Synthesis and secretion of renin in mice with induced genetic mutations

scientific article

Synthesis and secretion of renin in mice with induced genetic mutations is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1009022358
P356DOI10.1038/KI.2011.451
P932PMC publication ID3482822
P698PubMed publication ID22258323
P5875ResearchGate publication ID221760051

P50authorJosephine P BriggsQ58416671
P2093author name stringJurgen Schnermann
P2860cites workInhibition of the renin-angiotensin system upregulates cyclooxygenase-2 expression in the macula densaQ72997605
The neuronal isoform of constitutive nitric oxide synthase is up-regulated in the macula densa of angiotensinogen gene-knockout miceQ73093140
Renin expression in COX-2-knockout mice on normal or low-salt dietsQ73127501
Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibitionQ73446360
Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient miceQ73674844
Dietary salt loading decreases the expressions of neuronal-type nitric oxide synthase and renin in the juxtaglomerular apparatus of angiotensinogen gene-knockout miceQ74349746
Renal baroreceptor-stimulated renin in the eNOS knockout mouseQ77337019
Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangiumQ79848355
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptorsQ79953540
Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic receptorsQ80361660
Connexin40 regulates renin production and blood pressureQ80592747
Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptorsQ81322401
Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillationQ24294428
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IPQ24562129
ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granulesQ24563069
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinomaQ28244557
Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatasesQ28251419
Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulationQ28505894
Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene functionQ28508092
Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loadingQ28509056
Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretionQ28510538
Disruption of the dopamine D3 receptor gene produces renin-dependent hypertensionQ28511119
Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertilityQ28589515
Connexin40 is essential for the pressure control of renin synthesis and secretionQ28589707
Angiotensinogen-deficient mice with hypotensionQ28594906
Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathwayQ30412345
Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cellsQ30428002
Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension.Q30430501
Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependentQ30432127
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatenedQ30433495
Conduction of vasomotor responses in arterioles: a role for cell-to-cell coupling?Q30461323
Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzymeQ30470062
Salt-sensitive splice variant of nNOS expressed in the macula densa cellsQ33545563
Conducted vasomotor responses in arterioles: characteristics, mechanisms and physiological significanceQ33751233
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.Q33821507
Angiotensin II attenuates renal cortical cyclooxygenase-2 expressionQ33848631
Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.Q34329403
Increased renal renin content in mice lacking the Na+/H+ exchanger NHE2Q34477168
Physiology of local renin-angiotensin systems.Q34543927
Preserved macula densa-dependent renin secretion in A1 adenosine receptor knockout miceQ44244712
Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneysQ44869335
Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systemsQ45197555
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertensionQ46182917
Increased expression of renal cyclooxygenase-2 and neuronal nitric oxide synthase in hypertensive Cx40-deficient mice.Q46350571
Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout miceQ46520897
Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndromeQ46564573
Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cellsQ46573000
Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoformsQ46643862
Blood pressure-dependent inhibition of Renin secretion requires A1 adenosine receptorsQ46711549
Adenosine as a mediator of macula densa-dependent inhibition of renin secretionQ46816795
Neuronal nitric oxide synthase-deficient mice have impaired renin release but normal blood pressure.Q46842360
Influence of the adenosine A1 receptor on blood pressure regulation and renin release.Q46853125
Expression of neuronal type nitric oxide synthase and renin in the juxtaglomerular apparatus of angiotensin type-1a receptor gene-knockout miceQ48026139
Effect of genetic deficiency of angiotensinogen on the renin-angiotensin systemQ48404667
Targeting deletion of angiotensin type 1B receptor gene in the mouseQ48786167
Renin-1 Is Essential for Normal Renal Juxtaglomerular Cell Granulation and Macula Densa MorphologyQ50947288
Role of microsomal prostaglandin E synthase 1 in the kidney.Q51756533
Developmental renin expression in mice with a defective renin-angiotensin system.Q51927508
Targeted disruption of the neuronal nitric oxide synthase gene.Q52507290
Renal growth and development in mice lacking AT1A receptors for angiotensin II.Q52529044
Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney.Q54469629
Expression of cyclooxygenase-2 in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice.Q54642020
Arachidonic acid increases and indomethacin decreases plasma renin activity in the rabbitQ68806484
Role of cGMP as second messenger of adenosine in the inhibition of renin releaseQ69830836
Coexistence of renin and cathepsin B in epithelioid cell secretory granulesQ69909106
Prostaglandins stimulate renin secretion and renin mRNA in mouse renal juxtaglomerular cellsQ71645969
Interactions between angiotensin II and norepinephrine on renin release by juxtaglomerular cellsQ71795573
Angiotensin II Type 1a Receptor-deficient Mice with Hypotension and HyperreninemiaQ71977217
The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease.Q34690091
1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin systemQ34793842
The connexin 40 A96S mutation causes renin-dependent hypertension.Q35012387
Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.Q35019728
Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptorsQ35127628
Contribution of the basolateral isoform of the Na-K-2Cl- cotransporter (NKCC1/BSC2) to renin secretionQ35157510
Intrarenal dopamine deficiency leads to hypertension and decreased longevity in miceQ35572452
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restrictionQ35824725
Transcriptional regulation of renin: an updateQ35951220
Creation and characterization of a renin knockout rat.Q36441725
Augmented renal vascular nNOS and renin protein expression in angiotensin type 1 receptor null miceQ36574271
Elevated blood pressures in mice lacking endothelial nitric oxide synthase.Q36689446
Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure.Q36846713
Salt sensitivity of blood pressure in NKCC1-deficient miceQ36956763
Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathwayQ37100058
Functional expression of the olfactory signaling system in the kidneyQ37100981
Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis.Q37169153
Activation of the succinate receptor GPR91 in macula densa cells causes renin release.Q37181984
Intrarenal dopaminergic system regulates renin expressionQ37186566
Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cellsQ37360830
Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2Q37367715
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitusQ37518209
Morphology, physiology, and molecular biology of renin secretionQ37969158
Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cellsQ39795875
Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression.Q40085415
The pharmacologic alteration of renin release.Q40303943
Inhibition of nNOS expression in the macula densa by COX-2-derived prostaglandin E(2).Q40580522
A1 and A2 adenosine receptor activation inhibits and stimulates renin secretion of rat renal cortical slicesQ41360371
Cathepsin B is not the processing enzyme for mouse proreninQ41936540
Permissive role of nitric oxide in macula densa control of renin secretionQ42459954
Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aorta.Q42476351
Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptorsQ42485037
Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsalpha in juxtaglomerular cells.Q42497876
Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient miceQ42500934
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin systemQ42710726
Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesionQ43212308
Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1dQ43632146
Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient miceQ43771136
Inhibition of cyclooxygenase-2 attenuates urinary prostanoid excretion without affecting renal renin expressionQ43779564
Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake.Q44058272
Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.Q44107251
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)529-538
P577publication date2012-01-18
P1433published inKidney InternationalQ6404823
P1476titleSynthesis and secretion of renin in mice with induced genetic mutations
P478volume81

Reverse relations

cites work (P2860)
Q37142499AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1.
Q34281269Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation
Q43900303Elucidating mechanisms underlying altered renal autoregulation in diabetes
Q39380475Endocrine functions of the renal interstitium
Q30412908Endothelium-derived nitric oxide supports renin cell recruitment through the nitric oxide-sensitive guanylate cyclase pathway
Q90446723Juxtaglomerular Cell Tumor: Reviewing a Cryptic Cause of Surgically Correctable Hypertension
Q36197675Long-Range Control of Renin Gene Expression in Tsukuba Hypertensive Mice
Q34283842Metabolic control of renin secretion
Q35365322Newly stemming functions of macula densa-derived prostanoids.
Q34293723Nonclassical renin-angiotensin system and renal function
Q39158847Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update
Q92403193Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion
Q38055377Renal renin secretion as regulator of body fluid homeostasis

Search more.