ||
| The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis | Q37546931 | ||
| Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling | Q37621033 | ||
| A20: from ubiquitin editing to tumour suppression | Q37728850 | ||
| LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses. | Q37981793 | ||
| Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages. | Q38028343 | ||
| Deubiquitylases from genes to organism | Q38125278 | ||
| A20 in inflammation and autoimmunity | Q38163677 | ||
| NOD proteins: regulators of inflammation in health and disease | Q38171221 | ||
| Met1-linked ubiquitination in immune signalling | Q38233678 | ||
| The demographics of the ubiquitin system | Q38439051 | ||
| Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. | Q39252412 | ||
| Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration. | Q39452310 | ||
| Functional screening for proapoptotic genes by reverse transfection cell array technology | Q40311194 | ||
| Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest). | Q41015604 | ||
| Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. | Q41112588 | ||
| The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. | Q41774507 | ||
| The deubiquitinase activity of A20 is dispensable for NF-κB signaling. | Q42076015 | ||
| Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms. | Q42435971 | ||
| Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling | Q42614287 | ||
| Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity. | Q47073950 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| enzyme | Q8047 | ||
| signal transduction | Q828130 | ||
| ubiquitins | Q76506155 | ||
| deubiquitinase, acting on linear ubiquitin | Q27949119 | ||
| P304 | page(s) | 39-53 | |
| P577 | publication date | 2016-01-01 | |
| P1433 | published in | FEBS Journal | Q1388041 |
| P1476 | title | Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN | |
| P478 | volume | 283 |
| Q47547794 | 50 years of The FEBS Journal: looking back as well as ahead. |
| Q98280900 | ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers |
| Q39135148 | Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights |
| Q48293242 | Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases |
| Q55345582 | Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila. |
| Q38746358 | Geoepidemiology and Immunologic Features of Autoinflammatory Diseases: a Comprehensive Review. |
| Q58215556 | OTULIN limits cell death and inflammation by deubiquitinating LUBAC |
| Q28069531 | Quantitative proteomics and terminomics to elucidate the role of ubiquitination and proteolysis in adaptive immunity |
| Q37447982 | Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31. |
| Q91905036 | SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets |
| Q48182700 | Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse |
| Q39381317 | Structure and Function of Viral Deubiquitinating Enzymes. |
| Q94563216 | The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC |
| Q33625907 | The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death |
| Q104111361 | Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond |
| Q64946396 | Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. |
| Q91894275 | What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization |
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