Like a bolt from the blue: phthalocyanines in biomedical optics

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Like a bolt from the blue: phthalocyanines in biomedical optics is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES17010098
P8608Fatcat IDrelease_2zjxhjlzurhsdftajrlnpq3uai
P932PMC publication ID6269082
P698PubMed publication ID22198535
P5875ResearchGate publication ID51924248

P50authorTebello NyokongQ21448010
P2093author name stringHubert van den Bergh
Norbert Lange
Nawal Sekkat
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Photodynamic activity of BAM-SiPc, an unsymmetrical bisamino silicon(IV) phthalocyanine, in tumour-bearing nude mice.Q39542782
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Photochemical internalization as an adjunct to marginal surgery in a human sarcoma modelQ39843479
Effects of the number and position of the substituents on the in vitro photodynamic activities of glucosylated zinc(II) phthalocyaninesQ39864552
Highly photocytotoxic 1,4-dipegylated zinc(II) phthalocyanines. Effects of the chain length on the in vitro photodynamic activities.Q39911301
Glycosylated zinc(II) phthalocyanines as efficient photosensitisers for photodynamic therapy. Synthesis, photophysical properties and in vitro photodynamic activityQ39975073
Hexadecafluorinated zinc phthalocyanine: photodynamic properties against the EMT-6 tumour in mice and pharmacokinetics using 65Zn as a radiotracerQ39989981
Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugateQ40004339
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Highly photocytotoxic glucosylated silicon(IV) phthalocyanines. Effects of peripheral chloro substitution on the photophysical and photodynamic properties.Q40152449
Synthesis and properties of cell-targeted Zn(II)-phthalocyanine-peptide conjugates.Q40174430
Assembling a mixed phthalocyanine-porphyrin array in aqueous media through host-guest interactions.Q40184308
BAM-SiPc, a novel agent for photodynamic therapy, induces apoptosis in human hepatocarcinoma HepG2 cells by a direct mitochondrial action.Q40315595
The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cellsQ40324060
High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles.Q40370077
Synthesis and cellular studies of nonaggregated water-soluble phthalocyanines.Q40457495
Synthesis and in vitro photodynamic activity of new hexadeca-carboxy phthalocyaninesQ40507320
Killing efficacy of a new silicon phthalocyanine in human melanoma cells treated with photodynamic therapy by early activation of mitochondrion-mediated apoptosisQ40580803
Photodynamic therapy of human breast cancer xenografts lacking caspase-3.Q40746691
The role of lipoproteins in the delivery of tumour-targeting photosensitizersQ40773646
Preparation, phototoxicity and biodistribution studies of anti-carcinoembryonic antigen monoclonal antibody-phthalocyanine conjugatesQ40907379
Discordance between transferrin receptor expression and susceptibility to lysis by natural killer cellsQ40920176
A comparative study of the cellular uptake and photodynamic efficacy of three novel zinc phthalocyanines of differing chargeQ40955955
Photosensitization of human skin cell lines by ATMPn (9-acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene) in vitro: mechanism of actionQ40960351
Aluminium phthalocyanine mediated photodynamic therapy in experimental malignant glioma.Q40988640
Hydroxyphthalocyanines as potential photodynamic agents for cancer therapyQ41032674
Light scattering of human skin: a comparison between zinc (II)-phthalocyanine and photofrin II.Q41047975
Syntheses and photodynamic activities of novel trisulfonated zinc phthalocyanine derivativesQ41077068
Structure and biodistribution relationships of photodynamic sensitizersQ41111962
The synthesis, photophysical and photobiological properties and in vitro structure-activity relationships of a set of silicon phthalocyanine PDT photosensitizersQ41124199
Cytotoxic, nuclear, and growth inhibitory effects of photodynamic drugs on pancreatic carcinoma cellsQ41205192
Zn(II)-phthalocyanine as a photodynamic agent for tumours. II. Studies on the mechanism of photosensitised tumour necrosisQ41235155
Tumour photosensitizers: approaches to enhance the selectivity and efficiency of photodynamic therapyQ41322837
Phthalocyanine photosensitizers for the treatment of brain tumoursQ41382582
Stereochemical factors in the transport and binding of photosensitizers in biological systems and in photodynamic therapyQ41556938
Evidence for up-regulated low density lipoprotein receptor in human lung adenocarcinoma cell line A549.Q41584678
Effect of sulfonation on the cell and tissue distribution of the photosensitizer aluminum phthalocyanine.Q41725866
Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells.Q41847288
In-vitro and in-vivo evaluation of pH-responsive polymeric micelles in a photodynamic cancer therapy modelQ41920044
Cholesterol metabolism in cancer cells in monolayer culture. III. Low-density lipoprotein metabolismQ41924545
Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse xenograft systemQ41932696
Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancerQ41980066
Phthalocyanine dimerization-based molecular beacons using near-IR fluorescenceQ42010878
Specific targeting and toxicity of sulphonated aluminium phthalocyanine photosensitised liposomes directed to cells by monoclonal antibody in vitroQ42020730
Evidence for low-density lipoprotein receptor-mediated uptake of benzoporphyrin derivativeQ42109743
Water-soluble aluminium phthalocyanine-polymer conjugates for PDT: photodynamic activities and pharmacokinetics in tumour-bearing miceQ42279946
Parabolic quantitative structure-activity relationships and photodynamic therapy: application of a three-compartment model with clearance to the in vivo quantitative structure-activity relationships of a congeneric series of pyropheophorbide derivatQ42614127
In vitro resistance selection studies of RLP068/Cl, a new Zn(II) phthalocyanine suitable for antimicrobial photodynamic therapy.Q42929756
Photodynamic activity of a glucoconjugated silicon(IV) phthalocyanine on human colon adenocarcinomaQ43083520
Photophysics of zinc (II) phthalocyanine polymer and gel formulationQ43160756
Water-soluble cationic gallium(III) and indium(III) phthalocyanines for photodynamic therapyQ43190797
Synthesis of phthalocyanines-ALA conjugates: water-soluble compounds with low aggregation.Q43278612
Chloroaluminum phthalocyanine tetrasulfonate delivered via acid-labile diplasmenylcholine-folate liposomes: intracellular localization and synergistic phototoxicityQ43658872
Photosensitized and catalytic oxidation of DNA by metallophthalocyanine-oligonucleotide conjugates.Q43741738
Photodynamic efficacy of water-soluble Si(IV) and Ge(IV) phthalocyanines towards Candida albicans planktonic and biofilm culturesQ43991055
Chelation with metal is not essential for antitumor photodynamic activity of sulfonated phthalocyanines.Q43997869
Photodynamic properties of amphiphilic derivatives of aluminum tetrasulfophthalocyanineQ44113358
Targeting of the photocytotoxic compound AlPcS4 to Hela cells by transferrin conjugated PEG-liposomesQ44124095
Asymmetrical, water-soluble phthalocyanine dyes for covalent labeling of oligonucleotides.Q44222035
Optimizing pH-responsive polymeric micelles for drug delivery in a cancer photodynamic therapy modelQ44223189
Distribution of metal-free sulfonated phthalocyanine in subcutaneously transplanted murine tumors.Q44972325
New amphiphilic silicon(IV) phthalocyanines as efficient photosensitizers for photodynamic therapy: synthesis, photophysical properties, and in vitro photodynamic activities.Q45062732
Transferrin-conjugated liposome targeting of photosensitizer AlPcS4 to rat bladder carcinoma cells.Q45137105
Structure-photodynamic activity relationships of substituted zinc trisulfophthalocyaninesQ45228612
Photodynamic therapy of virus-associated precancer and early stages cancer of cervix uteriQ45385422
PEGylation strategies for active targeting of PLA/PLGA nanoparticlesQ46267770
Near IR emitting isothiocyanato-substituted fluorophores: their synthesis and bioconjugation to monoclonal antibodiesQ46565334
Photophysicochemical consequences of bovine serum albumin binding to non-transition metal phthalocyanine sulfonatesQ46573269
Mechanism of photodynamic occlusion using liposomal Zn(II)-phtalocyanineQ46601398
[Analysis of changes in the accumulation of the photosensitizer Photosens, its elimination kinetics and distribution in the tissues of the eye and eyelids in health and in some tumorous processes]Q46720013
Thrombin-sensitive photodynamic agents: a novel strategy for selective synovectomy in rheumatoid arthritisQ47790848
Experimental studies of the effects of ZnPcS2P2-based-photodynamic therapy on bone marrow purging.Q50486504
Homogeneous detection of nucleic acids by transient-state polarized fluorescence.Q50779868
Polyion complex micelles for photodynamic therapy: incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property.Q51201504
Phthalocyanine-polyamine conjugates as highly efficient photosensitizers for photodynamic therapy.Q51770486
Suspected anaphylactic reaction to Cremophor EL.Q51875835
Photosensitising drugs - their potential in oncology.Q52863288
Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect.Q52867335
ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment.Q55467832
Phthalocyanines and related complexes as electrocatalysts for the detection of nitric oxideQ58840303
In vitro photodynamic therapy on melanoma cell lines with phthalocyanineQ33263068
Photodynamic therapy and cancer: a brief sightseeing tourQ33276646
High-field magnetic resonance imaging of the response of human prostate cancer to Pc 4-based photodynamic therapy in an animal modelQ33303889
Topical photodynamic therapy of murine non-melanoma skin carcinomas with aluminum phthalocyanine chloride and a diode laser: pharmacokinetics, tumor response and cosmetic outcomesQ33324540
Phase I and pharmacokinetic study of photodynamic therapy for high-grade gliomas using a novel boronated porphyrinQ33336105
Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanineQ33383673
Photocytotoxic efficacy of sulphonated species of aluminium phthalocyanine against cell monolayers, multicellular spheroids and in vivo tumours.Q33421401
Photochemical internalization of bleomycin before external-beam radiotherapy improves locoregional control in a human sarcoma modelQ33491969
Monitoring interstitial m-THPC-PDT in vivo using fluorescence and reflectance spectroscopy.Q33508614
Sunlight triggered photodynamic ultradeformable liposomes against Leishmania braziliensis are also leishmanicidal in the dark.Q33667946
Silicon phthalocyanine (Pc 4) photodynamic therapy is a safe modality for cutaneous neoplasms: results of a phase 1 clinical trialQ33796958
Successful cutaneous delivery of the photosensitizer silicon phthalocyanine 4 for photodynamic therapyQ33915542
The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoterQ33937668
A delivery system to avoid self-aggregation and to improve in vitro and in vivo skin delivery of a phthalocyanine derivative used in the photodynamic therapy.Q33962996
Photodynamic therapy disinfection of carious tissue mediated by aluminum-chloride-phthalocyanine entrapped in cationic liposomes: an in vitro and clinical studyQ33978446
Facile synthesis of pegylated zinc(II) phthalocyanines via transesterification and their in vitro photodynamic activitiesQ34000156
Cerebral edema following photodynamic therapy using endogenous and exogenous photosensitizers in normal brainQ34050281
Photodynamic therapy for cancerQ34194073
Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agentsQ34201954
The present and future role of photodynamic therapy in cancer treatmentQ34337882
The history of photodetection and photodynamic therapy.Q34449139
Metallo-phthalocyanine near-IR fluorophores: oligonucleotide conjugates and their applications in PCR assaysQ34508239
Laser-induced photodynamic therapy with aluminum phthalocyanine tetrasulfonate as the photosensitizer: differential phototoxicity in normal and malignant human cells in vitroQ34514112
Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene deliveryQ34656031
Glucose transporters: expression, regulation and cancer.Q34747650
The role of apoptosis in response to photodynamic therapy: what, where, why, and how.Q35092776
Bombesin-like peptides: candidates as diagnostic and therapeutic tools.Q35100949
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane moleculesQ35600809
Polymeric micelles to deliver photosensitizers for photodynamic therapyQ35620842
Photochemical internalisation in drug and gene delivery.Q35620861
Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapyQ35633124
Photodynamic therapy of age-related macular degeneration: History and principlesQ35932469
Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondriaQ35955773
Biological activities of phthalocyanines--XVI. Tetrahydroxy- and tetraalkylhydroxy zinc phthalocyanines. Effect of alkyl chain length on in vitro and in vivo photodynamic activitiesQ35976959
CGP 55398, a liposomal Ge(IV) phthalocyanine bearing two axially ligated cholesterol moieties: a new potential agent for photodynamic therapy of tumoursQ35978442
In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomesQ35978486
Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiencyQ35981418
Photodynamic therapy with phthalocyanine sensitisation: quantitative studies in a transplantable rat fibrosarcomaQ36027994
Selective necrosis of malignant gliomas in mice using photodynamic therapyQ36028789
Correlation of distribution of sulphonated aluminium phthalocyanines with their photodynamic effect in tumour and skin of mice bearing CaD2 mammary carcinomaQ36081132
Tumour-localising and -photosensitising properties of a novel zinc(II) octadecylphthalocyanineQ36136333
The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosisQ36252799
The photodynamic response of two rodent tumour models to four zinc (II)-substituted phthalocyaninesQ36292176
5-Aminolevulinic acid derivatives in photomedicine: Characteristics, application and perspectivesQ36423131
Photodynamic therapy results in induction of WAF1/CIP1/P21 leading to cell cycle arrest and apoptosisQ36502053
Exploiting the enhanced permeability and retention effect for tumor targetingQ36578875
Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of geloninQ36615900
Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot studyQ36620119
Fluorescence imaging in vivo: recent advancesQ36711843
Apoptosis is an early event during phthalocyanine photodynamic therapy-induced ablation of chemically induced squamous papillomas in mouse skinQ36834318
Phthalocyanine photodynamic therapy: disparate effects of pharmacologic inhibitors on cutaneous photosensitivity and on tumor regressionQ36861438
Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeuticsQ36862390
Targeted pharmaceutical nanocarriers for cancer therapy and imagingQ36871933
Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticlesQ37441462
Photochemical internalization (PCI) in cancer therapy: from bench towards bedside medicine.Q37495033
On the cutting edge: protease-sensitive prodrugs for the delivery of photoactive compoundsQ37836419
Photosensitizers in clinical PDT.Q38232376
Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy.Q38282575
Strand displacement amplification--an isothermal, in vitro DNA amplification techniqueQ38329444
Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticlesQ38563687
Modulating the electronic properties of porphyrinoids: a voyage from the violet to the infrared regions of the electromagnetic spectrum.Q38572550
Targeting of a hydrophilic photosensitizer by use of internalizing monoclonal antibodies: A new possibility for use in photodynamic therapyQ39120026
Targeting of aluminum (III) phthalocyanine tetrasulfonate by use of internalizing monoclonal antibodies: improved efficacy in photodynamic therapyQ39121108
Comparison of aluminium (III) phthalocyanine tetrasulfonate- and meta-tetrahydroxyphenylchlorin-monoclonal antibody conjugates for their efficacy in photodynamic therapy in vitroQ39122815
Topical application of a first porphycene dye for photodynamic therapy--penetration studies in human perilesional skin and basal cell carcinomaQ39444267
In vitro and in vivo targeted delivery of photosensitizers to the tumor cells for enhanced photodynamic effects.Q39449513
Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapyQ39518288
Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcomes drug-resistance in vivoQ39521324
Excited triplet state photophysics of the sulphonated aluminium phthalocyanines bound to human serum albuminQ63546731
The distribution of the tumour photosensitizers Zn(II)-phthalocyanine and Sn(IV)-etiopurpurin among rabbit plasma proteinsQ67593139
Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouse lymphoma cellsQ68032753
Biological activities of phthalocyanines--VIII. Cellular distribution in V-79 Chinese hamster cells and phototoxicity of selectively sulfonated aluminum phthalocyaninesQ68270762
The plasma distribution of benzoporphyrin derivative and the effects of plasma lipoproteins on its biodistributionQ68672307
Photosensitization of Chinese hamster cells by water-soluble phthalocyaninesQ69600809
The phthalocyanines: a new class of mammalian cells photosensitizers with a potential for cancer phototherapyQ69866406
The effect of different liposomal formulations on the interaction of Zn(II)-phthalocyanine with isolated low and high density lipoproteinsQ70952016
Liposome-mediated delivery of photosensitizers: localization of zinc (II)-phthalocyanine within implanted tumors after intravenous administrationQ71074685
PEG-coated poly(lactic acid) nanoparticles for the delivery of hexadecafluoro zinc phthalocyanine to EMT-6 mouse mammary tumoursQ71573974
Photodynamic therapeutics: basic principles and clinical applicationsQ73102562
Pharmacokinetics and pharmacodynamics of tetra(m-hydroxyphenyl)chlorin in the hamster cheek pouch tumor model: comparison with clinical measurementsQ73254417
Eradication of multiple myeloma and breast cancer cells by TH9402-mediated photodynamic therapy: implication for clinical ex vivo purging of autologous stem cell transplantsQ73350152
Measurement of the penetration depths of red and near infrared light in human "ex vivo" tissuesQ73387609
Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugsQ73423000
Photodynamic activities and biodistribution of fluorinated zinc phthalocyanine derivatives in the murine EMT-6 tumour modelQ73503264
Tumour-localizing and tumour-photosensitizing properties of zinc(II)-octapentyl-phthalocyanineQ73577743
Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosaQ73945710
Photosensitization of cells with different metastatic potentials by liposome-delivered Zn(II)-phthalocyanineQ74141983
Efficacy and mechanism of aluminium phthalocyanine and its sulphonated derivatives mediated photodynamic therapy on murine tumoursQ74202090
[The optimization of a plan for the photodynamic therapy of sarcoma M1 using photosens]Q74282225
A comparative analysis of silicon phthalocyanine photosensitizers for in vivo photodynamic therapy of RIF-1 tumors in C3H miceQ74383939
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectneoplasmQ1216998
photochemotherapyQ1428072
radiosensitizerQ2126468
indolesQ55698578
P304page(s)98-144
P577publication date2011-12-23
P1433published inMoleculesQ151332
P1476titleLike a bolt from the blue: phthalocyanines in biomedical optics
P478volume17