Immunoglobulin light chain amyloidosis: 2013 update on diagnosis, prognosis, and treatment

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Immunoglobulin light chain amyloidosis: 2013 update on diagnosis, prognosis, and treatment is …
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scholarly articleQ13442814

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P356DOI10.1002/AJH.23400
P3181OpenCitations bibliographic resource ID4013879
P698PubMed publication ID23605846
P5875ResearchGate publication ID236254370

P50authorMorie A GertzQ57052163
P2860cites workCD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody-based therapyQ24649764
Low-dose continuous oral melphalan for the treatment of primary systemic (AL) amyloidosis.Q31075899
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The activity of lenalidomide with or without dexamethasone in patients with primary systemic amyloidosisQ33372805
Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimensQ33508070
Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosisQ33704832
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Association of melphalan and high-dose dexamethasone is effective and well tolerated in patients with AL (primary) amyloidosis who are ineligible for stem cell transplantation.Q34311781
Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical featuresQ34450428
Recent improvements in survival in primary systemic amyloidosis and the importance of an early mortality risk scoreQ34450910
Prevalence of monoclonal gammopathy of undetermined significanceQ34506801
Weekly and twice-weekly bortezomib in patients with systemic AL amyloidosis: results of a phase 1 dose-escalation studyQ34608501
Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, the American Association of Neuromuscular anQ34610169
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Amyloidosis: pathogenesis and new therapeutic options.Q35111771
High-dose melphalan and peripheral blood stem cell transplantation for light-chain amyloidosis with cardiac involvementQ35750326
Activity of pomalidomide in patients with immunoglobulin light-chain amyloidosisQ36015183
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Dermatologic adverse effects of lenalidomide therapy for amyloidosis and multiple myelomaQ36624286
The spectrum of localized amyloidosis: a case series of 20 patients and review of the literatureQ36633633
Transplantation for amyloidosisQ36726168
Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurementsQ36910372
Discordance between serum cardiac biomarker and immunoglobulin-free light-chain response in patients with immunoglobulin light-chain amyloidosis treated with immune modulatory drugsQ36950813
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Changes in serum-free light chain rather than intact monoclonal immunoglobulin levels predicts outcome following therapy in primary amyloidosisQ37172003
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Cardiac amyloidosis: approaches to diagnosis and managementQ37654514
Echocardiographic evaluation of cardiac amyloidQ37738051
Treatment of immunoglobulin light chain amyloidosisQ37738576
Pitfalls in the diagnosis of primary amyloidosisQ37761568
Systemic amyloidosis: a challenge for the rheumatologistQ37763504
Renal outcome and monoclonal immunoglobulin deposition disease in 289 old patients with blood cell dyscrasias: a single center experienceQ37767014
Asymptomatic immunoglobulin light chain amyloidosis (AL) at the time of diagnostic bone marrow biopsy in newly diagnosed patients with multiple myeloma and smoldering myeloma. A series of 144 cases and a review of the literatureQ37774301
Molecular imaging of amyloidosis: will the heart be the next target after the brain?Q37970935
Prognostication of survival using cardiac troponins and N-terminal pro-brain natriuretic peptide in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantationQ39128093
Serum uric acid: novel prognostic factor in primary systemic amyloidosisQ40117481
Sustained improvement in cardiac function with persistent amyloid deposition in a patient with multiple myeloma-associated cardiac amyloidosis treated with bortezomibQ42847216
Lenalidomide in combination with melphalan and dexamethasone in patients with newly diagnosed AL amyloidosis: a multicenter phase 1/2 dose-escalation studyQ42931881
Cyclophosphamide-bortezomib-dexamethasone (CyBorD) produces rapid and complete hematologic response in patients with AL amyloidosis.Q43050098
Bortezomib with or without dexamethasone in primary systemic (light chain) amyloidosisQ43189700
Amyloid in bone marrow smears of patients affected by multiple myelomaQ43247364
Thalidomide: a step forward in the treatment of malignant monoclonal gammopathies.Q44388184
Trends in day 100 and 2-year survival after auto-SCT for AL amyloidosis: outcomes before and after 2006.Q44468671
New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomesQ44572498
End-stage renal failure due to amyloidosis: outcomes in 490 ANZDATA registry cases.Q44907517
Ten-year survival after autologous stem cell transplantation for immunoglobulin light chain amyloidosisQ44960748
Long-term outcomes of patients with light chain amyloidosis (AL) after renal transplantation with or without stem cell transplantationQ45896840
Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomideQ46380099
Nodular senile pulmonary amyloidosis: a unique case confirmed by immunohistochemistry, mass spectrometry, and genetic studyQ46764637
Efficacy of bortezomib in systemic AL amyloidosis with relapsed/refractory clonal diseaseQ46775156
Bortezomib in the treatment of AL amyloidosis: targeted therapy?Q46892406
Amyloid load in fat tissue reflects disease severity and predicts survival in amyloidosisQ46904469
Serum free light chain analysis may miss monoclonal light chains that urine immunofixation electrophoreses would detectQ47895749
Glycosaminoglycans are part of amyloid fibrils: ultrastructural evidence in avian AA amyloid stained with cuprolinic blue and labeled with immunogold.Q50479496
Reliable typing of systemic amyloidoses through proteomic analysis of subcutaneous adipose tissue.Q50526227
Prevalence and origin of amyloid in kidney biopsies.Q50604623
Treatment of 100 patients with primary amyloidosis: a randomized trial of melphalan, prednisone, and colchicine versus colchicine only.Q51033339
Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: patients can have both monoclonal gammopathies and hereditary amyloid proteins.Q51954022
Amyloid in endomyocardial biopsies.Q52904497
Prognostic significance of strain Doppler imaging in light-chain amyloidosis.Q53066780
Troponin T level as an exclusion criterion for stem cell transplantation in light-chain amyloidosis.Q53504425
Living donor kidney and autologous stem cell transplantation for primary systemic amyloidosis (AL) with predominant renal involvement.Q53671959
Treatment of "primary" renal amyloidosis with melphalan.Q54196552
High-Dose Melphalan versus Melphalan plus Dexamethasone for AL AmyloidosisQ57218202
A phase 1/2 study of lenalidomide with low-dose oral cyclophosphamide and low-dose dexamethasone (RdC) in AL amyloidosisQ57904446
Cardiac changes in systemic amyloidosis: Visualisation by magnetic resonance imagingQ58009561
Salvage therapy with lenalidomide and dexamethasone in patients with advanced AL amyloidosis refractory to melphalan, bortezomib, and thalidomideQ58030111
Identification of Amyloidogenic Light Chains Requires the Combination of Serum-Free Light Chain Assay with Immunofixation of Serum and UrineQ58030328
Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosisQ58030485
Renal Transplantation in Systemic Amyloidosis-Importance of Amyloid Fibril Type and Precursor Protein AbundanceQ58853072
Cyclophosphamide, bortezomib, and dexamethasone therapy in AL amyloidosis is associated with high clonal response rates and prolonged progression-free survivalQ58853078
Outcome in Renal AL Amyloidosis After ChemotherapyQ58853111
High-Dose Melphalan versus Melphalan plus Dexamethasone for AL AmyloidosisQ58853165
Safety and efficacy of risk-adapted cyclophosphamide, thalidomide, and dexamethasone in systemic AL amyloidosisQ58853178
Autologous stem cell transplant for immunoglobulin light chain amyloidosis: a status reportQ60976607
High-Dose Chemotherapy with Autotransplantation in AL Amyloidosis: A Flawed Meta-analysisQ60976621
Effect of hematologic response on outcome of patients undergoing transplantation for primary amyloidosis: importance of achieving a complete responseQ60976697
A second course of high-dose melphalan and auto-SCT for the treatment of relapsed AL amyloidosisQ63413669
A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicineQ73247899
Classification of amyloidosis: misdiagnosing by way of incomplete immunohistochemistry and how to prevent itQ79765776
Predictors of survival in patients with systemic light-chain amyloidosis and cardiac involvement initially ineligible for stem cell transplantation and treated with oral melphalan and dexamethasoneQ81762674
Left ventricular hypertrophy: cardiac magnetic resonance may help differentiate amyloidosis from hypertrophic cardiomyopathyQ82831169
Primary localized cutaneous amyloidosis: a sign of immune dysregulation?Q83589494
Treatment with intravenous melphalan and dexamethasone is not able to overcome the poor prognosis of patients with newly diagnosed systemic light chain amyloidosis and severe cardiac involvementQ84019269
Bladder amyloidosisQ84077354
I don't know how to treat amyloidosisQ84617604
Efficacy of the combination of bortezomib and dexamethasone in systemic AL amyloidosisQ84990268
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)416-25
P577publication date2013-05-01
P1433published inAmerican Journal of HematologyQ4744246
P1476titleImmunoglobulin light chain amyloidosis: 2013 update on diagnosis, prognosis, and treatment
P478volume88

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cites work (P2860)
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