Principles and properties of ion flow in P2X receptors

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Principles and properties of ion flow in P2X receptors is …
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P356DOI10.3389/FNCEL.2014.00006
P3181OpenCitations bibliographic resource ID1391558
P932PMC publication ID3914235
P698PubMed publication ID24550775
P5875ResearchGate publication ID260254444

P2093author name stringZhiyuan Li
Damien S. K. Samways
Terrance M. Egan
P2860cites workTrimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypesQ24301398
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptorQ24306745
Characterization and chromosomal localization of a human P2X receptor from the urinary bladderQ24310346
Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologueQ24317169
P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channelsQ24533248
Molecular and functional properties of P2X receptors--recent progress and persisting challengesQ24617046
Ion access pathway to the transmembrane pore in P2X receptor channelsQ24629121
Single channel properties of P2X2 purinoceptorsQ24642353
Mechanism of ivermectin facilitation of human P2X4 receptor channelsQ24644507
Mammalian nicotinic acetylcholine receptors: from structure to functionQ24647069
Crystal structure of the ATP-gated P2X(4) ion channel in the closed stateQ24657193
The Hodgkin-Huxley heritage: from channels to circuitsQ26866491
Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexesQ27670938
Molecular mechanism of ATP binding and ion channel activation in P2X receptorsQ27678739
Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partnersQ28137807
A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X(2) ATP-gated channelsQ28140321
Allosteric control of gating and kinetics at P2X(4) receptor channelsQ28142880
Polar residues of the second transmembrane domain influence cation permeability of the ATP-gated P2X(2) receptorQ28201447
Molecular physiology of P2X receptorsQ28203477
Biophysics of P2X receptorsQ28240953
P2X receptors as cell-surface ATP sensors in health and diseaseQ28255603
Glutamate receptor ion channels: structure, regulation, and functionQ28290774
Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerizeQ28303030
Molecular properties of P2X receptorsQ28306596
Voltage and concentration dependence of Ca(2+) permeability in recombinant glutamate receptor subtypesQ28344390
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)Q28568856
Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes.Q48887894
Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336C.Q48906948
P2X7 purinoceptor expression in Xenopus oocytes is not sufficient to produce a pore-forming P2Z-like phenotypeQ48955005
The ATP4− Receptor-Operated Channel (P2Z Class) of Human Lymphocytes Allows Ba2+ and Ethidium+ Uptake: Inhibition of Fluxes by SuraminQ50125006
Role of action potentials and calcium influx in ATP- and UDP-induced noradrenaline release from rat cultured sympathetic neurones.Q50516631
Characteristics of P2X7 receptors from human B lymphocytes expressed in Xenopus oocytes.Q50722562
ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.Q50902451
ATP stimulates sympathetic transmitter release via presynaptic P2X purinoceptors.Q51482198
Ca2+-permeable P2X receptor channels in cultured rat retinal ganglion cells.Q52177757
The use of fura-2 for estimating Ca buffers and Ca fluxes.Q52324742
Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor.Q52536118
P2X4 receptor channels form large noncytolytic pores in resting and activated microglia.Q53186766
Conductance and kinetic properties of single nicotinic acetylcholine receptor channels in rat sympathetic neurones.Q54075759
Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptorsQ57908070
Changes in Cytoplasmic Calcium Induced by Purinergic P2x Receptor Activation in Vascular Smooth Muscle Cells and Sensory NeuronsQ67877613
Characterisation of the ATP4- receptor that mediates permeabilisation of rat mast cellsQ68364588
Single channel properties of ATP-gated cation channels (P2X receptors) heterologously expressed in Chinese hamster ovary cellsQ71618569
Nonselective cationic currents elicited by extracellular ATP in human B-lymphocytesQ71698449
Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cellsQ71877054
Gated access to the pore of a voltage-dependent K+ channelQ73564876
P2X7 receptors in Müller glial cells from the human retinaQ74139671
A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility methodQ74315052
Genomic structure, developmental distribution and functional properties of the chicken P2X(5) receptorQ40801628
Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptorQ40816581
Ion permeation and block of P2X(2) purinoceptors: single channel recordingsQ40916730
Pore dilation of neuronal P2X receptor channelsQ40960421
Co-expression of P2X1 and P2X5 receptor subunits reveals a novel ATP-gated ion channel.Q40987897
N-Linked glycosylation is essential for the functional expression of the recombinant P2X2 receptorQ41002033
The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridgeQ41003350
Membrane topology of an ATP-gated ion channel (P2X receptor).Q41034616
Topological analysis of the ATP-gated ionotropic [correction of ionotrophic] P2X2 receptor subunitQ41051612
Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptorsQ41065167
Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptorQ41080074
Identification of amino acid residues contributing to the pore of a P2X receptorQ41106961
Distinct ATP receptors on pain-sensing and stretch-sensing neurons.Q41109141
Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes.Q41468237
P2X receptor channels show threefold symmetry in ionic charge selectivity and unitary conductance.Q41526271
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.Q41646184
Mass spectrometry analysis of human P2X1 receptors; insight into phosphorylation, modelling and conformational changesQ42095503
Calcium-dependent decrease in the single-channel conductance of TRPV1.Q42139744
P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee jointQ42182102
Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat.Q42478786
Many ways to dilate the P2X7 receptor poreQ42789183
Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilationQ43067153
Stimulation of mouse cultured sympathetic neurons by uracil but not adenine nucleotides.Q43581280
The first transmembrane domain of the P2X receptor subunit participates in the agonist-induced gating of the channelQ43662761
A strategy for mapping and neutralizing conformational immunogenic sites on protein therapeuticsQ43938812
Evoked and spontaneous purinergic junctional Ca2+ transients (jCaTs) in rat small arteriesQ44145576
Single-channel properties of native and cloned rat vanilloid receptorsQ44218020
Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cellsQ44666463
Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.Q45056282
Activation of ureter nociceptors by exogenous and endogenous ATP in guinea pig.Q45157409
P2X7 receptor channels allow direct permeation of nanometer-sized dyes.Q45529200
P2X(1) receptor subunit contribution to gating revealed by a dominant negative PKC mutantQ45713476
ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brainQ47752743
Metals in proteins: correlation between the metal-ion type, coordination number and the amino-acid residues involved in the coordination.Q47864669
Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neuronesQ47977257
P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties.Q48601198
A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cellsQ28572405
A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATPQ28573068
Silver as a probe of pore-forming residues in a potassium channelQ30193514
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complexQ30479449
Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analogQ30500428
The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferensQ33193075
Calcium permeability of ligand-gated channelsQ33544676
Dynamic selectivity filters in ion channelsQ33731015
Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.Q33744436
P2X4 receptors in activated C8-B4 cells of cerebellar microglial originQ33763156
A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptorQ33855098
Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel poreQ33915081
Modulation of fast synaptic transmission by presynaptic ligand-gated cation channelsQ33951865
Purines, purinergic receptors, and cancerQ34034090
Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channelsQ34128440
Dimensions of the narrow portion of a recombinant NMDA receptor channelQ34128656
Side-chain accessibilities in the pore of a K+ channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesisQ34128675
Voltage-gated sodium channels at 60: structure, function and pathophysiologyQ34265707
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptorQ34292603
Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neuronsQ34296118
Pore-opening mechanism in trimeric P2X receptor channelsQ34313783
Structural changes during ion channel gatingQ34323269
Ion conduction and selectivity in K(+) channelsQ34415730
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockersQ34698238
Permeation and selectivity in calcium channels.Q35019750
Activation and regulation of purinergic P2X receptor channelsQ35122793
Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).Q35170819
Potassium channelsQ35589981
Ca2+ permeability of nicotinic acetylcholine receptorsQ35605952
Kinetics of P2X7 receptor-operated single channels currentsQ35781225
Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portalsQ35801949
Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.Q35849755
Ligand-gated ion channels: mechanisms underlying ion selectivityQ35853354
Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitisQ35874789
Contribution of residues in second transmembrane domain of ASIC1a protein to ion selectivityQ35921539
Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptorsQ36166147
P2X(7) receptor: Death or life?Q36173773
Structural changes during HCN channel gating defined by high affinity metal bridges.Q36209612
Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor familyQ36295984
Permeation of both cations and anions through a single class of ATP-activated ion channels in developing chick skeletal muscleQ36410494
The P2X7 receptor channel pore dilates under physiological ion conditionsQ36946691
Influences of membrane mimetic environments on membrane protein structures.Q37065765
Gating the pore of P2X receptor channelsQ37069023
A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP.Q37100017
Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels.Q37240556
On the origin of ion selectivity in the Cys-loop receptor familyQ37591406
C terminus of the P2X7 receptor: treasure hunting.Q37864114
P2X receptors in health and diseaseQ37876543
P2X7 receptors: channels, pores and moreQ38042107
P2X receptors as drug targetsQ38068620
An introduction to molecular architecture and permeability of ion channelsQ38175912
Permeation properties of a P2X receptor in the green algae Ostreococcus tauriQ38631509
Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gatingQ38673214
Is pannexin the pore associated with the P2X7 receptor?Q39154721
Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1.Q39354576
Pannexin 1 forms an anion-selective channelQ39400579
P2X7 receptor-pannexin 1 hemichannel association: effect of extracellular calcium on membrane permeabilization.Q39471255
P2X7 receptor activates multiple selective dye-permeation pathways in RAW 264.7 and human embryonic kidney 293 cellsQ39800258
A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice.Q39834758
Pharmacological properties of a pore induced by raising intracellular Ca2+.Q39868233
Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1.Q39929126
ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages.Q39941391
Tunable calcium current through TRPV1 receptor channelsQ39942483
TRPV1 shows dynamic ionic selectivity during agonist stimulation.Q39994761
On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptorQ40042581
Ionic selectivity revisited: The role of kinetic and equilibrium processes in ion permeation through channelsQ40081383
N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptorsQ40386629
Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamicsQ40489469
Are second messengers crucial for opening the pore associated with P2X7 receptor?Q40506943
Contribution of calcium ions to P2X channel responses.Q40571393
Subunit Arrangement in P2X ReceptorsQ40629382
Pharmacological and biophysical properties of the human P2X5 receptorQ40645853
P407language of work or nameEnglishQ1860
P304page(s)6
P577publication date2014-01-01
P1433published inFrontiers in Cellular NeuroscienceQ2131509
P1476titlePrinciples and properties of ion flow in P2X receptors
P478volume8