Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology

scientific article

Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology is …
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scholarly articleQ13442814

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P356DOI10.1016/J.TIPS.2015.10.005
P932PMC publication ID4922134
P698PubMed publication ID26651416

P50authorPeter Vee Sin LeeQ61822474
Alastair StewartQ63373438
P2093author name stringRamaswamy Krishnan
Chun Y Seow
Jin-Ah Park
P2860cites workImpact of dimensionality and network disruption on microrheology of cancer cells in 3D environmentsQ21145291
The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stressQ24292760
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failureQ24302551
Asthmatic and normal respiratory epithelial cells respond differently to mechanical apical stressQ42968475
Detection of Plasmodium falciparum-infected red blood cells by optical stretchingQ44816742
Microfabrication of human organs-on-chips.Q45924666
Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substratesQ46055143
Concepts in microvascular endothelial barrier regulation in health and diseaseQ46114873
Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine mannerQ47850264
Cell force measurements in 3D microfabricated environments based on compliant cantilevers.Q51526564
Tissue mechanics: Cell jam.Q51711198
Response of arterial smooth muscle to length perturbation.Q52541375
Effects of an antimitotic drug on mechanical behaviours of the cytoskeleton in distinct grades of colon cancer cells.Q52967381
Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a 'shear' delight!Q54486471
Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing.Q54550204
The adult respiratory distress syndrome. Clinical features, factors influencing prognosis and principles of management.Q54667241
Biomechanopharmacology: a new borderline disciplineQ61781469
Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesisQ71151143
The effect of deep inspiration on methacholine dose-response curves in normal subjectsQ73833240
Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungsQ77487133
Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic eventsQ79401111
Effect of bronchoconstriction on airway remodeling in asthmaQ84194759
Shear-activated nanotherapeutics for drug targeting to obstructed blood vesselsQ84531861
Aspiration of biological viscoelastic dropsQ85079955
Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?Q85094422
Alpha-actinin binding kinetics modulate cellular dynamics and force generationQ24337102
Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competenceQ24538594
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppressionQ24627446
Orthologous gene-expression profiling in multi-species models: search for candidate genesQ24801521
Mechanosensitive mechanisms in transcriptional regulationQ26828957
Mechanosensitivity and compositional dynamics of cell-matrix adhesionsQ26849684
Collective migration and cell jammingQ27006586
Talin Dependent Mechanosensitivity of Cell Focal AdhesionsQ27008881
Cell elasticity determines macrophage functionQ27333264
A microfluidic pipette array for mechanophenotyping of cancer cells and mechanical gating of mechanosensitive channelsQ27335311
Reinforcement versus fluidization in cytoskeletal mechanoresponsivenessQ27349353
Matrix elasticity directs stem cell lineage specificationQ27860761
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome NetworkQ27861021
Mechanically Activated Ion ChannelsQ28084779
A multiwell platform for studying stiffness-dependent cell biologyQ28744183
Geometric control of cell life and deathQ29615213
Molecular force transduction by ion channels: diversity and unifying principles.Q30419201
Biomechanics: cell research and applications for the next decadeQ30480670
Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.Q30492793
Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy.Q30588682
Micropipette aspiration of living cellsQ30828817
Force mapping in epithelial cell migrationQ30856290
Mechanobiology of cardiomyocyte developmentQ33509740
Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1.Q33613763
Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: atomic force microscopy force mapping of pulmonary endothelial monolayerQ33646887
A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screeningQ33792594
Airway contractility in the precision-cut lung slice after cryopreservationQ33799692
Tensegrity, cellular biophysics, and the mechanics of living systemsQ33957031
A silicone-based stretchable micropost array membrane for monitoring live-cell subcellular cytoskeletal responseQ33994720
Gene expression in the third dimension: the ECM-nucleus connectionQ34029103
Reconstituting organ-level lung functions on a chipQ34122591
Patterning, prestress, and peeling dynamics of myocytesQ34184701
The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancerQ34291977
Passive stiffness of airway smooth muscle: the next target for improving airway distensibility and treatment for asthma?Q38024921
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applicationsQ38112669
Mechanotherapy: revisiting physical therapy and recruiting mechanobiology for a new era in medicine.Q38116175
Nonsteroidal anti-inflammatory drugs and the heartQ38190795
YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growthQ38205678
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional frameworkQ38212169
Investigating cell mechanics with atomic force microscopyQ38318750
Heterogeneity in mechanisms influencing glucocorticoid sensitivity: the need for a systems biology approach to treatment of glucocorticoid-resistant inflammation.Q38321703
Quantitative diagnosis of malignant pleural effusions by single-cell mechanophenotypingQ38444461
Collective cell migration: guidance principles and hierarchiesQ38542134
Microdevice arrays of high aspect ratio poly(dimethylsiloxane) pillars for the investigation of multicellular tumour spheroid mechanical propertiesQ38994220
Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.Q39248514
Cytoskeletal stiffness, friction, and fluidity of cancer cell lines with different metastatic potentialQ39282749
Pinched-flow hydrodynamic stretching of single-cellsQ39378715
Mechanics of cell spreading within 3D-micropatterned environmentsQ39623692
Mechanotransduction through growth-factor shedding into the extracellular spaceQ40563816
Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflowQ41775746
Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancementQ41828281
Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness?Q42138768
Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forcesQ42212876
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessmentQ42438111
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiationQ42440768
Chronic intermittent mechanical stress increases MUC5AC protein expressionQ42560001
Mechanical control of cyclic AMP signalling and gene transcription through integrinsQ42796355
Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactionsQ42799931
Avoiding deep inspirations increases the maximal response to methacholine without altering sensitivity in non-asthmaticsQ42945235
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdeviceQ34310507
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.Q34331994
Pharmacological bronchodilation is partially mediated by reduced airway wall stiffnessQ34402775
Tensegrity: the architectural basis of cellular mechanotransductionQ34419882
Vascular TRP channels: performing under pressure and going with the flowQ34428913
Force maintenance and myosin filament assembly regulated by Rho-kinase in airway smooth muscleQ34801127
Collective cell guidance by cooperative intercellular forcesQ35103305
TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.Q35145453
3D surface topology guides stem cell adhesion and differentiationQ35232412
Mechanobiology and diseases of mechanotransductionQ35622033
Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspirationQ35766484
Bronchodilation response to deep inspirations in asthma is dependent on airway distensibility and air trappingQ35789357
Toward single cell traction microscopy within 3D collagen matrices.Q35835728
Mechanical stress is communicated between different cell types to elicit matrix remodelingQ35933851
Three-dimensional (3D) tumor spheroid invasion assayQ35972563
Transforming growth factor-β impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line.Q36110492
Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretchesQ36175601
Dilatation of the constricted human airway by tidal expansion of lung parenchymaQ36176881
TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxisQ36178070
High-throughput screening for modulators of cellular contractile forceQ36311468
Unjamming and cell shape in the asthmatic airway epithelium.Q36337484
Signaling mechanisms regulating endothelial permeabilityQ36350076
Tissue factor-bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivoQ36438085
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesionsQ36545669
Transforming growth factor-β-induced differentiation of airway smooth muscle cells is inhibited by fibroblast growth factor-2Q36703971
Universal physical responses to stretch in the living cellQ36737346
High wall shear stress and spatial gradients in vascular pathology: a reviewQ36800232
The tumor microenvironment is a dominant force in multidrug resistance.Q36856829
Putting the Squeeze on Airway EpitheliaQ36956289
GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signalingQ37159197
The COXIB experience: a look in the rearview mirrorQ37292637
Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear strQ37341184
Rho-kinase mediated cytoskeletal stiffness in skinned smooth muscleQ37346119
Mechanical activation of vinculin binding to talin locks talin in an unfolded conformationQ37693102
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbiomechanicsQ193378
drug screeningQ10505555
P304page(s)87-100
P577publication date2015-12-01
P1433published inTrends in Pharmacological SciencesQ2451474
P1476titleCellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology
P478volume37

Reverse relations

cites work (P2860)
Q61812467A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases
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Q89868230On-chip surface acoustic wave and micropipette aspiration techniques to assess cell elastic properties
Q88647362Small molecule targeting of the actin associating protein tropomyosin Tpm3.1 increases neuroblastoma cell response to inhibition of Rac-mediated multicellular invasion
Q42329900Translational Pharmacology

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