The role of miRNAs in regulating gene expression networks

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The role of miRNAs in regulating gene expression networks is …
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scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2013.03.007
P8608Fatcat IDrelease_yo6dyax7rrgjnkmponhlsivvo4
P3181OpenCitations bibliographic resource ID3552185
P932PMC publication ID3757117
P698PubMed publication ID23500488

P2093author name stringPhillip A. Sharp
Allan M. Gurtan
P2860cites workStem cells, the molecular circuitry of pluripotency and nuclear reprogrammingQ29614416
Control of the embryonic stem cell stateQ29614793
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cellsQ29615089
Gene silencing by microRNAs: contributions of translational repression and mRNA decayQ29615825
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cellsQ29615863
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cellsQ29616080
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotencyQ29616797
Human MicroRNA targetsQ21563637
miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifsQ24292787
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOTQ24292808
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activityQ24293207
The nuclear RNase III Drosha initiates microRNA processingQ24295234
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsQ24302072
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitmentQ24310207
miR-145 and miR-143 regulate smooth muscle cell fate and plasticityQ24311186
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targetsQ24339489
miR-15 and miR-16 induce apoptosis by targeting BCL2Q24536069
Characterization of a highly variable eutherian microRNA geneQ24537452
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAsQ24540256
Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient miceQ24567609
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zetaQ24600133
A common variant of HMGA2 is associated with adult and childhood height in the general populationQ24603211
Meta-analysis of genome-wide association data identifies two loci influencing age at menarcheQ24604815
miR-17~92 cooperates with RB pathway mutations to promote retinoblastomaQ24606181
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human diseaseQ24606673
MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and diseaseQ24608809
Selective blockade of microRNA processing by Lin28Q24609864
The Lin28/let-7 axis regulates glucose metabolismQ24620363
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studiesQ24628801
Genetic variation in LIN28B is associated with the timing of pubertyQ24629941
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicingQ24631683
A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegansQ29618304
Transcriptional activation of miR-34a contributes to p53-mediated apoptosisQ29619556
p53 and microRNA-34 are suppressors of canonical Wnt signaling.Q30424916
Small RNA-mediated regulation of iPS cell generation.Q30498334
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferationQ33382062
Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiationQ33497904
Structural insights into RNA interferenceQ33791962
Emerging roles for natural microRNA spongesQ33805820
Mammalian microRNAs: experimental evaluation of novel and previously annotated genesQ33839605
MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and functionQ33893114
Reprogramming of mouse and human cells to pluripotency using mature microRNAs.Q34027071
Expanding the microRNA targeting code: functional sites with centered pairingQ34125341
MicroRNA sponges: progress and possibilitiesQ34139023
Mir193b-365 is essential for brown fat differentiationQ34199261
MicroRNAs can generate thresholds in target gene expressionQ34209703
miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitionsQ34237504
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.Q34278940
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferasesQ34343364
Role of the high mobility group A proteins in human lipomasQ34384823
miR-34 - a microRNA replacement therapy is headed to the clinicQ34640230
Genome-wide association studies identify loci associated with age at menarche and age at natural menopauseQ24632585
Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humansQ24635323
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegansQ24644224
A mammalian microRNA expression atlas based on small RNA library sequencingQ24644709
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clustersQ24645192
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Q24646996
MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and MycQ24647579
Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesisQ24649696
Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomasQ24652219
miR-19 is a key oncogenic component of mir-17-92Q24652326
miR-34a repression of SIRT1 regulates apoptosisQ24652720
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processingQ24652787
Most mammalian mRNAs are conserved targets of microRNAsQ24655061
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elementsQ24656666
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationQ24658400
MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle developmentQ24670766
Extensive post-transcriptional regulation of microRNAs and its implications for cancerQ24672862
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammalsQ24680274
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progressionQ24681466
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexesQ27657724
The Crystal Structure of Human Argonaute2Q27678770
The Structure of Human Argonaute-2 in Complex with miR-20aQ27681032
Structure of yeast Argonaute with guide RNAQ27681293
Combinatorial microRNA target predictionsQ27860510
RAS is regulated by the let-7 microRNA familyQ27860522
Argonaute2 is the catalytic engine of mammalian RNAiQ27860545
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegansQ27860584
Induced pluripotent stem cell lines derived from human somatic cellsQ27860597
MicroRNAs modulate hematopoietic lineage differentiationQ27860661
Nuclear export of microRNA precursorsQ27860686
A microRNA polycistron as a potential human oncogeneQ27860720
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNAQ27860813
Role for a bidentate ribonuclease in the initiation step of RNA interferenceQ27860832
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Q27860849
Silencing of microRNAs in vivo with 'antagomirs'Q27860891
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timingQ27860903
c-Myc-regulated microRNAs modulate E2F1 expressionQ27861046
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAsQ27861053
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Q27861068
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNAQ27861092
The widespread regulation of microRNA biogenesis, function and decayQ28131796
Embryonic stem cell-specific MicroRNAsQ28201906
Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysisQ28237462
The role of let-7 in cell differentiation and cancerQ28259549
Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesisQ28260255
Identification of ten loci associated with height highlights new biological pathways in human growthQ28275237
Identification of let-7-regulated oncofetal genesQ28276555
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181Q28279673
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferationQ28280072
A steroid receptor-microRNA switch regulates life span in response to signals from the gonadQ28281375
miR-181a is an intrinsic modulator of T cell sensitivity and selectionQ28294631
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92Q28294917
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2Q28295844
A microRNA component of the p53 tumour suppressor networkQ28305330
Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signalingQ28477912
Members of the miRNA-200 family regulate olfactory neurogenesisQ28507645
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223Q28510667
Dicer is essential for mouse developmentQ28511142
Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanismQ28586556
p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replicationQ28587920
Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-CQ28588994
A role for Lin28 in primordial germ-cell development and germ-cell malignancyQ28589601
HMGA1 and HMGA2 protein expression in mouse spermatogenesisQ28592453
Genome-wide impact of a recently expanded microRNA cluster in mouseQ28592963
A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cellsQ28594295
miR-122 regulation of lipid metabolism revealed by in vivo antisense targetingQ29547487
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.Q37393628
In vivo modulation of HMGA2 expressionQ37685440
Ancestral roles of small RNAs: an Ago-centric perspectiveQ37784602
MicroRNAs and developmental timingQ37870321
Evolution of microRNA diversity and regulation in animalsQ37957677
MicroRNAs in the p53 network: micromanagement of tumour suppressionQ38035144
MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growthQ38298486
An E2F/miR-20a autoregulatory feedback loop.Q38307203
Mammary tumor induction in transgenic mice expressing an RNA-binding proteinQ38345871
The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastomaQ39621978
Nuclear hormone receptor regulation of microRNAs controls developmental progression.Q39864735
MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypesQ39926867
Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3.Q39945284
p53-mediated activation of miRNA34 candidate tumor-suppressor genes.Q40102003
Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cellsQ41780320
Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis.Q41915170
Genome-wide dissection of microRNA functions and cotargeting networks using gene set signaturesQ42161265
Intact p53-dependent responses in miR-34-deficient mice.Q42251432
MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cellsQ42808496
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineageQ42808536
Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factorsQ42833178
An elegant miRror: microRNAs in stem cells, developmental timing and cancerQ43140992
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formationQ47302451
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrestQ48078984
MicroRNA-34a regulates cardiac ageing and function.Q50320387
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.Q50781580
Misexpression of full-length HMGA2 induces benign mesenchymal tumors in miceQ80050810
The evolution of our thinking about microRNAsQ82234067
Lin28: A microRNA regulator with a macro roleQ83009545
IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2Q34687371
A skin microRNA promotes differentiation by repressing 'stemness'.Q34756894
Small RNAs in early mammalian development: from gametes to gastrulationQ34781377
Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs.Q34803039
miR-22 represses cancer progression by inducing cellular senescenceQ34825182
Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancerQ34924937
MiR-34, SIRT1 and p53: the feedback loopQ34946471
The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selectionQ34977214
Genome-wide association study identifies sequence variants on 6q21 associated with age at menarcheQ34981439
MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in miceQ35140989
Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defectsQ35180589
miR than meets the eye.Q35193208
MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changesQ35456159
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.Q35503722
HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genesQ35615694
microRNA-34a regulates neurite outgrowth, spinal morphology, and functionQ35641380
miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression.Q35783986
The microRNA miR-34 modulates ageing and neurodegeneration in DrosophilaQ35889746
Roles for microRNAs in conferring robustness to biological processesQ35955737
miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2.Q35962323
Mutant p53: one name, many proteinsQ36070574
Embryonic stem cell miRNAs and their roles in development and diseaseQ36186002
TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.Q36237549
Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction.Q36415757
miR-34 miRNAs provide a barrier for somatic cell reprogrammingQ36522839
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolismQ36708957
The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell nicheQ36791167
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferationQ36817889
An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesisQ36821086
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cellsQ36937559
Coherent but overlapping expression of microRNAs and their targets during vertebrate developmentQ37111303
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene clusterQ37328540
Lin28 promotes transformation and is associated with advanced human malignanciesQ37377572
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)3582-600
P577publication date2013-10-09
P1433published inJournal of Molecular BiologyQ925779
P1476titleThe role of miRNAs in regulating gene expression networks
P478volume425

Reverse relations

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Q42719038miR-137 inhibits renal cell carcinoma growth in vitro and in vivo
Q38858726miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins
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