Endoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition

scientific article

Endoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FONC.2014.00291
P932PMC publication ID4209815
P698PubMed publication ID25386408
P5875ResearchGate publication ID268228989

P50authorTomás GutierrezQ82413023
P2093author name stringThomas Simmen
P2860cites workCathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signalQ72306301
Folding of VSV G protein: sequential interaction with BiP and calnexinQ72752117
Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growthQ73023343
Secretory pathway kinetics and in vivo analysis of protein traffic from the Golgi complex to the cell surfaceQ73319946
Role of Sec61alpha in the regulated transfer of the ribosome-nascent chain complex from the signal recognition particle to the translocation channelQ73453521
CD91: a receptor for heat shock protein gp96Q73615235
Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell deathQ73615868
Sulfhydryl regulation of L-selectin shedding: phenylarsine oxide promotes activation-independent L-selectin shedding from leukocytesQ73644500
Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancerQ79450472
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligandsQ80591503
Calreticulin is a B cell molecular target in some gastrointestinal malignanciesQ82323331
The localization of the ER retrieval sequence for the calcium pump SERCA1Q83764086
Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanomaQ84742764
Autophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunityQ42215130
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress.Q42594025
Rer1p regulates the ER retention of immature rhodopsin and modulates its intracellular traffickingQ42771550
Calreticulin surface exposure is abrogated in cells lacking, chaperone-mediated autophagy-essential gene, LAMP2A.Q42911694
A link between ER tethering and COP-I vesicle uncoatingQ43275787
CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulinQ43566795
Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchangeQ44142827
The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signalingQ44592099
The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancerQ44809051
The rate of bulk flow from the endoplasmic reticulum to the cell surfaceQ45345734
Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulumQ45345946
Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling networkQ46134516
Saturation of the endoplasmic reticulum retention machinery reveals anterograde bulk flowQ52864915
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.Q53595113
Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking.Q53632605
The conformation of calreticulin is influenced by the endoplasmic reticulum luminal environment.Q54049232
Cell surface expression of the endoplasmic reticular heat shock protein gp96 is phylogenetically conservedQ56902083
Tumor-specific cell surface expression of the -KDEL containing endoplasmic reticular heat shock protein gp96Q60021885
Different sorting of Lys-Asp-Glu-Leu proteins in rat liverQ67848551
Localization of protein disulfide isomerase on plasma membranes of rat exocrine pancreatic cellsQ68149615
Depletion of intracellular calcium stores by calcium ionophore A23187 induces the genes for glucose-regulated proteins in hamster fibroblastsQ70355655
Localization of protein disulfide isomerase to the external surface of the platelet plasma membraneQ72030923
Coupling of coat assembly and vesicle budding to packaging of putative cargo receptorsQ22008843
Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78Q24293643
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activationQ24298757
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosisQ24302321
Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entryQ24306482
A human homologue of the yeast HDEL receptorQ24310841
Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and GolgiQ24317648
Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47Q24561405
Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of "ER-resident" molecular chaperonesQ24564774
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myelomaQ24598483
Endoplasmic reticulum stress sensing in the unfolded protein responseQ36626672
Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP.Q36721098
The subcellular distribution of calnexin is mediated by PACS-2Q36739888
Retrograde traffic from the Golgi to the endoplasmic reticulumQ36865153
Structure and function of major histocompatibility complex class I antigensQ37012868
Re-Examination of CD91 Function in GRP94 (Glycoprotein 96) Surface Binding, Uptake, and Peptide Cross-PresentationQ37029458
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epitheliumQ37039595
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell deathQ37133168
Pattern recognition receptors in the immune response against dying cellsQ37191778
Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathwayQ37226153
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapiesQ37285838
Hypoxia signalling through mTOR and the unfolded protein response in cancerQ37290935
The quality control of MHC class I peptide loadingQ37300625
Danger signalling during cancer cell death: origins, plasticity and regulation.Q37381745
Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.Q37433487
Localisation and trafficking of Toll-like receptors: an important mode of regulation.Q37671100
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPaseQ37726811
Protein sorting receptors in the early secretory pathwayQ37763713
GRP78 signaling hub a receptor for targeted tumor therapyQ37784290
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell deathQ24620548
Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cellsQ24648786
C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cellsQ24670661
Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44Q24672358
Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1Q24681842
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulumQ26860153
Structures and mechanisms of vesicle coat components and multisubunit tethering complexesQ27009146
Orchestration of secretory protein folding by ER chaperonesQ27013551
Molecular Basis for Recognition of Dilysine Trafficking Motifs by COPIQ27675211
Rules for the recognition of dilysine retrieval motifs by coatomerQ27676769
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2Q27679845
N-linked glycans direct the cotranslational folding pathway of influenza hemagglutinin.Q27863759
ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathwayQ27935834
Rab2 is essential for the maturation of pre-Golgi intermediatesQ28118777
Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblastsQ28191188
Protein quality control, retention, and degradation at the endoplasmic reticulumQ28252854
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survivalQ28255981
Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatusQ28258751
Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomersQ28269985
The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localizationQ28271461
Calreticulin exposure dictates the immunogenicity of cancer cell deathQ28280438
Rab18 and Rab43 have key roles in ER-Golgi traffickingQ28288974
Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 productionQ28534981
The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1‐LαQ28571513
Coatomer interaction with di-lysine endoplasmic reticulum retention motifsQ28609806
Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1Q28854589
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyteQ29615441
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in miceQ29615615
Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomasQ30425423
ER Import Sites and Their Relationship to ER Exit Sites: A New Model for Bidirectional ER-Golgi Transport in Higher PlantsQ30523967
A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expressionQ30828833
Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potentialQ33278631
Beyond receptor expression levels: the relevance of target accessibility in ligand-directed pharmacodelivery systemsQ33343814
Cellular mechanisms of membrane protein foldingQ33624056
Mouse proteome analysisQ33677663
The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?Q33717397
Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.Q33832578
Secretory protein trafficking and organelle dynamics in living cellsQ33921421
Calcium, a signaling molecule in the endoplasmic reticulum?Q33953214
Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress.Q34051194
Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.Q34118737
Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapyQ34284930
Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancerQ34375617
A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell deathQ34437578
Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12pQ34452783
Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44.Q34522219
Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.Q34533508
Calreticulin expression in infiltrating ductal breast carcinomas: relationships with disease progression and humoral immune responses.Q34555318
Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.Q34618673
Efficient export of the vesicular stomatitis virus G protein from the endoplasmic reticulum requires a signal in the cytoplasmic tail that includes both tyrosine-based and di-acidic motifsQ34664121
Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redoxQ34685501
The inflammatory response to cell deathQ34718276
The human PDI family: versatility packed into a single fold.Q34727849
Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).Q35111066
Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complexQ35153371
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signalingQ35692042
ER stress activates the NLRP3 inflammasome via an UPR-independent pathwayQ35723848
The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancerQ36015748
Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cellsQ36020814
Trial watch: Chemotherapy with immunogenic cell death inducersQ36038456
Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathwayQ36236056
Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomeraseQ36281651
Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growthQ36401336
Unfolded protein response to autophagy as a promising druggable target for anticancer therapyQ36403652
Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).Q36418911
Effect of celecoxib on Ca(2+) handling and viability in human prostate cancer cells (PC3).Q39428795
Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinomaQ39436362
ER stress impairs MHC Class I surface expression and increases susceptibility of thyroid cells to NK-mediated cytotoxicityQ39612923
Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM).Q39734860
Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.Q39749582
GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomibQ39807121
Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosisQ39856365
Grp94 is Tyr-phosphorylated by Fyn in the lumen of the endoplasmic reticulum and translocates to Golgi in differentiating myoblastsQ39919036
ERP57 membrane translocation dictates the immunogenicity of tumor cell death by controlling the membrane translocation of calreticulinQ39953260
The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell deathQ39984426
Transmembrane domain-dependent partitioning of membrane proteins within the endoplasmic reticulumQ39994820
A new tumor-specific variant of GRP78 as target for antibody-based therapyQ40014019
Reduction of endoplasmic reticulum Ca2+ levels favors plasma membrane surface exposure of calreticulin.Q40045975
The immunosuppressive and protective ability of glucose-regulated protein 78 for improvement of alloimmunity in beta cell transplantationQ40063531
Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serumQ40200746
Protein disulfide isomerase expression is related to the invasive properties of malignant gliomaQ40219026
(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.Q40230429
Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.Q40303607
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapyQ40321304
The cotranslational maturation of the type I membrane glycoprotein tyrosinase: the heat shock protein 70 system hands off to the lectin-based chaperone systemQ40409191
Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.Q40421034
Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality controlQ40597954
Major histocompatibility class one molecule associates with glucose regulated protein (GRP) 78 on the cell surfaceQ40789692
An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulumQ40791455
Protein-disulfide isomerase (PDI) in FRTL5 cells. pH-dependent thyroglobulin/PDI interactions determine a novel PDI function in the post-endoplasmic reticulum of thyrocytes.Q40906037
Humoral immune responses to cathepsin D and glucose-regulated protein 78 in ovarian cancer patientsQ40994712
Membrane-bound proteindisulfide isomerase (PDI) is involved in regulation of surface expression of thiols and drug sensitivity of B-CLL cells.Q41102445
Calcium binding and conformational response in EF-hand proteinsQ41145282
Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum.Q41439078
A dual role for COOH-terminal lysine residues in pre-Golgi retention and endocytosis of ERGIC-53.Q41481631
Heavy chain binding protein (BiP/GRP78) and endoplasmin are exported from the endoplasmic reticulum in rat exocrine pancreatic cells, similar to protein disulfide-isomeraseQ41617941
Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cellsQ41661789
A di-acidic (DXE) code directs concentration of cargo during export from the endoplasmic reticulumQ41666503
Multiple ways to make disulfidesQ37903530
The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and moreQ37973411
Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarksQ37994524
The DSL1 complex: the smallest but not the least CATCHR.Q38001076
Calreticulin in the immune system: ins and outsQ38041778
Rab proteins of the endoplasmic reticulum: functions and interactorsQ38061998
Crosstalk between ER stress and immunogenic cell deathQ38115887
Targeting the unfolded protein response in disease.Q38132652
The interplay between pathogen-associated and danger-associated molecular patterns: an inflammatory code in cancer?Q38150096
Protein disulfide isomerase: a promising target for cancer therapyQ38159179
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potentialQ38198491
Retention mechanisms for ER and Golgi membrane proteins.Q38209189
Targeting thapsigargin towards tumorsQ38234334
GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancerQ38436413
A positive signal prevents secretory membrane cargo from recycling between the Golgi and the ER.Q38971512
The key role of calreticulin in immunomodulation induced by chemotherapeutic agentsQ38980305
Detection of tumor-associated antigens in culture supernatants using autoantibodies in sera from patients with bladder cancerQ39020663
Overexpression of calreticulin contributes to the development and progression of pancreatic cancerQ39058690
Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.Q39134058
Whole-cell vaccine coated with recombinant calreticulin enhances activation of dendritic cells and induces tumour-specific immune responsesQ39242176
Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.Q39412402
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
molecular chaperonesQ422496
P304page(s)291
P577publication date2014-10-27
P1433published inFrontiers in OncologyQ26839986
P1476titleEndoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition
P478volume4

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