A novel respiratory syncytial virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models

scientific article

A novel respiratory syncytial virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2015PLoSO..1019509L
P356DOI10.1371/JOURNAL.PONE.0119509
P3181OpenCitations bibliographic resource ID5002096
P932PMC publication ID4368639
P698PubMed publication ID25793508
P5875ResearchGate publication ID274962864

P2093author name stringBodrey Ro
Christine Nelson
Elizabeth Stillman
Jennifer C Woo
Mia MacPhail
Roderick S Tang
Rosemary Sweetwood
Shahin Aslam
Stacie L Lambert
Yuk Man Lei
P2860cites workRespiratory syncytial virus vaccine developmentQ56893551
The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivoQ79485051
Toll-like receptors: linking innate and adaptive immunityQ81808287
Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvantQ21091066
Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titersQ27667876
Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing EpitopesQ27668015
A synthetic adjuvant to enhance and expand immune responses to influenza vaccinesQ28748680
T-cell quality in memory and protection: implications for vaccine designQ30014840
Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infectionQ30442832
Respiratory syncytial virus nephropathy in ratsQ33268031
Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infectionQ33781375
Modulation of adaptive immunity with Toll-like receptorsQ34016666
Molecular and cellular response profiles induced by the TLR4 agonist-based adjuvant Glucopyranosyl Lipid AQ34532064
Palivizumab in the prevention of respiratory syncytial virus diseaseQ34974757
Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cellsQ34977848
IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease.Q35069985
GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adultsQ35669044
Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical interventionQ35778982
An adjuvanted respiratory syncytial virus fusion protein induces protection in aged BALB/c miceQ36500189
Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy--a reviewQ36593301
Adults 65 years old and older have reduced numbers of functional memory T cells to respiratory syncytial virus fusion proteinQ36606731
Respiratory syncytial virus infection in C57BL/6 mice: clearance of virus from the lungs with virus-specific cytotoxic T cellsQ36797478
Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoproteinQ36838539
Fc-receptors as regulators of immunity.Q36991445
Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus.Q37071608
Age-related decline in immunity: implications for vaccine responsivenessQ37150322
Antigen-nonspecific activation of CD8+ T lymphocytes by cytokines: relevance to immunity, autoimmunity, and cancerQ37287399
IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammationQ37562241
Parainfluenza virus type 3 expressing the native or soluble fusion (F) Protein of Respiratory Syncytial Virus (RSV) confers protection from RSV infection in African green monkeysQ37568127
Targeting CD137 enhances vaccine-elicited anti-respiratory syncytial virus CD8+ T cell responses in aged miceQ37587807
Particulate vaccines: on the quest for optimal delivery and immune response.Q37875382
Respiratory syncytial virus infection in adult populationsQ37984109
Evaluation of the safety and immunogenicity in rhesus monkeys of a recombinant malaria vaccine for Plasmodium vivax with a synthetic Toll-like receptor 4 agonist formulated in an emulsionQ38284074
Intranasal proteosome-based respiratory syncytial virus (RSV) vaccines protect BALB/c mice against challenge without eosinophilia or enhanced pathologyQ38958797
Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles.Q39328333
Recombinant respiratory syncytial virus F protein expression is hindered by inefficient nuclear export and mRNA processingQ39746492
Physicochemical characterization and biological activity of synthetic TLR4 agonist formulationsQ39800494
Enhanced humoral and Type 1 cellular immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsionQ39812986
Recombinant respiratory syncytial virus lacking secreted glycoprotein G is attenuated, non-pathogenic but induces protective immunityQ40513366
Vaccination with the RSV fusion protein formulated with a combination adjuvant induces long-lasting protective immunity.Q42235080
Age related changes in T cell mediated immune response and effector memory to Respiratory Syncytial Virus (RSV) in healthy subjects.Q42357177
Duration of antiviral immunity after smallpox vaccinationQ43485360
Comparison of respiratory syncytial virus humoral immunity and response to infection in young and elderly adultsQ43979004
IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responsesQ44918119
Phase 1 study of the safety and immunogenicity of a live, attenuated respiratory syncytial virus and parainfluenza virus type 3 vaccine in seronegative childrenQ45363218
A dose-ranging study of a subunit Respiratory Syncytial Virus subtype A vaccine with and without aluminum phosphate adjuvantation in adults > or =65 years of age.Q45382330
Experimental infection of humans with A2 respiratory syncytial virusQ45571445
Risk factors for severe respiratory syncytial virus infection in elderly personsQ45699277
CpG containing oligodeoxynucleotides are potent adjuvants for parenteral vaccination with the fusion (F) protein of respiratory syncytial virus (RSV).Q45735797
CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infectionQ45757956
Adjuvants influence the quantitative and qualitative immune response in BALB/c mice immunized with respiratory syncytial virus FG subunit vaccineQ45762897
Induction of protective immunity in rodents by vaccination with a prokaryotically expressed recombinant fusion protein containing a respiratory syncytial virus G protein fragmentQ45763190
Safety and immunogenicity of a respiratory syncytial virus subunit vaccine (PFP-2) in ambulatory adults over age 60.Q45765792
Reversal of age-related deficient influenza virus-specific CTL responses and IFN-gamma production by monophosphoryl lipid A.Q45767285
Immunoprophylaxis and immunotherapy of respiratory syncytial virus-infected mice with respiratory syncytial virus-specific immune serumQ45777706
Immunoprophylaxis and immunotherapy of respiratory syncytial virus infection in the cotton rat.Q45828600
Immunity to and frequency of reinfection with respiratory syncytial virusQ45853042
Role of lipopolysaccharide in the induction of type I interferon-dependent cross-priming and IL-10 production in mice by meningococcal outer membrane vesiclesQ48004357
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectvirologyQ7215
P304page(s)e0119509
P577publication date2015-01-01
P1433published inPLOS OneQ564954
P1476titleA novel respiratory syncytial virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models
P478volume10