Cellular aspects of prion replication in vitro

scientific article

Cellular aspects of prion replication in vitro is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/V5010374
P932PMC publication ID3564126
P698PubMed publication ID23340381
P5875ResearchGate publication ID235326741

P50authorIna VorbergQ61142561
P2093author name stringJames Graham
Hanna Wolf
Julia Hofmann
Andrea Grassmann
P2860cites workCharacterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoformQ48767220
Identification of a protein that purifies with the scrapie prionQ48858653
Role of microglia and host prion protein in neurotoxicity of a prion protein fragmentQ49050987
GFP-tagged PrP supports compromised prion replication in transgenic mice.Q50744011
Proteasome inhibitors promote the sequestration of PrPSc into aggresomes within the cytosol of prion-infected CAD neuronal cells.Q51740431
Heparin enhances the cell-protein misfolding cyclic amplification efficiency of variant Creutzfeldt-Jakob disease.Q51768009
A novel generation of heparan sulfate mimetics for the treatment of prion diseases.Q51834544
Glypican-1 mediates both prion protein lipid raft association and disease isoform formationQ21131569
Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosisQ24292997
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotectionQ24534939
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewalQ24541459
Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion diseaseQ24550300
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cellsQ24610255
Assignment of the human and mouse prion protein genes to homologous chromosomesQ24629546
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cellsQ24633663
Transmission and spreading of tauopathy in transgenic mouse brainQ24651334
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synucleinQ24655848
Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregatesQ24657543
Formation of native prions from minimal components in vitroQ24676353
Staging of brain pathology related to sporadic Parkinson's diseaseQ28131702
Protein misfolding, functional amyloid, and human diseaseQ28131732
ClathrinQ28145011
The low-density lipoprotein receptor gene family: a cellular Swiss army knife?Q28205768
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion proteinQ28209519
Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycansQ28247513
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and hostQ28264821
Physiology of the prion proteinQ28275220
Prion protein gene variation among primatesQ28306403
Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptorQ28363055
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperonesQ28476253
Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion proteinQ28570280
Functionally different GPI proteins are organized in different domains on the neuronal surfaceQ28580230
Copper stimulates endocytosis of the prion proteinQ28589040
Novel proteinaceous infectious particles cause scrapieQ29547678
Eight prion strains have PrP(Sc) molecules with different conformationsQ29617277
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic miceQ29620597
Developmental expression of the prion protein gene in glial cellsQ52209886
In vitro propagation of the scrapie agent. I. Transformation of mouse glia and neuroblastoma cells after infection with the mouse-adapted scrapie strain c-506.Q53562199
The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein.Q54014038
Proteinase-resistant protein in human neuroblastoma cells infected with brain material from Creutzfeldt-Jakob patient.Q54177738
Endocytic Intermediates Involved with the Intracellular Trafficking of a Fluorescent Cellular Prion ProteinQ57372050
LRP1 controls biosynthetic and endocytic trafficking of neuronal prion proteinQ60405515
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitiveQ68318139
Failure of the scrapie agent to replicate in L5178Y mouse leukaemic cellsQ68640335
Isolation and partial characterization of high affinity laminin receptors in neural cellsQ70061816
A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cellsQ72227174
Heparin-like molecules bind differentially to prion-proteins and change their intracellular metabolic fateQ72656295
The majority of cellular prion protein released from endothelial cells is solubleQ73288199
Diverse patterns of expression of the 67-kD laminin receptor in human small intestinal mucosa: potential binding sites for prion proteins?Q73949292
Scrapie produced experimentally in goats with special reference to the clinical syndromeQ78964364
Prion proteins with insertion mutations have altered N-terminal conformation and increased ligand binding activity and are more susceptible to oxidative attackQ82553609
Prion infection of differentiated neurospheresQ83142947
Self-propagation and transmission of misfolded mutant SOD1: prion or prion-like phenomenon?Q83799357
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1.Q37335792
Synthesis and trafficking of prion proteins in cultured cellsQ37373585
Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissuesQ37396928
Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristicsQ37397268
Prions can infect primary cultured neurons and astrocytes and promote neuronal cell deathQ37484906
Cryo-immunogold electron microscopy for prions: toward identification of a conversion siteQ37484910
Tunnelling nanotubes: a highway for prion spreading?Q37496462
Prion-like propagation of cytosolic protein aggregates: insights from cell culture modelsQ37630197
Protection from cytosolic prion protein toxicity by modulation of protein translocationQ37671821
Glypican‐1 facilitates prion conversion in lipid raftsQ37777420
Allosteric function and dysfunction of the prion proteinQ37943799
Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.Q38287981
DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregationQ38295713
Structural insights into the interaction between prion protein and nucleic acidQ38311203
Asparagine-linked glycosylation of the scrapie and cellular prion proteinsQ38343527
Cell-surface prion protein interacts with glycosaminoglycansQ38363614
Assaying prions in cell culture: the standard scrapie cell assay (SSCA) and the scrapie cell assay in end point format (SCEPA).Q38476735
Sulfated glycosaminoglycans in amyloid plaques of prion diseasesQ39102794
Prion protein facilitates uptake of zinc into neuronal cellsQ39258090
Establishment of a cell line persistently infected with chronic wasting disease prionsQ39336080
Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.Q39368038
Rapid cell-surface prion protein conversion revealed using a novel cell systemQ39556052
Cultured cell sublines highly susceptible to prion infectionQ39590907
The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion proteinQ39644598
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranesQ39646797
Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion proteinQ39673524
PrP expression and replication by Schwann cells: implications in prion spreadingQ39682667
BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion proteinQ39686522
Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathwayQ39785389
The mechanism of internalization of glycosylphosphatidylinositol-anchored prion proteinQ39790846
Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cellsQ39800328
alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid raftsQ39908845
Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopyQ39932784
Genetic heterogeneity versus molecular analysis of prion susceptibility in neuroblasma N2a sublinesQ39951583
Proper axonal distribution of PrP(C) depends on cholesterol-sphingomyelin-enriched membrane domains and is developmentally regulated in hippocampal neuronsQ46684364
Antiprion properties of prion protein-derived cell-penetrating peptidesQ46736477
Characterization of the role of dendritic cells in prion transfer to primary neuronsQ48107300
Cytosolic prion protein in neurons.Q48232623
The truncated 23-230 form of the prion protein localizes to the nuclei of inducible cell lines independently of its nuclear localization signals and is not cytotoxicQ48484408
Neural stem cell model for prion propagationQ48513161
Murine bone marrow stromal cell culture with features of mesenchymal stem cells susceptible to mouse-adapted human TSE agent, Fukuoka-1.Q48515136
In vitro replication of scrapie agent in a neuronal model: infection of PC12 cellsQ48595899
Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell culturesQ30597888
Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosisQ31028422
Pathologic prion protein infects cells by lipid-raft dependent macropinocytosisQ33434501
Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cellsQ33463351
Infection of cell lines with experimental and natural ovine scrapie agentsQ33648916
Sulfated dextrans enhance in vitro amplification of bovine spongiform encephalopathy PrP(Sc) and enable ultrasensitive detection of bovine PrP(Sc).Q33722019
Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion proteinQ33794942
Deletion of beta-strand and alpha-helix secondary structure in normal prion protein inhibits formation of its protease-resistant isoformQ33847297
A simple, versatile and sensitive cell-based assay for prions from various speciesQ33926922
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibodyQ33930771
Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agentQ33931107
Prions in skeletal muscleQ34020521
Cell-based quantification of chronic wasting disease prionsQ34046147
Scrapie strains maintain biological phenotypes on propagation in a cell line in cultureQ34080020
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting diseaseQ34301796
Interaction of prion proteins with cell surface receptors, molecular chaperones, and other moleculesQ34304988
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-resQ34434726
Complementary hydropathy identifies a cellular prion protein receptorQ34449035
PrP polymorphisms tightly control sheep prion replication in cultured cellsQ34471219
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesisQ34480339
Cultured peripheral neuroglial cells are highly permissive to sheep prion infectionQ34553074
Prions hijack tunnelling nanotubes for intercellular spreadQ34938949
Prion infection of mouse neurospheresQ34944193
Fukuoka-1 strain of transmissible spongiform encephalopathy agent infects murine bone marrow-derived cells with features of mesenchymal stem cellsQ35038696
Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion proteinQ35053001
Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor.Q35085199
Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion proteinQ35311053
High CJD infectivity remains after prion protein is destroyedQ35449351
Abrogation of complex glycosylation by swainsonine results in strain- and cell-specific inhibition of prion replicationQ35562607
Microglial cell line established from prion protein-overexpressing mice is susceptible to various murine prion strainsQ35635237
PrPc on the road: trafficking of the cellular prion proteinQ35646000
Transmission of new bovine prion to miceQ35792647
Prion infection of muscle cells in vitroQ35857376
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.Q35899061
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in miceQ35946149
Trans-cellular propagation of Tau aggregation by fibrillar speciesQ36003836
The highways and byways of prion protein traffickingQ36032511
PrPc does not mediate internalization of PrPSc but is required at an early stage for de novo prion infection of Rov cellsQ36099038
Cell division modulates prion accumulation in cultured cellsQ36156685
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prionsQ36161465
Birth of a prion: spontaneous generation revisitedQ36211122
Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cellsQ36223171
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoformQ36235271
Chimeric prion protein expression in cultured cells and transgenic miceQ36277480
Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.Q36321586
Trafficking of prion proteins through a caveolae-mediated endosomal pathwayQ36325084
The prion protein and lipid raftsQ36447789
Cells release prions in association with exosomesQ36448448
Prion Protein Genes: Evolutionary and Functional AspectsQ36549301
Traffic of prion protein between different compartments on the neuronal surface, and the propagation of prion diseaseQ36555039
Searching for anti-prion compounds: cell-based high-throughput in vitro assays and animal testing strategiesQ36626116
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cellsQ36640586
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysisQ36682161
Prion strain discrimination in cell culture: the cell panel assayQ36693359
The spread of prions through the body in naturally acquired transmissible spongiform encephalopathiesQ36731460
Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cellsQ36780119
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant stateQ36828108
Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteinsQ36866642
Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.Q37039973
The Scrapie Agent In VitroQ37040434
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domainsQ37057378
The yeast Sup35NM domain propagates as a prion in mammalian cellsQ37062021
Cells expressing anchorless prion protein are resistant to scrapie infectionQ37157117
Identification of an intracellular site of prion conversionQ37170450
Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell cultureQ39966821
PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformationQ39968483
Canine MDCK cell lines are refractory to infection with human and mouse prionsQ39990591
Mouse neuroblastoma cells release prion infectivity associated with exosomal vesiclesQ39990786
A cell line infectible by prion strains from different speciesQ40033746
Transcriptional stability of cultured cells upon prion infectionQ40035094
Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteinsQ40139360
M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity.Q40146616
Packaging of prions into exosomes is associated with a novel pathway of PrP processing.Q40163902
Efficient dissemination of prions through preferential transmission to nearby cells.Q40179305
Copper-dependent co-internalization of the prion protein and glypican-1.Q40241315
The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanesQ40245615
Reactive oxygen species (ROS)-mediated beta-cleavage of the prion protein in the mechanism of the cellular response to oxidative stressQ40358582
Reciprocal interference between specific CJD and scrapie agents in neural cell culturesQ40359630
Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposureQ40383848
Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapieQ40394280
Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.Q40405368
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells.Q40417083
The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell linesQ40427322
Heparan sulfate is a cellular receptor for purified infectious prions.Q40466338
Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitroQ40558005
Scrapie-like prion protein is translocated to the nuclei of infected cells independently of proteasome inhibition and interacts with chromatin.Q40558969
Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agentsQ40595199
Dual mechanisms for shedding of the cellular prion proteinQ40601379
Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP releaseQ40734071
Transfer of scrapie prion infectivity by cell contact in cultureQ40739845
The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1.Q40817022
Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neuronsQ40859808
Cellular prion protein binds laminin and mediates neuritogenesisQ40893573
The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cellsQ41077192
Mutant and infectious prion proteins display common biochemical properties in cultured cells.Q41237869
Retrovirus infection strongly enhances scrapie infectivity release in cell cultureQ41445328
Evidence for synthesis of scrapie prion proteins in the endocytic pathwayQ41608575
Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cellsQ41682773
Cellular factors implicated in prion replicationQ41853767
Infection of a cell line of mouse L fibroblasts with scrapie agentQ41885514
Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4.Q41910802
Scrapie and cellular PrP isoforms are encoded by the same chromosomal geneQ41982232
Apolipoprotein E includes a binding site which is recognized by several amyloidogenic polypeptidesQ42203052
Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infectionQ42832124
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion proteinQ42976032
Up-regulation of functionally impaired insulin-like growth factor-1 receptor in scrapie-infected neuroblastoma cellsQ43680929
Identification of the heparan sulfate binding sites in the cellular prion proteinQ43908316
Characterization of scrapie infection in mouse neuroblastoma cellsQ44079577
Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cellsQ44090721
Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brainQ44424303
Cellular heparan sulfate participates in the metabolism of prionsQ44519369
Multiplication of Scrapie Agent in Cell CultureQ44726183
PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transductionQ45042655
Purification and properties of the cellular and scrapie hamster prion proteinsQ45166038
PrPSc incorporation to cells requires endogenous glycosaminoglycan expressionQ45236630
Glycosylinositol phospholipid anchors of the scrapie and cellular prion proteins contain sialic acidQ45935884
The low-density lipoprotein receptor-related protein-1 associates transiently with lipid raftsQ46089677
Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchorQ46096263
Scrapie prions aggregate to form amyloid-like birefringent rodsQ46201693
Identification of glycoinositol phospholipid linked and truncated forms of the scrapie prion proteinQ46251858
Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cellsQ46361947
Demonstration of scrapie strain diversity in infected PC12 cellsQ46665678
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectprotein biosynthesisQ211935
transmissible spongiform encephalopathyQ703961
prionQ47051
prion protein familyQ24724413
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)374-405
P577publication date2013-01-22
P1433published inVirusesQ7935305
P1476titleCellular aspects of prion replication in vitro
P478volume5

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cites work (P2860)
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