Stem cell treatment of degenerative eye disease

scientific article

Stem cell treatment of degenerative eye disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.SCR.2015.02.003
P3181OpenCitations bibliographic resource ID825205
P932PMC publication ID4434205
P698PubMed publication ID25752437
P5875ResearchGate publication ID272846517

P50authorAnn LoganQ42400796
Ben MeadQ85284976
P2093author name stringMartin Berry
Robert A H Scott
Ben A Scheven
Wendy Leadbeater
P2860cites workMolecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assayQ24309542
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.Q24534130
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathwayQ24644113
Nerve growth factor signaling, neuroprotection, and neural repairQ27919616
Retinal stem cells in the adult mammalian eyeQ28138858
Reactive astrocytes protect tissue and preserve function after spinal cord injuryQ28248202
Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degenerationQ28248372
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studiesQ28252926
Self-organizing optic-cup morphogenesis in three-dimensional cultureQ29616181
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II studyQ29617267
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cellsQ29618766
Embryonic stem cell trials for macular degeneration: a preliminary reportQ29620714
Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulpQ30160116
Pericytes derived from adipose-derived stem cells protect against retinal vasculopathyQ30418921
Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury.Q30496325
Immortalized multipotential mesenchymal cells and the hematopoietic microenvironmentQ30661170
Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic ratQ30975439
Stimulation of angiogenesis, neurogenesis and regeneration by side population cells from dental pulpQ42827843
Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection.Q42868128
Human adult bone marrow-derived somatic cells rescue vision in a rodent model of retinal degenerationQ42984720
Effects of bone marrow mesenchymal stem cell transplantation on light-damaged retinaQ43140504
Functional recovery after the transplantation of neurally differentiated mesenchymal stem cells derived from bone barrow in a rat model of spinal cord injuryQ43149471
In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule inductionQ43293862
Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of ratsQ43619965
Transplantation of ocular stem cells: the role of injury in incorporation and differentiation of grafted cells in the retinaQ44385280
Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in ratsQ44614314
Neural induction by the secreted polypeptide nogginQ44628705
Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.Q44774624
In vitro analysis of mesenchymal stem cells derived from human teeth and bone marrowQ44812171
Integration of neuronally predifferentiated human dental pulp stem cells into rat brain in vivoQ44838446
Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact?Q44947589
Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotypeQ44947592
Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury.Q44978640
Wnt signaling promotes Müller cell proliferation and survival after injury.Q45133272
Survival and integration of developing and progenitor-derived retinal ganglion cells following transplantationQ45757629
Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host diseaseQ45861396
Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cellsQ45886241
Simultaneous PKC and cAMP activation induces differentiation of human dental pulp stem cells into functionally active neurons.Q45940508
Umbilical cord blood mesenchymal stromal cells are neuroprotective and promote regeneration in a rat optic tract modelQ46075579
Human umbilical cord blood-derived mesenchymal stem cells do not differentiate into neural cell types or integrate into the retina after intravitreal grafting in neonatal ratsQ46456190
Neuronal differentiation potential of human adipose-derived mesenchymal stem cells.Q46531960
Morphological integration and functional assessment of transplanted neural progenitor cells in healthy and acute ischemic rat eyesQ46742730
Neural and head induction by insulin-like growth factor signalsQ46842475
Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injuryQ46844217
The anti-apoptotic and neuro-protective effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on acute optic nerve injury is transientQ47812058
Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro.Q47894301
Human adipose-derived mesenchymal stem cells can survive and integrate into the adult rat eye following xenotransplantation.Q48019368
Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats.Q48093574
Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injuryQ48179721
Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhageQ48244314
Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity.Q48267316
Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivoQ48333202
BDNF expression with functional improvement in transected spinal cord treated with neural stem cells in adult ratsQ48384931
Neurotrophin expression in neural stem cells grafted acutely to transected spinal cord of adult rats linked to functional improvement.Q48521723
Neurotrophins mediate human embryonic stem cell survival.Q48668710
Transplantation of human central nervous system stem cells - neuroprotection in retinal degeneration.Q48692858
Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells.Q48698275
Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury.Q48917701
Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury.Q49157684
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3Q39864495
Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation.Q40035754
Protective effects of bone marrow stromal cell transplantation in injured rodent brain: synthesis of neurotrophic factorsQ40425192
Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injuryQ40643190
Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injuryQ40703966
Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB.Q40893200
Cellular expression of neurotrophin mRNAs during tooth developmentQ41068043
Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient miceQ41927703
Genetically modified neural stem cells for a local and sustained delivery of neuroprotective factors to the dystrophic mouse retinaQ42259228
The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptorsQ42356709
Intravitreal injection of autologous bone marrow-derived mononuclear cells for hereditary retinal dystrophy: a phase I trial.Q50527381
Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse.Q50719908
Effects of bone marrow stromal cell injection in an experimental glaucoma model.Q50732297
Transplantation of human bone marrow mesenchymal stem cells as a thin subretinal layer ameliorates retinal degeneration in a rat model of retinal dystrophy.Q51772146
Axons from CNS neurones regenerate into PNS graftsQ59054929
Characteristics of Progenitor Cells Derived from Adult Ciliary Body in Mouse, Rat, and Human EyesQ60155756
Immune privilege extended to allogeneic tumor cells in the vitreous cavityQ68181711
Identification of neural progenitors in the adult mammalian eyeQ73642478
The combined effect of brain-derived neurotrophic factor and a free radical scavenger in experimental glaucomaQ74248003
Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cellsQ81598974
Ion channels in mesenchymal stem cells from rat bone marrowQ82581057
Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivativesQ83192248
Neuroprotective effect of intravitreal cell-based glucagon-like peptide-1 production in the optic nerve crush modelQ83796253
Transplantation of predifferentiated adipose-derived stromal cells for the treatment of spinal cord injuryQ84239768
Phagocytosis of photoreceptor outer segments by transplanted human neural stem cells as a neuroprotective mechanism in retinal degenerationQ85943776
The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damageQ86057244
Intraventricular injection of human dental pulp stem cells improves hypoxic-ischemic brain damage in neonatal ratsQ31121245
Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineageQ31847650
Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult ratsQ33202883
Transplantation of quantum dot-labelled bone marrow-derived stem cells into the vitreous of mice with laser-induced retinal injury: survival, integration and differentiation.Q33506858
Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucomaQ33516457
Retinal stem cells transplanted into models of late stages of retinitis pigmentosa preferentially adopt a glial or a retinal ganglion cell fateQ33662630
Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyesQ33875091
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative miceQ33895271
Recruitment of stem cells into the injured retina after laser injuryQ33895696
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cellsQ33913871
Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injuryQ34108759
Ocular neuroprotection by siRNA targeting caspase-2Q34192944
Neurotrophic factors, cellular bridges and gene therapy for spinal cord injuryQ34249936
Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regenerationQ34309248
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implantsQ34410761
The new paradigm: retinal pigment epithelium cells generated from embryonic or induced pluripotent stem cellsQ34494259
Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina.Q34512057
Potential for neural regeneration after neurotoxic injury in the adult mammalian retinaQ34550670
Wnt signaling promotes regeneration in the retina of adult mammals.Q34578573
Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cellsQ34587918
Stepwise differentiation of pluripotent stem cells into retinal cellsQ34607711
Self-formation of optic cups and storable stratified neural retina from human ESCs.Q34639338
Intravitreal autologous bone marrow CD34+ cell therapy for ischemic and degenerative retinal disorders: preliminary phase 1 clinical trial findingsQ34882870
Adult ciliary epithelial stem cells generate functional neurons and differentiate into both early and late born retinal neurons under non-cell autonomous influencesQ35024065
Efficient generation of retinal progenitor cells from human embryonic stem cells.Q35036440
Connecting the dots: trafficking of neurotrophins, lectins and diverse pathogens by binding to the neurotrophin receptor p75NTR.Q35072126
Neurotrophins and neurodegeneration.Q35145450
Microarray characterization of human embryonic stem cell--derived retinal culturesQ35220877
Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells: comparison with human bone marrow and adipose-derived mesenchymal stem cellsQ35309383
Putative dental pulp-derived stem/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of miceQ35559758
Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanismsQ35640614
Early steps in the development of the forebrainQ35666127
Long-term survival and differentiation of retinal neurons derived from human embryonic stem cell lines in un-immunosuppressed mouse retinaQ35910875
Neural regeneration in the chick retinaQ35989973
Embryonic stem cell-derived neural progenitors incorporate into degenerating retina and enhance survival of host photoreceptorsQ36054529
Generation and clonal isolation of retinal stem cells from human embryonic stem cellsQ36074893
The retinal pigment epithelium in visual functionQ36178984
Long-distance growth and connectivity of neural stem cells after severe spinal cord injury.Q36243106
The therapeutic potential of neural stem cellsQ36500191
Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursorsQ36672022
Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapsesQ36827836
Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.Q36947853
RPE transplantation and its role in retinal diseaseQ36962866
Neural Stem Cells Derived by Small Molecules Preserve Vision.Q37149391
Regeneration of axons in the visual system.Q37280447
Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina.Q37304490
Modeling early retinal development with human embryonic and induced pluripotent stem cellsQ37377238
Progranulin, a major secreted protein of mouse adipose-derived stem cells, inhibits light-induced retinal degenerationQ37516468
Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regenerationQ37537193
Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretomeQ37556986
Mesenchymal stem cells: mechanisms of inflammationQ37809081
Injectable hydrogels for central nervous system therapyQ37997938
New functions of Müller cellsQ38084625
Human embryonic stem cell applications for retinal degenerationsQ38123625
Exploiting mTOR signaling: a novel translatable treatment strategy for traumatic optic neuropathy?Q38155110
Mobilizing endogenous stem cells for retinal repairQ38170901
Induced pluripotent stem cells as custom therapeutics for retinal repair: progress and rationaleQ38188689
Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues.Q38513550
Trophic factors and neuronal survivalQ38772889
Neural stem cell-based intraocular administration of ciliary neurotrophic factor attenuates the loss of axotomized ganglion cells in adult miceQ38951804
Long-term neuroprotective effects of NT-4-engineered mesenchymal stem cells injected intravitreally in a mouse model of acute retinal injuryQ39309993
Effects of glial cell line-derived neurotrophic factor on dental pulp cellsQ39492719
Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanismsQ39511026
Crystallin-β-b2-overexpressing NPCs support the survival of injured retinal ganglion cells and photoreceptors in ratsQ39524018
Characterization of in vitro cultured bone marrow and adipose tissue-derived mesenchymal stem cells and their ability to express neurotrophic factorsQ39549965
Neurotrophic activity of human adipose stem cells isolated from deep and superficial layers of abdominal fat.Q39576745
Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cellsQ39667416
Human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells.Q39712429
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
stem cell transplantationQ65592366
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)243-257
P577publication date2015-02-24
2015-05-01
P1433published inStem Cell ResearchQ15762171
P1476titleStem cell treatment of degenerative eye disease
P478volume14

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