Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models

scientific article (publication date: 2015)

Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1155/2015/638968
P932PMC publication ID4537760
P698PubMed publication ID26300592
P5875ResearchGate publication ID281042310

P50authorJinming HanQ85955987
P2093author name stringJie Zhu
Xinmei Jiang
Xueli Fan
Tao Jin
Chenhong Lin
P2860cites workMyasthenia gravisQ72436386
The germinal center response is impaired in the absence of T cell-expressed CXCR5Q79435564
Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expressionQ79769520
CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'Q80796763
Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasiaQ83179551
Blood relatives of follicular helper T cellsQ83312173
CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitisQ83918246
Clinical features of neuromyelitis optica in a large Japanese cohort: comparison between phenotypesQ84339471
Association of circulating follicular helper T cells with disease course of NMO spectrum disordersQ86174352
Thymic TFH cells involved in the pathogenesis of myasthenia gravis with thymomaQ87274147
Defining the clinical course of multiple sclerosis: Results of an international surveyQ22241638
The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravisQ24308609
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin productionQ24676570
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiationQ28252247
Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaborationQ28253885
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damageQ28287540
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6Q28288702
Multiple sclerosisQ28299151
Follicular helper CD4 T cells (TFH)Q29615063
A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosisQ29615952
Regulatory T cells: mechanisms of differentiation and functionQ29620731
T follicular helper cell dynamics in germinal centersQ30573316
Current concept of neuromyelitis optica (NMO) and NMO spectrum disorders.Q30577078
Neuromyelitis optica: an overviewQ33541803
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responsesQ33656146
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cellsQ33866996
Involvement of the janus kinase/signal transducer and activator of transcription signaling pathway in multiple sclerosis and the animal model of experimental autoimmune encephalomyelitis.Q33988247
Myasthenia gravis: an update for the clinicianQ34377145
Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO.Q34377212
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cellsQ34383385
The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivoQ34440540
Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosusQ34532672
IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brainQ34548098
Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progressionQ34613311
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretionQ34615273
Follicular helper T Cells (Tfh) and IL-21 involvement in the pathogenesis of bullous pemphigoidQ34826941
Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosisQ35101760
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.Q50499734
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.Q50736370
Impaired regulatory function and enhanced intrathecal activation of B cells in neuromyelitis optica: distinct from multiple sclerosis.Q50944222
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis.Q51278070
Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency.Q51985886
Cortactin autoantibodies in myasthenia gravis.Q54324670
RGMA and IL21R show association with experimental inflammation and multiple sclerosisQ57224463
The Ex Vivo Production of IL-6 and IL-21 by CD4+ T Cells is Directly Associated with Neurological Disability in Neuromyelitis Optica PatientsQ59614759
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosusQ61411628
Immunopathogenesis of neuromyelitis opticaQ38175587
Diagnosis and classification of neuromyelitis optica (Devic's syndrome).Q38178483
Diagnostic and clinical classification of autoimmune myasthenia gravis.Q38188287
Bcl-6 controlled TFH polarization and memory: the known unknownsQ38192415
B cells in MS and NMO: pathogenesis and therapyQ38212081
Experimental Autoimmune Myasthenia Gravis (EAMG): from immunochemical characterization to therapeutic approachesQ38223709
Neuromyelitis optica spectrum disorders.Q38229823
T follicular helper cell differentiation, function, and roles in diseaseQ38264816
Blood Tfh cells come with colorsQ38916112
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.Q41949877
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.Q42261388
RNA interference targeting Bcl-6 ameliorates experimental autoimmune myasthenia gravis in miceQ43656574
The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligandsQ44675588
Higher frequency of peripheral blood interleukin 21 positive follicular helper T cells in patients with ankylosing spondylitisQ45099346
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.Q46006953
Altered expression of chemokine receptor CXCR5 on T cells of myasthenia gravis patientsQ46743437
Follicular helper T cells may play an important role in the severity of primary Sjögren's syndromeQ46884492
Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.Q47357498
Arrest of B lymphocyte terminal differentiation by CD40 signaling: mechanism for lack of antibody-secreting cells in germinal centersQ47877284
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.Q48200750
Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritisQ35978986
The origins, function, and regulation of T follicular helper cellsQ36118326
Follicular B helper T cells in antibody responses and autoimmunity.Q36302329
T follicular helper cell diversity and plasticityQ36823844
Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapiesQ36911907
T follicular helper (TFH) cells in normal and dysregulated immune responsesQ37049341
SAP-controlled T-B cell interactions underlie germinal centre formationQ37119530
Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targetsQ37436035
Type 17 T helper cells-origins, features and possible roles in rheumatic diseaseQ37478061
Loss of circulating CD4 T cells with B cell helper function during chronic HIV infectionQ37548026
CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditionsQ37646434
AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevanceQ37773790
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.Q37777431
The elusive identity of T follicular helper cellsQ37784588
A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosisQ37818921
Follicular helper T cells poise immune responses to the development of autoimmune pathologyQ37822013
Th17 cell, the new player of neuroinflammatory process in multiple sclerosis.Q37845414
The regulation and role of T follicular helper cells in immunityQ37951500
Myasthenia and the neuromuscular junctionQ38034658
Autoimmune mechanisms in myasthenia gravis.Q38039921
Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity.Q38057541
Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4.Q38093711
Mechanisms associated with the pathogenicity of antibodies against muscle-specific kinase in myasthenia gravisQ38093885
Roles of T helper 17 cells and interleukin-17 in neuroautoimmune diseases with emphasis on multiple sclerosis and Guillain-Barré syndrome as well as their animal modelsQ38105052
The good, the bad and the ugly - TFH cells in human health and diseaseQ38107389
Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cellsQ38108059
The unique features of follicular T cell subsetsQ38121496
Autoimmune myasthenia gravis: autoantibody mechanisms and new developments on immune regulationQ38133301
Priming of T follicular helper cells by dendritic cellsQ38154469
Follicular T-helper cells: controlled localization and cellular interactionsQ38154470
Human T follicular helper (Tfh) cells and diseaseQ38154471
Control of TFH cell numbers: why and how?Q38159861
Follicular helper T-cell memory: establishing new frontiers during antibody responseQ38159862
Pathogenic immune mechanisms at the neuromuscular synapse: the role of specific antibody-binding epitopes in myasthenia gravis.Q38161532
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
cellQ7868
autoimmune disease of the nervous systemQ18556300
hemic and immune systemsQ70202933
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)638968
P577publication date2015-08-02
P1433published inMediators of InflammationQ2144494
P1476titleFollicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models
P478volume2015

Reverse relations

cites work (P2860)
Q64044796Advances in autoimmune myasthenia gravis management
Q39085433Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications
Q26749131Double Roles of Macrophages in Human Neuroimmune Diseases and Their Animal Models
Q37667437Follicular T Cells from smB- Common Variable Immunodeficiency Patients Are Skewed Toward a Th1 Phenotype
Q55236740Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives.
Q64072217Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation
Q33784969Regulatory T cells in multiple sclerosis and myasthenia gravis.
Q55396042Relapsing-Remitting Multiple Sclerosis Is Characterized by a T Follicular Cell Pro-Inflammatory Shift, Reverted by Dimethyl Fumarate Treatment.
Q55287599The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons.
Q90426166Unbalanced Expression of ICOS and PD-1 in Patients with Neuromyelitis Optica Spectrum Disorder

Search more.