MEG3 noncoding RNA: a tumor suppressor

scientific article

MEG3 noncoding RNA: a tumor suppressor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1530/JME-12-0008
P3181OpenCitations bibliographic resource ID2353916
P932PMC publication ID3738193
P698PubMed publication ID22393162
P5875ResearchGate publication ID221890730

P2093author name stringX. Zhang
Y. Zhou
A. Klibanski
P2860cites workA Pituitary-Derived MEG3 Isoform Functions as a Growth Suppressor in Tumor CellsQ24299283
Activation of p53 by MEG3 non-coding RNAQ24310760
Mdm2 promotes the rapid degradation of p53Q24322597
Mfold web server for nucleic acid folding and hybridization predictionQ24498105
Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functionsQ24623420
BRCA1 regulates p53-dependent gene expressionQ24685083
Regulation of p53 stability by Mdm2Q27860744
Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structureQ27860806
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progressionQ28115872
Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomasQ28117410
Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesisQ28206371
Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiationQ28269495
Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 geneQ28585506
Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in miceQ28588399
Increased expression of angiogenic genes in the brains of mouse meg3-null embryosQ28590418
The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNAQ28594499
Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control regionQ29036897
Blinded by the Light: The Growing Complexity of p53Q29547590
Role of angiogenesis in tumor growth and metastasisQ29614309
The p53 pathway: positive and negative feedback loopsQ29617535
Effects of an Rb mutation in the mouseQ29619196
GonadotropinomasQ30310432
The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centersQ33619072
VEGFs, receptors and angiogenesisQ33644265
TP53 mutations in human cancers: origins, consequences, and clinical useQ33685392
The ARF/p53 pathwayQ33840421
Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q.Q33897694
Clinically nonfunctioning pituitary tumors are monoclonal in originQ34256956
Animal models of tumor-suppressor genes.Q34432219
Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter regionQ34540991
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein networkQ34825957
The functional role of long non-coding RNA in human carcinomasQ34995156
Silencing of the imprinted DLK1-MEG3 locus in human clinically nonfunctioning pituitary adenomasQ35235761
Genomic imprinting at the mammalian Dlk1-Dio3 domainQ37159981
p53 regulation by ubiquitinQ37882073
TP53 mutations in human cancer: database reassessment and prospects for the next decadeQ37894331
Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19.Q38293388
Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferationQ39414139
Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.Q40415818
Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumourQ40441171
A human pituitary tumor-derived folliculostellate cell lineQ40893501
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancerQ41830068
Requirement for a functional Rb-1 gene in murine developmentQ44462954
Clonal origin of pituitary adenomasQ45035533
Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumorsQ45219910
Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12.Q48231351
Clonal origins of adrenocorticotropin-secreting pituitary tissue in Cushing's diseaseQ48415480
Expression of cell growth negative regulators MEG3 and GADD45γ is lost in most sporadic human pituitary adenomas.Q48944595
Loss of Expression ofGADD45γ, a Growth Inhibitory Gene, in Human Pituitary Adenomas: Implications for TumorigenesisQ56602254
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
Tumor suppressor genesQ68264184
Tumor suppressor genesQ72883741
Loss of heterozygosity on chromosome 14 in nasopharyngeal carcinomaQ77354036
Loss of heterozygosity of 14q32 in colorectal carcinomaQ77809187
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)R45-53
P577publication date2012-06-01
P1433published inJournal of Molecular EndocrinologyQ15716709
P1476titleMEG3 noncoding RNA: a tumor suppressor
P478volume48

Reverse relations

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Q99561822Roles of Noncoding RNAs in Islet Biology
Q35567632Roles of long non-coding RNAs in gastric cancer metastasis
Q47099122Roles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy
Q39398940SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers
Q90699354Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1
Q37716132Shining the Light on Senescence Associated LncRNAs
Q38688209Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells
Q40414194Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163.
Q57018188Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells
Q92422983Specific and Non-Specific Biomarkers in Neuroendocrine Gastroenteropancreatic Tumors
Q46824742Sperm DNA methylation analysis in swine reveals conserved and species-specific methylation patterns and highlights an altered methylation at the GNAS locus in infertile boars
Q35731289TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair
Q92839390Targeting long non-coding RNA HERC2P3 inhibits cell growth and migration in human gastric cancer cells
Q38752040Targeting noncoding RNAs in disease
Q33627977The Activity-Induced Long Non-Coding RNA Meg3 Modulates AMPA Receptor Surface Expression in Primary Cortical Neurons.
Q35680700The Long Noncoding RNA MEG3 Is Downregulated and Inversely Associated with VEGF Levels in Osteoarthritis
Q33828371The Missing lnc(RNA) between the pancreatic β-cell and diabetes
Q58694197The Network of Non-coding RNAs in Cancer Drug Resistance
Q92137481The Regulatory Roles of Long Noncoding RNAs in Acute Myeloid Leukemia
Q92852980The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia
Q38914193The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma
Q37356325The complexity of bladder cancer: long noncoding RNAs are on the stage
Q38626016The emerging role of lncRNAs in cancer
Q39022806The emerging role of long non-coding RNA in gallbladder cancer pathogenesis.
Q28392415The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer
Q38896754The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis
Q61796082The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells
Q51751763The long non-coding RNA maternally expressed gene 3 activates p53 and is downregulated in esophageal squamous cell cancer.
Q28271675The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis
Q26830047The molecular pathogenesis of pituitary adenomas: an update
Q37401950The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas
Q38274982The role of genetic and epigenetic changes in pituitary tumorigenesis
Q38630563The role of lncRNAs in hepatocellular carcinoma: opportunities as novel targets for pharmacological intervention.
Q90482676The role of noncoding RNAs in epithelial cancer
Q59791075The roles of lncRNA in hepatic fibrosis
Q49961986Therapeutic Targeting of Long Non-Coding RNAs in Cancer.
Q34530150Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment
Q36161900Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line
Q39196669Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression.
Q50954583Upregulated lncRNA-PCAT1 is closely related to clinical diagnosis of multiple myeloma as a predictive biomarker in serum.
Q41262517Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 Transcription
Q36355609Urinary long noncoding RNAs in nonmuscle-invasive bladder cancer: new architects in cancer prognostic biomarkers.
Q38581149Urothelial cancer associated 1: a long noncoding RNA with a crucial role in cancer
Q95832005Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques
Q52752598[Non-coding RNA : Innovative regulators with therapeutic perspective].
Q52721285lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
Q59804839lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression
Q91712585lncRNA MIAT promotes cell invasion and migration in esophageal cancer
Q39012355lncRNAs: novel players in intervertebral disc degeneration and osteoarthritis
Q57470836locus-derived LncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity
Q58553627miR-506 attenuates methylation of lncRNA to inhibit migration and invasion of breast cancer cell lines via targeting SP1 and SP3
Q40120040microRNA dependent and independent deregulation of long non-coding RNAs by an oncogenic herpesvirus.
Q35797313ncRDeathDB: A comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system

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