Applications of RNA Interference in Schistosomiasis: Gene Function Identification and Development of New Therapies

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Applications of RNA Interference in Schistosomiasis: Gene Function Identification and Development of New Therapies is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.5402/2013/247036
P932PMC publication ID4890885
P698PubMed publication ID27335847
P5875ResearchGate publication ID258404998

P50authorGustavo BorgesQ87734960
P2093author name stringIscia Lopes-Cendes
Tiago Campos Pereira
Eliana Maria Zanotti-Magalhães
Luiz Augusto Magalhães
Cláudia Carolina Silva Evangelista
P2860cites workWhole-genome sequence of Schistosoma haematobiumQ22122084
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The Schistosoma japonicum genome reveals features of host-parasite interplayQ22122229
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegansQ24791911
The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesisQ27315898
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansQ27860867
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug targetQ28469234
Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug TargetQ28469289
A schistosome cAMP-dependent protein kinase catalytic subunit is essential for parasite viabilityQ28475964
The 26S proteasome in Schistosoma mansoni: bioinformatics analysis, developmental expression, and RNA interference (RNAi) studies.Q53525699
Schistosoma mansoni: evaluation of an RNAi-based treatment targeting HGPRTase gene.Q54548743
Vector-based RNA interference of cathepsin B1 in Schistosoma mansoniQ58023128
RNA-mediated gene silencing in Candida albicans: inhibition of hyphae formation by use of RNAi technologyQ61505351
RNA-Mediated Gene Silencing in Candida albicans: Inhibition of Hyphae Formation by Use of RNAi TechnologyQ62083151
RNA therapy beckons as firms prepare for clinical trialsQ80237921
The Schistosoma mansoni soluble proteome: a comparison across four life-cycle stagesQ80899185
Companies jostle for lead in RNAi, despite uncertaintiesQ81568084
RNAi silencing of calcium-regulated heat-stable protein of 24 kDa in Schistosoma japonicum affects parasite growthQ82495623
RNAi silencing of type V collagen in Schistosoma japonicum affects parasite morphology, spawning, and hatchingQ84230334
Is silence still golden? Mapping the RNAi patent landscapeQ84306756
Genetic knockdown and pharmacological inhibition of parasite multidrug resistance transporters disrupts egg production in Schistosoma mansoniQ28478288
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion diseaseQ30482741
Transcriptome analysis of the acoelomate human parasite Schistosoma mansoniQ30788653
Role of the endogenous antioxidant system in the protection of Schistosoma mansoni primary sporocysts against exogenous oxidative stressQ30894397
The Schistosoma mansoni gene index: gene discovery and biology by reconstruction and analysis of expressed gene sequencesQ31142819
Enzymatic production of RNAi libraries from cDNAs.Q33196418
Potential role of a CD36-like class B scavenger receptor in the binding of modified low-density lipoprotein (acLDL) to the tegumental surface of Schistosoma mansoni sporocystsQ33232217
TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoniQ33281290
Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interferenceQ33492321
Schistosoma mansoni: signal transduction processes during the development of the reproductive organsQ33531955
Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnoverQ33564382
The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: the surface aquaporin SmAQP is a lactate transporterQ33573516
Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian hostQ33598437
Polyethyleneimine (PEI) mediated siRNA gene silencing in the Schistosoma mansoni snail host, Biomphalaria glabrataQ33963996
RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascadeQ34034127
Genetic manipulation of Schistosoma haematobium, the neglected schistosome.Q34056375
A somatically diversified defense factor, FREP3, is a determinant of snail resistance to schistosome infection.Q34222749
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathwaysQ34530552
Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomesQ35272787
Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thalianaQ35703160
Caspar-like gene depletion reduces Leishmania infection in sand fly host Lutzomyia longipalpisQ35921576
Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survivalQ36156039
Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expressionQ37143365
RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs.Q37250199
Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult fliesQ37371055
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1Q42321933
siRNA-mediated knockdown of two tyrosinase genes from Schistosoma japonicum cultured in vitroQ43511626
Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts.Q44438136
Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth.Q46631911
Three researchers developing therapies based on RNA interference talk about their experiences leaving academia for biotech companiesQ48567261
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectschistosomiasisQ221159
RNA interferenceQ201993
P304page(s)247036
P577publication date2012-12-31
P1433published inISRN parasitologyQ27727472
P1476titleApplications of RNA Interference in Schistosomiasis: Gene Function Identification and Development of New Therapies
P478volume2013