| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Roman Jerala | Q5344 |
| Mateja Manček-Keber | Q60444838 | ||
| P2860 | cites work | MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4 | Q22009943 |
| Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene | Q22299417 | ||
| Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran | Q24292781 | ||
| The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex | Q24316449 | ||
| Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock | Q41970918 | ||
| Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4. | Q42165203 | ||
| Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands | Q42755753 | ||
| Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance | Q42832316 | ||
| Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage | Q43016846 | ||
| Signal integration in lipopolysaccharide (LPS)-stimulated murine macrophages | Q43753725 | ||
| Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. | Q44314755 | ||
| Noncanonical inflammasome activation by intracellular LPS independent of TLR4. | Q44450840 | ||
| Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids | Q44514690 | ||
| Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. | Q45935599 | ||
| CD14 is required for MyD88-independent LPS signaling. | Q45990170 | ||
| Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures | Q46584409 | ||
| Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel | Q46685847 | ||
| Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. | Q46743982 | ||
| Characterization of heme as activator of Toll-like receptor 4. | Q47787071 | ||
| Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii | Q48112512 | ||
| Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain | Q48502190 | ||
| Essential role of MD-2 in LPS responsiveness and TLR4 distribution | Q50109313 | ||
| A polymeric bacterial protein activates dendritic cells via TLR4. | Q52568593 | ||
| Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. | Q53386864 | ||
| Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4. | Q53582823 | ||
| The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway. | Q54291298 | ||
| Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. | Q54630390 | ||
| A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation | Q60998567 | ||
| Bacterial endotoxin is an active component of cigarette smoke | Q74619159 | ||
| Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner | Q74768767 | ||
| Nonspecific interactions alter lipopolysaccharide patterns and protein mobility on sodium dodecyl sulfate polyacrylamide gels | Q78139547 | ||
| Endotoxin-free heat-shock protein 70 fails to induce APC activation | Q78759447 | ||
| The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo | Q79485051 | ||
| Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes | Q81231160 | ||
| Saturated fatty acids do not directly stimulate Toll-like receptor signaling | Q84365640 | ||
| Mechanism of anticancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling | Q94466029 | ||
| A family of human receptors structurally related to Drosophila Toll | Q24321888 | ||
| A mouse model of Salmonella typhi infection | Q24610761 | ||
| Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein | Q24617663 | ||
| Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization | Q24631966 | ||
| CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer | Q24642646 | ||
| Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2 | Q27678726 | ||
| UCSF Chimera--a visualization system for exploratory research and analysis | Q27860666 | ||
| A human homologue of the Drosophila Toll protein signals activation of adaptive immunity | Q28131769 | ||
| Separate Functional Domains of Human MD-2 Mediate Toll-Like Receptor 4-Binding and Lipopolysaccharide Responsiveness | Q28182897 | ||
| Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock | Q28244377 | ||
| High mobility group box 1 protein interacts with multiple Toll-like receptors | Q28280114 | ||
| Cryopyrin activates the inflammasome in response to toxins and ATP | Q28291313 | ||
| Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages | Q28565498 | ||
| Gangliosides trigger inflammatory responses via TLR4 in brain glia | Q28572427 | ||
| TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification | Q28586721 | ||
| Identification of Lps2 as a key transducer of MyD88-independent TIR signalling | Q28587545 | ||
| Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling | Q28593045 | ||
| Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome | Q29547419 | ||
| Tolerance, danger, and the extended family | Q29547532 | ||
| CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein | Q29615189 | ||
| The NALP3 inflammasome is involved in the innate immune response to amyloid-beta | Q29615595 | ||
| Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration | Q29615596 | ||
| Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling | Q29616024 | ||
| Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy | Q29619961 | ||
| K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter | Q29620146 | ||
| NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity | Q30446504 | ||
| Solution structure of polymyxins B and E and effect of binding to lipopolysaccharide: an NMR and molecular modeling study. | Q30584946 | ||
| Cutting edge: Gln22 of mouse MD-2 is essential for species-specific lipopolysaccharide mimetic action of taxol | Q31724267 | ||
| Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2. | Q33887629 | ||
| Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. | Q33940165 | ||
| Neutralization of endotoxin in vitro and in vivo by a human lactoferrin-derived peptide | Q34000667 | ||
| Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain | Q34061948 | ||
| The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. | Q34246151 | ||
| The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition | Q34270392 | ||
| Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin | Q34310509 | ||
| Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14. | Q34400469 | ||
| Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa. | Q39964197 | ||
| MD-2 as the target of curcumin in the inhibition of response to LPS. | Q40112020 | ||
| Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages | Q40212651 | ||
| Toll-like receptor 4 signalling is neither sufficient nor required for oxidised phospholipid mediated induction of interleukin-8 expression | Q40230710 | ||
| Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD-2. | Q40238448 | ||
| HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. | Q40249835 | ||
| Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling | Q40265496 | ||
| Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa. | Q40331306 | ||
| C-reactive protein-induced in vitro endothelial cell activation is an artefact caused by azide and lipopolysaccharide | Q40440401 | ||
| The Toll-like receptor 4 region Glu24-Pro34 is critical for interaction with MD-2. | Q40461576 | ||
| Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress | Q40527936 | ||
| Heat-shock protein 70 and heat-shock protein 90 associate with Toll-like receptor 4 in response to bacterial lipopolysaccharide | Q40532447 | ||
| Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein | Q40643736 | ||
| Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages | Q40657222 | ||
| Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis | Q40681790 | ||
| Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells | Q40691206 | ||
| Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages | Q40693930 | ||
| Human Toll-like receptor 4 recognizes host-specific LPS modifications. | Q40742533 | ||
| Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. | Q40751982 | ||
| The extra domain A of fibronectin activates Toll-like receptor 4. | Q40832345 | ||
| Differential activation of murine macrophages by angelan and LPS. | Q40854035 | ||
| Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2. | Q40903298 | ||
| Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. | Q41613089 | ||
| Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica | Q34446653 | ||
| Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors | Q34501763 | ||
| LPS/TLR4 signal transduction pathway | Q34756268 | ||
| Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells | Q34945846 | ||
| Thematic review series: The immune system and atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis | Q36011463 | ||
| The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis | Q36170278 | ||
| Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum | Q36352797 | ||
| Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide | Q36362840 | ||
| Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) | Q36367812 | ||
| Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. | Q36376473 | ||
| A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo | Q36452968 | ||
| Structure and function of Toll receptors and their ligands | Q36760336 | ||
| Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal | Q37003216 | ||
| The TLR4 antagonist Eritoran protects mice from lethal influenza infection | Q37051987 | ||
| Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin | Q37200871 | ||
| MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant | Q37243896 | ||
| Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis | Q37306009 | ||
| Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation | Q37339321 | ||
| Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations | Q37356770 | ||
| Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4. | Q37502155 | ||
| Endogenous ligands of TLR2 and TLR4: agonists or assistants? | Q37697340 | ||
| Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway | Q37872780 | ||
| A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide | Q38207185 | ||
| Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. | Q38313210 | ||
| Transcriptional network dynamics in macrophage activation | Q38313362 | ||
| Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner. | Q39125365 | ||
| Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators. | Q39149244 | ||
| Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. | Q39416382 | ||
| Variability in the lipooligosaccharide structure and endotoxicity among Bordetella pertussis strains. | Q39635833 | ||
| Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand. | Q39921921 | ||
| Taxanes inhibit human TLR4 signaling by binding to MD-2. | Q39922545 | ||
| Helicobacter pylori protein HP0175 transactivates epidermal growth factor receptor through TLR4 in gastric epithelial cells | Q39937536 | ||
| Paclitaxel binding to human and murine MD-2. | Q39957984 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | toll-like receptor | Q408004 |
| P304 | page(s) | 356-70 | |
| P577 | publication date | 2015-02-01 | |
| P1433 | published in | European Journal of Immunology | Q5412727 |
| P1476 | title | Postulates for validating TLR4 agonists | |
| P478 | volume | 45 |
| Q89565938 | Blockade of TLR4 using TAK-242 (resatorvid) enhances anti-cancer effects of chemotherapeutic agents: a novel synergistic approach for breast and ovarian cancers |
| Q36810015 | Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4. |
| Q36503451 | Combination of the toll like receptor agonist and α-Galactosylceramide as an efficient adjuvant for cancer vaccine. |
| Q40068149 | Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. |
| Q39403516 | Graphene and the Immune System: A Romance of Many Dimensions |
| Q40083110 | Gut-homing Δ42PD1(+)Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection. |
| Q38986650 | Influence of rimonabant treatment on peripheral blood mononuclear cells; flow cytometry analysis and gene expression profiling |
| Q37736840 | Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells |
| Q46256979 | Lipopolysaccharide (LPS)-mediated priming of toll-like receptor 4 enhances oxidant-induced prostaglandin E2 biosynthesis in primary murine macrophages |
| Q37698019 | Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2. |
| Q37595395 | TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection. |
| Q38664083 | Toll-like receptor-4 signaling pathway in aorta aging and diseases: "its double nature". |
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