The axonal cytoskeleton: from organization to function

scientific article (publication date: 2015)

The axonal cytoskeleton: from organization to function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNMOL.2015.00044
P8608Fatcat IDrelease_rnsswcugyvck7lpw63a3iptaje
P3181OpenCitations bibliographic resource ID3291162
P932PMC publication ID4536388
P698PubMed publication ID26321907
P5875ResearchGate publication ID281393687

P2093author name stringCasper C Hoogenraad
Josta T Kevenaar
P2860cites workBasic mechanisms for recognition and transport of synaptic cargosQ21198895
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tauQ24294296
The synaptic vesicle cycleQ24297813
Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neuronsQ24306055
Axonal transport and the delivery of pre-synaptic componentsQ37308044
NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteinsQ37360104
Rapid assembly of functional presynaptic boutons triggered by adhesive contactsQ37361929
Establishment of axon-dendrite polarity in developing neurons.Q37463169
The balance between capture and dissociation of presynaptic proteins controls the spatial distribution of synapsesQ37503931
Actin in axons: stable scaffolds and dynamic filamentsQ37543120
Traffic control: regulation of kinesin motors.Q37620153
Axonal transport: how high microtubule density can compensate for boundary effects in small-caliber axonsQ37621463
Selective microtubule-based transport of dendritic membrane proteins arises in concert with axon specification.Q37650167
The architecture of an excitatory synapseQ37702037
Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filamentsQ37703484
Building and maintaining the axon initial segmentQ37764128
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeletonQ37764505
The axon initial segment and the maintenance of neuronal polarity.Q37772757
Which way to go? Cytoskeletal organization and polarized transport in neuronsQ37785317
Microtubule +TIPs at a glanceQ37798624
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.Q37811131
Mechanisms and molecules of neuronal wiring: a primerQ37814719
Neuronal polarization: the cytoskeleton leads the way.Q37873901
Regulation of microtubule dynamics by kinesins.Q37946052
Molecular organization and plasticity of the cytomatrix at the active zoneQ37949766
Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environmentQ48641358
Stages of synapse development defined by dependence on F-actin.Q48822724
Actin Migration Driven by Directional Assembly and Disassembly of Membrane-Anchored Actin Filaments.Q50254956
STED nanoscopy reveals the ubiquity of subcortical cytoskeleton periodicity in living neurons.Q50598032
Synaptic democracy and vesicular transport in axons.Q50918346
KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons.Q51022734
A diffusion barrier maintains distribution of membrane proteins in polarized neurons.Q52534153
A presynaptic role of microtubule-associated protein 1/Futsch in Drosophila: regulation of active zone number and neurotransmitter release.Q52771784
Kinesin-1 plays a role in transport of SNAP-25 to the plasma membraneQ57076517
CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradationQ60708310
Spectrin- and ankyrin-based membrane domains and the evolution of vertebratesQ86692165
The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursorsQ24307447
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neuronsQ24311721
The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial traffickingQ24319150
Local F-actin network links synapse formation and axon branchingQ24321432
An intramolecular interaction between the FHA domain and a coiled coil negatively regulates the kinesin motor KIF1AQ24610172
Syntabulin-mediated anterograde transport of mitochondria along neuronal processesQ24669723
Neurofascin assembles a specialized extracellular matrix at the axon initial segmentQ24682746
The MAP2/Tau family of microtubule-associated proteinsQ24805413
The presynaptic active zoneQ26269863
Axonal transport: cargo-specific mechanisms of motility and regulationQ26827748
Branch management: mechanisms of axon branching in the developing vertebrate CNSQ27022646
Axon initial segments: diverse and dynamic neuronal compartmentsQ27025814
A dynamic formin-dependent deep F-actin network in axons.Q27309123
Pavarotti/MKLP1 regulates microtubule sliding and neurite outgrowth in Drosophila neurons.Q27316679
Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injuryQ27331607
The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of AutoinhibitionQ27671699
Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs SynaptogenesisQ27681560
Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-IQ28141879
Association of the kinesin motor KIF1A with the multimodular protein liprin-alphaQ28202542
The molecular motor toolbox for intracellular transportQ28211349
The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23Q28217101
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondriaQ28275966
Role of axonal transport in neurodegenerative diseasesQ28284096
KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondriaQ28287180
The cytoskeletal and signaling mechanisms of axon collateral branchingQ28305090
KLP6: a newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cellsQ28569929
Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cellsQ28569976
End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segmentQ28580184
Differential regulation of dynein and kinesin motor proteins by tauQ28589618
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendritesQ28594138
Dynamic instability of microtubule growthQ29547522
The establishment of polarity by hippocampal neurons in cultureQ29616334
The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B.Q30157896
Molecular architecture of synaptic actin cytoskeleton in hippocampal neurons reveals a mechanism of dendritic spine morphogenesisQ30436753
Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule.Q30442624
Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axonsQ30477062
Multiple-motor based transport and its regulation by Tau.Q30478710
Microtubules have opposite orientation in axons and dendrites of Drosophila neuronsQ30483775
{alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamicsQ30491703
Growth cone-like waves transport actin and promote axonogenesis and neurite branching.Q30493874
Trafficking kinesin protein (TRAK)-mediated transport of mitochondria in axons of hippocampal neuronsQ30500228
Coordinated trafficking of synaptic vesicle and active zone proteins prior to synapse formationQ30500621
The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodiaQ30503395
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cellsQ30539497
Actin dynamics in growth cone motility and navigationQ30575707
Dynamic mechanisms of neuroligin-dependent presynaptic terminal assembly in living cortical neuronsQ30580211
Kinesin-1-powered microtubule sliding initiates axonal regeneration in Drosophila cultured neuronsQ30652986
Nerve growth factor promotes reorganization of the axonal microtubule array at sites of axon collateral branchingQ30741119
Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition.Q33288865
Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendriteQ33666684
Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanismsQ33916085
Microtubule "plus-end-tracking proteins": The end is just the beginningQ33947998
Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathyQ34079297
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functionsQ34232911
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulinQ34243042
Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1).Q34274065
Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axonsQ34317568
Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1.Q34472870
Syntabulin-kinesin-1 family member 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly.Q34646100
Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticityQ34762533
Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations.Q35000461
Actin in a supporting roleQ35055634
Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotypeQ35111093
Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transportQ35130196
Post-translational modifications of tubulin: pathways to functional diversity of microtubulesQ35132313
Terminal axonal arborization and synaptic bouton formation critically rely on abp1 and the arp2/3 complexQ35171147
Miro's N-terminal GTPase domain is required for transport of mitochondria into axons and dendrites.Q35307797
Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in NeurodevelopmentQ35527346
Piccolo regulates the dynamic assembly of presynaptic F-actinQ35533808
X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon bindingQ35590409
Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.Q35649570
Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture.Q35803998
Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane.Q35870286
Molecular motors and mechanisms of directional transport in neuronsQ36042285
Linking molecular motors to membrane cargoQ36085781
Differential trafficking of transport vesicles contributes to the localization of dendritic proteinsQ36128474
The actin cytoskeleton: integrating form and function at the synapseQ36200197
Light chain-dependent regulation of Kinesin's interaction with microtubulesQ36255879
Neurofilaments at a glanceQ36450980
The distribution and targeting of neuronal voltage-gated ion channelsQ36514764
Networks of polarized actin filaments in the axon initial segment provide a mechanism for sorting axonal and dendritic proteins.Q36872581
Initial neurite outgrowth in Drosophila neurons is driven by kinesin-powered microtubule slidingQ36913309
The role of MAP1A light chain 2 in synaptic surface retention of Cav2.2 channels in hippocampal neuronsQ37001355
JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motorsQ37071736
The actin cytoskeleton in presynaptic assemblyQ37085743
Formation of Golgi-derived active zone precursor vesicles.Q37117339
Motile axonal mitochondria contribute to the variability of presynaptic strengthQ37133024
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacyQ37143121
Cell biology in neuroscience: cellular and molecular mechanisms underlying presynapse formationQ37233597
The functional organization and assembly of the axon initial segment.Q37272829
Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilizationQ37273587
The role of the cytoskeleton during neuronal polarizationQ37302021
Molecular basis of axonal dysfunction and traffic impairments in CMT.Q38010901
Axonal transport deficits and neurodegenerative diseasesQ38077679
The changing scene of amyotrophic lateral sclerosisQ38086771
Microtubule-based transport - basic mechanisms, traffic rules and role in neurological pathogenesisQ38111344
Neuronal cytoskeleton in synaptic plasticity and regeneration.Q38154639
No Pasaran! Role of the axon initial segment in the regulation of protein transport and the maintenance of axonal identity.Q38163250
Microtubules and neurodevelopmental disease: the movers and the makersQ38163457
Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegenerationQ38202141
Axon and dendritic traffickingQ38206894
Integrin signalling and traffic during axon growth and regeneration.Q38209083
Macromolecular complexes at active zones: integrated nano-machineries for neurotransmitter releaseQ38218893
Microtubule dynamics in axon guidanceQ38223509
Cytoskeletal and signaling mechanisms of neurite formationQ38235653
Lost after translation: missorting of Tau protein and consequences for Alzheimer diseaseQ38249863
Kinesin superfamily proteins and the regulation of microtubule dynamics in morphogenesisQ38263021
Relevance of presynaptic actin dynamics for synapse function and mouse behavior.Q38314597
Fine structure of synaptogenesis in the vertebrate central nervous systemQ38628822
Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated formsQ38874926
Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling.Q39018528
CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.Q39080254
KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.Q39752721
β-Tubulin mutations that cause severe neuropathies disrupt axonal transportQ40752898
Dynamic microtubules drive circuit rewiring in the absence of neurite remodelingQ40860973
Molecular Remodeling of the Presynaptic Active Zone of Drosophila Photoreceptors via Activity-Dependent Feedback.Q41042257
Hierarchical microtubule organization controls axon caliber and transport and determines synaptic structure and stability.Q41176894
Cross-linker system between neurofilaments, microtubules, and membranous organelles in frog axons revealed by the quick-freeze, deep-etching methodQ41384055
Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.Q41895025
Unique function of Kinesin Kif5A in localization of mitochondria in axonsQ42016005
Ultrastructural localization of active zone and synaptic vesicle proteins in a preassembled multi-vesicle transport aggregateQ42941268
Evidence from in vivo imaging that synaptogenesis guides the growth and branching of axonal arbors by two distinct mechanisms.Q43602075
ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and ExocytosisQ43671370
Axon branching requires interactions between dynamic microtubules and actin filaments.Q43819985
ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain.Q45905953
A selective filter for cytoplasmic transport at the axon initial segmentQ46096953
Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesiclesQ46432365
Microtubule orientation and spacing within bundles is critical for long-range kinesin-1 motilityQ46816451
Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegansQ47069257
Characterizing KIF16B in neurons reveals a novel intramolecular "stalk inhibition" mechanism that regulates its capacity to potentiate the selective somatodendritic localization of early endosomes.Q48211544
Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization.Q48274256
Fluorogenic probes for live-cell imaging of the cytoskeletonQ48306982
Mixed microtubules steer dynein-driven cargo transport into dendritesQ48317864
Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesiclesQ48323672
Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).Q48342203
Actin has a molecular scaffolding, not propulsive, role in presynaptic functionQ48405526
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
P304page(s)44
P577publication date2015-01-01
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleThe axonal cytoskeleton: from organization to function
P478volume8

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