Anti-tumor effects of metformin in animal models of hepatocellular carcinoma: a systematic review and meta-analysis

scientific article

Anti-tumor effects of metformin in animal models of hepatocellular carcinoma: a systematic review and meta-analysis is …
instance of (P31):
scholarly articleQ13442814
systematic reviewQ1504425
review articleQ7318358
meta-analysisQ815382

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P819ADS bibcode2015PLoSO..1027967L
P356DOI10.1371/JOURNAL.PONE.0127967
P932PMC publication ID4451077
P698PubMed publication ID26030161
P5875ResearchGate publication ID277902468

P50authorPratika Y HernandaQ85267879
Maikel P PeppelenboschQ51363232
Wichor M. BramerQ35703475
Qiuwei PanQ39066373
P2093author name stringJuan Li
Judith van Luijk
P2860cites workMetformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablationQ83247914
Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway.Q39275139
Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studiesQ39317976
Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC.Q39340562
Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.Q39370938
Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 miceQ42250436
Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinomaQ42276934
Preventive effect of Metformin against N-nitrosodiethylamine-initiated hepatocellular carcinoma in ratsQ42557069
Metformin and reduced risk of hepatocellular carcinoma in diabetic patients: a meta-analysis.Q45909685
In vitro and in vivo antitumoral action of metformin on hepatocellular carcinomaQ46473638
Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo.Q51786739
Role of AMP-activated protein kinase in mechanism of metformin actionQ22241898
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressQ24633606
Sorafenib in advanced hepatocellular carcinomaQ27861075
Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cellsQ28534922
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trialQ29547903
AMP-activated protein kinase suppresses the in vitro and in vivo proliferation of hepatocellular carcinomaQ31158130
Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical tQ34023560
SYRCLE's risk of bias tool for animal studiesQ35130894
The Effect of Metformin Treatment on CRBP-I Level and Cancer Development in the Liver of HBx Transgenic MiceQ37297707
Anti-diabetic medications and the risk of hepatocellular cancer: a systematic review and meta-analysisQ38079130
Rationale of personalized immunosuppressive medication for hepatocellular carcinoma patients after liver transplantationQ38174585
Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivoQ38997403
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
liver neoplasmQ18558073
systematic reviewQ1504425
hepatocellular carcinomaQ1148337
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)e0127967
P577publication date2015-06-01
P1433published inPLOS OneQ564954
P1476titleAnti-tumor effects of metformin in animal models of hepatocellular carcinoma: a systematic review and meta-analysis
P478volume10