Tumor necrosis factor α inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis

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Tumor necrosis factor α inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...738136S
P356DOI10.1371/JOURNAL.PONE.0038136
P932PMC publication ID3365004
P698PubMed publication ID22675442
P5875ResearchGate publication ID225276572

P50authorSubhankar MukhopadhyayQ59487610
Wendy S GarrettQ91152376
Adam Lacy-HulbertQ41770819
P2093author name stringBobby J Cherayil
Estela Trebicka
Lijian Wang
Carey Ann Gallini
Shiri Ellenbogen
Nanda Kumar N Shanmugam
P2860cites workInterleukin-6 induces hepcidin expression through STAT3Q24296906
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cellsQ24299672
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulationQ24301291
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signalQ24301688
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expressionQ24316099
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidinQ24568204
A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelAQ24610268
STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.Q52576434
Iron absorption and distribution in TNFΔARE/+ mice, a model of chronic inflammationQ62066198
Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophagesQ79234100
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune systemQ24680733
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balanceQ24682390
Hepcidin and iron regulation, 10 years laterQ27690828
Bone morphogenetic protein receptors and signal transductionQ28258965
Lack of the bone morphogenetic protein BMP6 induces massive iron overloadQ28510138
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensingQ28510853
Diagnosis and management of iron deficiency anemia in patients with IBD.Q34141999
Host-mediated regulation of superinfection in malariaQ34356504
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expressionQ34658174
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.Q34876574
Iron homeostasis and the inflammatory responseQ35024676
The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel diseaseQ35116191
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrinsQ36013422
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expressionQ36539421
Iron depletion limits intracellular bacterial growth in macrophagesQ36787471
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteinsQ36838785
Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferiQ37334631
Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in miceQ37403137
Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammationQ37458338
Regulation of hepcidin and iron-overload diseaseQ37463068
Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB.Q37467764
Iron sequestration and anemia of inflammationQ37604592
Role of the tumor necrosis factor antagonists in the treatment of inflammatory bowel disease: an updateQ37604844
The iron efflux protein ferroportin regulates the intracellular growth of Salmonella entericaQ40290550
Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replicationQ40346674
Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infectionQ40404046
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolismQ41871982
Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alphaQ42507445
Serum hepcidin and prohepcidin concentrations in inflammatory bowel diseaseQ44215391
Hepcidin and inflammatory bowel disease: dual role in host defence and iron homoeostasisQ46099907
Hepcidin is regulated during blood-stage malaria and plays a protective role in malaria infectionQ47994913
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcolitisQ2453464
murine modelQ122890741
P304page(s)e38136
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleTumor necrosis factor α inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis
P478volume7

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cites work (P2860)
Q43735862Anti-mouse CD52 monoclonal antibody ameliorates iron-deficient anaemia in IL-10 knockout mice
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Q37689953Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients
Q64086672Curcumin induces mild anemia in a DSS-induced colitis mouse model maintained on an iron-sufficient diet
Q37057480Effects of Testosterone on Erythropoiesis in a Female Mouse Model of Anemia of Inflammation
Q54695719Expression of iron-related proteins in the duodenum is up-regulated in patients with chronic inflammatory disorders.
Q36326588Helicobacter pylori infection and low dietary iron alter behavior, induce iron deficiency anemia, and modulate hippocampal gene expression in female C57BL/6 mice
Q90417221Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communication
Q53504354In-vivo monitoring of acute DSS-Colitis using Colonoscopy, high resolution Ultrasound and bench-top Magnetic Resonance Imaging in Mice.
Q33940769Intestinal inflammation modulates expression of the iron-regulating hormone hepcidin depending on erythropoietic activity and the commensal microbiota
Q34548797Iron and inflammation - the gut reaction
Q59808741Iron in the Tumor Microenvironment-Connecting the Dots
Q36056154Pathophysiology of Iron Homeostasis during Inflammatory States
Q37362772Serum-induced up-regulation of hepcidin expression involves the bone morphogenetic protein signaling pathway
Q92454557Supercritical Fluid Extract of Angelica sinensis and Zingiber officinale Roscoe Ameliorates TNBS-Induced Colitis in Rats
Q37464105The liver: conductor of systemic iron balance
Q37683823The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6.