AMPA receptors as a molecular target in epilepsy therapy

scientific article

AMPA receptors as a molecular target in epilepsy therapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/ANE.12099
P932PMC publication ID4506648
P698PubMed publication ID23480151
P5875ResearchGate publication ID264515377

P2093author name stringM. A. Rogawski
P2860cites workAdjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304Q24621743
ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and traumaQ24651797
Limbic Network Synchronization and Temporal Lobe EpilepsyQ26829366
Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonistQ27022395
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding coreQ27628494
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonistsQ27648934
Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activityQ27667622
6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonistsQ27676408
Synaptic plasticity: multiple forms, functions, and mechanismsQ28242702
The neurobiology of antiepileptic drugsQ28267900
Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII)Q28278051
Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonistsQ32020572
Competitive AMPA receptor antagonistsQ33253052
Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II.Q33405238
Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: the Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives.Q34068562
Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moietyQ34150442
Bicuculline-induced epileptogenesis in the human neocortex maintained in vitroQ48826718
Cellular mechanism of neuronal synchronization in epilepsyQ48944149
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemiaQ49105194
Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonistsQ50508039
A venus flytrap mechanism for activation and desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors.Q50761820
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.Q51768833
The non-NMDA receptor antagonist NBQX does not affect rats performance in the object recognition task.Q52014707
AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations.Q52024740
Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: Results of randomized global phase III study 305Q56960260
The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsyQ67650018
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in miceQ67864155
Probenecid pretreatment enhances anticonvulsant action of NBQX in miceQ68011398
Synchronous discharges in the rat entorhinal cortex in vitro: site of initiation and the role of excitatory amino acid receptorsQ68463385
How do seizures begin? Clues from hippocampal slicesQ69062464
Involvement of non-NMDA receptors in picrotoxin-induced epileptiform activity in the hippocampusQ69378276
Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the CA3 region of the in vitro hippocampusQ69929245
The kainate/quisqualate receptor antagonist, CNQX, blocks the fast component of spontaneous epileptiform activity in organotypic cultures of rat hippocampusQ69931570
YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonistQ70891947
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBQX in maximal electroshock and chemoconvulsant seizure modelsQ72101996
New non competitive AMPA antagonistsQ72995294
Excitatory amino acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasksQ34178907
Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala.Q34315838
(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.Q34356576
In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.Q34368594
Non-competitive AMPA antagonists of 2,3-benzodiazepine typeQ34595297
YM872: a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist.Q35025108
The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunitsQ35058291
Ionotropic and metabotropic glutamate receptor structure and pharmacologyQ36054635
Regulation of AMPA receptor trafficking and synaptic plasticity.Q36083970
Regulatory mechanisms of AMPA receptors in synaptic plasticityQ36712947
Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal deathQ36726811
The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity.Q36854587
AMPA receptors and synaptic plasticity: a chemist's perspectiveQ37676916
TARPs differentially decorate AMPA receptors to specify neuropharmacologyQ37706709
Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?Q38003608
Excitatory amino acid receptors in the vertebrate central nervous systemQ38316536
Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approachQ39991874
Molecular analysis of the interaction of the pyrazine derivatives RPR119990 and RPR117824 with human AMPA-type glutamate receptor channelsQ40339267
Molecular mechanism of AMPA receptor noncompetitive antagonismQ40359241
Excitatory synaptic interactions between CA3 neurones in the guinea-pig hippocampusQ41904635
Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARsQ42287869
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedsideQ43113304
9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): selective anticonvulsive and neuroprotective AMPA antagonist.Q43911240
Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonistQ44378881
Expression of transcripts encoding AMPA receptor subunits and associated postsynaptic proteins in the macaque brainQ44702192
Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in ratsQ45025717
Synaptic and intrinsic conductances shape picrotoxin-induced synchronized after-discharges in the guinea-pig hippocampal sliceQ46177192
Inhibitory control of local excitatory circuits in the guinea-pig hippocampusQ46539366
Stargazin modulates AMPA receptor antagonismQ46672870
Single neurones can initiate synchronized population discharge in the hippocampusQ46865979
Effect of YM872, a selective and highly water-soluble AMPA receptor antagonist, in the rat kindling and rekindling model of epilepsyQ46887470
Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures.Q47880985
New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neuronsQ48087676
Effects of YM90K, a selective AMPA receptor antagonist, on amygdala-kindling and long-term hippocampal potentiation in the rat.Q48152058
Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsyQ48171460
The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizuresQ48178824
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activityQ48205226
Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.Q48278700
Electrophysiological substrates for focal epilepsiesQ48291431
GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responsesQ48392369
NBQX does not affect learning and memory tasks in mice: a comparison with D-CPPene and ifenprodilQ48470338
Low-calcium field burst discharges of CA1 pyramidal neurones in rat hippocampal slicesQ48627089
The involvement of excitatory amino acids in neocortical epileptogenesis: NMDA and non-NMDA receptorsQ48824426
P433issue197
P407language of work or nameEnglishQ1860
P304page(s)9-18
P577publication date2013-01-01
P1433published inActa neurologica Scandinavica. SupplementumQ27020379
P1476titleAMPA receptors as a molecular target in epilepsy therapy

Reverse relations

cites work (P2860)
Q41917625A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy
Q36202511AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets
Q38134724Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?
Q36575895BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice
Q38154633BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy
Q51749309Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.
Q55300091Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel.
Q90004768Cost-effectiveness of perampanel for the treatment of primary generalized tonic-clonic seizures (PGTCS) in epilepsy: A Spanish perspective
Q46748196Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.
Q38675314Current role of perampanel in pediatric epilepsy.
Q38088290Development of perampanel in epilepsy
Q57788206Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions
Q36174777EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors
Q37571770Early-life stress impacts the developing hippocampus and primes seizure occurrence: cellular, molecular, and epigenetic mechanisms
Q90390690Efficacy and tolerability of perampanel in children and adolescents with pharmacoresistant epilepsy: The first real-world evaluation in Asian pediatric neurology clinics
Q30728243Efficacy of perampanel: a review of pooled data
Q27715636Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy
Q36284015Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.
Q30008868Expression of SHANK3 in the Temporal Neocortex of Patients with Intractable Temporal Epilepsy and Epilepsy Rat Models
Q66679720Functional Nutrients for Epilepsy
Q34233508Ganglioside regulation of AMPA receptor trafficking
Q41792375GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile
Q34048502Glutamate as a neurotransmitter in the healthy brain
Q38535033Glutamatergic Mechanisms Associated with Seizures and Epilepsy
Q39011258Guanosine protects C6 astroglial cells against azide-induced oxidative damage: a putative role of heme oxygenase 1.
Q59795983High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology
Q88687361Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability
Q90520789Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
Q39120013Lens Biology is a Dimension of Neurobiology
Q57970623Leptin: role over central nervous system in epilepsy
Q28272457Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet
Q47771228Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders.
Q92490611Modulation of AMPA Receptor Gating by the Anticonvulsant Drug, Perampanel
Q47601255On Rhythms in Neuronal Networks with Recurrent Excitation
Q64076569Perampanel Affects Up-Stream Regulatory Signaling Pathways of GluA1 Phosphorylation in Normal and Epileptic Rats
Q57175088Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus
Q26796447Perampanel in the management of partial-onset seizures: a review of safety, efficacy, and patient acceptability
Q21131943Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons
Q30819017Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy
Q30837245Precision therapy for a new disorder of AMPA receptor recycling due to mutations in ATAD1.
Q27022395Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist
Q35117565Reactive astrogliosis causes the development of spontaneous seizures
Q47112846Regulation of AMPA Receptor Trafficking by Protein Ubiquitination.
Q90481628Regulation of Ion Channels by MicroRNAs and the Implication for Epilepsy
Q64274255Role of the Angiotensin Pathway and its Target Therapy in Epilepsy Management
Q41598077Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
Q92628295Successful Treatment of Primary Orthostatic Tremor Using Perampanel
Q40016074Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy
Q34395565Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy.
Q38205934The AMPA receptor antagonist perampanel is a new hope in the treatment for epilepsy
Q36909520The New Antiepileptic Drugs: Their Neuropharmacology and Clinical Indications
Q37559828The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: autism spectrum disorders and fragile x syndrome.
Q27349241Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity
Q36097600Volterra representation enables modeling of complex synaptic nonlinear dynamics in large-scale simulations.
Q34679478X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism
Q59356159ZDHHC8 critically regulates seizure susceptibility in epilepsy

Search more.