Cytokine production and dysregulation in HIV pathogenesis: lessons for development of therapeutics and vaccines

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Cytokine production and dysregulation in HIV pathogenesis: lessons for development of therapeutics and vaccines is …
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scholarly articleQ13442814

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P356DOI10.1016/J.CYTOGFR.2012.05.005
P3181OpenCitations bibliographic resource ID1434883
P932PMC publication ID3582023
P698PubMed publication ID22743036

P50authorMichael R. BettsQ88295419
P2093author name stringCarolina Pombo
Morgan A. Reuter
P2860cites workCutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAPQ22009938
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Microbial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hostsQ22251065
Interleukin-10 and the interleukin-10 receptorQ24290912
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cellsQ24306205
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genesQ24321949
HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell functionQ24600313
Role of PD-1 in HIV pathogenesis and as target for therapyQ24634293
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeQ24648628
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activationQ24675931
Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)Q24682863
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infectionsQ36915902
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigensQ36954734
Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infectionQ37078512
Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune controlQ37169129
Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expressionQ37678595
Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiationQ37764002
The elusive identity of T follicular helper cellsQ37784588
Pathogenic Mechanisms of HIV DiseaseQ37804860
Mechanism of T cell exhaustion in a chronic environmentQ37869551
The influence of HIV on CD127 expression and its potential implications for IL-7 therapyQ37994025
Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV.Q38319280
IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients.Q39214135
Altered receptor expression and decreased sensitivity of T-cells to the stimulatory cytokines IL-2, IL-7 and IL-12 in HIV infectionQ39561892
Molecular basis of the dual functions of 2B4 (CD244).Q39975619
A TH1-->TH2 switch is a critical step in the etiology of HIV infectionQ40709038
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cellsQ40757721
IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp).Q40977801
IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expressionQ41025968
Membrane tumor necrosis factor (TNF) induced cooperative signaling of TNFR60 and TNFR80 favors induction of cell death rather than virus production in HIV-infected T cellsQ41135083
Synergistic stimulatory effects of tumour necrosis factor alpha and interferon gamma on replication of human immunodeficiency virus type 1 and on apoptosis of HIV-1-infected host cellsQ41208701
Interleukin 2-independent interleukin 7 activity enhances cytotoxic immune response of HIV-1-infected individuals.Q41492588
Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cellsQ42251342
IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responsesQ42453465
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.Q42739331
Cytokines alter production of HIV-1 from primary mononuclear phagocytesQ44548244
Germinal centre CD4+ T cells are an important site of HIV replication in vivo.Q44588643
IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccineQ44624519
Interleukin-10 determines viral clearance or persistence in vivoQ27486832
Comparisons of CD8+ T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 ResponsivenessQ27487966
Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus InfectionsQ27488278
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Molecular and biological characterization of a murine ligand for CD40Q28186605
Interferon-γ: an overview of signals, mechanisms and functionsQ28207081
Control of HIV-1 replication in elite suppressorsQ28278044
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγtQ28589692
Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adultsQ28740321
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsQ28754733
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trialQ28972526
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional propertiesQ29547848
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionQ29618956
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania majorQ29619125
Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunityQ29619700
T cell exhaustionQ29620463
Abundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival timeQ33354070
Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite controlQ33594461
Interleukin-7: physiological roles and mechanisms of actionQ33668794
T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.Q33709760
IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infectionQ33733943
Interleukin 2 induces CD8+ T cell-mediated suppression of human immunodeficiency virus replication in CD4+ T cells and this effect overrides its ability to stimulate virus expressionQ33747965
Serological markers for inflammatory bowel disease in AIDS patients with evidence of microbial translocationQ33761406
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiationQ33829736
Interleukin-2 therapy in patients with HIV infectionQ33847543
Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell cloneQ33847737
Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infectionQ33869806
HIV preferentially infects HIV-specific CD4+ T cellsQ33958893
Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsetsQ34018408
Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustionQ34072842
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responsesQ36229406
Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individualsQ36230977
Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmidQ36276936
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania majorQ36362926
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Q36368095
Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15Q36369750
Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cellsQ36369770
HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacityQ36371562
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.Q36402501
Germinal-center organization and cellular dynamicsQ36459345
Th17: the third member of the effector T cell trilogyQ36528977
Presence of suppressor HIV-specific CD8+ T cells is associated with increased PD-1 expression on effector CD8+ T cellsQ36666548
Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycleQ36691272
Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251.Q36808324
Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene deliveryQ36825473
Preservation of FoxP3+ regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4+ T-cell activation.Q36845770
Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesisQ34118839
HIV-induced T-cell activation/exhaustion in rectal mucosa is controlled only partially by antiretroviral treatmentQ34140484
Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeatQ34295016
The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cellsQ34417483
Living in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIVQ34514374
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV diseaseQ34555620
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionQ34570127
Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10Q34683647
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnoverQ34692601
2B4+ CD8+ T cells play an inhibitory role against constrained HIV epitopesQ34714101
A therapeutic dendritic cell-based vaccine for HIV-1 infectionQ34764392
A fundamental role for interleukin-21 in the generation of T follicular helper cellsQ34792475
Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expressionQ34870550
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.Q34891171
Interleukin 1 induces expression of the human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: inhibition of inductive effects by the interleukin 1 receptor antagonistQ34900183
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infectionQ35001605
Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic controlQ35022846
Responsiveness of HIV-specific CD4 T cells to PD-1 blockadeQ35140996
Biological functions of tumor necrosis factor cytokines and their receptorsQ35145609
Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollersQ35363011
Perforin and the granule exocytosis cytotoxicity pathwayQ35538157
Proliferation-dependent HIV-1 infection of monocytes occurs during differentiation into macrophagesQ35600426
Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individualsQ35652583
Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replicQ35677099
DCs and NK cells: critical effectors in the immune response to HIV-1.Q35752667
Changes in paracrine interleukin-2 requirement, CCR7 expression, frequency, and cytokine secretion of human immunodeficiency virus-specific CD4+ T cells are a consequence of antigen loadQ35784804
Enhancement of human immunodeficiency virus type 1-DNA vaccine potency through incorporation of T-helper 1 molecular adjuvantsQ35826378
Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individualsQ35844592
A push-pull vaccine strategy using Toll-like receptor ligands, IL-15, and blockade of negative regulation to improve the quality and quantity of T cell immune responsesQ35871793
Natural regulatory T cells in infectious diseaseQ36078051
Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppressionQ36081615
CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytesQ36086676
Understanding the benign nature of SIV infection in natural hostsQ36099429
Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infectionQ45223808
Suppressive activity of regulatory T cells correlates with high CD4(+) T-cell counts and low T-cell activation during chronic simian immunodeficiency virus infectionQ45370466
Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infectionQ45370561
Increased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infectionQ45405292
Influence of interleukin-15 on CD8+ natural killer cells in human immunodeficiency virus type 1-infected chimpanzeesQ45407910
Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2.Q45723591
Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected personsQ45764071
Interferon-gamma-induced downregulation of CD4 inhibits the entry of human immunodeficiency virus type-1 in primary monocytesQ45772177
Dysregulation of interleukin-7 receptor may generate loss of cytotoxic T cell response in human immunodeficiency virus type 1 infectionQ45784847
Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replicationQ45786225
Similar changes in plasmacytoid dendritic cell and CD4 T-cell counts during primary HIV-1 infection and treatment.Q45955459
The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-alpha treatmentQ46445396
IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activationQ46610378
Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection.Q46902933
A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and diseaseQ46950134
Co-immunization with plasmid IL-12 generates a strong T-cell memory response in miceQ47805056
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremiaQ48023288
HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control.Q51051553
Molecular signature of CD8+ T cell exhaustion during chronic viral infection.Q51970485
Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.Q51977322
Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.Q51991024
Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.Q52011176
Therapeutic immunization of HIV-infected chimpanzees using HIV-1 plasmid antigens and interleukin-12 expressing plasmids.Q52844166
HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages.Q54524214
Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell countQ56334717
Expansion of FOXP3+ CD8 T cells with suppressive potential in colorectal mucosa following a pathogenic simian immunodeficiency virus infection correlates with diminished antiviral T cell response and viral controlQ56899705
Elite control of HIV infection: implications for vaccine designQ56994404
SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaquesQ57081543
IL-15 enhances survival and function of HIV-specific CD8+ T cellsQ58479905
PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosisQ58779416
CXCR4 overexpression during the course of HIV-1 infection correlates with the emergence of X4 strainsQ60199574
Seventeen-colour flow cytometry: unravelling the immune systemQ62577376
Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytesQ67543297
Interferon-gamma enhances expression of cellular receptors for tumor necrosis factorQ70128457
Interferon-gamma inhibits HIV-induced invasiveness of monocytesQ71587224
Regulation of HIV production by blood mononuclear cells from HIV-infected donors: I. Lack of correlation between HIV-1 production and T cell activationQ72798405
A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosisQ73196828
Antigen-specific humoral and cellular immune responses can be modulated in rhesus macaques through the use of IFN-gamma, IL-12, or IL-18 gene adjuvantsQ73262403
Modulation of antigen-specific cellular immune responses to DNA vaccination in rhesus macaques through the use of IL-2, IFN-gamma, or IL-4 gene adjuvantsQ73636717
Coimmunization with IFN-gamma or IL-2, but not IL-13 or IL-4 cDNA can enhance Th1-type DNA vaccine-induced immune responses in vivoQ73669406
Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patientsQ74330262
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsQ78342521
Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients--effects of antiretroviral therapyQ79817109
CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitroQ80104585
CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediatorQ80487900
The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressorsQ82644038
Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathwayQ82855791
P433issue4-5
P407language of work or nameEnglishQ1860
P921main subjectpathogenesisQ372016
vaccine developmentQ27133094
P304page(s)181-91
P577publication date2012-01-01
P1433published inCytokine and Growth Factor ReviewsQ15763303
P1476titleCytokine production and dysregulation in HIV pathogenesis: lessons for development of therapeutics and vaccines
P478volume23

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cites work (P2860)
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