| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | David Xiong | Q64009898 |
| Erik Musiek | Q42970994 | ||
| David M. Holtzman | Q56827171 | ||
| P2860 | cites work | High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase | Q21563543 |
| Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons | Q23761011 | ||
| Measuring sleep: accuracy, sensitivity, and specificity of wrist actigraphy compared to polysomnography | Q23918442 | ||
| Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists | Q24629345 | ||
| Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle | Q24644961 | ||
| Circadian clocks are resounding in peripheral tissues | Q25255989 | ||
| Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1 | Q27314013 | ||
| Mop3 is an essential component of the master circadian pacemaker in mammals | Q28591939 | ||
| APP processing and synaptic function | Q29615873 | ||
| Cellular senescence impairs circadian expression of clock genes in vitro and in vivo | Q82312042 | ||
| Sleep and Alzheimer disease pathology--a bidirectional relationship | Q37691522 | ||
| Melatonin as a natural ally against oxidative stress: a physicochemical examination. | Q37900675 | ||
| Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin | Q37959556 | ||
| The circadian system in Alzheimer's disease: disturbances, mechanisms, and opportunities | Q38070232 | ||
| Health consequences of circadian disruption in humans and animal models | Q38125290 | ||
| Sleep and Alzheimer's disease | Q38213352 | ||
| Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial | Q38389742 | ||
| Effect of 1 night of total sleep deprivation on cerebrospinal fluid β-amyloid 42 in healthy middle-aged men: a randomized clinical trial. | Q38429137 | ||
| Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men. | Q39262156 | ||
| A change in sleep pattern may predict Alzheimer disease | Q39365562 | ||
| Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. | Q40237749 | ||
| Melatonin rhythmicity: effect of age and Alzheimer's disease | Q40609056 | ||
| Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia | Q41513820 | ||
| The suprachiasmatic nucleus: a 25-year retrospective | Q41745849 | ||
| SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging | Q41965359 | ||
| Central and peripheral circadian clocks in mammals | Q29616556 | ||
| Circadian integration of metabolism and energetics | Q29619638 | ||
| Sleep drives metabolite clearance from the adult brain | Q29620065 | ||
| Circadian rhythms in isolated brain regions. | Q30308429 | ||
| A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. | Q30405370 | ||
| Vascular disease in mice with a dysfunctional circadian clock | Q30490924 | ||
| Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling | Q30496197 | ||
| Self-reported sleep and β-amyloid deposition in community-dwelling older adults | Q30571257 | ||
| 3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress | Q33818420 | ||
| Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex. | Q34062527 | ||
| Relationships between the circadian system and Alzheimer's disease-like symptoms in Drosophila | Q34110020 | ||
| Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system | Q34215733 | ||
| Sleep and quantitative EEG in neurodegenerative disorders | Q34323865 | ||
| Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons | Q34354571 | ||
| Neuronal activity regulates the regional vulnerability to amyloid-β deposition | Q35009626 | ||
| Regional slow waves and spindles in human sleep | Q35026849 | ||
| Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons | Q35085345 | ||
| Circadian regulation of ATP release in astrocytes. | Q35103975 | ||
| The Role of Actigraphy in the Study of Sleep and Circadian Rhythms | Q35128463 | ||
| Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women | Q35630404 | ||
| Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening | Q35657707 | ||
| Sleep quality and 1-year incident cognitive impairment in community-dwelling older adults | Q35812463 | ||
| Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals | Q35875614 | ||
| Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity | Q35973444 | ||
| Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology | Q36845156 | ||
| Sleep quality and preclinical Alzheimer disease | Q36913338 | ||
| Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease | Q37070699 | ||
| Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease | Q37097780 | ||
| Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker | Q37115125 | ||
| The clock proteins, aging, and tumorigenesis | Q37141089 | ||
| Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice | Q37148516 | ||
| Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease | Q37189923 | ||
| Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice | Q37373211 | ||
| Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. | Q37383982 | ||
| Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep | Q37384609 | ||
| The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease | Q37682380 | ||
| The polymorphism of CLOCK gene 3111T/C C>T is associated with susceptibility of Alzheimer disease in Chinese population | Q44213884 | ||
| Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels | Q44530237 | ||
| Polymorphism of CLOCK gene rs 4580704 C > G is associated with susceptibility of Alzheimer's disease in a Chinese population | Q44650658 | ||
| Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia | Q44785336 | ||
| Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease | Q45007608 | ||
| Effects of exogenous melatonin on sleep: a meta-analysis | Q45223376 | ||
| Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission | Q45263139 | ||
| Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. | Q45963204 | ||
| Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials | Q46390270 | ||
| Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease | Q46842802 | ||
| Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study | Q46970981 | ||
| Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles | Q48119911 | ||
| Sleep disturbance is associated with incident dementia and mortality | Q48162950 | ||
| Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes | Q48197464 | ||
| Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain | Q48241110 | ||
| Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease. | Q48242382 | ||
| Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock. | Q48247182 | ||
| EEG, Activity, and Sleep Architecture in a Transgenic AβPPswe/PSEN1A246E Alzheimer's Disease Mouse | Q48339814 | ||
| The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia | Q48453920 | ||
| Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock". | Q48480022 | ||
| Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation | Q48533960 | ||
| Sleep deprivation induces the unfolded protein response in mouse cerebral cortex | Q48562258 | ||
| The light-dark cycle controls peripheral rhythmicity in mice with a genetically ablated suprachiasmatic nucleus clock. | Q48636203 | ||
| Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse | Q48771399 | ||
| Sleep EEG in Korsakoff's psychosis and Alzheimer's disease | Q49016777 | ||
| Changes in the sleep and waking EEGs of nondemented and demented elderly subjects | Q49147511 | ||
| Disturbances of sleep and cognitive functioning in patients with dementia | Q49150879 | ||
| Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population. | Q50895633 | ||
| VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease. | Q51045591 | ||
| Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. | Q53274559 | ||
| Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients | Q59449484 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported | Q19125045 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | circadian rhythm | Q208353 |
| pathogenesis | Q372016 | ||
| Alzheimer's disease | Q11081 | ||
| sleep | Q35831 | ||
| physiological phenomenon | Q66615932 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | e148 | |
| P577 | publication date | 2015-03-13 | |
| P1433 | published in | Experimental and Molecular Medicine | Q15758292 |
| P1476 | title | Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease | |
| P478 | volume | 47 |
| Q37213267 | Aberrant brain stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease |
| Q89685520 | Acute Sleep-Wake Cycle Shift Results in Community Alteration of Human Gut Microbiome |
| Q99590938 | Age, Sex Hormones, and Circadian Rhythm Regulate the Expression of Amyloid-Beta Scavengers at the Choroid Plexus |
| Q33914477 | Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation |
| Q46506577 | An EEG Investigation of Sleep Homeostasis in Healthy and CLN5 Batten Disease Affected Sheep. |
| Q55510296 | Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions. |
| Q47857808 | Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being. |
| Q92596034 | Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors |
| Q38770352 | Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system |
| Q64060065 | Cell Kinetics in the Adult Neurogenic Niche and Impact of Diet-Induced Accelerated Aging |
| Q47095817 | Central and peripheral circadian clocks and their role in Alzheimer's disease. |
| Q50199042 | Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects |
| Q92401437 | Changes in sleep duration and 3-year risk of mild cognitive impairment in Chinese older adults |
| Q33850996 | Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource. |
| Q92884337 | Chronic Sleep Disruption Potentiates Locus Ceruleus Tauopathy in a Mouse Model of Alzheimer's Disease |
| Q47768829 | Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta-Amyloid Deposition in Mice via BACE1-Antisense Activation |
| Q39190597 | Circadian Disruption Associated with Alzheimer's Disease |
| Q52338672 | Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms. |
| Q64785507 | Circadian Rest-Activity Rhythms Predict Cognitive Function in Early Parkinson's Disease Independently of Sleep |
| Q42365799 | Circadian Rhythm Disruption and Subsequent Neurological Disorders in Night-Shift Workers |
| Q64882308 | Circadian Rhythm and Alzheimer's Disease. |
| Q47648230 | Circadian Rhythms in AD pathogenesis: A Critical Appraisal |
| Q59335778 | Circadian Rhythms in Fractal Features of EEG Signals |
| Q55002622 | Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease. |
| Q64066929 | Circadian control of stress granules by oscillating EIF2α |
| Q41838423 | Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease |
| Q92006235 | Circadian variations in electric current responses at ryodoraku points across the waking stage: A prospective observational study |
| Q26772851 | Clinical management of sleep disturbances in Alzheimer's disease: current and emerging strategies |
| Q40371181 | Cognitive function and insulin resistance in elderly patients with type 2 diabetes |
| Q46463478 | Combinatorial Treatment Effects in a Cell Culture Model of Alzheimer's Disease. |
| Q64237109 | DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder |
| Q39312074 | Daily Physical Activity Patterns During the Early Stage of Alzheimer's Disease |
| Q37400125 | Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE(-/-) mice: implications for Alzheimer's disease |
| Q98186330 | Dementia prevention, intervention, and care: 2020 report of the Lancet Commission |
| Q47122394 | Development of a Measure of Sleep, Circadian Rhythms, and Mood: The SCRAM Questionnaire. |
| Q60046418 | Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer's Disease |
| Q37738358 | Does selection for short sleep duration explain human vulnerability to Alzheimer's disease? |
| Q47667953 | Dysfunction of GABAergic neurons in the parafacial zone mediates sleep disturbances in a streptozotocin-induced rat model of sporadic Alzheimer's disease |
| Q90429688 | Effect of sleep quality on amnestic mild cognitive impairment vulnerable brain regions in cognitively normal elderly individuals |
| Q46159810 | Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease |
| Q64937259 | Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation. |
| Q38594487 | EphA4 is Involved in Sleep Regulation but Not in the Electrophysiological Response to Sleep Deprivation |
| Q92702813 | Evaluation of waist-worn actigraphy monitors for the assessment of sleep in older adults with and without Alzheimer's disease |
| Q53397904 | Fractal regulation and incident Alzheimer's disease in elderly individuals. |
| Q91822555 | From clock to functional pacemaker |
| Q42760212 | Functional conservation of MBD proteins: MeCP2 and Drosophila MBD proteins alter sleep. |
| Q37413462 | Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments |
| Q48100550 | Hypocretin underlies the evolution of sleep loss in the Mexican cavefish |
| Q47675160 | Impact of Alzheimer disease patients' sleep disturbances on their caregivers |
| Q38885836 | Impairments of neural circuit function in Alzheimer's disease |
| Q91682965 | Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease |
| Q90261938 | Inhibition of casein kinase 1δ/εimproves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease |
| Q90485708 | Interaction between the progression of Alzheimer's disease and fractal degradation |
| Q55083969 | Interactions between stress and physical activity on Alzheimer's disease pathology. |
| Q90267428 | Intracerebroventricular streptozotocin-induced Alzheimer's disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex |
| Q64095712 | Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice |
| Q36840174 | Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies. |
| Q47580999 | Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice |
| Q53448459 | Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease. |
| Q41429910 | Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study. |
| Q64990755 | Loss of DmGluRA exacerbates age-related sleep disruption and reduces lifespan. |
| Q38834700 | Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases. |
| Q36302335 | Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology |
| Q93159431 | Molecular dynamics simulations of nucleotide release from the circadian clock protein KaiC reveal atomic-resolution functional insights |
| Q92448025 | Molecular mechanism of tumour necrosis factor alpha regulates hypocretin (orexin) expression, sleep and behaviour |
| Q64061289 | Mutant huntingtin disturbs circadian clock gene expression and sleep patterns in Drosophila |
| Q58571286 | Neurodegeneration-associated FUS is a novel regulator of circadian gene expression |
| Q99730750 | Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes |
| Q33644324 | Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease |
| Q47557441 | New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation |
| Q28315261 | Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer's disease-risk genes |
| Q91743627 | Oxidized cholesterol species as signaling molecules in the brain: diabetes and Alzheimer's disease |
| Q90568291 | Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need |
| Q64056852 | Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease |
| Q27308084 | Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers. |
| Q40322969 | Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. |
| Q45810823 | Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning |
| Q38692513 | Rest-activity rhythms in small scale homelike care and traditional care for residents with dementia |
| Q97530319 | Robust light-dark patterns and reduced amyloid load in an Alzheimer's disease transgenic mouse model |
| Q91867201 | Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep |
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| Q39227542 | Self-Reported Sleep Apnea and Dementia Risk: Findings from the Prevention of Alzheimer's Disease with Vitamin E and Selenium Trial |
| Q90825195 | Sex differences in sleep and sleep loss-induced cognitive deficits: The influence of gonadal hormones |
| Q36904896 | Sex differences in the circadian regulation of sleep and waking cognition in humans |
| Q92582409 | Significant association between GPR50 hypomethylation and AD in males |
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| Q91687564 | Sleep and β-Amyloid Deposition in Alzheimer Disease: Insights on Mechanisms and Possible Innovative Treatments |
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| Q96136920 | The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer's Disease-related Pathogenesis |
| Q38683219 | The Neural Basis for Sleep Regulation - Data Assimilation from Animal to Model. |
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| Q33915828 | The natural Disc1-deletion present in several inbred mouse strains does not affect sleep. |
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| Q50645228 | [Connections between sleep and Alzheimer's disease : Insomnia, amnesia and amyloid]. |
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