Role of the intercalated disc in cardiac propagation and arrhythmogenesis

scientific article

Role of the intercalated disc in cardiac propagation and arrhythmogenesis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2014.00404
P932PMC publication ID4201087
P698PubMed publication ID25368581
P5875ResearchGate publication ID267814082

P2093author name stringJeffrey E. Saffitz
Andre G. Kleber
P2860cites workBasic Mechanisms of Cardiac Impulse Propagation and Associated ArrhythmiasQ22337019
The Electrical Constants of a Crustacean Nerve FibreQ22337112
SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytesQ24317140
Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heartQ24548349
Paradigm of genetic mosaicism and lone atrial fibrillation: physiological characterization of a connexin 43-deletion mutant identified from atrial tissueQ28116497
Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated discQ28238713
Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytesQ28254076
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43Q28506915
Emerging issues of connexin channels: biophysics fills the gap.Q30167614
Ephaptic conduction in a cardiac strand model with 3D electrodiffusion.Q30481809
Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardiumQ30492558
Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane.Q30538574
Cx43 associates with Na(v)1.5 in the cardiomyocyte perinexus.Q33856632
Involvement of the calcium inward current in cardiac impulse propagation: induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644.Q33916844
Vortex shedding as a precursor of turbulent electrical activity in cardiac muscleQ34017314
Modulation of cardiac gap junction expression and arrhythmic susceptibility.Q34207091
Cardiac myocytes express multiple gap junction proteinsQ34233299
Cardiac connexins, mutations and arrhythmias.Q34258068
Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivoQ34475384
A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.Q34780267
The gap junction life cycleQ35534264
Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexinsQ35749969
Localization of sodium channels in intercalated disks modulates cardiac conductionQ35836821
Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium currentQ35839115
Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductanceQ35921229
Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43Q36054423
Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmiaQ36140564
Functional consequences of heterogeneous gap junction channel formation and its influence in health and diseaseQ36162581
Three-dimensional transmural organization of perimysial collagen in the heartQ36893291
Intercellular electrical communication in the heart: a new, active role for the intercalated diskQ37488279
Arrhythmogenic right ventricular cardiomyopathy: new insights into disease mechanisms and diagnosisQ37642545
Arrhythmogenic cardiomyopathy: etiology, diagnosis, and treatmentQ37670848
Visualizing cardiac ion channel trafficking pathways.Q39658460
Coexpression of connexin 45 with connexin 43 decreases gap junction size.Q39958151
Heteromeric mixing of connexins: compatibility of partners and functional consequencesQ40725288
Cardiac action potentials, membrane currents, and some personal reminiscencesQ40893528
Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping. Role of tissue discontinuitiesQ41222651
Connexin43 and the regulation of intercalated disc functionQ41768466
Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.Q41892305
Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout miceQ44932498
Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growthQ47246756
Relationship between connexins and atrial activation during human atrial fibrillationQ47933334
Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heartQ47985654
On dynamic equilibrium in the heartQ48146457
Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes.Q50710952
Slow conduction in cardiac tissue, I: effects of a reduction of excitability versus a reduction of electrical coupling on microconduction.Q51497168
A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.Q51772909
Cardiac tissue geometry as a determinant of unidirectional conduction block: assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer modelQ52343580
Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes.Q52388125
PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.Q54097430
Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling.Q54107288
Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties.Q54193717
The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle.Q54704648
Laminar structure of the heart: ventricular myocyte arrangement and connective tissue architecture in the dogQ57594757
Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctionsQ59212248
Electrical turbulence as a result of the critical curvature for propagation in cardiac tissueQ60183833
Heterogeneous Expression of Gap Junction Channels in the Heart Leads to Conduction Defects and Ventricular DysfunctionQ63425482
Patterned growth of neonatal rat heart cells in culture. Morphological and electrophysiological characterizationQ68177100
Thin collagenous septa in cardiac muscleQ69108916
A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissueQ69443100
Distribution and three-dimensional structure of intercellular junctions in canine myocardiumQ69485568
Block of impulse propagation at an abrupt tissue expansion: evaluation of the critical strand diameter in 2- and 3-dimensional computer modelsQ71806051
Immunocytochemical localization of rH1 sodium channel in adult rat heart atria and ventricle. Presence in terminal intercalated disksQ71958314
The stochastic nature of cardiac propagation at a microscopic level. Electrical description of myocardial architecture and its application to conductionQ72553613
The electrical constants of Purkinje fibresQ72990538
A note on conduction velocityQ73589188
Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction couplingQ73833055
Capacity of muscle fiber membraneQ74440674
Cell coupling between ventricular myocyte pairs from connexin43-deficient murine heartsQ79074160
Nonsyncytial nature of cardiac muscle: membrane resistance of single cellsQ79271639
Nonlinear behaviour of conduction and block in cardiac tissue with heterogeneous expression of connexin 43Q87588535
P407language of work or nameEnglishQ1860
P304page(s)404
P577publication date2014-01-01
P1433published inFrontiers in PhysiologyQ2434141
P1476titleRole of the intercalated disc in cardiac propagation and arrhythmogenesis
P478volume5

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cites work (P2860)
Q36937246Angular Approach Scanning Ion Conductance Microscopy.
Q48623367Antiarrhythmic effect of growth factor-supplemented cardiac progenitor cells in chronic infarcted heart.
Q89018075At the heart of inter- and intracellular signaling: the intercalated disc
Q33565907Beyond the Electrocardiogram: Mutations in Cardiac Ion Channel Genes Underlie Nonarrhythmic Phenotypes
Q60047644Competing Mechanisms of Stress-Assisted Diffusivity and Stretch-Activated Currents in Cardiac Electromechanics
Q41422153Editorial: Cardiac electronic remodeling and susceptibility to arrhythmias: an introduction and brief historical overview
Q39270856Genetic and epigenetic regulation of arrhythmogenic cardiomyopathy
Q55191103In silico study of multicellular automaticity of heterogeneous cardiac cell monolayers: Effects of automaticity strength and structural linear anisotropy.
Q99557327Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart
Q91557750Molecular mechanisms of arrhythmogenic cardiomyopathy
Q39038606Murine Electrophysiological Models of Cardiac Arrhythmogenesis
Q92217698Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics
Q40440471Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress
Q38532371Role of connexins and pannexins in cardiovascular physiology
Q34574809Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking
Q55177920Sudden Unexplained Nocturnal Death Syndrome: The Hundred Years' Enigma.
Q90629009The Cardiac Gap Junction has Discrete Functions in Electrotonic and Ephaptic Coupling
Q47706161The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart

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