| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Allan E Rettie | |
| Amanda L Johnson | |||
| Rheem A Totah | |||
| Katheryne Z Edson | |||
| P2860 | cites work | Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4 | Q22004251 |
| Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11 | Q22011198 | ||
| Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase | Q24321523 | ||
| CYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variant | Q24322624 | ||
| Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11 | Q24322910 | ||
| Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases | Q24324593 | ||
| A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase | Q24329233 | ||
| Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11 | Q24338572 | ||
| Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases | Q27004077 | ||
| Resolution phase lipid mediators of inflammation: agonists of resolution | Q27687489 | ||
| Tumor angiogenesis: therapeutic implications | Q27860595 | ||
| Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides | Q28143376 | ||
| Oxidation of prostaglandin H(2) and prostaglandin H(2) analogues by human cytochromes P450: analysis of omega-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I(1) by mass spectrometry | Q28205818 | ||
| Prostaglandins and leukotrienes: advances in eicosanoid biology | Q28208246 | ||
| Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid | Q28241946 | ||
| Leukotriene E4 elimination and metabolism in normal human subjects | Q28243042 | ||
| Expression of rabbit cytochromes P4504A which catalyze the omega-hydroxylation of arachidonic acid, fatty acids, and prostaglandins. | Q36755658 | ||
| Biosynthesis and metabolism of leukotrienes | Q36876280 | ||
| Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation | Q36929610 | ||
| Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes | Q36951768 | ||
| PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators | Q37002053 | ||
| Vascular cytochrome p450 enzymes: physiology and pathophysiology. | Q37060993 | ||
| Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo | Q37085203 | ||
| Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock | Q37138417 | ||
| Prostanoids in health and disease | Q37354582 | ||
| Epoxyeicosatrienoic acids: formation, metabolism and potential role in tissue physiology and pathophysiology | Q37510865 | ||
| 20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo | Q37603893 | ||
| Endothelial precursors in vascular repair | Q37698702 | ||
| Esterified eicosanoids: generation, characterization and function | Q37971413 | ||
| Analysis of eicosanoids by LC-MS/MS and GC-MS/MS: a historical retrospect and a discussion | Q38205276 | ||
| Cancer, inflammation, and therapy: effects on cytochrome p450-mediated drug metabolism and implications for novel immunotherapeutic agents. | Q38225574 | ||
| The gluconeogenicity of fatty acids in mammals | Q38767950 | ||
| 20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells | Q40065601 | ||
| Cytochrome p450 epoxygenase promotes human cancer metastasis | Q40105564 | ||
| Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. | Q40185278 | ||
| 9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A. | Q40340300 | ||
| Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. | Q41135351 | ||
| 20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule | Q41264412 | ||
| Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid) | Q41834836 | ||
| Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids | Q42108073 | ||
| Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism | Q36064383 | ||
| Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism | Q36122179 | ||
| CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. | Q36143432 | ||
| Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016. | Q36175877 | ||
| CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant | Q36294398 | ||
| Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid | Q36366640 | ||
| 20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells | Q36531189 | ||
| Cytochrome P450 4F subfamily: at the crossroads of eicosanoid and drug metabolism | Q36574121 | ||
| Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide | Q36611878 | ||
| Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers | Q36737986 | ||
| Angiogenesis in cancer | Q36746626 | ||
| Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation | Q28244417 | ||
| Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease | Q28248677 | ||
| Lipid mediators in the resolution of inflammation | Q28250668 | ||
| Inside epoxyeicosatrienoic acids and cardiovascular disease | Q28252156 | ||
| Cytochrome P450 eicosanoids in hypertension and renal disease | Q28252210 | ||
| Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid | Q28252674 | ||
| Vascular actions of 20-HETE | Q28259468 | ||
| Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants | Q28260351 | ||
| Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3) | Q28277320 | ||
| Omega-oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of omega-hydroxy and omega-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4 | Q28280612 | ||
| Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids | Q28294130 | ||
| Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. | Q28343514 | ||
| HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme | Q28365824 | ||
| Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism | Q28385509 | ||
| The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain | Q28392416 | ||
| The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands | Q28578924 | ||
| Prostaglandin and leukotriene omega-hydroxylases | Q28620124 | ||
| Cyclooxygenases 1 and 2 | Q29615645 | ||
| Cyclooxygenases: structural, cellular, and molecular biology | Q29616510 | ||
| Leukotrienes and lipoxins: structures, biosynthesis, and biological effects | Q29617543 | ||
| Breast cancer metastasis: markers and models | Q29618061 | ||
| P-450 metabolites of arachidonic acid in the control of cardiovascular function | Q29620578 | ||
| Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids | Q30482728 | ||
| 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. | Q30827044 | ||
| Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response | Q30843051 | ||
| Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11. | Q30981862 | ||
| Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2). | Q31389061 | ||
| Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma | Q33200791 | ||
| Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes | Q33671358 | ||
| Vascular characterization of mice with endothelial expression of cytochrome P450 4F2. | Q33775129 | ||
| Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase | Q33868385 | ||
| Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells | Q33906310 | ||
| Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells | Q33931951 | ||
| Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension | Q33943987 | ||
| Calibration of the channel that determines the omega-hydroxylation regiospecificity of cytochrome P4504A1: catalytic oxidation of 12-HALODOdecanoic acids | Q33947774 | ||
| Eicosanoids and cancer | Q33966203 | ||
| Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport | Q34014771 | ||
| Alternative splicing determines the function of CYP4F3 by switching substrate specificity | Q34084417 | ||
| Lipoxins: revelations on resolution | Q34085413 | ||
| Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin | Q34121190 | ||
| Profiling the expression of cytochrome P450 in breast cancer | Q34131684 | ||
| Cytochrome P450-derived eicosanoids: the neglected pathway in cancer | Q34143118 | ||
| Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock. | Q34151380 | ||
| Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer | Q34152658 | ||
| The enzymology of prostaglandin endoperoxide H synthases-1 and -2. | Q34159094 | ||
| Omega-3 fatty acids in inflammation and autoimmune diseases | Q34164525 | ||
| Prostaglandins and inflammation | Q34179727 | ||
| 20-HETE-producing enzymes are up-regulated in human cancers. | Q34288316 | ||
| Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. | Q34290867 | ||
| Targeting 20-HETE producing enzymes in cancer - rationale, pharmacology, and clinical potential | Q34338086 | ||
| Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors | Q34359645 | ||
| Conditional regulation of the human CYP4X1 and CYP4Z1 genes | Q34407244 | ||
| Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis | Q34419306 | ||
| Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites | Q34428688 | ||
| Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A. | Q34440503 | ||
| Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers | Q34462038 | ||
| Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin | Q34586649 | ||
| Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury | Q34705038 | ||
| Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway | Q34715847 | ||
| Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid. | Q34906403 | ||
| 20-Hydroxylation is the CYP-dependent and retinoid-inducible leukotriene B4 inactivation pathway in human and mouse skin cells | Q34982901 | ||
| Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases. | Q34997982 | ||
| Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. | Q35008976 | ||
| Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. | Q35030324 | ||
| Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. | Q35032512 | ||
| The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood | Q35122891 | ||
| Mass spectrometry based lipidomics: an overview of technological platforms | Q35193597 | ||
| Resolvins and protectins in inflammation resolution. | Q35332873 | ||
| Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice | Q35640579 | ||
| CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury | Q42128844 | ||
| Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes | Q42257673 | ||
| Effects of a 20-HETE antagonist and agonists on cerebral vascular tone | Q42457671 | ||
| Western blots versus selected reaction monitoring assays: time to turn the tables? | Q42595907 | ||
| Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels | Q42833184 | ||
| Suppression of hepatocyte nuclear factor-4alpha by acyl-CoA thioesters of hypolipidemic peroxisome proliferators | Q43574299 | ||
| Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor | Q43803513 | ||
| Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes | Q43830180 | ||
| CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis | Q44274467 | ||
| Differential expression of cytochrome P450 omega-hydroxylase isoforms and their association with clinicopathological features in pancreatic ductal adenocarcinoma. | Q44362268 | ||
| Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats | Q44396063 | ||
| Urinary metabolites of leukotriene B4 in the human subject | Q44412878 | ||
| Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors | Q44670150 | ||
| Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides | Q44897935 | ||
| Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition | Q46178229 | ||
| Characterization of the active site properties of CYP4F12. | Q46431804 | ||
| Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism | Q46520416 | ||
| WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes | Q47770934 | ||
| Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinemia IIb. | Q47862536 | ||
| Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators | Q47877643 | ||
| Tumor-specific expression of cytochrome P450 CYP1B1. | Q48657856 | ||
| Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors. | Q50496603 | ||
| Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E. coli. | Q54661547 | ||
| Oxidation of prostaglandin H2 and prostaglandin H2 analogues by human cytochromes P450: analysis of ω-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I1 by mass spectrometry11Abbreviations: CYP, cytochrome P450; HHT, ( | Q56594078 | ||
| Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats | Q57222889 | ||
| Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens | Q59072082 | ||
| Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions | Q61632740 | ||
| Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue | Q64445223 | ||
| Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha | Q68664961 | ||
| Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes | Q68726619 | ||
| Conversion of arachidonic acid to two novel products by a cytochrome P450-dependent mixed-function oxidase in polymorphonuclear leukocytes | Q70500858 | ||
| Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes | Q72389890 | ||
| Segregated coupling of phospholipases A2, cyclooxygenases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages | Q74336632 | ||
| Distribution of COX-1 and COX-2 in normal and inflamed tissues | Q74454815 | ||
| OMEGA-OXIDATION OF LONG CHAIN FATTY ACIDS IN RAT LIVER | Q76707110 | ||
| Transcellular regulation of eicosanoid biosynthesis | Q77796361 | ||
| Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators | Q77958214 | ||
| The cytochromes P450 (CYP) response to allergic inflammation of the lung | Q79325392 | ||
| P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPARalpha-dependent peroxisomal proliferation | Q79596635 | ||
| Studies on omega-oxidation of fatty acids in vitro. I. Overall reaction and intermediate | Q79703158 | ||
| Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production | Q79838379 | ||
| Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways | Q81331990 | ||
| Leukotrienes | Q81542824 | ||
| Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation | Q83785218 | ||
| A search for reliable molecular markers of prognosis in prostate cancer: a study of 240 cases | Q84131673 | ||
| Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders | Q84805975 | ||
| Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102 | Q93927609 | ||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | inflammation | Q101991 |
| P304 | page(s) | 223-62 | |
| P577 | publication date | 2015-01-01 | |
| P1433 | published in | Advances in Pharmacology | Q15753809 |
| P1476 | title | Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer | |
| P478 | volume | 74 |
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| Q50523183 | A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine. |
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| Q47824410 | Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae. |
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