The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands (scientific article (publication date: 2014))

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Q101476452	Deciphering cell-cell interactions and communication from gene expression
Q37686138	Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers
Q37084892	Detecting moxifloxacin-induced QTc prolongation in thorough QT and early clinical phase studies using a highly automated ECG analysis approach
Q42559814	Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.
Q39157622	Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis
Q97552575	Diabetic nephropathy produces alterations in the tissue expression profile of the orphan receptors GPR149, GPR153, GPR176, TAAR3, TAAR5 and TAAR9 in Wistar rats
Q36830115	Diacylglycerol lipase β inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain.
Q38949654	Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability
Q36342144	Dietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt
Q36744208	Differences in asthma study models and the effectiveness of β2 -adrenoceptor ligands: response to Lipworth et al.
Q34619471	Different apoptotic effects of [Pt(O,O'-acac)(γ-acac)(DMS)] and cisplatin on normal and cancerous human epithelial breast cells in primary culture
Q35739137	Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells
Q35111456	Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine
Q35223927	Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red.
Q36797363	Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice
Q35911773	Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway
Q36395003	Dipeptidyl peptidase 4 promotes epithelial cell transformation and breast tumourigenesis via induction of PIN1 gene expression
Q35595863	Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels
Q36599646	Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose
Q35538516	Divergent effects of the 'biased' 5-HT1 A receptor agonists F15599 and F13714 in a novel object pattern separation task.
Q36893893	Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle.
Q47951444	Docking and Virtual Screening in Drug Discovery
Q43101490	Dopamine D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells
Q28256783	Dopamine receptors - IUPHAR Review 13
Q35692993	Dose-dependent biphasic leptin-induced proliferation is caused by non-specific IL-6/NF-κB pathway activation in human myometrial cells
Q41295260	Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1
Q36830132	Drp-1, a potential therapeutic target for brain ischaemic stroke
Q42551182	Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling
Q94960045	Drug repositioning or target repositioning: A structural perspective of drug-target-indication relationship for available repurposed drugs
Q38568763	Drug-target interaction prediction: databases, web servers and computational models
Q36507791	Dynamics of Phosphoinositide-Dependent Signaling in Sympathetic Neurons.
Q38889914	Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-κB activation
Q36036258	Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells
Q37085527	Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours
Q40625919	Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia
Q42552831	Effect of erythropoietin on hepatic cytochrome P450 expression and function in an adenine-fed rat model of chronic kidney disease
Q34939900	Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord
Q42412797	Effect of polyphenolic phytochemicals on ectopic oxidative phosphorylation in rod outer segments of bovine retina
Q35573896	Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels
Q35846206	Effective suppression of pro-inflammatory molecules by DHCA via IKK-NF-κB pathway, in vitro and in vivo.
Q38694069	Effects of P2Y12 receptor antagonists beyond platelet inhibition--comparison of ticagrelor with thienopyridines
Q43019107	Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin-dependent protein kinase II.
Q34914328	Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice
Q42114497	Effects of chronic treatment with the new ultra-long-acting β2 -adrenoceptor agonist indacaterol alone or in combination with the β1 -adrenoceptor blocker metoprolol on cardiac remodelling
Q36903400	Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.
Q35895873	Effects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract
Q41432075	Effects of receptor tyrosine kinase inhibitors on VEGF165 a- and VEGF165 b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2.
Q37084868	Effects of the imidazoline I2 receptor agonist 2-BFI on the development of tolerance to and behavioural/physical dependence on morphine in rats
Q35538521	Effects of the novel BK (KCa 1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BKβ subunits
Q36124232	Eicosapentaenoic acid prevents TCDD-induced oxidative stress and inflammatory response by modulating MAP kinases and redox-sensitive transcription factors
Q36342111	Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases
Q34559604	Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta
Q35682184	Enantioselective inhibition of d-serine transport by (S)-ketamine
Q34953319	Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey
Q42107964	Endocannabinoids modulate human blood-brain barrier permeability in vitro
Q38235155	Endothelial atypical cannabinoid receptor: do we have enough evidence?
Q26767156	Endothelin
Q36016411	Endothelin ETA receptor/lipid peroxides/COX-2/TGF-β1 signalling underlies aggravated nephrotoxicity caused by cyclosporine plus indomethacin in rats
Q43101498	Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors.
Q37084544	Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species
Q40559309	Endothelin-1 shifts the mediator of bradykinin-induced relaxation from NO to H2 O2 in resistance arteries from patients with cardiovascular disease
Q37686147	Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells
Q41891837	Endothelin-converting enzyme 2 differentially regulates opioid receptor activity
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Q35286438	Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model
Q36506903	Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells
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Q35631463	Epigenetics in the perioperative period
Q35865417	Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels
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Q34954104	Evaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile
Q35223907	Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains.
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Q35204841	Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats
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Q27021649	Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS
Q35286339	Extracellular signalling molecules in the ischaemic/reperfused heart - druggable and translatable for cardioprotection?
Q35111461	FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation.
Q36599618	Fasting protects against the side effects of irinotecan treatment but does not affect anti-tumour activity in mice
Q37686153	Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway
Q28649345	Finding small molecules for the 'next Ebola'
Q27021274	Fine-tuning somatostatin receptor signalling by agonist-selective phosphorylation and dephosphorylation: IUPHAR Review 5
Q37446861	Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding.
Q34435307	Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase.
Q42926933	From mouse to man: predicting biased effects of beta-blockers in asthma.
Q37686113	Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A.
Q28087460	Future technology insight: mass spectrometry imaging as a tool in drug research and development
Q28081099	G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets
Q35538506	GPCR dimerization in brainstem nuclei contributes to the development of hypertension.
Q39959829	GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature
Q36398022	GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis.
Q27005640	Gaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessors
Q36599642	Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells
Q37084887	Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon
Q28087587	Generic GPCR residue numbers - aligning topology maps while minding the gaps
Q36036232	Genetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation.
Q40834847	Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin
Q37686132	Genipin alleviates sepsis-induced liver injury by restoring autophagy
Q36342172	Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice
Q39090278	Genomic variant annotation workflow for clinical applications
Q38921881	Glial cell line-derived neurotrophic factor-mediated enhancement of noradrenergic descending inhibition in the locus coeruleus exerts prolonged analgesia in neuropathic pain
Q28067465	Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes
Q35538527	Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics.
Q38974021	Glutathione administration reduces mitochondrial damage and shifts cell death from necrosis to apoptosis in ageing diabetic mice hearts during exercise
Q35484483	Haloperidol inhibits the development of atherosclerotic lesions in LDL receptor knockout mice
Q31053398	Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk
Q34953430	Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling
Q36744223	High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with the neuromyelitis optica autoantibody, NMO-IgG.
Q36744177	High glucose-induced changes in hyaloid-retinal vessels during early ocular development of zebrafish: a short-term animal model of diabetic retinopathy
Q35223938	High-affinity σ1 protein agonist reduces clinical and pathological signs of experimental autoimmune encephalomyelitis.
Q36546975	High-density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin-1.
Q37005127	High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice
Q40160363	Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated-neurotransmission in vitro and in vivo
Q38264340	Histamine H₄ receptors in the gastrointestinal tract.
Q36744218	Homoharringtonine binds to and increases myosin-9 in myeloid leukaemia
Q37084539	Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression
Q92219065	How to Develop a Drug Target Ontology: KNowledge Acquisition and Representation Methodology (KNARM)
Q35693003	HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration
Q42606979	Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block.
Q35484400	Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells
Q35846184	Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.
Q42317689	Hydrogen peroxide activates store-operated Ca(2+) entry in coronary arteries.
Q34795751	Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling
Q38236845	Hydrogen sulfide: physiological properties and therapeutic potential in ischaemia.
Q35314338	Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota.
Q38564991	Hypersensitivity to intravenous iron: classification, terminology, mechanisms and management
Q38808680	Hypoglycemia unawareness prevention: Targeting glucagon production
Q34914125	IL-1β and IL-18: inflammatory markers or mediators of hypertension?
Q35978086	IL-1β reduces tonic contraction of mesenteric lymphatic muscle cells, with the involvement of cycloxygenase-2 and prostaglandin E2.
Q35865421	Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
Q37084901	Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.
Q40954666	Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method.
Q38833147	Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors
Q36744202	Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase
Q39909994	Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation
Q34402836	Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer
Q36016417	Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target
Q34447665	Identification of muscarinic receptor subtypes involved in catecholamine secretion in adrenal medullary chromaffin cells by genetic deletion
Q34669726	Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy.
Q36830137	Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars
Q37183342	Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.
Q38978556	Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays
Q38720041	Identifying ligands at orphan GPCRs: current status using structure-based approaches
Q35911759	Imidazole-based alkaloid derivative LCB54-0009 suppresses ocular angiogenesis and lymphangiogenesis in models of experimental retinopathy and corneal neovascularization.
Q36547012	Immunoinflammatory diseases of the central nervous system - the tale of two cytokines
Q36797398	Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18.
Q90295510	In Silico Target Prediction for Small Molecules
Q47168067	In silico prediction of chemical mechanism of action via an improved network-based inference method
Q34571432	In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.
Q35538532	In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin
Q34914312	In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1.
Q34953409	In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice
Q35039228	Indoline-3-propionate and 3-aminopropyl carbamates reduce lung injury and pro-inflammatory cytokines induced in mice by LPS
Q37686319	Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock.
Q38263512	Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells
Q36546979	Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.
Q36546990	Inflammation in acute CNS injury: a focus on the role of substance P
Q42552830	Inflammation: maladies, models, mechanisms and molecules
Q35693020	Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation.
Q41861087	Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction
Q35911749	Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, by down-regulating EGFR expression.
Q36941262	Inhibition of fatty acid synthase is protective in pulmonary hypertension
Q34994542	Inhibition of monoacylglycerol lipase reduces nicotine withdrawal
Q40920822	Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864.
Q37686101	Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling
Q56980193	Insights into Transporter Classifications: an Outline of Transporters as Drug Targets
Q41635414	Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling.
Q37686098	Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses.
Q58104031	Integrative Data Mining, Scaffold Analysis, and Sequential Binary Classification Models for Exploring Ligand Profiles of Hepatic Organic Anion Transporting Polypeptides (OATPs)
Q36016439	Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis.
Q35111472	Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.
Q41912702	Interplay between the kinin B1 receptor and inducible nitric oxide synthase in insulin resistance
Q36941272	Intersubunit interactions at putative sites of ethanol action in the M3 and M4 domains of the NMDA receptor GluN1 and GluN2B subunits
Q36830128	Intranasal exposure to monoclonal antibody Fab fragments to Japanese cedar pollen Cry j1 suppresses Japanese cedar pollen-induced allergic rhinitis
Q36599633	Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection
Q35631488	Involvement of neuronal TGF-β activated kinase 1 in the development of tolerance to morphine-induced antinociception in rat spinal cord
Q37084878	Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinol
Q36599656	Involvement of transglutaminase 2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries.
Q92756951	Ion Channel Expression in Human Melanoma Samples: In Silico Identification and Experimental Validation of Molecular Targets
Q34994519	Ionic mechanisms underlying the negative chronotropic action of propofol on sinoatrial node automaticity in guinea pig heart
Q40046136	Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway
Q27000466	Ischaemic conditioning: pitfalls on the path to clinical translation
Q35692999	Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels
Q34480719	Ketamine and phencyclidine: the good, the bad and the unexpected
Q40920574	Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat.
Q36533102	Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines
Q39116722	Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors.
Q39960011	LPS exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea pig model of asthma
Q42173694	Lack of weight gain after angiotensin AT1 receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway
Q40720078	Large-Scale Combinatorial Deorphanization of Platynereis Neuropeptide GPCRs
Q50936162	Large-scale identification of potential drug targets based on the topological features of human protein-protein interaction network.
Q57434536	Ligand-Mediated Toxicology: Characterization and Translational Prospects
Q34954084	Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway
Q35039240	Localization of sunitinib, its metabolites and its target receptors in tumour-bearing mice: a MALDI-MS imaging study
Q27022641	Localization of α-adrenoceptors: JR Vane Medal Lecture
Q35978075	Long-lasting partnership between insulin resistance and endothelial dysfunction: role of metabolic memory.
Q36744182	Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity
Q38825816	Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).
Q40849897	Luminal 5-HT stimulates colonic bicarbonate secretion in rats
Q34025135	Lysophospholipid receptor nomenclature review: IUPHAR Review 8.
Q38863938	MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis
Q42109896	MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis
Q35484424	MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway
Q92724567	Machine learning approaches and databases for prediction of drug-target interaction: a survey paper
Q36394984	Macrolides increase the expression of 11β-hydroxysteroid dehydrogenase 1 in human sinonasal epithelium, contributing to glucocorticoid activation in sinonasal mucosa
Q37686310	Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon
Q27943500	Many InChIs and quite some feat
Q37685010	Mapping the function of neuronal ion channels in model and experiment
Q38809010	Mass spectrometric analysis of synaptosomal membrane preparations for the determination of brain receptors, transporters and channels
Q35204865	Measurement of NO in biological samples
Q28601949	Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker
Q36016433	Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium
Q37686121	Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia
Q34795689	Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells
Q37686103	Medial prefrontal cortex TRPV1 channels modulate the baroreflex cardiac activity in rats
Q42107527	Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action
Q36506877	Meningeal blood flow is controlled by H2 S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway
Q35865424	Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice.
Q30885784	Metabolic Profiling and Phenotyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions
Q34953372	Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma
Q38567309	Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias
Q37686108	Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation
Q34402820	Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F NaV 1.7 sodium channels.
Q38692790	Microglia antioxidant systems and redox signalling
Q36547001	Microglial M1/M2 polarization and metabolic states
Q36546971	Microglial activation and progressive brain changes in schizophrenia
Q36506889	Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1 -adrenoceptor blockade
Q35223924	Mitochondrial (dys)function - a factor underlying the variability of efavirenz-induced hepatotoxicity?
Q41056910	Model-based prediction of the acute and long-term safety profile of naproxen in rats
Q36797402	Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats.
Q42088341	Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies
Q42554178	Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants
Q39062474	Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2.
Q36211191	Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.
Q42221343	Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor
Q42700069	Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.
Q35039217	Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3.
Q38597820	Molecular switches under TGFβ signalling during progression from cardiac hypertrophy to heart failure
Q34914164	Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus
Q36599623	Monoclonal antibodies: the new magic bullets for allergy: IUPHAR Review 17.
Q43019372	Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity
Q34559591	Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine--a quantitative EEG study in rats
Q35187070	Multiple roles of the PGE2 -EP receptor signal in vascular permeability
Q36599662	N-terminally and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor
Q38691764	NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease
Q40920604	NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia
Q35851832	NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function.
Q40324920	Natural and synthetic flavonoid modulation of TRPC5 channels
Q88785856	Network-Based Disease Module Discovery by a Novel Seed Connector Algorithm with Pathobiological Implications
Q88973776	Network-based Drug Repurposing for Human Coronavirus
Q92872703	Network-based Prediction of Drug-Target Interactions using an Arbitrary-Order Proximity Embedded Deep Forest
Q55643995	Network-based approach to prediction and population-based validation of in silico drug repurposing.
Q90482543	Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Q64099168	Network-based prediction of drug combinations
Q36744227	Neural correlates of interactions between cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications for medical cannabis
Q36394976	Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats.
Q37005143	Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease
Q34914245	Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders
Q35978159	Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors.
Q38263507	Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2.
Q51210141	New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies.
Q38779697	New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases
Q35978145	New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit?
Q36903409	New use for an old drug: COX-independent anti-inflammatory effects of sulindac in models of cystic fibrosis.
Q39674355	Nicergoline inhibits human platelet Ca(2+) signalling through triggering a microtubule-dependent reorganization of the platelet ultrastructure
Q91826855	NicheNet: modeling intercellular communication by linking ligands to target genes
Q34572211	Nicotinic acetylcholine receptors control acetylcholine and noradrenaline release in the rodent habenulo-interpeduncular complex
Q38264366	Noble gases as cardioprotectants - translatability and mechanism
Q37084897	Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma
Q35111445	Novel Nrf2 activators from microbial transformation products inhibit blood-retinal barrier permeability in rabbits.
Q36941258	Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway.
Q34953338	Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability
Q35484363	Novel immunosuppressive agent caerulomycin A exerts its effect by depleting cellular iron content
Q36342131	Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases
Q36342140	Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms.
Q36342177	Oestrogen inhibits BMP4-induced BMP4 expression in cardiomyocytes: a potential mechanism of oestrogen-mediated protection against cardiac hypertrophy
Q38710840	On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targets
Q35286353	Opioid receptors and cardioprotection - 'opioidergic conditioning' of the heart
Q38631744	Optical probes based on G protein-coupled receptors - added work or added value?
Q34559586	Orexin A activates hypoglossal motoneurons and enhances genioglossus muscle activity in rats.
Q35471045	Orphan nuclear receptors as drug targets for the treatment of prostate and breast cancers
Q38960964	Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody
Q34518822	Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity
Q92676934	P2X4 receptors, immunity, and sepsis
Q34402844	PAR1-dependent COX-2/PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes
Q36016406	PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis
Q100733548	PIMD: An Integrative Approach for Drug Repositioning Using Multiple Characterization Fusion
Q43105838	PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels.
Q36016445	PKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitization
Q35865449	PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.
Q37686110	PPARγ agonists regulate bidirectional transport of amyloid-β across the blood-brain barrier and hippocampus plasticity in db/db mice
Q34914220	PPemd26, an anthraquinone derivative, suppresses angiogenesis via inhibiting VEGFR2 signalling
Q34571380	Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB₁ receptors and TRPV1 channels
Q34795735	Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent
Q36941269	Pancreatic polypeptide and its central Y4 receptors are essential for cued fear extinction and permanent suppression of fear
Q35978108	Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer
Q35978127	Pharmacological actions of nobiletin in the modulation of platelet function.
Q38909233	Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel
Q34402775	Pharmacological bronchodilation is partially mediated by reduced airway wall stiffness
Q36797357	Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo
Q36599638	Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4
Q35911768	Pharmacological inhibition of caspase-8 limits lung tumour outgrowth.
Q34407191	Pharmacological manipulations in animal models of anorexia and binge eating in relation to humans.
Q38915494	Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo.
Q35693011	Pharmacological modulation of autophagy to protect cardiomyocytes according to the time windows of ischaemia/reperfusion
Q34466872	Pharmacological profile of novel psychoactive benzofurans
Q35223930	Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat.
Q34402759	Pharmacological regulators of autophagy and their link with modulators of lupus disease
Q34994550	Pharmacological targeting of GSK3β confers protection against podocytopathy and proteinuria by desensitizing mitochondrial permeability transition
Q38218546	Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginners
Q39176672	Pharmacologically distinct phenotypes of α1B -adrenoceptors: variation in binding and functional affinities for antagonists.
Q36211219	Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line
Q28084793	Phosphodiesterase 4D: an enzyme to remember
Q35039202	Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury
Q40946825	Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage
Q42205768	Pleiotropic, heart rate-independent cardioprotection by ivabradine.
Q36797368	PnPP-19, a spider toxin peptide, induces peripheral antinociception through opioid and cannabinoid receptors and inhibition of neutral endopeptidase
Q36599652	Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth
Q38787139	Possible role for anisodamine in organophosphate poisoning
Q27021021	Postconditioning signalling in the heart: mechanisms and translatability
Q38752093	Posttranscriptional regulation of FOXO expression: microRNAs and beyond
Q34472557	Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088 on rheumatoid arthritis synovial membrane cells
Q34795742	Preclinical development of AMG 139, a human antibody specifically targeting IL-23
Q36094756	Prediction of compound-target interactions of natural products using large-scale drug and protein information.
Q90456344	Prediction of the allergic mechanism of haptens via a reaction-substructure-compound-target-pathway network system
Q36351777	Predictive Modeling of Drug Treatment in the Area of Personalized Medicine
Q28077186	Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm
Q35039222	Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission
Q36797353	Presynaptic, release-regulating mGlu2 -preferring and mGlu3 -preferring autoreceptors in CNS: pharmacological profiles and functional roles in demyelinating disease
Q34994537	Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats
Q35978121	Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism
Q36903395	Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats
Q36394997	Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor
Q36547016	Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury
Q35978103	Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats
Q36394973	Propranolol decreases retention of fear memory by modulating the stability of surface glutamate receptor GluA1 subunits in the lateral amygdala
Q34494513	Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
Q37686116	Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP.
Q38722647	Protease-activated receptor 4: from structure to function and back again
Q36797390	Protection against cardiac hypertrophy by geniposide involves the GLP-1 receptor / AMPKα signalling pathway
Q28606782	Protective effect of 23-hydroxybetulinic acid on doxorubicin-induced cardiotoxicity: a correlation with the inhibition of carbonyl reductase-mediated metabolism
Q43200667	Protective effect of exogenous nitrite in postoperative ileus
Q38835918	Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.
Q43114230	Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.
Q34795775	Protective role of olesoxime against wild-type α-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells
Q28647166	Proteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connection
Q43101504	Protons modulate perivascular axo-axonal neurotransmission in the rat mesenteric artery
Q34402767	Purinergic neuromuscular transmission in the gastrointestinal tract; functional basis for future clinical and pharmacological studies
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Q35538485	Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues
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Q35978155	Quinazoline-4-piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells
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Q35911736	Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression
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Q35484280	Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues
Q28274664	Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)
Q35692991	Structural apelin analogues: mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury
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Q35223902	Structure-function analysis of apical membrane-associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control
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Q34795679	Synthetic (+)-antroquinonol exhibits dual actions against insulin resistance by triggering AMP kinase and inhibiting dipeptidyl peptidase IV activities
Q34619444	Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice
Q41761883	TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells
Q43127401	TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery
Q35223934	TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleus
Q34402827	Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer.
Q38866310	Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146.
Q34994532	Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling
Q38231327	Targeting the histone orthography of cancer: drugs for writers, erasers and readers
Q34994509	Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept.
Q26849417	Ten things you should know about protein kinases: IUPHAR Review 14
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Q35978150	The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis
Q35484349	The Ca(2+) channel inhibitor 2-APB reverses β-amyloid-induced LTP deficit in hippocampus by blocking BAX and caspase-3 hyperactivation
Q37005139	The D1CT-7 mouse model of Tourette syndrome displays sensorimotor gating deficits in response to spatial confinement
Q36903392	The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.
Q35978114	The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis
Q42594089	The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells
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Q28603128	The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
Q47139831	The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.
Q91135369	The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY
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Q41374415	The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives
Q26770007	The Warburg effect and drug resistance
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Q37682000	The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels
Q35911754	The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors.
Q42070708	The behavioural response of mice lacking NK₁ receptors to guanfacine resembles its clinical profile in treatment of ADHD.
Q41865064	The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice
Q40559527	The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced obesity in rats
Q38258238	The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism
Q38927458	The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells
Q34914286	The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death
Q38263517	The contribution of astrocytes and microglia to traumatic brain injury
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Q26822987	The effects of microRNA on the absorption, distribution, metabolism and excretion of drugs
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Q37682003	The endocannabinoid system regulates synaptic transmission in nucleus accumbens by increasing DAGL-α expression following short-term morphine withdrawal
Q35631478	The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia.
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Q34795724	The role of adenylyl cyclase isoform 6 in β-adrenoceptor signalling in murine airways
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Q41762813	The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue
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Q37686313	The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma.
Q36342116	The virtual heart as a platform for screening drug cardiotoxicity
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Q28081591	Therapeutic targets of triple-negative breast cancer: a review
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Q34419654	Therapeutic use of botulinum toxin in migraine: mechanisms of action
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Q37686150	Time-dependent activation of prostacyclin and nitric oxide pathways during continuous i.v. infusion of serelaxin (recombinant human H2 relaxin)
Q36124220	Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus
Q35846211	Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis
Q42593944	Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension
Q35974649	Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome
Q39034639	Toward the next step in G protein-coupled receptor research: a knowledge-driven analysis for the next potential targets in drug discovery.
Q35484265	Transdermal patches: history, development and pharmacology.
Q39963734	Translational mixed-effects PKPD modelling of recombinant human growth hormone - from hypophysectomized rat to patients.
Q34619478	Treatment with LPS plus INF-γ induces the expression and function of muscarinic acetylcholine receptors, modulating NIH3T3 cell proliferation: participation of NOS and COX.
Q34914207	Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation.
Q36797382	Trimetazidine does not alter metabolic substrate oxidation in cardiac mitochondria of target patient population.
Q36506880	Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1
Q34994529	Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.
Q38400921	Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors.
Q34402789	Ulinastatin activates haem oxygenase 1 antioxidant pathway and attenuates allergic inflammation
Q38768616	Ultra-rare genetic variation in common epilepsies: a case-control sequencing study
Q35161111	Unravelling the theories of pre-eclampsia: are the protective pathways the new paradigm?
Q28308192	Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7
Q35223911	Urinary bladder inflammation induces changes in urothelial nerve growth factor and TRPV1 channels
Q38973928	Ursodeoxycholyl lysophosphatidylethanolamide attenuates hepatofibrogenesis by impairment of TGF-β1/Smad2/3 signalling
Q35978134	Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches
Q37441534	Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model
Q34402797	Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370
Q92355875	Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz
Q38927398	WMJ-S-001, a novel aliphatic hydroxamate derivative, exhibits anti-inflammatory properties via MKP-1 in LPS-stimulated RAW264.7 macrophages
Q36124216	WTC-01, a novel synthetic oxime-flavone compound, destabilizes microtubules in human nasopharyngeal carcinoma cells in vitro and in vivo
Q26998084	What can isolated skeletal muscle experiments tell us about the effects of caffeine on exercise performance?
Q38646773	What is the evidence for the role of TRP channels in inflammatory and immune cells?
Q46020276	Why Data Citation Is a Computational Problem.
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Q34795766	YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells
Q35865429	Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity
Q35846216	cAMP-dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide
Q27001653	p38 MAPK in cardioprotection - are we there yet?
Q35223945	Δ(9) Tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells
Q41373553	α-Galactosylceramide suppresses murine eosinophil production through interferon-γ-dependent induction of NO synthase and CD95.
Q42356377	α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats
Q37686129	α1B -Adrenoceptor signalling regulates bone formation through the up-regulation of CCAAT/enhancer-binding protein δ expression in osteoblasts.
Q42176718	α7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation
Q37084535	β-Arrestin 2 dependence of δ opioid receptor agonists is correlated with alcohol intake
Q36211207	β-Blockers have differential effects on the murine asthma phenotype
Q38849244	δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine.
Q41813091	δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes
Q35039212	κ-Opioid receptors are not necessary for the antidepressant treatment of neuropathic pain
Q34914351	σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain

P8978	DBLP publication ID	journals/nar/PawsonSBFABDMPSSYHN14
P356	DOI	10.1093/NAR/GKT1143
P3181	OpenCitations bibliographic resource ID	281297
P932	PMC publication ID	3965070
P698	PubMed publication ID	24234439
P5875	ResearchGate publication ID	262045204

P50	author	Helen E Benson	Q55475662
		Elena Faccenda	Q55475664
		Joanna L. Sharman	Q55475667
		Christopher Southan	Q28133217
		Michael Spedding	Q42388779
		Adam J Pawson	Q42660485
		Steve Alexander	Q42922475
		Anthony P Davenport	Q43161913
P2093	author name string	Anthony J Harmar
		John A Peters
		John C McGrath
		NC-IUPHAR
		O Peter Buneman
		Wenyuan Yu
P2860	cites work	Novelty in the target landscape of the pharmaceutical industry	Q57338670
		Open Babel: An open chemical toolbox	Q21198766
		IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels	Q24259024
		The Protein Data Bank	Q24515306
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		International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands	Q24605072
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P275	copyright license	Creative Commons Attribution 3.0 Unported	Q14947546
P6216	copyright status	copyrighted	Q50423863
P433	issue	Database issue
P407	language of work or name	English	Q1860
P921	main subject	pharmacology	Q128406
		knowledge base	Q593744
		IUPHAR/BPS Guide to PHARMACOLOGY	Q17091219
P304	page(s)	D1098-106
P577	publication date	2014-01-01
P1433	published in	Nucleic Acids Research	Q135122
P1476	title	The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
P478	volume	42

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

scientific article (publication date: 2014)

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