Modulation of antioxidant enzymatic activities by certain antiepileptic drugs (valproic acid, oxcarbazepine, and topiramate): evidence in humans and experimental models

scientific article

Modulation of antioxidant enzymatic activities by certain antiepileptic drugs (valproic acid, oxcarbazepine, and topiramate): evidence in humans and experimental models is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1155/2013/598493
P932PMC publication ID3877618
P698PubMed publication ID24454986
P5875ResearchGate publication ID259879471

P50authorNoemí Cárdenas-RodríguezQ80755047
P2093author name stringElvia Coballase-Urrutia
Hortencia Montesinos-Correa
Liliana Carmona-Aparicio
Liliana Rivera-Espinosa
Esaú Floriano-Sánchez
Daniel Ortega-Cuellar
Aristides Sampieri
Arantxa Romero-Toledo
P2860cites workModern antiepileptic drug development has failed to deliver: ways out of the current dilemmaQ27693823
Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against EpilepsyQ28243859
Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against EpilepsyQ28273764
Attenuation by valproate of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicinQ28378961
In vivo administration of valproate reduces the nerve terminal (synaptosomal) activity of GABA aminotransferase in discrete brain areas of ratsQ28577946
Free radicals, metals and antioxidants in oxidative stress-induced cancerQ29547711
Future directions for epilepsy researchQ34436797
Mitochondrial Generation of Reactive Oxygen Species and its Role in Aerobic LifeQ34542381
Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009.Q34965263
Clinical pharmacokinetics of oxcarbazepineQ35213465
Mitochondria, oxidative stress, and temporal lobe epilepsyQ35609763
Role of oxidative stress in refractory epilepsy: evidence in patients and experimental modelsQ36590070
Novel animal models of pediatric epilepsyQ37998957
Concepts of epilepsyQ38051366
Antioxidant activity of topiramate: an antiepileptic agent.Q39337872
Role of xanthine oxidase and granulocytes in ischemia-reperfusion injuryQ39547917
Effects of the anticonvulsant sodium valproate on gamma-aminobutyrate and aldehyde metabolism in ox brainQ39721571
The relation of oxidative stress and hyperexcitation to neurological diseaseQ40496930
Di-n-propylacetate and GABA degradation. Preferential inhibition of succinic semialdehyde dehydrogenase and indirect inhibition of GABA-transaminaseQ41051016
Effects of valproic acid in cultured mammalian neuronsQ41364426
Similar potency of carbamazepine, oxcarbazepine, and lamotrigine in inhibiting the release of glutamate and other neurotransmittersQ41652075
Valproate suppresses N-methyl-D-aspartate-evoked, transient depolarizations in the rat neocortex in vitroQ41862181
Selenium protects cerebral ischemia in rat brain mitochondriaQ42164558
Temporalspatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid-induced seizuresQ42277605
Effects of valproate, carbamazepine, and levetiracetam on the antioxidant and oxidant systems in epileptic patients and their clinical importanceQ43054464
Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative stress, and prevention by topiramateQ43061450
Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acidQ43286981
Effects of Gabapentin and Topiramate in primary rat astrocyte culturesQ43642861
Changes in the antioxidant system in epileptic children receiving antiepileptic drugs: two-year prospective studies.Q43711273
The effect of sodium valproate on extracellular GABA and other amino acids in the rat ventral hippocampus: an in vivo microdialysis studyQ43841305
Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapyQ43873855
Free radical-mediated cell damage after experimental status epilepticus in hippocampal slice cultures.Q44238717
Prolonged glutamate excitotoxicity: effects on mitochondrial antioxidants and antioxidant enzymesQ44348409
An In Vitro Study of New Antiepileptic Drugs and AstrocytesQ44597530
Lipid peroxidation in adult epileptic patients treated with valproic acidQ44749243
Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neuronsQ44870775
The effect of antiepileptic drug therapy on antioxidant enzyme activity and serum lipid peroxidation in young patients with epilepsyQ44918799
The effects of oxcarbazepine on oxidative stress in epileptic patients.Q45023824
Effect of topiramate on the kainate-induced status epilepticus, lipid peroxidation and immunoreactivity of ratsQ45183144
Blood levels of trace elements, electrolytes, and oxidative stress/antioxidant systems in epileptic patientsQ45187417
Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsyQ46100357
Effects of selenium and topiramate on lipid peroxidation and antioxidant vitamin levels in blood of pentylentetrazol-induced epileptic ratsQ46173046
Oxidant status in children after febrile seizuresQ46207237
Topiramate and vitamin e modulate antioxidant enzyme activities, nitric oxide and lipid peroxidation levels in pentylenetetrazol-induced nephrotoxicity in ratsQ46347797
Tenoxicam modulates antioxidant redox system and lipid peroxidation in rat brain.Q46702244
Valproate increases glutaminase and decreases glutamine synthetase activities in primary cultures of rat brain astrocytes.Q48169986
Valproic acid suppresses the synaptic response mediated by the NMDA receptors in rat amygdalar slicesQ48226078
Evidence of stimulation of the gamma-aminobutyric acid shunt by valproate and E-delta 2-valproate in neonatal rat brainQ48322945
An in vitro approach to assess the neurotoxicity of valproic acid-induced oxidative stress in cerebellum and cerebral cortex of young ratsQ48384147
Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteineQ48556782
Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure thresholdQ48617665
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acidQ48875966
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c miceQ49015046
Requirement for superoxide in excitotoxic cell deathQ49133494
Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice.Q51890975
Mechanisms of Action of Antiepileptic DrugsQ56568067
Selenium and brain function: a poorly recognized liaisonQ56611276
Neuronal activity, amino acid concentration and amino acid release in the substantia nigra of the rat after sodium valproateQ69259189
Effect of Inhibitors of GABA Aminotransferase on the Metabolism of GABA in Brain Tissue and Synaptosomal FractionsQ70878224
Effect of valproate on cerebral metabolism and blood flow: an 18F-2-deoxyglucose and 15O water positron emission tomography studyQ71103408
Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivoQ71377105
Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. II. Modulation of high-voltage-activated calcium currentsQ71734556
Plasma trace element, plasma glutathione peroxidase, and superoxide dismutase levels in epileptic children receiving antiepileptic drug therapyQ71734579
Effect of acute and chronic administration of sodium valproate on lipid peroxidation and antioxidant system in rat liverQ73340695
The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic childrenQ73514452
Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detectionQ73702161
Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsyQ73828252
Erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children with valproate and carbamazepine monotherapyQ73890716
Introduction: epilepsy in the worldQ74641901
The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic childrenQ79442371
Evaluation of the influence of antiepileptic therapy on antioxidant enzyme activity and lipid peroxidation in erythrocytes of children with epilepsyQ80257055
Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsyQ82639711
[Effects of sodium valproate on neutrophils' oxidative metabolism and oxidant status in children with idiopathic epilepsy]Q83414641
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanismQ95805364
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectenzymeQ8047
antioxidantQ133948
mechanism of actionQ3271540
anticonvulsant agentQ576618
animal disease modelQ64732998
biomedical investigative techniqueQ66648976
P304page(s)598493
P577publication date2013-12-17
P1433published inOxidative medicine and cellular longevityQ26840015
P1476titleModulation of antioxidant enzymatic activities by certain antiepileptic drugs (valproic acid, oxcarbazepine, and topiramate): evidence in humans and experimental models
P478volume2013

Reverse relations

cites work (P2860)
Q88336695A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures
Q60919999Effects of Valproate Monotherapy on the Oxidant-Antioxidant Status in Mexican Epileptic Children: A Longitudinal Study
Q26774228Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis
Q26799344Overview of Nrf2 as Therapeutic Target in Epilepsy
Q54495014Oxcarbazepine-induced liver injury after sensitization by valproic acid: a case report.
Q26830615Relevance of the glutathione system in temporal lobe epilepsy: evidence in human and experimental models
Q27692712Seizure-induced oxidative stress in temporal lobe epilepsy
Q90014096Sodium valproate ameliorates aluminum-induced oxidative stress and apoptosis of PC12 cells
Q37288222Status epilepticus: Using antioxidant agents as alternative therapies.
Q46178715The role of antiepileptic drugs in free radicals generation and antioxidant levels in epileptic patients
Q40508690Topiramate Improves Neuroblast Differentiation of Hippocampal Dentate Gyrus in the D-Galactose-Induced Aging Mice via Its Antioxidant Effects
Q64956341Topiramate exhibits anti-tumorigenic and metastatic effects in ovarian cancer cells.

Search more.