Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies

scientific article

Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BST20120010
P3181OpenCitations bibliographic resource ID1288443
P932PMC publication ID3431553
P698PubMed publication ID22817712
P5875ResearchGate publication ID229434013

P2093author name stringAmos B. Smith
Carlo Ballatore
John Q. Trojanowski
Kurt R. Brunden
Virginia M.-Y. Lee
P2860cites workModulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tauQ24294296
Repeat motifs of tau bind to the insides of microtubules in the absence of taxolQ24540276
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson diseaseQ24596763
Genome-wide association study reveals genetic risk underlying Parkinson's diseaseQ24646654
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse modelQ28115206
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse modelsQ28119018
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17Q28274687
Differential regulation of dynein and kinesin motor proteins by tauQ28589618
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's diseaseQ28910345
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseQ29617286
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse modelQ29617937
Tau-mediated neurodegeneration in Alzheimer's disease and related disordersQ29618148
Neurodegenerative tauopathiesQ29619895
Multiple-motor based transport and its regulation by Tau.Q30478710
Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitroQ31111749
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy modelQ33715257
Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathiesQ34211969
Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of TauopathyQ34218584
Physical and chemical properties of purified tau factor and the role of tau in microtubule assemblyQ34275737
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.Q34324670
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathiesQ34587678
Novel microtubule-targeting agents - the epothilones.Q34611212
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.Q34722347
Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative diseaseQ35234889
Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament FormationQ35749171
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic miceQ35875920
Biochemistry and molecular biology of tauopathiesQ36642466
Targeting the microtubules in breast cancer beyond taxanes: the epothilonesQ36779179
Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairmentsQ37238270
Design, synthesis, and biological evaluation of new-generation taxoidsQ37325768
Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.Q37361338
Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisationQ38357011
Microtubule stabilizing drugs for the treatment of Alzheimer's diseaseQ40496709
Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerizationQ41236012
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stressQ41830251
Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathiesQ41998110
Phosphate analysis and dephosphorylation of modified tau associated with paired helical filamentsQ44812655
Tau interaction with microtubules in vivoQ45163054
Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the blood-brain barrier in vitro and in situQ45249730
Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutationQ47602087
Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivoQ48134444
Structure and novel exons of the human tau geneQ48149325
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule bindingQ48277664
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.Q48338403
Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)Q48532140
Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complexQ48586971
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.Q48654126
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's diseaseQ48820847
Plaques, tangles and dementia. A quantitative studyQ48874775
Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's diseaseQ48934697
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.Q52200995
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.Q52221648
Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau IsoformQ54965151
A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's DiseaseQ58202813
Domains of tau protein and interactions with microtubulesQ72146653
Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxelQ80585219
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stageQ94526211
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
tauopathyQ2397106
microtubuleQ189933
P304page(s)661-6
P577publication date2012-08-01
P1433published inBiochemical Society TransactionsQ864226
P1476titleBrain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies
P478volume40

Reverse relations

cites work (P2860)
Q26752846A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer
Q38534263Are there treatments for atypical parkinsonism? An update on actual options
Q38957250Axonal pathology in Krabbe's disease: The cytoskeleton as an emerging therapeutic target
Q38232821Axonal transport defects in Alzheimer's disease
Q36852550Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies
Q38223118Clinical trials: past, current, and future for atypical Parkinsonian syndromes
Q50566064Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.
Q36898998Direct modulation of microtubule stability contributes to anthracene general anesthesia
Q41240654Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy
Q53397873Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.
Q36934113MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease
Q47240527Microfluidic platforms for the study of neuronal injury in vitro.
Q38307155Microtubule-Targeting Agents Enter the Central Nervous System (CNS): Double-edged Swords for Treating CNS Injury and Disease.
Q92782695Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder?
Q92761855Neuroprotective Approach of Anti-Cancer Microtubule Stabilizers Against Tauopathy Associated Dementia: Current Status of Clinical and Preclinical Findings
Q38162441Notch signalling in adult neurons: a potential target for microtubule stabilization.
Q99631302Postnatal Role of the Cytoskeleton in Adult Epileptogenesis
Q35103703Rescue of tau-induced synaptic transmission pathology by paclitaxel
Q37449999Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer's disease
Q40354154Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
Q36968220The importance of tau phosphorylation for neurodegenerative diseases

Search more.