Cutaneous wound healing: recruiting developmental pathways for regeneration

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Cutaneous wound healing: recruiting developmental pathways for regeneration is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1046955249
P356DOI10.1007/S00018-012-1152-9
P3181OpenCitations bibliographic resource ID1049877
P932PMC publication ID3663196
P698PubMed publication ID23052205
P5875ResearchGate publication ID232228933

P2093author name stringSaeid Amini-Nik
Benjamin A. Alman
Kirsten A. Bielefeld
P2860cites workThe TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesisQ22010468
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The basement membrane of hair follicle stem cells is a muscle cell nicheQ24293556
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Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermisQ24620091
Comparison between human fetal and adult skinQ24652683
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A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healingQ24683724
Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null miceQ24805609
Mature and juvenile tissue models of regeneration in small fish speciesQ26824303
Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healingQ27307639
Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebratesQ27307724
Integrins: bidirectional, allosteric signaling machinesQ27860700
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skinQ28190343
Cells keep a memory of their tissue origin during axolotl limb regenerationQ28250620
Signalling via integrins: implications for cell survival and anticancer strategiesQ28272370
Notch pathway modulation on bone marrow-derived vascular precursor cells regulates their angiogenic and wound healing potentialQ28474088
Canonical notch signaling functions as a commitment switch in the epidermal lineageQ28506621
Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicleQ28506996
A role for the primary cilium in Notch signaling and epidermal differentiation during skin developmentQ28510710
Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular developmentQ28511544
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory responseQ28512142
Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulatorsQ28569442
A homolog of Drosophila grainy head is essential for epidermal integrity in miceQ28585220
Sonic hedgehog signaling is essential for hair developmentQ28586200
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle inductionQ28586747
Transforming growth factor beta 3 (TGF beta 3) accelerates wound healing without alteration of scar prominence. Histologic and competitive reverse-transcription-polymerase chain reaction studiesQ73529155
Roles for Fgf signaling during zebrafish fin regenerationQ73849422
Delayed wound healing in immunodeficient TGF-beta 1 knockout miceQ73969136
Involvement of follicular stem cells in forming not only the follicle but also the epidermisQ74244902
Keratinocytes suppress transforming growth factor-beta1 expression by fibroblasts in cultured skin substitutesQ77418015
Preclinical promise of becaplermin (rhPDGF-BB) in wound healingQ77430242
Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3Q77487332
Randomised placebo-controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burnsQ77683226
Essential role for Sonic hedgehog during hair follicle morphogenesisQ77771288
Expression of transforming growth factor beta 1, 2, and 3 proteins in keloidsQ78148901
Safety and effect of transforming growth factor-beta(2) for treatment of venous stasis ulcersQ79437336
Epidermal stem cells arise from the hair follicle after woundingQ79666857
Smad7-induced beta-catenin degradation alters epidermal appendage developmentQ80206807
Age-dependent differential expression of fibronectin variants in skin and airway mucosal woundsQ81310587
The role of R-spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarringQ82901140
Transforming growth factor-beta signaling in skin: stromal to epithelial cross-talkQ82948854
Antisense inhibition of connective tissue growth factor (CTGF/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in vivoQ83155840
Randomized phase II clinical trial of avotermin versus placebo for scar improvementQ84208053
Avotermin for scar improvement following scar revision surgery: a randomized, double-blind, within-patient, placebo-controlled, phase II clinical trialQ84436109
Discovery and development of avotermin (recombinant human transforming growth factor beta 3): a new class of prophylactic therapeutic for the improvement of scarringQ84599690
Systemic Therapy for a Genetic Skin DiseaseQ84984667
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanismQ36890830
Cell-matrix adhesionQ36902965
The role of Smads in skin development.Q37109200
Memory encoded throughout our bodies: molecular and cellular basis of tissue regenerationQ37143914
Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetesQ37298101
beta-Catenin has sequential roles in the survival and specification of ventral dermisQ37319306
Wnt signaling from development to disease: insights from model systemsQ37342306
Growth factors and cytokines in wound healingQ37364066
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?Q37373460
Wnt signaling in skin organogenesisQ37412954
Beyond early development: Xenopus as an emerging model for the study of regenerative mechanismsQ37413168
Interactions between extracellular matrix and growth factors in wound healingQ37423377
Notch1 Deficiency Results in Decreased Inflammation during Wound Healing and Regulates Vascular Endothelial Growth Factor Receptor-1 and Inflammatory Cytokine Expression in MacrophagesQ37460657
Connective tissue growth factor: context-dependent functions and mechanisms of regulationQ37486405
Noncanonical transforming growth factor beta signaling in scleroderma fibrosisQ37588466
Dishevelled: The hub of Wnt signalingQ37652897
The TAK1-TRAF6 signalling pathwayQ37671306
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healingQ37675931
The regulation of differentiation in mesenchymal stem cellsQ37784032
Macrophages in skin injury and repairQ37833809
Dynamic reciprocity in the wound microenvironmentQ37848470
The axolotl model for regeneration and aging research: a mini-reviewQ37849512
Cell-extracellular matrix interactions in normal and diseased skinQ37858332
Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skinQ37880788
How do they do Wnt they do?: regulation of transcription by the Wnt/β-catenin pathway.Q37882048
Primary cilia and organogenesis: is Hedgehog the only sculptor?Q37884484
Heal thyself: using endogenous regeneration to repair boneQ37891067
Non-Smad signaling pathwaysQ37893980
TGF-β signaling in fibrosisQ37899212
Molecular mediators of mesenchymal stem cell biologyQ37962744
Activation of keratinocyte fibronectin receptor function during cutaneous wound healingQ38194108
Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblastQ38340928
Distinct Wnt signaling pathways have opposing roles in appendage regenerationQ38507574
Reprogramming adult dermis to a neonatal state through epidermal activation of β-cateninQ38979314
Hedgehog signaling is essential for normal wound healingQ39164310
Epidermal stem cell diversity and quiescenceQ39912494
TGF-beta modulates beta-Catenin stability and signaling in mesenchymal proliferationsQ40113599
Enhancement of wound healing by topical treatment with epidermal growth factorQ69507377
The role of the fetal fibroblast and transforming growth factor-beta in a model of human fetal wound repairQ71658412
Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarringQ71702949
Occurrence and localization of transforming growth factor-beta (TGF-beta 1, beta 2) during rabbit skin developmentQ72561832
Enhanced expression of mRNA for transforming growth factor-beta, type I and type III procollagen in human post-burn hypertrophic scar tissuesQ72575498
Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMPQ73042158
Effect of growth factors on dermal fibroblast contraction in normal skin and hypertrophic scarQ73088218
Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studiesQ73189615
Role of wound healing myofibroblasts on re-epithelialization of human skinQ73343339
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiationQ28591262
Early evolution of animal cell signaling and adhesion genesQ28767751
Regulation of wound healing by growth factors and cytokinesQ29615242
Proximal events in Wnt signal transductionQ29616162
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skinQ29616492
Wound healing--aiming for perfect skin regenerationQ29616715
Wound repair and regenerationQ29617949
Cutaneous wound healingQ29618894
WNT signals are required for the initiation of hair follicle developmentQ29619115
Convergence of Wnt, beta-catenin, and cadherin pathwaysQ29619504
Non-Smad pathways in TGF-beta signalingQ29620040
TGF-beta signaling and the fibrotic responseQ29620099
Human skin wounds: a major and snowballing threat to public health and the economyQ30227432
Ultrafast mid-IR laser scalpel: protein signals of the fundamental limits to minimally invasive surgeryQ30479231
Equine CTNNB1 and PECAM1 nucleotide structure and expression analyses in an experimental model of normal and pathological wound repairQ30840661
Can thermal lasers promote skin wound healing?Q30873921
Physiological implications of laser beamsQ33190718
Involvement of notch signaling in wound healingQ33305435
Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contractionQ33443489
Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closureQ33556254
Planarian Hedgehog/Patched establishes anterior-posterior polarity by regulating Wnt signalingQ33564284
Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferationQ33583459
TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathwayQ33890533
Laser and intense pulsed light therapy for the treatment of hypertrophic scars: a systematic reviewQ33944720
CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling networkQ33961583
Factors affecting wound healingQ33993981
Bone patterning is altered in the regenerating zebrafish caudal fin after ectopic expression of sonic hedgehog and bmp2b or exposure to cyclopamineQ34065768
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous woundsQ34068062
CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury modelQ34090214
Scarless Fetal Wound Healing: A Basic Science ReviewQ34141074
Plasticity and reprogramming of differentiated cells in amphibian regenerationQ34142489
Pax7 expressing cells contribute to dermal wound repair, regulating scar size through a β-catenin mediated process.Q34198828
The use of becaplermin (rhPDGF-BB) gel for chronic nonhealing ulcers. A retrospective analysis.Q34246338
sFRP2 Suppression of Bone Morphogenic Protein (BMP) and Wnt Signaling Mediates Mesenchymal Stem Cell (MSC) Self-renewal Promoting Engraftment and Myocardial RepairQ34285194
Extracellular matrix and keratinocyte migration.Q34419124
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermisQ34467701
Drosophila innate immunity: an evolutionary perspectiveQ34507042
TGF-beta signaling is required for multiple processes during Xenopus tail regenerationQ40129136
Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloidsQ40250400
Dorsal dermis development depends on a signal from the dorsal neural tube, which can be substituted by Wnt-1.Q40829156
The molecular basis of keloid and hypertrophic scar formationQ40867502
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermisQ41390151
Fibroblast migration and proliferation during in vitro wound healing. A quantitative comparison between various growth factors and a low molecular weight blood dialysate used in the clinic to normalize impaired wound healingQ41585089
alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice.Q41860571
Wnt signaling in axial patterning and regeneration: lessons from planariaQ41898596
Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblastsQ41955517
Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healingQ42150675
Cell proliferation during blastema formation in the regenerating teleost fin.Q42167072
CCN2: a bona fide target for anti-fibrotic drug interventionQ42274125
The Notch signalling pathway in hair growthQ42465554
Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.Q42479308
Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactionsQ42481896
Basic fibroblast growth factor reduces scar formation in acute incisional woundsQ42520948
Polarized notum activation at wounds inhibits Wnt function to promote planarian head regenerationQ42555211
An epidermal barrier wound repair pathway in Drosophila is mediated by grainy headQ42653591
Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cellsQ42728761
An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution.Q42820170
Epidermal growth factor in clinical practice - a review of its biological actions, clinical indications and safety implicationsQ43242639
Scarless wound repair: a human fetal skin modelQ43662435
Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblastsQ43701879
Are keloids really "gli-loids"?: High-level expression of gli-1 oncogene in keloidsQ43770695
A novel TGF-beta antagonist speeds reepithelialization and reduces scarring of partial thickness porcine burns.Q43960747
Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.Q44245074
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinasesQ44754701
Identification of differentially regulated genes in fetal wounds during regenerative repairQ44998714
Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodelingQ45858335
Fin regeneration from tail segment with musculature, endoskeleton, and scales.Q46032557
Exogenous Transforming Growth Factor-Beta Amplifies Its Own Expression and Induces Scar Formation in a Model of Human Fetal Skin RepairQ46052327
Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila.Q46176840
Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regenerationQ46570809
The small GTPase Rac plays multiple roles in epithelial sheet fusion--dynamic studies of Drosophila dorsal closureQ47072045
Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healingQ47343515
Acceleration of wound healing in aged rats by topical application of transforming growth factor-beta(1).Q47899615
R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signalingQ50336904
Smed-Evi/Wntless is required for beta-catenin-dependent and -independent processes during planarian regeneration.Q51826212
Multiple roles of Notch signaling in the regulation of epidermal development.Q51959619
Nerve-dependent and -independent events in blastema formation during Xenopus froglet limb regeneration.Q52039763
Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing.Q52094884
Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate.Q52100460
Expression of Wnt genes in early wound healing.Q52183216
Genetic control of epithelial tube fusion during Drosophila tracheal development.Q52199219
The canonical Wg and JNK signaling cascades collaborate to promote both dorsal closure and ventral patterning.Q52581002
Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.Q52587547
Scar prevention: the healing touch.Q52660290
Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue HealingQ53528097
Recombinant human epidermal growth factor (REGEN-D 150): effect on healing of diabetic foot ulcers.Q54437340
Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring.Q54603562
Differential expression and localization of WNTs in an animal model of skin wound healing.Q54641867
Requirement for Wnt and FGF signaling in Xenopus tadpole tail regenerationQ59398863
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the SkinQ63406949
Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pigQ67925174
Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouseQ34531372
Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous woundsQ34554227
Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis.Q34560727
Planarian regeneration: its end is its beginningQ34564498
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after woundingQ34629066
Epidermal Notch signalling: differentiation, cancer and adhesionQ34761852
Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in DrosophilaQ34765996
Hair follicle dermal papilla cells at a glanceQ35047410
Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healingQ35084866
Wound healing studies in transgenic and knockout mice. A reviewQ35161955
Wnt/beta-catenin signaling regulates vertebrate limb regenerationQ35204724
Temporal smad7 transgene induction in mouse epidermis accelerates skin wound healingQ35235837
A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in miceQ35484843
Adult reserve stem cells and their potential for tissue engineeringQ35675157
Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.Q35797987
Ontogenetic transition in fetal wound transforming growth factor-beta regulation correlates with collagen organizationQ35843286
miRNA in wound inflammation and angiogenesisQ36102225
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.Q36221328
The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-cateninQ36229078
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblastsQ36232642
Ontogenetic decline of regenerative ability and the stimulation of human regenerationQ36249866
Mesenchymal-epithelial interactions in the skin: aiming for site-specific tissue regenerationQ36255628
Some principles of regeneration in mammalian systemsQ36322744
Limb regeneration in higher vertebrates: developing a roadmapQ36322749
Hedgehog signalling in skin development and cancerQ36553688
Identification of a Drosophila activin receptorQ36594541
Formation and function of the myofibroblast during tissue repairQ36735389
Notch Signaling in the VasculatureQ36861805
Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseasesQ36877127
Treatment of scars: a reviewQ36887092
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectintegumentary systemQ483213
signal transductionQ828130
wound healingQ1509074
P304page(s)2059-81
P577publication date2013-06-01
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleCutaneous wound healing: recruiting developmental pathways for regeneration
P478volume70

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Q28073897Wound Healing Problems in the Mouth
Q58778415Wound Healing in Streptozotocin-Induced Diabetic Rats Using Atmospheric-Pressure Argon Plasma Jet
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