Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering

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Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering is …
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scholarly articleQ13442814

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P356DOI10.3390/TOXINS4111082
P932PMC publication ID3509699
P698PubMed publication ID23202307
P5875ResearchGate publication ID233828621

P2093author name stringJon-Paul Bingham
Zachary Bergeron
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A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.Q44463878
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Interior surface modification of bacteriophage MS2.Q44810692
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Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillationQ45101337
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A genetically encoded fluorescent amino acid.Q46034866
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Direct solid-phase synthesis and fluorescence labeling of large, monodisperse mannosylated dendrons in a peptide synthesizerQ46666775
Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cellsQ36174761
Potassium channels--multiplicity and challengesQ36364450
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Potential therapeutic applications of the cyclotides and related cystine knot mini-proteinsQ36802602
Production of active eukaryotic proteins through bacterial expression systems: a review of the existing biotechnology strategiesQ36943800
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Kv7.1 (KCNQ1) properties and channelopathies.Q37049827
Animal toxins acting on voltage-gated potassium channelsQ37264924
Kaliotoxin (1-37) shows structural differences with related potassium channel blockersQ27729405
3D structure of kaliotoxin: is residue 34 a key for channel selectivity?Q27742115
Solution structure of TsKapa, a charybdotoxin-like scorpion toxin fromTityus serrulatus with high affinity for apamin-sensitive Ca2+-activated K+ channelsQ27747236
Scorpion toxins specific for Na+-channelsQ28144635
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2Q28145423
A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsyQ28198095
An expanded eukaryotic genetic codeQ28201981
Role of disulfide bonds in folding and activity of leiurotoxin I: just two disulfides sufficeQ28201993
Catalytic Activity and Chaperone Function of Human Protein-disulfide Isomerase Are Required for the Efficient Refolding of ProinsulinQ28203834
Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer fociQ28237061
Expanding the genetic codeQ28239578
Antiretroviral prophylaxis for occupational exposure to HIVQ28241415
Synthetic peptides as tools to investigate the structure and pharmacology of potassium channel-acting short-chain scorpion toxinsQ28270835
Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequencesQ28271375
Adding amino acids to the genetic repertoireQ28279678
Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune diseaseQ28280077
Use of chlorotoxin for targeting of primary brain tumorsQ28288404
Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sitesQ28289825
Discovery and characterization of a linear cyclotide from Viola odorata: implications for the processing of circular proteinsQ28298155
The cyclotides and related macrocyclic peptides as scaffolds in drug designQ28303989
Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulusQ28323401
Parameters affecting in vitro oxidation/folding of maurotoxin, a four-disulphide-bridged scorpion toxinQ28349037
Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motifQ28743024
125IMargatoxin, an Extraordinarily High Affinity Ligand for Voltage-Gated Potassium Channels in Mammalian BrainQ29014303
Synthesis of proteins by native chemical ligationQ29616750
Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.Q30351969
Synthesis of a biotin derivative of iberiotoxin: binding interactions with streptavidin and the BK Ca2+-activated K+ channel expressed in a human cell lineQ30483021
Phage randomization in a charybdotoxin scaffold leads to CD4-mimetic recognition motifs that bind HIV-1 envelope through non-aromatic sequencesQ30686326
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Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligationQ30872871
Novel structural class of four disulfide-bridged peptides from Tityus serrulatus venomQ30887168
Were arachnids the first to use combinatorial peptide libraries?Q31138298
Design and synthesis of a solid-phase fluorescent mass tag.Q33225174
ATDB: a uni-database platform for animal toxinsQ33302479
Site directed mutants of Noxiustoxin reveal specific interactions with potassium channelsQ47851912
Primary structure determination and cloning of the cDNA encoding toxin 4 of the scorpion Centruroides noxius HoffmannQ48128156
Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channelsQ48320626
Noxiustoxin and leiurutoxin III, two homologous peptide toxins with binding properties to synaptosomal membrane K+ channelsQ48443326
[125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channelsQ48797903
Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels.Q48829352
Agitoxin footprinting the shaker potassium channel poreQ49020246
Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminalsQ49158543
Localization and developmental expression of BK channels in mammalian cochlear hair cells.Q50475244
Solution structure of BTK-2, a novel hKv1.1 inhibiting scorpion toxin, from the eastern Indian scorpion Mesobuthus tamulusQ50547885
The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriaeQ50643321
Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct disulfide bridge patterns.Q50723911
Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxinQ52477856
Strategic location of calcium channels at transmitter release sites of frog neuromuscular synapsesQ33508349
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Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channelsQ33572883
Post-translationally modified neuropeptides from Conus venomsQ33734580
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligationQ33896261
An ERG channel inhibitor from the scorpion Buthus eupeusQ33929814
Structural basis for alpha-K toxin specificity for K+ channels revealed through the solution 1H NMR structures of two noxiustoxin-iberiotoxin chimerasQ33954623
K(+) channels as therapeutic drug targetsQ33960965
ArachnoServer: a database of protein toxins from spidersQ34010298
Proteomic analysis provides insights on venom processing in Conus textileQ34019951
A new class of scorpion toxin binding sites related to an A-type K+ channel: pharmacological characterization and localization in rat brainQ34084108
State-specific mortality from sudden cardiac death--United States, 1999.Q34118993
Scorpion toxins as natural scaffolds for protein engineeringQ34123764
A potent potassium channel blocker from Mesobuthus eupeus scorpion venomQ34131423
Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus.Q34174746
Computational simulations of interactions of scorpion toxins with the voltage-gated potassium ion channelQ34185962
Cone snail milked venom dynamics--a quantitative study of Conus purpurascensQ34231068
Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin.Q34253169
CysView: protein classification based on cysteine pairing patterns.Q34328889
Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.Q34358892
The scorpion envenoming syndromeQ34373831
Synthesis of an iberiotoxin derivative by chemical ligation: a method for improved yields of cysteine-rich scorpion toxin peptidesQ34387133
SCORPION, a molecular database of scorpion toxinsQ34402027
hERG potassium channels and cardiac arrhythmiaQ34504394
The role of nicotinic acetylcholine receptors in the mechanisms of anesthesiaQ34534755
Kv4 channels sensitive to BmTX3 in rat nervous system: autoradiographic analysis of their distribution during brain ontogenesisQ34567397
Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapyQ34917475
Accelerated chemical synthesis of peptides and small proteinsQ34983403
Subcellular protein localization by using a genetically encoded fluorescent amino acid.Q35220252
Unique interaction of scorpion toxins with the hERG channelQ35770279
Solution Structure of Kurtoxin: A Gating Modifier Selective for Cav3 Voltage-Gated Ca2+ ChannelsQ35807764
Novel forms of chemical protein diversity -- in nature and in the laboratoryQ35961241
Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companiesQ36173574
Folding motifs induced and stabilized by distinct cystine frameworksQ52565927
Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reactionQ53752825
Engineering a uniquely reactive thiol into a cysteine-rich peptideQ54637204
A New Method of Forming Peptide BondsQ56815799
Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged TyrosineQ57431053
Click-enabled heterotrifunctional template for sequential bioconjugationsQ58293314
Scorpamins: the Toxic Proteins of Scorpion VenomsQ58977133
Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscleQ59079770
Expanding the Genetic CodeQ60432486
Characterization of γ-Carboxylated Tryptic Peptides by Collision-Induced Dissociation and Electron Transfer Dissociation Mass SpectrometryQ61043260
Reversed-phase high-performance liquid chromatography of protected peptide segmentsQ61713974
Structure-activity studies on scorpion toxins that block potassium channelsQ62900101
Determination of the three-dimensional structure of iberiotoxin in solution by 1H nuclear magnetic resonance spectroscopyQ67542555
Solution synthesis of charybdotoxin (ChTX), A K+ channel blockerQ67666889
Synthesis and structural characterization of charybdotoxin, a potent peptidyl inhibitor of the high conductance Ca2(+)-activated K+ channelQ67674609
Three-dimensional structure of natural charybdotoxin in aqueous solution by 1H-NMR. Charybdotoxin possesses a structural motif found in other scorpion toxinsQ67683940
Characterization of high affinity binding sites for charybdotoxin in sarcolemmal membranes from bovine aortic smooth muscle. Evidence for a direct association with the high conductance calcium-activated potassium channelQ69117655
Disulfide bonds of toxin II of the scorpion Androctonus australis HectorQ69361401
Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portionQ69653582
Changing the structural context of a functional beta-hairpin. Synthesis and characterization of a chimera containing the curaremimetic loop of a snake toxin in the scorpion alpha/beta scaffoldQ71142719
Synthesis and biological evaluation of an iodinated iberiotoxin analogue, [mono-iodo-Tyr5, Phe36]-iberiotoxinQ71689402
Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter releaseQ72096278
Purification and Some Properties of the Neurotoxins of Androctonus australis Hector*Q72279548
Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition?Q72639503
Contribution of NMR spectroscopy to the study of structure-function relations of proteins and peptidesQ72752703
Chemical synthesis and structure-activity relationships of Ts kappa, a novel scorpion toxin acting on apamin-sensitive SK channelQ73187129
Synthesis, 1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore the consensus motif of scorpion toxinsQ73731329
Consequence of the Removal of Evolutionary Conserved Disulfide Bridges on the Structure and Function of Charybdotoxin and Evidence That Particular Cysteine Spacings Govern Specific Disulfide Bond FormationQ74229090
Semisynthesis and folding of the potassium channel KcsAQ74540695
MASS SPECTROMETRYQ76794298
DETERMINATION OF AMINO ACID SEQUENCES IN OLIGOPEPTIDES BY MASS SPECTROMETRY. I. THE STRUCTURE OF FORTUITINE, AN ACYLNONAPEPTIDE METHYL ESTERQ78394115
The voltage-gated potassium channel subunit, Kv1.3, is expressed in epitheliaQ79079948
Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporterQ79299460
Kv1.3/Kv1.5 heteromeric channels compromise pharmacological responses in macrophagesQ79421562
ConoServer, a database for conopeptide sequences and structuresQ80160913
The solution structure of BmTx3B, a member of the scorpion toxin subfamily alpha-KTx 16Q81044044
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectscorpionQ19125
bioengineeringQ580689
charybdotoxinQ5087002
potassium channel blockerQ7234689
scorpion venomQ75034359
P304page(s)1082-119
P577publication date2012-11-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inToxinsQ15724569
P1476titleScorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering
P478volume4

Reverse relations

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