Eukaryotic DNA polymerase ζ

scientific article

Eukaryotic DNA polymerase ζ is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.DNAREP.2015.02.012
P3181OpenCitations bibliographic resource ID1311263
P932PMC publication ID4426032
P698PubMed publication ID25737057

P2093author name stringAlena V. Makarova
Peter M. Burgers
P2860cites workIsolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extractsQ22009456
Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7Q24291530
Spartan/C1orf124 is important to prevent UV-induced mutagenesisQ24296499
Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1Q24299886
A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zetaQ24323043
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesisQ24594244
Yeast DNA polymerase epsilon participates in leading-strand DNA replicationQ24652913
Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1Q24798898
X-ray structure of the complex of regulatory subunits of human DNA polymerase deltaQ27652299
3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerasesQ27655731
Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol)  , and PolQ27671098
Structural Basis of Recruitment of DNA Polymerase   by Interaction between REV1 and REV7 ProteinsQ27671106
NMR mapping of PCNA interaction with translesion synthesis DNA polymerase Rev1 mediated by Rev1-BRCT domainQ27684788
Def1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage--induced mutagenesis in Saccharomyces cerevisiaeQ27930388
Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.Q27930823
Deoxycytidyl transferase activity of yeast REV1 proteinQ27931173
Dividing the workload at a eukaryotic replication forkQ37149735
Translesion synthesis of 8,5'-cyclopurine-2'-deoxynucleosides by DNA polymerases η, ι, and ζ.Q37213767
Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase zeta.Q37235387
Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast.Q37240545
DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.Q37261808
The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesisQ37302944
DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesisQ37365913
DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structuresQ37416977
Structural insights into yeast DNA polymerase delta by small angle X-ray scattering.Q37465558
Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiaeQ37484678
Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypassQ37612640
Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis.Q37688821
Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerasesQ37764540
Proliferating cell nuclear antigen promotes translesion synthesis by DNA polymerase zetaQ38326585
Structure and processivity of two forms of Saccharomyces cerevisiae DNA polymerase deltaQ38335236
ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stressQ39062429
Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluoreneQ39095697
The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathwayQ39097785
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damageQ39127447
Regulation of error-prone translesion synthesis by Spartan/C1orf124.Q39223512
The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiaeQ27931291
A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damageQ27931627
Specificity of DNA lesion bypass by the yeast DNA polymerase eta.Q27933149
Overproduction and affinity purification of Saccharomyces cerevisiae replication factor C.Q27933788
The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: insights into Pol zeta- and Pol eta-dependent frameshift mutagenesisQ27934540
A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.Q27934602
Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycolQ27934657
Mutants of yeast defective in mutation induced by ultraviolet lightQ27935336
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, PoletaQ27935465
The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damageQ27935475
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.Q27935769
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damageQ27937572
Thymine-thymine dimer bypass by yeast DNA polymerase zetaQ27938043
The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanismQ27938714
Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathwayQ27938949
Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiaeQ27939180
Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeastsQ27939188
The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunitQ27939620
SOS Repair Hypothesis: Phenomenology of an Inducible DNA Repair Which is Accompanied by MutagenesisQ28141658
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2Q28144150
Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexesQ28254040
DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δQ28263318
Rev1 employs a novel mechanism of DNA synthesis using a protein templateQ28274770
Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage toleranceQ28275269
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigenQ28303106
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zetaQ28354217
Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sitesQ28363488
Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damageQ28507940
The transcription factor TFII-I promotes DNA translesion synthesis and genomic stabilityQ28539614
A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiaeQ28652503
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugationQ29619155
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesisQ29619757
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteinsQ29619879
Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ.Q36140297
REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymeraseQ36182950
Mutator alleles of yeast DNA polymerase zeta.Q36247787
Complex formation of yeast Rev1 with DNA polymerase eta.Q36315930
A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesisQ36478058
Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.Q36533084
The effect of sequence context on spontaneous Polzeta-dependent mutagenesis in Saccharomyces cerevisiaeQ36580706
Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responsesQ36637565
The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cellsQ36643870
Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta.Q36701342
DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions in Saccharomyces cerevisiae.Q36918652
Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesisQ36990200
Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free post-replication repair but not for damage-induced mutagenesisQ39530638
The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.Q39819211
Hypersensitivity to cisplatin after hRev3 mRNA knockdown in head and neck squamous cell carcinoma cellsQ39945760
PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.Q39979416
REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivoQ40253053
The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27.Q41076954
Genetic analysis of gamma-ray mutagenesis in yeast. I. Reversion in radiation-sensitive strainsQ41169505
The origin of spontaneous mutation in Saccharomyces cerevisiae.Q41616101
The catalytic function of the Rev1 dCMP transferase is required in a lesion-specific manner for translesion synthesis and base damage-induced mutagenesisQ41761731
Dissection of the functions of the Saccharomyces cerevisiae RAD6 postreplicative repair group in mutagenesis and UV sensitivityQ41761925
The architecture of yeast DNA polymerase ζ.Q41855180
Mutagenic bypass of the butadiene-derived 2'-deoxyuridine adducts by polymerases eta and zetaQ42926488
S. cerevisiae has three pathways for DNA interstrand crosslink repairQ43819402
Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zetaQ44246963
DNA polymerase ζ as a potential biomarker of chemoradiation resistance and poor prognosis for cervical cancer.Q45832606
DNA polymerase zeta regulates cisplatin cytotoxicity, mutagenicity, and the rate of development of cisplatin resistance.Q45972378
DNA polymerase zeta accounts for the reduced cytotoxicity and enhanced mutagenicity of cisplatin in human colon carcinoma cells that have lost DNA mismatch repairQ46550392
Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase deltaQ47791987
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.Q52163744
Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro.Q52541352
Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.Q52541355
cdc7-1 a temperature sensitive cell-cycle mutant which interferes with induced mutagenesis in Saccharomyces cerevisiae.Q54525777
RecA + -dependent mutagenesis occurring before DNA replication in UV- and -irradiated Escherichia coli.Q54665880
The Influence of the Cdc27 Subunit on the Properties of theSchizosaccharomyces pombeDNA Polymerase δQ57824508
Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA PolymeraseQ58424602
The roles of PCNA SUMOylation, Mms2-Ubc13 and Rad5 in translesion DNA synthesis in Saccharomyces cerevisiaeQ59708410
Yeast Rev1 is cell cycle regulated, phosphorylated in response to DNA damage and its binding to chromosomes is dependent upon MEC1Q63965502
Induction of forward mutations in mutationally defective yeastQ69218557
Studies on radiation-sensitive mutants of E. coli. 3. Participation of the rec system in induction of mutation by ultraviolet irradiationQ69875405
REV7, a new gene concerned with UV mutagenesis in yeastQ69905798
DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiaeQ73406613
An essential role for REV3 in mammalian cell survival: absence of REV3 induces p53-independent embryonic deathQ74250699
The Pol32 Subunit of DNA Polymerase δ Contains Separable Domains for Processive Replication and Proliferating Cell Nuclear Antigen (PCNA) BindingQ79241756
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesionsQ29619958
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesisQ29871514
Requirement of Rad5 for DNA polymerase zeta-dependent translesion synthesis in Saccharomyces cerevisiaeQ29976894
The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repairQ32010161
Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctionsQ33251608
The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.Q33257520
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpointQ33267615
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammalsQ33400985
REV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapyQ33574535
Participation of DNA polymerase zeta in replication of undamaged DNA in Saccharomyces cerevisiaeQ33628462
Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1pQ33770262
Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adductQ33827666
Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damageQ33853216
Effect of Genes Controlling Radiation Sensitivity on Chemically Induced Mutations in SACCHAROMYCES CEREVISIAEQ33991298
The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae.Q34016548
Error-prone replication bypass of the primary aflatoxin B1 DNA adduct, AFB1-N7-GuaQ34073971
Eukaryotic DNA polymerases: proposal for a revised nomenclature.Q34093113
Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domainQ34097492
hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblastsQ34161894
Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1Q34234530
Eukaryotic mutagenesis and translesion replication dependent on DNA polymerase zeta and Rev1 proteinQ34253002
REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibilityQ34255750
Loss of DNA polymerase zeta enhances spontaneous tumorigenesisQ34432676
Yeast DNA polymerase zeta is an efficient extender of primer ends opposite from 7,8-dihydro-8-Oxoguanine and O6-methylguanineQ34473133
The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimerQ34570808
CDC7/DBF4 functions in the translesion synthesis branch of the RAD6 epistasis group in Saccharomyces cerevisiaeQ34645971
hRev7, putative subunit of hPolzeta, plays a critical role in survival, induction of mutations, and progression through S-phase, of UV((254nm))-irradiated human fibroblastsQ34764288
Mechanism of replication-coupled DNA interstrand crosslink repairQ34832238
A novel function of DNA polymerase zeta regulated by PCNA.Q35040027
Mms2-Ubc13-dependent and -independent roles of Rad5 ubiquitin ligase in postreplication repair and translesion DNA synthesis in Saccharomyces cerevisiaeQ35131692
Lesion bypass by S. cerevisiae Pol ζ alone.Q35136551
Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesionsQ35221381
The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesisQ35311897
DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agentsQ35996723
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligaseQ36054241
P407language of work or nameEnglishQ1860
P304page(s)47-55
P577publication date2015-05-01
P1433published inDNA RepairQ3894086
P1476titleEukaryotic DNA polymerase ζ
P478volume29

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cites work (P2860)
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Q33554097Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

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