An indirubin derivative, indirubin-3'-monoxime suppresses oral cancer tumorigenesis through the downregulation of survivin

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An indirubin derivative, indirubin-3'-monoxime suppresses oral cancer tumorigenesis through the downregulation of survivin is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...870198L
P356DOI10.1371/JOURNAL.PONE.0070198
P932PMC publication ID3742732
P698PubMed publication ID23967071
P5875ResearchGate publication ID256073025

P2093author name stringWan-Yu Lo
Nai-Wen Chang
P2860cites workControl of apoptosis and mitotic spindle checkpoint by survivinQ22008570
Global cancer statisticsQ22241238
HBXIP functions as a cofactor of survivin in apoptosis suppressionQ24303423
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the familyQ24670396
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cellsQ28346772
IAP proteins: blocking the road to death's doorQ29619844
The specificities of protein kinase inhibitors: an updateQ30014834
IAP regulation of metastasisQ33638504
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cellsQ33770989
The plasminogen activation system in tumor growth, invasion, and metastasisQ34008816
Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell.Q34157601
Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in ChinaQ35103342
Signaling pathways responsible for cancer cell invasion as targets for cancer therapyQ35793957
Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicineQ35876121
State-of-the-art management of locally advanced head and neck cancerQ36104471
4-nitroquinoline-1-oxide induced experimental oral carcinogenesis.Q36382888
Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.Q37098746
The importance of determining the aggressiveness of prostate cancer using serum and tissue molecular markersQ37135804
Cancer cells survive with survivinQ37185505
Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesisQ37255286
Survivin multifaceted activity in head and neck carcinoma: current evidence and future therapeutic challengesQ37424024
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The role of focal adhesion kinase in tumor initiation and progression.Q37582150
Crude extracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathwayQ39541448
Safrole induces apoptosis in human oral cancer HSC-3 cells.Q39617685
Up-regulation of survivin in oral squamous cell carcinoma correlates with poor prognosis and chemoresistanceQ39651833
Evaluation of survivin as a prognostic marker in oral squamous cell carcinomaQ39755799
Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9.Q39878536
Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cellsQ39996865
Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK.Q40126914
An IAP-IAP complex inhibits apoptosisQ40541576
Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activityQ40886640
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinasesQ40918567
Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivoQ42905361
(-)-Epigallocatechin-3-gallate decreases thrombin/paclitaxel-induced endothelial tissue factor expression via the inhibition of c-Jun terminal NH2 kinase phosphorylationQ43234514
Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesisQ43258735
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?Q43507724
Quantitative detection of serum survivin and its relationship with prognostic factors in ovarian cancer.Q44157108
Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44.Q46611975
Phase I clinical trial of survivin-derived peptide vaccine therapy for patients with advanced or recurrent oral cancer.Q51739914
Indirubin-3'-oxime induces mitochondrial dysfunction and triggers growth inhibition and cell cycle arrest in human neuroblastoma cells.Q53136248
Survivin expression predicts poorer prognosis in patients with areca quid chewing-related oral squamous cell carcinoma in Taiwan.Q53357514
5'-Nitro-indirubinoxime, an indirubin derivative, suppresses metastatic ability of human head and neck cancer cells through the inhibition of Integrin β1/FAK/Akt signaling.Q54598990
Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic miceQ73693790
Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerizationQ74190401
Serum and urine survivin levels in breast cancerQ79182821
Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: a possible relationshipQ80146078
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectlip and oral cavity carcinomaQ55790434
P304page(s)e70198
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titleAn indirubin derivative, indirubin-3'-monoxime suppresses oral cancer tumorigenesis through the downregulation of survivin
P478volume8

Reverse relations

cites work (P2860)
Q50163458Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression
Q26784341Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases
Q47831357Proteomic analysis of oral cancer reveals new potential therapeutic targets involved in the Warburg effect.
Q33627725Stable Internal Reference Genes for Normalizing Real-Time Quantitative PCR in Baphicacanthus cusia under Hormonal Stimuli and UV Irradiation, and in Different Plant Organs.
Q38988591The Role of Indirubins in Inflammation and Associated Tumorigenesis.

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